个人简介

B.S., Caltech, 1964; Ph.D., Harvard University, 1967. Noyes Research Instructor, Caltech, 1967-69; Assistant Professor, 1969-71; Associate Professor, 1971-74; Professor, 1974-2000; Ferkel Professor, 2000-.

研究领域

Chemistry

Major research interests include the development of new instruments and techniques for studies of the structures, reaction dynamics, and properties of organic, inorganic and biological molecules and ions in the gas phase, in solution, and at the air-water interface. Current endeavors include development and application of reagents and methods for structure elucidation of proteins, glycans and lipids, investigations of the structure and reaction dynamics of complex molecules at gas-liquid interfaces, development of instrumentation for in situ elemental and chemical analysis on Mars and Titan, and the development of methods to detect potential biomarkers in cryovolcanic emissions from subsurface oceans on icy moons (e.g. Enceladus). An exciting new experimental methodology being explored involves the use of tailored acoustic fields to trap millimeter droplets in the gas phase for extended periods of time. The technique of field induced droplet ionization, developed in our laboratory, makes it possible to sample intact molecules such as lipids and amphiphilic proteins from the air-water interface of the trapped droplet. This facilitates elucidation of the detailed reaction mechanisms of reactive species such as ozone and hydroxyl radicals with complex molecules at the air-water interface, with applications in environmental science. Photochemical studies can be conducted as well, an example being the elucidation of the mechanism of photodynamic cancer therapy used to treat squamous cell carcinomas of the neck and face. New designs of acoustic levitators will make possible studies in which two droplets are brought together and mix on a sub-millisecond time scale. A contemplated application is the rupture of single cells, followed by mass spectrometric analysis of cell components.

