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陈春英 研究员 收藏
中国科学院国家纳米科学中心    
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个人简介

陈春英,国家纳米科学中心研究员、博士生导师。1996年获得华中理工大学生物医学工程专业医学博士学位。1996年11月至2006年5月,中国科学院高能物理研究所博士后并留所工作;2001年9月-2002年9月,瑞典卡罗林斯卡大学诺贝尔医学生物化学研究所博士后。2006年6月加入国家纳米科学中心。先后主持科技部973项目、国家仪器专项、国家自然科学基金、欧盟第六、第七框架计划(EU-FP6&FP7 )、国际原子能机构协调研究计划(IAEA)等多项国内与国际合作项目。中国毒理学会及国际纯粹与应用化学联合会员,担任《Metallomics》、《Nanotoxicology》、《Particle and Fibre Toxicology》和《Current Drug Metabolism》编委。相关研究成果已在Nat Methods, Nat Commun, Chem Soc Rev, Acc Chem Res, PNAS, Nano Lett, Adv Mater, ACS Nano, Small, Biomaterials等国际著名刊物发表学术论文150余篇。中国授权专利14项,国际授权专利1项。2008年获“北京市科学技术二等奖(第二获奖人)”,2011年获“中国标准化杰出人物—创新人物”奖,2012年获“国家自然科学二等奖(第二获奖人)”,2014年获“国家杰出青年科学基金”资助以及“中国青年女科学家奖”,并入选“国家百千万人才工程”、Thomson Reuters公布的“2014年全球高引用科学家”以及“中科院百人计划”。

研究领域

目前主要研究方向:(1)高效低毒抗肿瘤纳米药物的研制及其作用机制的研究;(2)典型纳米材料与生物体相互作用的规律及其影响因素;(3)核分析与同步辐射技术及组学技术用于生物体系纳米颗粒暴露和效应标志物的研究;(4)易感人群环境污染物长期暴露的分子毒理学研究。

