Skip to main content
SpringerLink
Log in

Elicitation: “A Trump Card” for Enhancing Secondary Metabolites in Plants

  • Published:
Journal of Plant Growth Regulation Aims and scope Submit manuscript

Abstract

Elicitation, the process of stimulating plants to enhance the production of valuable secondary metabolites, has emerged as a significant avenue in the field of plant biotechnology. This review paper provides a comprehensive examination of elicitation, encompassing its mechanisms, the imperative for its utilization, and the diverse array of elicitors employed, including abiotic, biotic, and nanoparticle-based agents. By exploring the intricate signaling pathways and molecular responses triggered by external stimuli in this review, we gain insights into how plants tailor their metabolite production in reaction to their environment. Intricately intertwined with the mechanisms, the types of elicitors utilized are extensively discussed. Abiotic elicitors, encompassing physical factors and chemicals, biotic elicitors involving microbe-derived molecules, plant hormones and symbiotic microorganisms, and the emerging application of nanoparticles as elicitation agents are explored. The review further examines the application of these elicitors in both in-vitro and in-vivo cultures, showcasing their practical utility in controlled laboratory settings and real-world environments. By assessing the efficacy of diverse elicitors, this paper provides valuable insights into tailoring elicitation strategies to enhance secondary metabolite yields for various applications. Addressing the limitations and leveraging emerging technologies will undoubtedly steer elicitation research towards innovative breakthroughs, further enhancing our capacity to harness plants for sustainable and efficient secondary metabolite production.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Abbasi BH, Stiles AR, Saxena PK, Liu CZ (2012) Gibberellic acid increases secondary metabolite production in Echinacea purpurea hairy roots. Appl Biochem Biotechnol 168:2057–2066

    Article  CAS  PubMed  Google Scholar 

  • Adesemoye AO, Torbert HA, Kloepper JW (2009) Plant growth-promoting rhizobacterium allow reduced application rates of chemical fertilizers. Microb Ecol 58:921–929

    Article  CAS  PubMed  Google Scholar 

  • Ahemad M, Kibret M (2014) Mechanisms and applications of plant growth promoting rhizobacterium: Current perspective. J King Saud Univ Sci 26:1–20

    Article  Google Scholar 

  • Ahmad I, Younas Z, Mashwani ZUR, Raja NI, Akram A (2023) Phytomediated selenium nanoparticles improved physio-morphological, antioxidant, and oil bioactive compounds of sesame under induced biotic stress. ACS Omega 8(3):3354–3366

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ajungla L, Patil PP, Barmukh RB, Nikam TD (2009) Influence of biotic and abiotic elicitors on accumulation of hyoscyamine and scopolamine in root cultures of Datura metel L. Indian J Biotechnol 2009:317–322

    Google Scholar 

  • Akhgari A, Laakso I, Maaheimo H, Choi YH, Seppänen-Laakso T, Oksman-Caldentey KM, Rischer H (2019) Methyljasmonate elicitation increases terpenoid indole alkaloid accumulation in Rhazya stricta hairy root cultures. Plants 8(12):534

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Akhzari D, Attaeian B, Arami A, Mahmoodi F, Aslani F (2015) Effects of vermicompost and arbuscular mycorrhizal fungi on soil properties and growth of Medicago polymorpha L. Compost Sci Utilization 23:142–153

    Article  CAS  Google Scholar 

  • Algar E, Gutierrez-Mañero FJ, Bonilla A, Lucas JA, Radzki W, Ramos-Solano B (2012) Pseudomonas fluorescens N21.4 metabolites enhance secondary metabolism isoflavones in soybean (Glycine max) calli cultures. J Agric Food Chem 60(44):11080–11087

    Article  CAS  PubMed  Google Scholar 

  • Ali A, Mohammad S, Khan MA, Raja NI, Arif M, Kamil A, Mashwani ZUR (2019) Silver nanoparticles elicited in vitro callus cultures for accumulation of biomass and secondary metabolites in Caralluma tuberculata. Artif Cells Nanomed Biotechnol 47(1):715–724

    Article  CAS  PubMed  Google Scholar 

  • Aliniaeifard S, Shomali A, Seifikalhor M, Lastochkina O (2020) Calcium signaling in plants under drought. In: Hasanuzzaman M, Tanveer M (eds) Salt and drought stress tolerance in plants: signaling networks and adaptive mechanisms. Springer, Cham, pp 259–298

