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Peroxidase-like active Cu-ZIF-8 with rich copper(I)-nitrogen sites for excellent antibacterial performances toward drug-resistant bacteria

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Abstract

Bacterial pathogens pose a serious threat to human health, and there is an urgent need to develop highly effective antibacterial materials to eliminate the increasingly serious contamination of drug-resistant bacteria. Here, a Cu-doped ZIF-8 particle with unsaturated copper exhibits high peroxidase-like activity. 99.998% antibacterial efficiency against S. aureus can be achieved for 30 min at a low concentration of 50 µg·mL−1, as well as complete sterilization against E. coli (up to 8 log). 99.999% antibacterial efficiency against Methicillin-resistant Staphylococcus aureus can be achieved, performing orders of magnitude higher than Vancomycin. The mechanism shows that the unsaturated Cu-Nx sites are enzyme-like active centers, which could promote the consumption of bacteria reducing substances by H2O2, and the generated *OH further aggravates bacterial oxidative stress and membrane damage. More importantly, the oxidation activity of adsorbed oxygen species on Cu-ZIF-8 is enhanced by charge transfer and structural changes between the ligand and copper center like natural enzymes. Cu-doped ZIF-8 with peroxidase-like activity shows great potential in antibacterial application and the revealed catalytic mechanism is helpful for understanding the high antibacterial activity of nanoparticles with Cu-Nx sites.

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Acknowledgements

This work was financially supported by the National Key R&D Program of China (No. 2022YFC3702800), Beijing Natural Science Foundation (No. 2232017) and the research fund of State Key Laboratory of Mesoscience and Engineering (Nos. MESO-23-A07, and MESO-23-T02).

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Authors and Affiliations

  1. State Key Laboratory of Mesoscience and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China

    Xiaoze Wang, Jingkun Zhang, Ning Han, Wenjun Ma, Donghai Zhang, Mingshui Yao & Yunfa Chen

  2. University of the Chinese Academy of Sciences, Beijing, 100049, China

    Xiaoze Wang, Jingkun Zhang, Ning Han, Wenjun Ma, Donghai Zhang, Mingshui Yao & Yunfa Chen

  3. Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory of Nanosystem and Hierarchial Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China

    Hui Wang

  4. China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100021, China

    Xianliang Wang

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Correspondence to Mingshui Yao, Xianliang Wang or Yunfa Chen.

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Peroxidase-like active Cu-ZIF-8 with rich copper(I)-nitrogen sites for excellent antibacterial performances toward drug-resistant bacteria

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Wang, X., Wang, H., Zhang, J. et al. Peroxidase-like active Cu-ZIF-8 with rich copper(I)-nitrogen sites for excellent antibacterial performances toward drug-resistant bacteria. Nano Res. (2024). https://doi.org/10.1007/s12274-024-6699-x

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