Xia, Yan - Stanford University - Department of Chemistry

个人简介

Prof. Xia studied chemistry at Peking University (B.S. 2002), McMaster University (M.S. 2005), and Caltech (Ph.D. 2010). Following his PhD, he worked at Dow Chemical and MIT before joining the chemistry faculty at Stanford in the summer of 2013. His longstanding research interest is to develop novel organic materials at the interface of chemistry and materials science.

研究领域

Designing and synthesizing exotic small and giant molecules for unusual properties, Associate Professor Yan Xia works at the interface of chemistry and materials science. His research combines catalysis, organic and polymer chemistry, and a range of advanced characterizations to create, control, and study novel (macro)molecular structures and organic materials with tailored conformations, nanostructures, properties, and functions. These new soft materials have interesting and unusual properties/functions for applications in energy-efficient molecular separations, sustainable plastics, electronics, and therapeutics. Research in the Xia Group combines vigorous function-driven syntheses, rational molecular design, and in-depth understanding of (macro)molecular reactivity, property, and function. Powerful synthetic methods are the enabling force behind their development of novel organic materials. They have developed various types of chemistry to generate diverse molecular ladder materials with high microporosity, antiaromaticity, or responsive behaviors; polymers with controlled microstructures and degradation; dynamic polymer networks and hydrogels.

近期论文

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A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization. Nature chemistry Feist, J. D., Lee, D. C., Xia, Y. 2021 Predictably Engineering the Viscoelastic Behavior of Dynamic Hydrogels via Correlation with Molecular Parameters. Advanced materials (Deerfield Beach, Fla.) Lou, J., Friedowitz, S., Will, K., Qin, J., Xia, Y. 2021: e2104460 Understanding the Mechanochemistry of Ladder-Type Cyclobutane Mechanophores by Single Molecule Force Spectroscopy. Journal of the American Chemical Society Horst, M., Yang, J., Meisner, J., Kouznetsova, T. B., Martinez, T. J., Craig, S. L., Xia, Y.2021 Bicyclohexene-peri-naphthalenes: Scalable Synthesis, Diverse Functionalization, Efficient Polymerization, and Facile Mechanoactivation of Their Polymers. Journal of the American Chemical Society Yang, J., Horst, M., Werby, S. H., Cegelski, L., Burns, N. Z., Xia, Y. 2020; 142 (34): 14619–26 Enol Ethers Are Effective Monomers for Ring-Opening Metathesis Polymerization: Synthesis of Degradable and Depolymerizable Poly(2,3-dihydrofuran). Journal of the American Chemical Society Feist, J. D., Xia, Y. 2020 The cascade unzipping of ladderane reveals dynamic effects in mechanochemistry. Nature chemistry Chen, Z., Zhu, X., Yang, J., Mercer, J. A., Burns, N. Z., Martinez, T. J., Xia, Y. 2020 Precise Placement of Single Monomer Units in Living Ring-Opening Metathesis Polymerization CHEM Elling, B. R., Su, J. K., Feist, J. D., Xia, Y. 2019; 5 (10): 2691–2701 Dynamic Hyaluronan Hydrogels with Temporally Modulated High Injectability and Stability Using a Biocompatible Catalyst. Advanced materials (Deerfield Beach, Fla.) Lou, J., Liu, F., Lindsay, C. D., Chaudhuri, O., Heilshorn, S. C., Xia, Y. 2018; 30 (22): e1705215 Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene Science Chen, Z., Mercer, J. A., Zhu, X., Romaniuk, J. A., Pfattner, R., Cegelski, L., Martinez, T. J., Burns, N. Z., Xia, Y. 2017; 357 (6350): 475-479 Regioselective Synthesis of [3]Naphthylenes and Tuning of Their Antiaromaticity. Journal of the American Chemical Society Jin, Z. n., Teo, Y. C., Teat, S. J., Xia, Y. n. 2017; 139 (44): 15933–39 Efficient Synthesis of Rigid Ladder Polymers via Palladium Catalyzed Annulation. Journal of the American Chemical Society Liu, S., Jin, Z., Teo, Y. C., Xia, Y. 2014; 136 (50): 17434-17437 Comparative experimental and computational study of synthetic and natural bottlebrush polyelectrolyte solutions. The Journal of chemical physics Horkay, F., Chremos, A., Douglas, J. F., Jones, R., Lou, J., Xia, Y. 2021; 155 (7): 074901 Enhancing Mechanical and Combustion Performance of Boron/Polymer Composites via Boron Particle Functionalization. ACS applied materials & interfaces Jiang, Y., Dincer Yilmaz, N. E., Barker, K. P., Baek, J., Xia, Y., Zheng, X. 2021 Mechanochemical generation of acid-degradable poly(enol ether)s CHEMICAL SCIENCE Yang, J., Xia, Y. 2021; 12 (12): 4389–94 Engineered Matrices Enable the Culture of Human Patient-Derived Intestinal Organoids ADVANCED SCIENCE Hunt, D. R., Klett, K. C., Mascharak, S., Wang, H. Y., Gong, D., Lou, J., Li, X., Cai, P. C., Suhar, R. A., Co, J. Y., LeSavage, B. L., Foster, A. A., Guan, Y., Amieva, M. R., Peltz, G., Xia, Y., Kuo, C. J., Heilshorn, S. C.2021 Polymerization of Cyclopropenes: Taming the Strain for the Synthesis of Controlled and Sequence-Regulated Polymers. Accounts of chemical research Elling, B. R., Su, J. K., Xia, Y. 2020 Mechanochemical synthesis of an elusive fluorinated polyacetylene. Nature chemistry Boswell, B. R., Mansson, C. M., Cox, J. M., Jin, Z., Romaniuk, J. A., Lindquist, K. P., Cegelski, L., Xia, Y., Lopez, S. A., Burns, N. Z.2020 Ring-Opening Metathesis Polymerization of 1,1-Disubstituted 1-Methylcyclopropenes MACROMOLECULES Su, J. K., Lee, S., Elling, B. R., Xia, Y. 2020; 53 (14): 5833–38 Catalytic Arene (oxa)Norbornene Annulation (CANAL) TRENDS IN CHEMISTRY Leibham, A. M., Xia, Y. 2020; 2 (7): 680–81 Systematic investigation of synthetic polyelectrolyte bottlebrush solutions by neutron and dynamic light scattering, osmometry, and molecular dynamics simulation. The Journal of chemical physics Horkay, F., Chremos, A., Douglas, J. F., L Jones, R., Lou, J., Xia, Y. 2020; 152 (19): 194904