    Chapter  Google Scholar 

  • Al-Oubaidi HKM, Kasid NM (2015) Increasing phenolic and flavonoids compounds of Cicer arietinum L. from embryo explant using titanium dioxide nanoparticle in vitro. World J Pharm Res 4(11):1791–1799

    CAS  Google Scholar 

  • Amer A (2019) Biotechnology approaches for in vitro production of flavonoids. J Microbiol Biotechnol Food Sci 2019:457–468

    Google Scholar 

  • Anand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N (2019) A comprehensive review on medicinal plants as antimicrobial therapeutics: potential avenues of biocompatible drug discovery. Metabolites 9(11):258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Angelova Z, Georgiev S, Roos W (2006) Elicitation of plants. Biotechnol Biotechnol Equip 20(2):72–83

    Article  CAS  Google Scholar 

  • Anjum S, Anjum I, Hano C, Kousar S (2019) Advances in nanomaterials as novel elicitors of pharmacologically active plant specialized metabolites: current status and future outlooks. RSC Adv 9(69):40404–40423

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Asadollahei MV, Tabatabaeian J, Yousefifard M, Mahdavi SME, Nekonam MS (2023) Impact of elicitors on essential oil compositions and phytochemical constituents in Lavandula stoechas L. Plant Physiol Biochem 194:722–730

    Article  CAS  PubMed  Google Scholar 

  • Aslam S, Gul N, Mir MA, Asgher M, Al-Sulami N, Abulfaraj AA, Qari S (2021) Role of jasmonates, calcium, and glutathione in plants to combat abiotic stresses through precise signaling cascade. Front Plant Sci 12:668029

    Article  PubMed  PubMed Central  Google Scholar 

  • Back K, Tan DX, Reiter RJ (2016) Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts. J Pineal Res 61(4):426–437

    Article  CAS  PubMed  Google Scholar 

  • Baenas N, García-Viguera C, Moreno DA (2014) Biotic elicitors effectively increase the glucosinolates content in Brassicaceae sprouts. J Agric Food Chem 62(8):1881–1918

    Article  CAS  PubMed  Google Scholar 

  • Bajwa MN, Bibi A, Idrees MZ, Zaman G, Farooq U, Bhatti TT (2021) Elicitation, a mechanistic approach to change the metabolic pathway of plants to produce pharmacological important compounds in in-vitro cell cultures. Glob J Eng 8:10

    Google Scholar 

  • Baskar V, Nayeem S, Kuppuraj SP, Muthu T, Ramalingam S (2018) Assessment of the effects of metal oxide nanoparticles on the growth, physiology and metabolic responses in in vitro grown eggplant (Solanum melongena). 3 Biotech 8:1–12

    Article  Google Scholar 

  • Begum P, Fugetsu B (2012) Phytotoxicity of multi-walled carbon nanotubes on red spinach (Amaranthus tricolor L) and the role of ascorbic acid as an antioxidant. J Hazard Mater 243:212–222

    Article  CAS  PubMed  Google Scholar 

  • Bhaskar R, Xavier LSE, Udayakumaran G, Kumar DS, Venkatesh R, Nagella P (2022) Biotic elicitors: a boon for the in-vitro production of plant secondary metabolites. Plant Cell Tiss Organ Cult 149(1–2):7–24

    Article  CAS  Google Scholar 

  • Bhat AH, Sharma H (2020) Medicinal plants: a potent source of diuretics. In: Singh A, Singh P, Bithel N (eds) Advanced pharmacological uses of medicinal plants and natural products. IGI Global, Hershey, p 67

    Chapter  Google Scholar 

  • Boots AW, Haenen GR, Bast A (2008) Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 585(2–3):325–337

    Article  CAS  PubMed  Google Scholar 

  • Bosmaia TC, Agarwal P, Dangariya M, Khedia J, Gangapur DR, Agarwal PK (2023) Transcriptomic analysis towards identification of defence-responsive genes and pathways upon application of Sargassum seaweed extract on tomato plants infected with Macrophomina phaseolina. 3 Biotech 13(6):179

    Article  PubMed  Google Scholar 

  • Campobenedetto C, Agliassa C, Mannino G, Vigliante I, Contartese V, Secchi F, Bertea CM (2021) A biostimulant based on seaweed (Ascophyllum nodosum and Laminaria digitata) and yeast extracts mitigates water stress effects on tomato (Solanum lycopersicum L.). Agriculture 11(6):557

