Issue 20, 2024
From the journal:

RSC Advances

An easy and simple method for the immobilization of dyes through click reactions: activated alkyne, copper not needed

Julia Sánchez-Bodón,a   Ane García-García,ab   Maria Diaz-Galbarriatu,a   José Luis Vilas-Vilela ORCID logo *ab  and  Isabel Moreno-Benítez ORCID logo *c  

* Corresponding authors

a Grupo de Química Macromolecular (LABQUIMAC), Departamento de Química Física, Facultad de Ciencia y Tecnología, Universidad del País Vasco UPV/EHU, 48940 Leioa, Spain

b BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain

c Grupo de Química Macromolecular (LABQUIMAC), Departamento de Química Orgánica e Inorgánica, Facultad de Ciencia y Tecnología, Universidad del País Vasco UPV/EHU, 48940 Leioa, Spain
E-mail: mariaisabel.moreno@ehu.eus

Abstract

The copper-free azide–alkyne click reaction has shown to be a successful alternative to immobilize covalently a fluorescente compound onto poly(-L-lactic) acid (PLLA) surfaces. Proceded by basic hydrolysis and amidation reaction, typical surface characterization techniques have validated each functionaliztion step and the success of the conjugation. This method offers a catalyst-free option for various surface conjugations, extremely demanded in biomedical and biosensory fields.

Graphical abstract: An easy and simple method for the immobilization of dyes through click reactions: activated alkyne, copper not needed

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Article information

DOI
https://doi.org/10.1039/D4RA01776E
Article type
Paper
Submitted
07 Mar 2024
Accepted
25 Apr 2024
First published
30 Apr 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 14289-14295

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An easy and simple method for the immobilization of dyes through click reactions: activated alkyne, copper not needed

J. Sánchez-Bodón, A. García-García, M. Diaz-Galbarriatu, J. L. Vilas-Vilela and I. Moreno-Benítez, RSC Adv., 2024, 14, 14289 DOI: 10.1039/D4RA01776E

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