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Functional Calixphyrins: Synthetic Strategies and Applications

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Abstract

Calixphyrins are hybrid macrocycles that contain both sp2- and sp3-hybridized carbon atoms and hence bear analogy to both porphyrins and calixpyrroles. Due to the presence of sp3-hybridized carbon atoms, π-conjugation is disrupted in calixphyrins, which leads to conformational flexibility. Hence, these molecules find a use in anion binding, host-guest chemistry and metal-coordination chemistry. During the last decade, studies on calixphyrins have been a topic of wide interest to researchers. Various functionalities have been introduced to the structure of calixphyrins, leading to the development of expanded calixphyrins, core-modified calixphyrins and N-confused calixphyrins with diverse applications. This review outlines the detailed historical origin of the synthesis of calixphyrins with emphasis on current research and development in this area. The modular syntheses of normal calixphyrins, expanded calixphyrins, core-modified calixphyrins and N-confused calixphyrins are also discussed, along with their applicative aspects.

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Acknowledgements

The author acknowledges Council of Scientific and Industrial Research (CSIR), New Delhi, India for financial support during this research work.

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  1. Department of Chemistry, University of Delhi, Delhi, 110 007, India

    Anchal Singhal

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  1. Anchal Singhal
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Singhal, A. Functional Calixphyrins: Synthetic Strategies and Applications. Top Curr Chem (Z) 376, 21 (2018). https://doi.org/10.1007/s41061-018-0199-y

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