Issue 21, 2024
From the journal:

RSC Advances

Recent progress and prospects in the organocatalytic Morita–Baylis–Hillman reaction

Mohammed Maneesha,a   S. H. Haritha,b   Thaipparambil Aneejaa  and  Gopinathan Anilkumar ORCID logo *ac  

* Corresponding authors

a School of Chemical Sciences, Mahatma Gandhi University, Priyadarsini Hills P. O., Kottayam, Kerala 686560, India
E-mail: anilgi1@yahoo.com, anil@mgu.ac.in

b Postgraduate Department of Chemistry, Sree Narayana College, Sivagiri, Sreenivasapuram P. O., Varkala, Thiruvananthapuram, Kerala 695145, India

c Institute for Integrated Programs and Research in Basic Sciences (IIRBS), Mahatma Gandhi University, Priyadarsini Hills P. O., Kottayam, Kerala 686560, India

Abstract

The organocatalytic asymmetric Morita–Baylis–Hillman (MBH) reaction produces a significant carbon–carbon bond formation that involves the addition of α,β-unsaturated carbonyl compounds to activated alkenes to give α-methylene-β-hydroxycarbonyl compounds. Commercially available starting materials, excellent atom economy, mild reaction conditions, and flexible products are the major highlights of this method. In this review, we discuss the recent developments in the organocatalytic MBH reaction, covering literature from 2018 to 2023.

Graphical abstract: Recent progress and prospects in the organocatalytic Morita–Baylis–Hillman reaction

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Article information

DOI
https://doi.org/10.1039/D4RA02369B
Article type
Review Article
Submitted
28 Mar 2024
Accepted
23 Apr 2024
First published
08 May 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 14949-14963

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Recent progress and prospects in the organocatalytic Morita–Baylis–Hillman reaction

M. Maneesha, S. H. Haritha, T. Aneeja and G. Anilkumar, RSC Adv., 2024, 14, 14949 DOI: 10.1039/D4RA02369B

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