Brown, M. Kevin - Indiana University - Department of Chemistry

个人简介

Associate Professor at Indiana University 2017-present Assistant Professor at Indiana University 2011-2017 NIH Post-doctoral fellow at Harvard University (with E. J. Corey) 2008-2011 Graduate student at Boston College (with Amir Hoveyda) 2002-2008

研究领域

The Brown group is focused on the development of new methods and strategies for organic chemical synthesis. Inspiration for problem selection comes from the structures of important molecules that are currently difficult, or impossible, to access with current technologies. Our group is broadly interested in three research areas: 1) Stereoselective [2+2] cycloaddition to prepare cyclobutanes, 2) Cu-catalyzed cross-coupling/interrupted cross-coupling reactions, and 3) stereoselective cross-coupling of Csp3-nucleophiles by Pd/Cu synergistic catalysis.

近期论文

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Catalyst Controlled Regiodivergent Arylboration of Dienes Stephen R. Sardini and M. Kevin Brown, J. Am. Chem. Soc. 2017, 139, 9823 Intramolecular Chirality Transfer [2 + 2] Cycloadditions of Allenoates and Alkenes Yao Xu, Young J. Hong, Dean J. Tantillo, and M. Kevin Brown, Org. Lett. 2017, 19, 3703 Regioselective Arylboration of Isoprene and its Derivatives by Cu/Pd Cooperative Catalysis Kevin B. Smith and M. Kevin Brown, J. Am. Chem. Soc., 2017, 139, 7721 Catalytic Enantioselective Arylboration of Alkenylarenes Kaitlyn M. Logan and M. Kevin Brown, Angew. Chem. Int. Ed., 2017, 56, 851-855 Bringing Organic Chemistry to the Public: Structure and Scent in a Science Museum M. Kevin Brown*, and Laura C. Brown*, Karen Jepson-Innes, Michael Lindeau, and Jeremy Stone J. Chem. Educ., 2017, 94, 251–255 Synthesis of Cyclobutanes by Lewis Acid-Promoted Ketene-Alkene [2+2] cycloaddtions Christopher M. Rasik, Eleni Salyers, and M. Kevin Brown, Org. Synth. 2016, 93, 401 Synthesis of 1,3-substituted Cyclobutanes by Allenoate-Alkene [2+2] Cycloaddition Michael L. Conner and M. Kevin Brown, J. Org. Chem., 2016, 81, 8050-8060 An Unexpected Lewis Acid Catalyzed Diels-Alder Cycloaddition of Aryl Allenes and Acrylates Michael L. Conner and M. Kevin Brown, Tetrahedron, 2016, 72, 3759-3765 Collaborative Total Synthesis: Routes to (±)-Hippolachnin A Enabled by Quadricyclane Cycloaddition and Late-Stage C-H Oxidation Monica E. McCallum*, Christopher M. Rasik*, John L. Wood†, and M. Kevin Brown†, J. Am. Chem. Soc., 2016, 138, 2437-2442 Catalytic Enantioselective Diarylation of Alkenes Wei You and M. Kevin Brown, J. Am. Chem. Soc., 2015, 137, 14578-14581 Lewis Acid-Promoted [2+2] Cycloadditions of Alkenes with Arylketenes E. M. Rigsbee, C. Zhou, C. M. Rasik, A. Z. Spitz, A. J. Nichols and M. Kevin Brown, Org. Biomol. Chem., 2016, 14, 5477-5480 Cyclobutane Synthesis by Catalytic Enantioselective [2+2] Cycloaddition Yao Xu and Michael L. Conner and M. Kevin Brown, Angew. Chem. Int. Ed. 2015, 54, 11918-11928. Catalytic Enantioselective Allenoate-Alkene [2+2] Cycloadditions Michael L. Conner*, Yao Xu* and M. Kevin Brown, J. Am. Chem. Soc. 2015, 137, 3482-3485. Copper/Palladium Synergistic Catalysis for the syn- and anti-Selective Carboboration of Alkenes Kaitlyn M. Logan*, Kevin B. Smith* and M. Kevin Brown, Angew. Chem. Int. Ed. 2015, 54, 5228-5231. Total Synthesis of Gracilioether F: Development and Application of Lewis Acid-Promoted Ketene-Alkene [2+2]-Cycloadditions and Late Stage C-H Oxidation Christopher M. Rasik and M. Kevin Brown, Angew. Chem. Int. Ed. 2014, 53, 14522-14526 Diarylation of Alkenes by a Cu-Catalyzed Migratory Insertion/Cross Coupling Cascade Wei You, and M. Kevin Brown, J. Am. Chem. Soc. 2014, 136, 14730–14733 Origins of Diastereoselectivity in Lewis Acid Promoted Ketene–Alkene [2 + 2] Cycloadditions Christopher M. Rasik, Young J. Hong, Dean J. Tantillo, and M. Kevin Brown, Org. Lett. 2014, 16, 5168-5171 Alkene Carboboration Enabled by Synergistic Catalysis Kevin B. Smith, Kaitlyn M. Logan, Wei You, and M. Kevin Brown, Chem. Eur. J. 2014, 20, 12032-12036 Copper-Catalyzed Cross-Coupling of Boronic Esters with Aryl Iodides and Application to a Carboboration of Alkynes and Allenes Yiqing Zhou*, Wei You*, Kevin B. Smith and M. Kevin Brown, Angew. Chem. Int. Ed. 2014, 53, 3475-3479. Intermolecular Ketene-Alkene [2+2] Cycloadditions: The Significance of Lewis Acid-Promoted Variants Christopher M. Rasik and M. Kevin Brown, Synlett. 2014, 25, 760-765. Stereoselective Synthesis of All-Carbon Tetrasubstituted Alkenes from In Situ Generated Ketenes and Organometallic Reagents Wei You, Yan Li and M. Kevin Brown, Org. Lett. 2013,15, 1610–1613. Lewis Acid-Promoted Ketene–Alkene [2 + 2] Cycloadditions Christopher M. Rasik and M. Kevin Brown, J. Am. Chem. Soc. 2013, 135, 1673-1676.