    Article  CAS  Google Scholar 

  • Chambard M, Ben Mlouka MA, Jing L, Plasson C, Cosette P, Leprince J, Boulogne I (2022) Elicitation of roots and AC-DC with PEP-13 peptide shows differential defense responses in multi-omics. Cells 11(16):2605

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chamkhi I, Benali T, Aanniz T, El Menyiy N, Guaouguaou FE, El Omari N, Bouyahya A (2021) Plant-microbial interaction: the mechanism and the application of microbial elicitor induced secondary metabolites biosynthesis in medicinal plants. Plant Physiol Biochem 167:269–295

    Article  CAS  PubMed  Google Scholar 

  • Chan LK, Koay SS, Boey PL, Bhatt A (2010) Effects of abiotic stress on biomass and anthocyanin production in cell cultures of Melastoma malabathricum. Biol Res 43(1):127–135

    Article  CAS  PubMed  Google Scholar 

  • Chen X, Ding Y, Yang Y, Song C, Wang B, Yang S, Gong Z (2021) Protein kinases in plant responses to drought, salt, and cold stress. J Integr Plant Biol 63(1):53–78

    Article  CAS  PubMed  Google Scholar 

  • Chen H, Chen J, Qi Y, Chu S, Ma Y, Xu L, Liang Z (2022) Endophytic fungus Cladosporium tenuissimum DF11, an efficient inducer of tanshinone biosynthesis in Salvia miltiorrhiza roots. Phytochemistry 194:113021

    Article  CAS  PubMed  Google Scholar 

  • Chomel M, Guittonny-Larchevêque M, Fernandez C, Gallet C, DesRochers A, Paré D, Baldy V (2016) Plant secondary metabolites: a key driver of litter decomposition and soil nutrient cycling. J Ecol 104(6):1527–1541

    Article  Google Scholar 

  • Chung IM, Rajakumar G, Subramanian U, Venkidasamy B, Thiruvengadam M (2019) Impact of copper oxide nanoparticles on enhancement of bioactive compounds using cell suspension cultures of Gymnema sylvestre (Retz) R Br. Appl Sci 9(10):2165

    Article  CAS  Google Scholar 

  • Coleman AD, Maroschek J, Raasch L, Takken FL, Ranf S, Hückelhoven R (2021) The Arabidopsis leucine-rich repeat receptor-like kinase MIK2 is a crucial component of early immune responses to a fungal-derived elicitor. New Phytol 229(6):3453–3466

    Article  CAS  PubMed  Google Scholar 

  • Cope KR, Prates ET, Miller JI, Demerdash ON, Shah M, Kainer D, Kalluri UC (2023) Exploring the role of plant lysin motif receptor-like kinases in regulating plant-microbe interactions in the bioenergy crop Populus. Comput Struct Biotechnol J 21:1122–1139

    Article  CAS  PubMed  Google Scholar 

  • Cuéllar-Torres EA, Aguilera-Aguirre S, Hernández-Oñate MÁ, López-García UM, Vega-Arreguín J, Montalvo-González E, Chacón-López A (2023) Molecular aspects revealed by omics technologies related to the defense system activation in fruits in response to elicitors: a review. Horticulturae 9(5):558

    Article  Google Scholar 

  • Dheeranupattana S, Wangprapa M, Jatisatienr A (2007) Effect of sodium acetate on stevioside production of Stevia rebaudiana. Acta Hortic. https://doi.org/10.17660/ActaHortic.2008.786.31

    Article  Google Scholar 

  • Ebadollahi R, Jafarirad S, Kosari-Nasab M, Mahjouri S (2019) Effect of explant source, perlite nanoparticles and TiO2/perlite nanocomposites on phytochemical composition of metabolites in callus cultures of Hypericum perforatum. Sci Rep 9(1):12998

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • El-Saber MM, Diab M, Hendawey M, Farroh K (2021) Magnetite nanoparticles different sizes effectiveness on growth and secondary metabolites in Ginkgo biloba L. callus. Egypt J Chem 64(9):4523–5432

    Google Scholar 

  • Ferrusquía-Jiménez NI, González-Arias B, Rosales A, Esquivel K, Escamilla-Silva EM, Ortega-Torres AE, Guevara-González RG (2022) Elicitation of bacillus cereus-amazcala (Bc-A) with SiO2 nanoparticles improves its role as a plant growth-promoting bacteria (PGPB) in Chili pepper plants. Plants 11(24):3445