近期论文

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Mass Spectrometric Sampling of a Liquid Surface by Nanoliter Droplet Generation from Bursting Bubbles and Focused Acoustic Pulses: Application to Studies of Interfacial Chemistry . Thomas, Daniel A.; Wang, Lingtao; Goh, Byoungsook; Kim, Eun Sok; Beauchamp, J. L.; Anal. Chem. 2015, Just Accepted, Hydrogen Bonding Constrains Free Radical Reaction Dynamics at Serine and Threonine Residues in Peptides . Thomas, Daniel A.; Sohn, Chang Ho; Gao, Jinshan; Beauchamp, J. L.; J. Phys. Chem. A 2014, 118, 8380-8392 Biomimetic Reagents for the Selective Free Radical and Acid−Base Chemistry of Glycans: Application to Glycan Structure Determination . Gao, Jinshan; Thomas, Daniel A.; Sohn, Chang Ho; Beauchamp, J. L.; J. Am. Chem. Soc. 2013, 135, 10684-10692 Ion Mobility-Mass Spectrometry with a Radial Opposed Migration Ion and Aerosol Classifier (ROMIAC) . Mui, Wilton; Thomas, Daniel A.; Downard, Andrew J.; Beauchamp, J. L.; Seinfeld, John. H.; Flagan, Richard C. Anal. Chem. 2013, 85, 6319-6326 Continuous Flow Ion Mobility Separation with Mass Spectrometric Detection using a nano-Radial Differential Mobility Analyzer at Low Flow Rates . Brunelli, Nicholas; Neidholdt, Evan L.; Giapis, Konstantinos; Flagan, Richard; Beauchamp, J. L. Anal. Chem. 2013, 85, 4335-4341 Designer Reagents for Mass Spectrometry-Based Proteomics: Clickable Cross-Linkers for Elucidation of Protein Structures and Interactions. Sohn, Chang Ho*; Agnew, Heather D.*; Lee, J. Eugene; Sweredoski, Michael J.; Graham, Robert L. J.; Smith, Geoffrey T.; Hess, Sonja; Czerwieniec, Gregg; Loo, Joseph A.; Heath, James R.; Deshaies; Raymond J.; Beauchamp, J. L. *These authors contribute equally to this work. Anal. Chem. 2012, 84, 2662-2669 Click Chemistry Facilitates Formation of Reporter Ions and Simplified Synthesis of Amine-Reactive Multiplexed Isobaric Tags for Protein Quantification. Sohn, Chang Ho; Lee, J. Eugene; Sweredoski, Michael J.; Graham, Robert L. J.; Smith, Geoffrey T.; Hess, Sonja; Czerwieniec, Gregg; Loo, Joseph A.; Deshaies; Raymond J.; Beauchamp, J. L. J. Am. Chem. Soc. 2012, 134, 2672-2680 Studying Interfacial Reactions of Cholesterol Sulfate in an Unsaturated Phosphatidylglycerol Layer with Ozone Using Field Induced Droplet Ionization Mass Spectrometry . Ko, Jae Yoon; Choi, Sun Mi; Rhee, Young Min; Beauchamp, J. L.; Kim, Hugh I. J. Am. Soc. Mass Spectrom. 2012, 23, 141-152 Switched Ferroelectric Plasma Ionizer (SwiFerr) for Ambient Mass Spectrometry. Neidholdt, Evan L.; Beauchamp, J. L. Anal. Chem. 2011, 83, 38-43 Time Resolved Studies of Interfacial Reactions of Ozone with Pulmonary Phospholipid Surfactants Using Field Induced Droplet Ionization Mass Sepctrometry. Kim, Hugh I.; Kim, Hyungjun; Shin, Young Shik; Beegle, Luther W.; Goddard, William A.; Heath, James R.; Kanik, Isik; Beauchamp, J. L. J. Phys. Chem. B. 2010, 114, 9496-9503 Evaporation and Discharge Dynamics of Highly Charged Multicomponent Droplets Generated by Electrospray Ionization . Grimm, Ronald L.; Beauchamp, J. L. J. Phys. Chem. A 2010, 114, 1411-1419 Interfacial Reactions of Ozone with Surfactant Protein B in a Model Lung Surfactant System . Kim, Hugh I.; Kim, Hyungjun; Shin, Young Shik; Beegle, Luther W.; Jang, Seung Soon; Neidholdt, Evan L.; Goddard, William A.; Heath, James R.; Kanik, Isik; Beauchamp, J. L. J. Am. Chem. Soc. 2010, 132, 2254-2263 Ionization Mechanism of the Ambient Pressure Pyroelectric Ion Source (APPIS) and Its Applications to Chemical Nerve Agent Detection. Neidholdt, Evan L.; Beauchamp, J. L. J. Am. Soc. Mass. Spectrom. 2009, 20, 2093-2099 Probing the Mechanism of Electron Capture and Electron Transfer Dissociation Using Tags with Variable Electron Affinity . Sohn, Chang Ho; Chung, Cheol K.; Yin, Sheng; Ramachandran, Prasanna; Loo, Joseph A.; Beauchamp, J. L. J. Am. Chem. Soc. 2009, 131, 5444-5459 Also, the paper was featured in Analytical Chemistry. Mapping Disulfide Bonds in Insulin with the Route 66 Method: Selective Cleavage of S-C Bonds Using Alkali and Alkaline Earth Metal Enolate Complexes. Kim, Hugh I.;Beauchamp, J. L. J. Am. Soc. Mass Spectrom. 2009, 20, 157-166 Cover Article An Experimental and Theoretical Investigation into the Correlation between Mass and Ion Mobility for Choline and Other Ammonium Cations in N2. Kim, Hyungjun*; Kim, Hugh I.*; Johnson, Paul V.; Beegle, Luther W.; Beauchamp, J. L.; Goddard, W. A.; and kanik, I. *Authors equal contribution Analytical Chemistry 2008, 80, 1928-1936 Identifying the Presence of a Disulfide Linkage in Peptides by the Selective Elimination of Hydrogen Disulfide from Collisionally Activated Alkali and Alkaline Earth Metal Complexes. Kim, Hugh I.;Beauchamp, J. L. Journal of the American Chemical Society 2008, 130, 1245-1257 Cluster Phase Chemistry: Collisions of Vibrationally Excited Cationic Dicarboxylic Acid Cluster with Water Molecules Initiate Dissociation of Cluster Components. Kim, Hugh I.;Beauchamp, J. L. Journal of Physical Chemistry A 2007, 111, 5954-5967. Ambient Pressure Pyroelectric Ion Source for Mass Spectrometry. Neidholdt, Evan L.; Beauchamp J. L. Analytical Chemistry 2007, 79, 3945-3948. Probing Interfacial Chemistry of Single Droplets with Field-Induced Droplet Ionization Mass Spectrometry: Physical Adsorption of Polycyclic Aromatic Hydrocarbons, and Ozonolysis of Oleic Acid and Related Compounds.. Grimm, Ronald L.; Hodyss, Robert; Beauchamp J. L. Analytical Chemistry 2006, 78, 3800-3806.