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MnO nanoparticles with unique excitation-dependent fluorescence for multicolor cellular imaging and MR imaging of brain glioma

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Abstract

The authors describe MnO nanoparticles (NPs) with unique excitation-dependent fluorescence across the entire visible spectrum. These NPs are shown to be efficient optical nanoprobe for multicolor cellular imaging. Synthesis of the NPs is accomplished by a thermal decomposition method. The MnO NPs exhibit a high r1 relaxivity of 4.68 mM−1 s−1 and therefore give an enhanced contrast effect in magnetic resonance (MR) studies of brain glioma. The cytotoxicity assay, hemolysis analysis, and hematoxylin and eosin (H&E) staining tests verify that the MnO NPs are biocompatible. In the authors’ perception, the simultaneous attributes of multicolor fluorescence and excellent MR functionality make this material a promising dual-modal nanoprobe for use in bio-imaging.

A direct method to synthesize fluorescent MnO NPs is reported. The NPs are biocompatible and have been successfully applied for multicolor cellular imaging and MR detection of brain glioma.

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Acknowledgements

The authors gratefully acknowledge the financial supports from the Key Project from Beijing Commission of Education (KZ201610025022), National Natural Science Foundation of China (81271639) and Beijing Natural Science Foundation (7162023). The instrumental supports from the Core Facility Center (CFC) at Capital Medical University are greatly acknowledged.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Capital Medical University, Beijing, 100069, People’s Republic of China

    Junxin Lai, Fengqiang Shi, Wei Gu & Ling Ye

  2. Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, 100093, People’s Republic of China

    Tingjian Wang

  3. Department of Anatomy, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, People’s Republic of China

    Hao Wang

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  1. Junxin Lai
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Correspondence to Wei Gu or Ling Ye.

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Lai, J., Wang, T., Wang, H. et al. MnO nanoparticles with unique excitation-dependent fluorescence for multicolor cellular imaging and MR imaging of brain glioma. Microchim Acta 185, 244 (2018). https://doi.org/10.1007/s00604-018-2779-5

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