Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Liver cancer

Sensitizing hepatocellular carcinoma to oncolytic virus therapy

Oncolytic viruses have made headlines owing to increasing numbers of reports of clinical success. Compelling data now indicate that small anticancer molecules can serve as potent sensitizers of tumour cells in hepatocellular carcinoma to enhance the oncolytic potential of systemically applied viruses.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Valosin-containing protein inhibitors cooperate with M1 virus to trigger irresolvable endoplasmic reticulum stress and apoptosis in hepatocellular carcinoma cells.

References

  1. NCI-Staff. FDA approves talimogene laherparepvec to treat metastatic melanoma. National Cancer Institutehttps://www.cancer.gov/news-events/cancer-currents-blog/2015/t-vec-melanoma (2015).

  2. Zhang, H. et al. Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma. Sci. Transl Med. 9, eaam7996 (2017).

    Article  PubMed  Google Scholar 

  3. Lin, Y. et al. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc. Natl Acad. Sci. USA 111, E4504–E4512 (2014).

    Article  CAS  PubMed  Google Scholar 

  4. Li, K. et al. Activation of cyclic adenosine monophosphate pathway increases the sensitivity of cancer cells to the oncolytic virus M1. Mol. Ther. 24, 156–165 (2016).

    Article  CAS  PubMed  Google Scholar 

  5. Mahoney, D. J. et al. Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death. Cancer Cell 20, 443–456 (2011).

    Article  CAS  PubMed  Google Scholar 

  6. Tardif, K. D. et al. Hepatitis C virus suppresses the IRE1–XBP1 pathway of the unfolded protein response. J. Biol. Chem. 279, 17158–17164 (2004).

    Article  CAS  PubMed  Google Scholar 

  7. Zhou, H. J. et al. Discovery of a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase (CB-5083). J. Med. Chem. 58, 9480–9497 (2015).

    Article  CAS  PubMed  Google Scholar 

  8. Russell, S. J., Peng, K. W. & Bell, J. C. Oncolytic virotherapy. Nat. Biotechnol. 30, 658–670 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Miest, T. S. & Cattaneo, R. New viruses for cancer therapy: meeting clinical needs. Nat. Rev. Microbiol. 12, 23–34 (2014).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jennifer Altomonte.

Ethics declarations

Competing interests

The author declares no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Altomonte, J. Sensitizing hepatocellular carcinoma to oncolytic virus therapy. Nat Rev Gastroenterol Hepatol 15, 8–10 (2018). https://doi.org/10.1038/nrgastro.2017.153

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2017.153

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research