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Phytochemical-encapsulated nanoplatform for “on-demand” synergistic treatment of multidrug-resistant bacteria

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Abstract

Though phytochemicals are a promising alternative to traditional antibiotics for combating resistant bacteria, the low water solubility and lack of selectivity seriously hinder their widespread applications. Herein, we constructed a hyaluronidase-activated “on-demand” delivery nanocarrier to encapsulate plant essential oils (PEOs) for the synergistic treatment of multidrug-resistant bacteria. The bioavailability and selectivity of PEOs was enhanced and the antibacterial effect was significantly improved by combining with the photothermal effect of the nanocarrier. This antibacterial system was successfully applied for healing methicillin-resistant Staphylococcus aureus-infected wound with negligible cytotoxicity and biotoxicity in mice. Given the increasing risk of antibiotic resistance, we believe that this phytochemical-encapsulated nanoplatform would provide a long-term solution and be a new powerful tool for skin-associated bacterial infections.

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Acknowledgements

We acknowledge financial support from the National Natural Science Foundation of China (Nos. 21210002, 21431007, 21533008, 21403209, 21601175, and 21673223) and the Jilin Province Science and Technology Development Plan Project (No. 20140101039JC).

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Authors and Affiliations

  1. State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Panpan Sun, Yan Zhang, Xiang Ran, Zhenzhen Wang, Jinsong Ren & Xiaogang Qu

  2. Department of Respiratory Medicine, First Affiliated Hospital, Jilin University, Changchun, 130021, China

    Chaoying Liu

  3. University of Science and Technology of China, Hefei, 230029, China

    Panpan Sun

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  1. Panpan Sun
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  2. Yan Zhang
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  3. Xiang Ran
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  4. Chaoying Liu
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  5. Zhenzhen Wang
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  6. Jinsong Ren
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  7. Xiaogang Qu
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Correspondence to Chaoying Liu, Jinsong Ren or Xiaogang Qu.

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Sun, P., Zhang, Y., Ran, X. et al. Phytochemical-encapsulated nanoplatform for “on-demand” synergistic treatment of multidrug-resistant bacteria. Nano Res. 11, 3762–3770 (2018). https://doi.org/10.1007/s12274-017-1947-y

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  • DOI: https://doi.org/10.1007/s12274-017-1947-y

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