    Article  PubMed  PubMed Central  Google Scholar 

  • Fróna D, Szenderák J, Harangi-Rákos M (2021) Economic effects of climate change on global agricultural production. Nat Conserv 44:117–139

    Article  Google Scholar 

  • Gadzovska Simic S, Tusevski O, Maury S, Delaunay A, Joseph C, Hagège D (2014) Effects of polysaccharide elicitors on secondary metabolite production and antioxidant response in Hypericum perforatum L. shoot cultures. Sci World J 2014:10

    Article  Google Scholar 

  • Garcia-Caparros P, De Filippis L, Gul A, Hasanuzzaman M, Ozturk M, Altay V, Lao MT (2021) Oxidative stress and antioxidant metabolism under adverse environmental conditions: a review. Bot Rev 87:421–466

    Article  Google Scholar 

  • García-García AL, Matos AR, Feijão E, Cruz de Carvalho R, Boto A, Marques da Silva J, Jiménez-Arias D (2023) The use of chitosan oligosaccharide to improve artemisinin yield in well-watered and drought-stressed plants. Front Plant Sci 14:1200898

    Article  PubMed  PubMed Central  Google Scholar 

  • Garcia-Mier L et al (2019) Strategies that influence the production of secondary metabolites in plants. In: Jaiwal P, Chhillar A, Chaudhary D, Jaiwal R (eds) Nutritional quality improvement in plants: concepts and strategies in plant sciences. Springer, Cham

    Google Scholar 

  • Gohari G, Mohammadi A, Akbari A, Panahirad S, Dadpour MR, Foto-poulos V, Kimura S (2020) Titanium dioxide nanoparticles (TiO2 NPs) promote growth and ameliorate salinity stress efects on essential oil profle and biochemical attributes of Dracocepha-lum moldavica. Sci Rep 10(1):1–14

    Article  Google Scholar 

  • Gómez-Merino FC, Trejo-Téllez LI (2018) The role of beneficial elements in triggering adaptive responses to environmental stressors and improving plant performance. In: Vats S (ed) Biotic and abiotic stress tolerance in plants. Springer, Singapore, pp 137–172

    Chapter  Google Scholar 

  • Goossens A, Häkkinen ST, Laakso I, Seppänen-Laakso T, Biondi S, De Sutter V, Oksman-Caldentey KM (2003) A functional genomics approach toward the understanding of secondary metabolism in plant cells. Proc Natl Acad Sci 100(14):8595–8600

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grover JK, Yadav SP (2004) Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol 93(1):123–132

    Article  CAS  PubMed  Google Scholar 

  • Gupta S, Chaturvedi P (2019) Enhancing secondary metabolite production in medicinal plants using endophytic elicitors: a case study of Centella asiatica (Apiaceae) and asiaticoside. In: Hodkinson TR, Doohan FM, Saunders MJ, Murphy BR (eds) Endophytes for a growing world. Cambridge University Press, Cambridge, pp 310–323

    Chapter  Google Scholar 

  • Gupta P, Sharma S, Saxena S (2015) Biomass yield and steviol glycoside production in callus and suspension culture of Stevia rebaudiana treated with proline and polyethylene glycol. Appl Biochem Biotechnol 176:863–874

    Article  CAS  PubMed  Google Scholar 

  • Guru A, Dwivedi P, Kaur P, Pandey DK (2022) Exploring the role of elicitors in enhancing medicinal values of plants under in vitro condition. S Afr J Bot 149:1029–1043

    Article  CAS  Google Scholar 

  • Halder M, Sarkar S, Jha S (2019) Elicitation: a biotechnological tool for enhanced production of secondary metabolites in hairy root cultures. Eng Life Sci 19(12):880–895

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hassanen SA, Hegazi GA, Diab MI, Mahdi AA, Hendawey MH, Farroh KY (2021) Effect of coumarin and phenylalanine conjugated with chitosan nanoparticles on secondary metabolites synthesis in callus of Silybium marianum. Plant Cell Biotechnol Mol Biol 22(71):112–130