近期论文

Ying Liu, Chunying Chen, Pengxu Qian, Xuefei Lu, Baoyun Sun, Xiao Zhang, Liming Wang, Xingfa Gao, Han Li, Zhiyun Chen, JinglongTang, Weijie Zhang, Jinquan Dong, Ru Bai, Peter E. Lobie, Qingfa Wu, Suling Liu, Huafeng Zhang, Feng Zhao, Max S. Wicha, Tao Zhu*, Yuliang Zhao*. Gd-metallofullerenol nanomaterial as a non-toxic breast cancer stem cell specific inhibitor. Nature Communications, 2015, 6, 5988. (pdf)   Liming Wang, Qiang Sun, Xin Wang, Tao Wen, Junjie Yin, Pengyang Wang, Ru Bai, Xiang-Qian Zhang, Lu-Hua Zhang, An-Hui Lu*, Chunying Chen*. Using Hollow Carbon Nanospheres as a Light-induced Free Radical Generator to Overcome Chemotherapy Resistance. Journal of the American Chemical Society, 2015, 137(5): 1947-1955. (pdf) Jing Liu, Xiaopeng Zheng, Liang Yan, Liangjun Zhou, Gan Tian, Wenyan Yin, Liming Wang, Ying Liu, Zhongbo Hu, Zhanjun Gu*, Chunying Chen*, Yuliang Zhao*. Bismuth Sulfide Nanorods as a Precision Nanomedicine for in Vivo Multimodal Imaging-Guided Photothermal Therapy of Tumor. ACS Nano, 2015, 9(1): 696-707. (pdf)  Zhenjiang Zhang, Jing Wang, Xin Nie, Tao Wen, Yinglu Ji, Xiaochun Wu, Yuliang Zhao, Chunying Chen*. Near Infrared Laser Induced Targeted Cancer Therapy Using Thermo-Responsive Polymer Encapsulated Gold Nanorods. Journal of the American Chemical Society, 2014, 136(20): 7317-7326. (pdf) Rui Chen, Lingling Huo, Xiaofei Shi, Ru Bai, Zhenjiang Zhang, Yuliang Zhao, Yanzhong Chang*, Chunying Chen*. Endoplasmic Reticulum Stress Induced by Zinc Oxide Nanoparticles Is an Earlier Biomarker for Nanotoxicological Evaluation. ACS Nano, 2014, 8(3): 2562-2574. (pdf)   Liming Wang, Xiaoying Lin, Jing Wang, Zhijian Hu, Yinglu Ji, Shuai Hou, Yuliang Zhao, Xiaochun Wu*, Chunying Chen*. Novel Insights into Combating Cancer Chemotherapy Resistance Using a Plasmonic Nanocarrier: Enhancing Drug Sensitiveness and Accumulation Simultaneously with Localized Mild Photothermal Stimulus of Femtosecond Pulsed Laser. Advanced Functional Materials, 2014, 24, 4229-4239.(front cover) (pdf) Teng Zhou, Meifang Yu, Bo Zhang, Liming Wang, Xiaochun Wu, Hejiang Zhou, Yipeng Du, Junfeng Hao, Yaping Tu, Chunying Chen*, Taotao Wei*. Inhibition of Cancer Cell Migration by Gold Nanorods: Molecular Mechanisms and Implications for Cancer Therapy. Advanced Functional Materials, 2014, 24, 6922-6932. (back cover) (pdf) Chunying Chen, Yu-Feng Li, Ying Qu, Zhifang Chai, Yuliang Zhao*. Advanced nuclear analytical and related techniques for the growing challenges in nanotoxicology. Chemical Society Reviews, 2013, 42(21): 8266-303. (pdf) Ying Liu, Yuliang Zhao, Baoyun Sun*, Chunying Chen*. Understanding the Toxicity of Carbon Nanotubes. Accounts of Chemical Research, 2013, 46 (3): 702–713. (pdf) Liming Wang, Jingyuan Li, Jun Pan, Xiumei Jiang, Yinglu Ji, Yufeng Li, Ying Qu, Yuliang Zhao, Wiaochun Wu*, Chunying Chen*. Revealing the Binding Structure of the Protein Corona on Gold Nanorods Using Synchrotron Radiation-Based Techniques: Understanding the Reduced Damage in Cell Membranes. JACS, 2013, 135, 17359−17368. (pdf) Ligeng Xu, Ye Liu, Zhiyun Chen,Wei Li, Ying Liu, Liming Wang, Liying Ma, Yiming Shao*, Yuliang Zhao*, Chunying Chen*. Morphologically Virus-like Fullerenol Nanoparticles Act as the Dual-functional Nanoadjuvant for HIV-1 Vaccine. Advanced Materials, 2013, 25(41): 5928–5936. (pdf) Zhenjiang Zhang, Jing Wang, Chunying Chen*. Near-Infrared Light-Mediated Nanoplatforms for Cancer Thermo-Chemotherapy and Optical Imaging. Advanced Materials, 2013, 25(28):3869-3880. (pdf)   Seung-gu Kang, Guoqiang Zhou, Ping Yang, Ying Liu, Baoyun Sun, Tien Huynh, Huan Meng, Lina Zhao, Gengmei Xing, Chunying Chen*, Yuliang Zhao*, Ruhong Zhou*. Molecular mechanism of pancreatic tumor metastasis inhibition by Gd@C82(OH)22 and its implication for de novo design of nanomedicine. PNAS, 2012, 109(38): 15431-15436. (Highlighted in this issue of PNAS, 15073–15528 and EMSL http://www.emsl.pnnl.gov/news/viewArticle.jsp?articleId=416) (pdf) Zhenjiang Zhang, Liming Wang, Jing Wang, Xiumei Jiang, Xiaohui Li, Zhijian Hu,Yinglu Ji, Xiaochun Wu*, Chunying Chen*,Mesoporous Silica-coated Gold Nanorods as a Light-mediated Multifunctional Theranostic Platform for Cancer Treatment. Advanced Materials, 2012, 24: 1418-1423. 2012年第11期,cover image, 入选Advanced Materials Most Accessed 12/2011–11/2012,排名第16位. (pdf) Ligeng Xu, Ye Liu, Zhiyun Chen, Wei Li, Ying Liu, Liming Wang, Yong Liu, Xiaochun Wu*, Yinglu Ji, Yuliang Zhao, Liying Ma, Yiming Shao, Chunying Chen*.Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment. Nano Letters, 2012, 12(4): 2003-2012. (pdf)   Cuicui Ge, Jiangfeng Du, Lina Zhao, Liming Wang, Ying Liu, Denghua Li, Yanlian Yang, Yuliang Zhao, Ruhong Zhou*, Yuliang Zhao*, Zhifang Chai, Chunying*. Binding of Blood Proteins to Carbon Nanotubes Reduces Cytotoxicity. PNAS, 2011, 108(41): 16968-16973. Highlight by NPG Asia Materials and Small (pdf)   Liming Wang, Ying Liu, Wei Li, Xiumei Jiang, Yinglu Ji, Xiaochun Wu*, Ligeng Xu, Yang Qiu, Kai Zhao, Taotao Wei, Yufeng Li, Yuliang Zhao, Chunying Chen*. Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy. Nano Letters, 2011, 11(2), 772-780. Highlighted by Nanotimes (pdf) Ying Qu, Wei Li, Yunlong Zhou, Xuefeng Liu, Lili Zhang, Liming Wang, Yu-Feng Li, Atsuo Iida, Zhiyong Tang*, Yuliang Zhao, Zhifang Chai, Chunying Chen*. Full Assessment of Fate and Physiological Behavior of Quantum Dots Utilizing Caenorhabditis elegans as a Model Organism. Nano Letters, 2011, 11(8), 3174-3183. (pdf)   Feng Zhao, Ying Zhao, Ying Liu, Xueling Chang, Chunying Chen*, Yuliang Zhao*. Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials. Small, 2011, 7(10), 1322-1337. 入选Small Most Accessed 12/2011–11/2012,排名第18位. (pdf) Fang Lao; Long Chen; Wei Li; Cuicui Ge; Ying Qu; Quanmei Sun; Yuliang Zhao; Dong Han*; Chunying Chen*. Fullerene nanoparticles selectively enter oxidation-damaged cerebral microvessel endothelial cells and inhibit JNK-related apoptosis. ACS Nano, 2009, 3 (11), 3358–3368. Highlighted by Chemical Research in Toxicology 2010, 23 (1), p5. (pdf)

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