陈弓 - 南开大学 - 元素有机化学国家重点实验室

个人简介

Education 1998 BS, Nanjing University, China 2004 PhD, Columbia University, USA Academic career 2023-present Hongqin Endowered Professor of Chemistry, State Key Laboratory of Elemento-organic Chemistry, Nankai University, China 2015-present Professor, State Key Laboratory of Elemento-organic Chemistry, Nankai University, China 2018-2021 Adjunct professor, The Pennsylvania State University, USA 2014-2015 Associate Professor, Department of Chemistry, The Pennsylvania State University, USA 2008-2014 Assistant Professor, Department of Chemistry, The Pennsylvania State University, USA 2005-2008 Postdoctoral fellow, Memorial Sloan-Kettering Cancer Center, USA Honors ACP lectureship awards in Japan and Malaysia, 2018 National Natural Science Fund for Distinguished Young Scholars of China, 2017 WuXi AppTec Scholar Award in Life Science and Chemistry, 2016 Distinguished Junior Faculty Award by Chinese-American Chemistry & Chemical Biology Professor Association (CAPA), 2014 Amgen Young Investigator Award, 2013 Thieme Chemistry Journal Award, 2011 National Science Foundation (NSF) CAREER Award, 2011

研究领域

Metal catalysis Development of metal-catalyzed C-H functionalization reactions (e.g. Pd, Cu) Metal-catalyzed asymmetric reactions Radical chemistry Development of radical-mediated C-H functionalization reactions (hypervalent iodine chemistry) Other radical-mediated reactions Peptide and carbohydrate Total synthesis of complex peptide natural products (celogentin, hibispeptin) Antibiotic peptides (e.g. mannopeptimycin, teixobactin) Synthetic and biological studies of oligosaccharides (e.g. mannose-6-phosphate)