    Google Scholar 

  • Hidangmayum A, Dwivedi P, Katiyar D, Hemantaranjan A (2019) Application of chitosan on plant responses with special reference to abiotic stress. Physiol Mol Biol Plants 25:313–326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Humbal A, Pathak B (2023) Influence of exogenous elicitors on the production of secondary metabolite in plants: a review (“VSI: secondary metabolites”). Plant Stress 8:100166

    Article  CAS  Google Scholar 

  • Hussain MS, Fareed S, Ansari S, Rahman MA, Ahmad IZ, Saeed M (2012) Current approaches toward production of secondary plant metabolites. J Pharm Bioallied Sci 4(1):10

    Article  PubMed  PubMed Central  Google Scholar 

  • Hussain F, Hadi F, Akbar F (2019) Magnesium oxide nanoparticles and thidiazuron enhance lead phytoaccumulation and antioxidative response in Raphanus sativus L. Environ Sci Pollut Res 26:30333–30347

    Article  CAS  Google Scholar 

  • Iqbal Z, Iqbal MS, Hashem A, Abd-Allah EF, Ansari MI (2021) Plant defense responses to biotic stress and its interplay with fluctuating dark/light conditions. Front Plant Sci 12:631810

    Article  PubMed  PubMed Central  Google Scholar 

  • Isah T (2019) Stress and defense responses in plant secondary metabolites production. Biol Res. https://doi.org/10.1186/s40659-019-0246-3

    Article  PubMed  PubMed Central  Google Scholar 

  • Islek C, Ustun AS, Koc ESRA (2014) The effects of cellulase on capsaicin production in freely suspended cells and immobilized cell cultures of Capsicum annuum L. Pak J Bot 46(5):1883–1887

    Google Scholar 

  • Jain C, Khatana S, Vijayvergia R (2019) Bioactivity of secondary metabolites of various plants: a review. Int J Pharm Sci Res 10(2):494–504

    CAS  Google Scholar 

  • Jalal A, da Silva Oliveira CE, Galindo FS, Rosa PAL, Gato IMB, de Lima BH, Teixeira Filho MCM (2023) Regulatory mechanisms of plant growth-promoting rhizobacteria and plant nutrition against abiotic stresses in brassicaceae family. Life 13(1):211

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jaleel CA, Manivannan P, Sankar B, Kishorekumar A, Gopi R, Somasundaram R, Panneerselvam R (2007) Pseudomonas fluorescens enhances biomass yield and ajmalicine production in Catharanthus roseus under water deficit stress. Colloids Surf B 60(1):7–11

    Article  CAS  Google Scholar 

  • Jaleel CA, Gopi R, Gomathinayagam M, Panneerselvam R (2009) Traditional and non-traditional plant growth regulators alters phytochemical constituents in Catharanthus roseus. Process Biochem 44(2):205–209

    Article  CAS  Google Scholar 

  • Jan R, Asaf S, Numan M, Kim KM (2021) Plant secondary metabolite biosynthesis and transcriptional regulation in response to biotic and abiotic stress conditions. Agronomy 11(5):968

    Article  CAS  Google Scholar 

  • Jiang J, Ling WF, Wei HW (2005) Evidences for involvement of endogenous cAMP in Arabidopsis defense responses to Verticillium toxins. Cell Res 15(8):585–592

    Article  CAS  PubMed  Google Scholar 

  • Jiao J, Gai QY, Wang X, Qin QP, Wang ZY, Liu J, Fu YJ (2018) Chitosan elicitation of Isatis tinctoria L. hairy root cultures for enhancing flavonoid productivity and gene expression and related antioxidant activity. Ind Crops Prod 124:28–35

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jimenez-Garcia SN, Vazquez-Cruz MA, Guevara-Gonzalez RG, Torres-Pacheco I, Cruz-Hernandez A, Feregrino-Perez AA (2013) Current approaches for enhanced expression of secondary metabolites as bioactive compounds in plants for agronomic and human health purposes—a review. Pol J Food Nutr Sci 63(2):67

    Article  CAS  Google Scholar 

  • Jogawat A, Yadav B, Lakra N, Singh AK, Narayan OP (2021) Crosstalk between phytohormones and secondary metabolites in the drought stress tolerance of crop plants: a review. Physiol Plant 172(2):1106–1132

    Article  CAS  PubMed  Google Scholar 

  • Jurić S, Sopko Stracenski K, Król-Kilińska Ż, Žutić I, Uher SF, Đermić E, Vinceković M (2020) The enhancement of plant secondary metabolites content in Lactuca sativa L. by encapsulated bioactive agents. Sci Rep 10(1):1–12

