Libraries of functionalized small-molecule fragments that can be screened in whole cells could take phenotypic drug discovery to the next level, providing new opportunities against undertargeted proteins.
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Baker, M. Fragment-based phenotypic screening is a hit. Nat Rev Drug Discov 16, 225–226 (2017). https://doi.org/10.1038/nrd.2017.56
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DOI: https://doi.org/10.1038/nrd.2017.56
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