Certain subsets of patients with multiple myeloma or its precursor conditions are overtreated with current approaches to therapy. Herein, we highlight several key areas where we believe de-escalation of treatment is needed. Dedicated trials to assess these de-escalation approaches and urgent changes to current clinical practices are needed.
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G.R.M. has received royalties from MashupMD for writing, and his institution has received research funding from Janssen as part of his role as a site principal investigator of a clinical trial. A.M.G. has acted as a consultant of Seattle Genetics.
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Mohyuddin, G.R., Goodman, A.M. Overtreatment of multiple myeloma and its precursor states: de-escalation is an urgent need in clinical practice and trials. Nat Rev Clin Oncol (2024). https://doi.org/10.1038/s41571-024-00895-x
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DOI: https://doi.org/10.1038/s41571-024-00895-x