    Article  Google Scholar 

  • Kabiri R, Naghizadeh M, Hatami A (2016) Protective role of arginine against oxidative damage induced by osmotic stress in ajwain (Trachyspermum ammi) seedlings under hydroponic culture. J Plant Physiol Breed 6(1):13–22

    Google Scholar 

  • Kandoudi W, Nemeth-Zamborine E (2022) Stimulating secondary compound accumulation by elicitation: is it a realistic tool in medicinal plants in vivo? Phytochem Rev 21:1–19

    Article  Google Scholar 

  • Kandoudi W, Radácsi P, Gosztola B, Zámboriné Németh É (2022) Elicitation of medicinal plants in vivo—is it a realistic tool? The effect of methyl jasmonate and salicylic acid on lamiaceae species. Horticulturae 8(1):5

    Article  Google Scholar 

  • Kang SM, Min JY, Kim YD, Kang YM, Park DJ, Jung HN, Choi MS (2006) Effects of methyl jasmonate and salicylic acid on the production of bilobalide and ginkgolides in cell cultures of Ginkgo biloba. In Vitro Cell Dev Biol Plant 42:44–49

    Article  CAS  Google Scholar 

  • Kanthaliya B, Joshi A, Arora J, Alqahtani MD, Abd-Allah EF (2023) Effect of biotic elicitors on the growth, antioxidant activity and metabolites accumulation in in vitro propagated shoots of Pueraria tuberosa. Plants 12(6):1300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Karpiński TM (2020) Essential oils of Lamiaceae family plants as antifungals. Biomolecules 10(1):103

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaur H, Kaur H, Kaur H, Srivastava S (2022a) The beneficial roles of trace and ultratrace elements in plants. Plant Growth Regul 2022:1–18

    Google Scholar 

  • Kaur S, Tiwari V, Kumari A, Chaudhary E, Sharma A, Ali U, Garg M (2022b) Protective and defensive role of anthocyanins under plant abiotic and biotic stresses: an emerging application in sustainable agriculture. J Biotechnol 361:12

    Article  PubMed  Google Scholar 

  • Keshavan B, Srinivas NS, Tamizh MM, Vairamani M, Pachaiappan R (2022) In vitro elicitation of Camptothecin by challenging with biotic elicitors in Nothapodytes nimmoniana (J. Graham) Mabb. S Afr J Bot 144:325–331

    Article  CAS  Google Scholar 

  • Khan AK, Kousar S, Tungmunnithum D, Hano C, Abbasi BH, Anjum S (2021) Nano-elicitation as an effective and emerging strategy for in vitro production of industrially important flavonoids. Appl Sci 11(4):1694

    Article  CAS  Google Scholar 

  • Khezerluo M, Hosseini B, Amiri J (2018) Sodium nitroprusside stimulated production of tropane alkaloids and antioxidant enzymes activity in hairy root culture of Hyoscyamus reticulatus L. Acta Biol Hung 69(4):437–448

    Article  CAS  PubMed  Google Scholar 

  • Kim HJ, Chen F, Wang X, Rajapakse NC (2006) Effect of methyl jasmonate on secondary metabolites of sweet basil (Ocimum basilicum L.). J Agric Food Chem 54(6):2327–2332

    Article  CAS  PubMed  Google Scholar 

  • Knez M, Ranic M, Gurinovic M, Glibetic M, Savic J, Mattas K, Yercan M (2023) Causes and conditions for reduced cultivation and consumption of underutilized crops: is there a solution? Sustainability 15(4):3076

    Article  CAS  Google Scholar 

  • Kochan E, Balcerczak E, Lipert A, Szymańska G, Szymczyk P (2018) Methyl jasmonate as a control factor of the synthase squalene gene promoter and ginsenoside production in American ginseng hairy root cultured in shake flasks and a nutrient sprinkle bioreactor. Ind Crops Prod 115:182–193

    Article  CAS  Google Scholar 

  • Kolenčík M, Ernst D, Urík M, Ďurišová Ľ, Bujdoš M, Šebesta M, Kratošová G (2020) Foliar application of low concentrations of titanium dioxide and zinc oxide nanoparticles to the common sunflower under field conditions. Nanomaterials 10(8):1619

