* Corresponding authors

^a State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, No. 2 linggong Road, Ganjingzi, District, Dalian 116023, China
E-mail: liufengyu@dlut.edu.cn

^b Systems Biology Laboratory, Department of Computer Information Science and Engineering, University of Florida, Gainesville, FL, USA
E-mail: suchen@cise.ufl.edu

^c Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, China
E-mail: sunsg@nwsuaf.edu.cn

^d Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, China
E-mail: sunsg@nwsuaf.edu.cn