近期论文

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Formaldehyde-mediated Hydride Liberation of Alkylamines for Intermolecular Reactions in HFIP Shaokun Cai+, Hong Tang+, Bo Li+, Yingbo Shao, Danqi Zhang, Hanliang Zheng, Xin Chu, Gang He, Xiao-Song Xue*, Gong Chen* Submitted.https://chemrxiv.org/engage/chemrxiv/article-details/65132cb6ade1178b242add98 Palladium-Catalyzed Enantioselective Directed C(sp3)−H Functionalization Using C5 ‑Substituted 8‑Aminoquinoline Auxiliaries Yi Huang, Xiaoyan Lv, Hua-Rong Tong, Wenji He, Ziqian Bai, Hao Wang, Gang He,* and Gong Chen* Org. Lett. 2024, 26, 94−99 Ligand-promoted Iron-catalyzed Nitrene Transfer for the Synthesis of Hydrazines and Triazanes through N-Amidation of Arylamines Shi-Yang Zhu, Wen-Ji He, Guan-Chi Shen, Zi-Qian Bai, Fang-Fang Song, Gang He, Hao Wang*, Gong Chen* Angew. Chem., Int. Ed. 2023, e202312465. DOI: 10.1002/anie.202312465. Visible-Light-Promoted Aliphatic C−H Chlorination and Bromination Using Haloform as the Halogen Donor and Azidobenziodoxole as the Mediator Peng Yang+, Qin He+, Zehui Cao+, Yangyang Zhang, Gong Chen*, Yaxin Wang* Adv. Synth. Catal. 2023, ASAP. https://doi.org/10.1002/adsc.202300416. Teraryl Braces in Macrocycles: Synthesis and Conformational Landscape Remodeling of Peptides.Peng Yang, Martynas J. Širvinskas, Bo Li, Nicholas W. Heller, Hua Rong, Gang He, Andrei K. Yudin*, and Gong Chen*J. Am. Chem. Soc. 2023, ASAP. https://doi.org/10.1021/jacs.3c03512 Bioconjugation via Hetero-selective Clamping of Two Amines with ortho-Phthalaldehyde. Xin Chu, Bo Li, Hao-Yang Liu, Xiaowei Sun, Xiaochen Yang, Gang He, Chuanzheng Zhou, Weimin Xuan, Shu-Lin Liu*, and Gong Chen*, Angew. Chem., Int. Ed. 2023, xx, accepted. DOI: 10.1002/anie.202212199 Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols. Ziqian Bai, Shiyang Zhu, Yiyao Hu, Peng Yang, Xin Chu, Gang He, Hao Wang*, and Gong Chen*. Nat. Commun. 2022, 13, 6445. DOI: 10.1039/d2qo01114j Preface – Special topic in asymmetric C-H functionalization (editorial as guest editor). Gong Chen*, and Shigeki Matsunaga*, Synthesis 2022, 54, 4690-4690. DOI: 10.1055/s-0040-1720049 Hypervalent-iodine promoted selective cleavage of C(sp3)–C(sp3) bonds in ethers. Yaxin Wang*, Qin He, Cehui Cao, Peng Wang, Gong Chen*, and Matthias Beller*, Org. Chem. Front 2022, 9, 5592-5598. DOI: 10.1039/d2qo01114j Palladium-Catalyzed Methionine-Facilitated β and γ C(sp3)–H Arylation of N-Terminal Aliphatic Amino Acids of Peptides Xiangxiang Chen, Bo Li, Huarong Tong, Liping Qi, Gang He, Gong Chen. Chin. J. Chem. 2022, 40, 2502-2506. Introduction to ‘Synthesis and chemical biology of macrocycles’ (editorial as guest editor). Gong Chen, Monika Raj, and Andrei Yudin. RSC Chem. Biol. 2022, 3, 993-993. DOI: 10.1039/d2cb90018a Ruthenium-Catalyzed Pyridine-Directed Aryl C–H Glycosylation with Glycosyl Chlorides. Shaokun Cai, Qikai Sun, Quanquan Wang, Gang He* and Gong Chen*. J. Org. Chem. 2022, 87, 8811–8818. Construction of Complex Macromulticyclic Peptides via Stitching with Formaldehyde and Guanidine. Bo Li+, Zhao Wan+, Hanliang Zheng, Shaokun Cai, Hanwen Tian, Hong Tang, Xin Chu, Gang He, Dong-Sheng Guo, Xiao-Song Xue*, and Gong Chen*. (+co-first author) J. Am. Chem. Soc. 2022, 144, 10080–10090. Iron-Catalysed Reductive Cross-Coupling of Glycosyl Radicals for the Stereoselective Synthesis of C-glycosides. Quanquan Wang+, Qikai Sun+, Yi Jiang, Huixing Zhang, Lu Yu, Changlin Tian, Gong Chen*, & Ming Joo Koh* Nat. Synth. 2022, 1, 235–244. (+co-first author) Extendable Stapling of Unprotected Peptides via Crosslinking Two Amines with o-Phthalaldehyde. Bo Li, Lan Wang, Xiangxiang Chen, Xin Chu, Hong Tang, Jie Zhang, Gang He, Li Li*, and Gong Chen* Nat. Commun. 