    Article  PubMed  PubMed Central  Google Scholar 

  • Komaraiah P, Ramakrishna SV, Reddanna P, Kishor PK (2003) Enhanced production of plumbagin in immobilized cells of Plumbago rosea by elicitation and in situ adsorption. J Biotechnol 101(2):181–187

    Article  CAS  PubMed  Google Scholar 

  • Koza NA, Adedayo AA, Babalola OO, Kappo AP (2022) Microorganisms in plant growth and development: roles in abiotic stress tolerance and secondary metabolites secretion. Microorganisms 10(8):1528

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kruszka D, Sawikowska A, Selvakesavan RK, Krajewski P, Kachlicki P, Franklin G (2020) Silver nanoparticles affect phenolic and phytoalexin composition of Arabidopsis thaliana. Sci Total Environ 716:135361

    Article  CAS  PubMed  Google Scholar 

  • Kruszka D, Selvakesavan RK, Kachlicki P, Franklin G (2022) Untargeted metabolomics analysis reveals the elicitation of important secondary metabolites upon treatment with various metal and metal oxide nanoparticles in Hypericum perforatum L. cell suspension cultures. Ind Crops Prod 178:114561

    Article  CAS  Google Scholar 

  • Kumari S, Chhillar H, Chopra P, Khanna RR, Khan MIR (2021) Potassium: A track to develop salinity tolerant plants. Plant Physiol Biochem 167:1011–1023

    Article  CAS  PubMed  Google Scholar 

  • Kuzel S, Vydra JAN, Triska JAN, Vrchotova N, Hruby M, Cigler P (2009) Elicitation of pharmacologically active substances in an intact medical plant. J Agric Food Chem 57(17):7907–7911

    Article  CAS  PubMed  Google Scholar 

  • Largia MJV, Shilpha J, Satish L, Swamy MK, Ramesh M (2023) Elicitation: an efficient strategy for enriched production of plant secondary metabolites. Phytochemical genomics: plant metabolomics and medicinal plant genomics. Springer, Cham, pp 477–497

    Google Scholar 

  • Le KC, Im WT, Paek KY, Park SY (2018) Biotic elicitation of ginsenoside metabolism of mutant adventitious root culture in Panax ginseng. Appl Microbiol Biotechnol 102:1687–1697

    Article  CAS  PubMed  Google Scholar 

  • Lei Z, Mingyu S, Chao L, Liang C, Hao H, Xiao W, Xiaoqing L, Fan Y, Fengqing G, Fashui H (2007) Efects of nanoanatase TiO 2 on photosynthesis of spinach chloroplasts under diferent light illumination. Biol Trace Elem Res 119(1):68–76

    Article  PubMed  Google Scholar 

  • Li B, Wang B, Li H, Peng L, Ru M, Liang Z, Zhu Y (2016) Establishment of Salvia castanea Diels f. tomentosa Stib. hairy root cultures and the promotion of tanshinone accumulation and gene expression with Ag+, methyl jasmonate, and yeast extract elicitation. Protoplasma 253:87–100

    Article  CAS  PubMed  Google Scholar 

  • Linh TM, Mai NC, Hoe PT, Ngoc NT, Thao PTH, Ban NK, Van NT (2021) Development of a cell suspension culture system for promoting alkaloid and vinca alkaloid biosynthesis using endophytic fungi isolated from local Catharanthus roseus. Plants 10(4):672

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liu CZ, Guo C, Wang YC, Ouyang F (2002) Effect of light irradiation on hairy root growth and artemisinin biosynthesis of Artemisia annua L. Process Biochem 38(4):581–585

    Article  CAS  Google Scholar 

  • López-Vargas ER, Ortega-Ortíz H, Cadenas-Pliego G, de Alba Romenus K, Cabrera de la Fuente M, Benavides-Mendoza A, Juárez-Maldonado A (2018) Foliar application of copper nanoparticles increases the fruit quality and the content of bioactive compounds in tomatoes. Appl Sci 8(7):1020

    Article  Google Scholar 

  • Mahfouz SA, Shamf-Eldin MA (2007) Effect of mineral vs. biofertilizer on growth, yield, and essential oil content of fennel (Foeniculum vulgare Mill.). Int Agrophys 21:361–366. https://doi.org/10.1055/s-2007-987419

    Article  CAS  Google Scholar 

  • Maleck K, Levine A, Eulgem T, Morgan A, Schmid J, Lawton KA, Dietrich RA (2000) The transcriptome of Arabidopsis thaliana during systemic acquired resistance. Nat Gene 26(4):403–410

