Rhodium-catalyzed three-component C(sp3)/C(sp2)–H activation enabled by a two-fold directing group strategy

Fu-Cheng Hou; Jia-Le Zhang; Zi-Rui Wang; Zhong-Yuan Li

doi:10.1039/D4CC00827H

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Rhodium-catalyzed three-component C(sp³)/C(sp²)–H activation enabled by a two-fold directing group strategy†

Fu-Cheng Hou,^a Jia-Le Zhang,^a Zi-Rui Wang^a and Zhong-Yuan Li

*^a

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* Corresponding authors

^a The Key Laboratory of Functional Molecular Solids, Ministry of Education, School of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China
E-mail: zhongyuanli@ahnu.edu.cn

Abstract

Rh-catalyzed three-component C(sp³)/C(sp²)–H activation has been achieved through a two-directing group strategy. This protocol provides a convenient and efficient pathway for the construction of diverse 8-alkyl quinoline derivatives in one-pot. Furthermore, mechanistic studies revealed that the first C–H amidation was significantly faster than the sequential C–H alkylation.

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Article information

DOI: https://doi.org/10.1039/D4CC00827H
Article type: Communication
Submitted: 20 Feb 2024
Accepted: 23 Apr 2024
First published: 23 Apr 2024

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Chem. Commun., 2024, Advance Article

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Rhodium-catalyzed three-component C(sp³)/C(sp²)–H activation enabled by a two-fold directing group strategy

F. Hou, J. Zhang, Z. Wang and Z. Li, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC00827H

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