2022, 13, 311. Synthesis of 2-Deoxy-C-Glycosides via Iridium-Catalyzed sp2 and sp3 C–H Glycosylation with Unfunctionalized Glycals. Wanjun Zhu, Qikai Sun, Huixing Zhang, Hai Chang, Hui-Xing Zhang, Quanquan Wang, Gong Chen*, and Gang He*. Chin. J. Chem. 2022, 40, 571-576. Arene C–H Iodination Using 2-Nitrophenyl Iodides as the Iodinating Reagents (highlight) Huarong Tong and Gong Chen*. Chin. J. Org. Chem. 2021, 41, 4103-4104. DOI: 10.6023/cjoc202100077 Construction of Peptide Macrocycles via Palladium-Catalyzed Multiple S-Arylation: An Effective Strategy to Expand the Structural Diversity of Crosslinkers. Xin Chu, Linhua Shen, Bo Li, Peng Yang, Chengzhuo Du, Xiaoye Wang, Gang He, Samir Messaoudi*, and Gong Chen*. Org. Lett. 2021, 23, 8001–8006. Solid Phase Synthesis of Thioether-linked Peptide Macrocycles via Palladium-Catalyzed Intramolecular S-Arylation and S-Alkenylation. Peng Yang, Chao Zhang, Bo Li, Gang He, and Gong Chen*. Asian J. Org. Chem. 2021, 10, 2888-2891. Tunable System for Electrochemical Reduction of Ketones and Phthalimides. Yaxin Wang*, Jianyou Zhao, Qiuping Zhao, Jian Zhang, and Gong Chen. Chin. J. Chem. 2021, 39, 3297-3302. Nitrene-mediated P–N Coupling Under Iron Catalysis Ziqian Bai, Fangfang Song, Hao Wang,* Wangxing Cheng (本科生), Shiyang Zhu, Yi Huang, Gang He, and Gong Chen* CCS Chem. 2021, 3, 2538-2546. DOI: 10.31635/ccschem.021.202101056. Stereoselective Synthesis of C-Vinyl Glycosides via Palladium-Catalyzed C–H Glycosylation of Alkenes Qikai Sun, Huixing Zhang, Quanquan Wang, Tianjiao Qiao, Gang He,* and Gong Chen* Angew. Chem., Int. Ed. 2021, 60, 19620-19625. DOI: 10.1002/anie.202104430 and 10.1002/ange.202104430 Iridium-catalyzed intermolecular N—N coupling for hydrazide synthesis using N-benzoyloxycarbamates as acyl nitrene precursor Fangfang Song, Shiyang Zhu, Hao Wang,* and Gong Chen* Chin. J. Org. Chem. 2021, 41(10), 4050-4058. DOI: 10.6023/cjoc202105045. Photoredox-Mediated Mono- and Difluorination of Remote Unactivated Methylene C(sp3)–H Bonds of N-Alkyl Sulfonamides Zhiqiang Deng, Zhenxiang Zhao, Gang He, Gong Chen* Org. Lett. 2021, 23, 3631-3635. DOI: 10.1021/acs.orglett.1c01020. β-Lactam Synthesis via Copper-Catalyzed Directed Aminoalkylation of Unactivated Alkenes with Cyclobutanone O-Benzoyloximes Heng Zhang, Xiaoyan Lv, Hanrui Yu (本科生), Zibo Bai, Gong Chen*, and Gang He* Org. Lett. 2021,23, 3620-3625. DOI: 10.1021/acs.orglett.1c01007. Streamlined Construction of Peptide Macrocycles via Palladium-catalyzed Intramolecular S-Arylation in Solution and on DNA Peng Yang, Xuan Wang, Bo Li, Yixuan Yang, Jingfeng Yue, Yanrui Suo, Huarong Tong, Gang He, Xiaojie Lu*, and Gong Chen*Chem. Sci., 2021,12, 5804-5810. DOI:10.1039/D1SC00789K. Chiral Bicyclo[2.2.2]octane-FusedCyclopentadienyl Rhodium Complexes: Synthesis and Potential Use in Asymmetric C-H Activation Yi Huang, Gong Chen*Chin. J. Org. Chem. 2021, 41, 420～422 DOI: 10.6023/cjoc202100002 Construction of peptide macrocycles via radical-mediated intramolecular C-H alkylations.Xiafei Hu+, Xiangxiang Chen+, Bo Li, Gang He, and Gong Chen*. (+co-first author)Org. Lett. 2021, 23, 716-721, DOI: 10.1021/acs.orglett.0c03940 Nitrene-mediated Intermolecular N-N coupling for Efficient Synthesis of Hydrazides.Hao Wang, Hoimin Jung, Fangfang Song, Shiyang Zhu, Danye Chen (本科生), Gang He, Sukbok Chang*, and Gong Chen*.Nat. Chem. 2021, 13, 378-385. DOI: 10.1038/s41557-021-00650-0. Enantioselective Alkylamination of Unactivated Alkenes under Copper Catalysis.Zibo Bai, Heng Zhang, Hao Wang*, Hanrui Yu (本科生), Gong Chen*, and Gang He*J. Am. Chem. Soc. 2021, 143, 1195-1202. DOI: 10.1021/jacs.0c12333 A Rapid and Sensitive Method for Chiroptical Sensing of -Amino Acids via Click-like Labeling with o-Phthaladehyde and p-Toluenethiol.Bo Li+, Jie Zhangi+, Li Li*, and Gong Chen* (+co-first author) Chem. Sci. 2021, 12, 2504-2508. DOI: 10.1039/D0SC05749E Cooperative Stapling of Native Peptides at Lysine and Tyrosine or Arginine with Formaldehyde.Bo Li, Hong Tang, Aneta Turlik, Zhao Wan, Xiao-Song Xue, Li Li, Xiaoxiao Yang, Jiuyuan Li, Gang He， K.N. Houk*, and Gong Chen* Angew. Chem., Int. Ed. 2021, 60, 6646-6652. DOI: 10.1002/anie.202016267