    Article  CAS  Google Scholar 

  • Marchev AS, Yordanova ZP, Georgiev MI (2020) Green (cell) factories for advanced production of plant secondary metabolites. Crit Rev Biotechnol 40(4):443–458

    Article  CAS  PubMed  Google Scholar 

  • Memelink J, Kijne JW, van der Heijden R, Verpoorte R (2001) Genetic modification of plant secondary metabolite pathways using transcriptional regulators. Plant Cells. https://doi.org/10.1007/3-540-45302-4_4

    Article  Google Scholar 

  • Mishra UN, Saha D, Chauhan J, Kumar V, Jatav HS, Lal D, Chandra K (2022) Emerging roles of osmoprotectants in response to multiple abiotic stress tolerance in plants. In: Aftab T (ed) Omics analysis of plants under abiotic stress. Apple Academic Press, Boca Raton, pp 179–206

    Chapter  Google Scholar 

  • Mithöfer A, Schulze B, Boland W (2004) Biotic and heavy metal stress response in plants: evidence for common signals. FEBS Lett 566(1–3):1–5

    Article  PubMed  Google Scholar 

  • Moharrami F, Hosseini B, Sharafi A, Farjaminezhad M (2017) Enhanced production of hyoscyamine and scopolamine from genetically transformed root culture of Hyoscyamus reticulatus L. elicited by iron oxide nanoparticles. In Vitro Cell Dev Biol Plant 53:104–111

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morteza E, Moaveni P, Farahani HA, Kiyani M (2013) Study of photosynthetic pigments changes of maize (Zea mays L.) under nano TiO2 spraying at various growth stages. Springerplus 2(1):1–5

    Article  Google Scholar 

  • Mostofa MG, Rahman MM, Ghosh TK, Kabir AH, Abdelrahman M, Khan MAR, Tran LSP (2022) Potassium in plant physiological adaptation to abiotic stresses. Plant Physiol Biochem. https://doi.org/10.1016/j.plaphy.2022.07.011

    Article  PubMed  Google Scholar 

  • Mun BG, Lee WH, Kang SM, Lee SU, Lee SM, Lee DY, Lee IJ (2020) Streptomyces sp. LH 4 promotes plant growth and resistance against Sclerotinia sclerotiorum in cucumber via modulation of enzymatic and defense pathways. Plant Soil 448:87–103

    Article  CAS  Google Scholar 

  • Murugaragavan Ramasamy TG, Yuvaraj M (2020) Role of biofertilizers in plant growth and soil health. In: Rigobelo EC, Serra AP (eds) Nitrogen fixation. IntechOpen, London, p 1

    Google Scholar 

  • Naik PM, Al-Khayri JM (2016) Impact of abiotic elicitors on in vitro production of plant secondary metabolites: a review. J Adv Res Biotechnol 1(2):1–7

    Article  Google Scholar 

  • Nair PMG, Chung IM (2014) Impact of copper oxide nanoparticles exposure on Arabidopsis thaliana growth, root system development, root lignificaion, and molecular level changes. Environ Sci Pollut Res 21:12709–12722

    Article  CAS  Google Scholar 

  • Narayani M, Srivastava S (2017) Elicitation: a stimulation of stress in in vitro plant cell/tissue cultures for enhancement of secondary metabolite production. Phytochem Rev 16:1227–1252

    Article  CAS  Google Scholar 

  • Nourozi E, Hosseini B, Maleki R, Abdollahi Mandoulakani B (2019) Iron oxide nanoparticles: a novel elicitor to enhance anticancer flavonoid production and gene expression in Dracocephalum kotschyi hairy-root cultures. J Sci Food Agric 99(14):6418–6430

    Article  CAS  PubMed  Google Scholar 

  • Nourozi E, Hosseini B, Maleki R, Mandoulakani BA (2021) Inductive effect of titanium dioxide nanoparticles on the anticancer compounds production and expression of rosmarinic acid biosynthesis genes in Dracocephalum kotschyi transformed roots. Plant Physiol Biochem 167:934–945

    Article  CAS  PubMed  Google Scholar 

  • Olsen AN, Ernst HA, Leggio LL, Skriver K (2005) NAC transcription factors: structurally distinct, functionally diverse. Trends Plant Sci 10(2):79–87

    Article  CAS  PubMed  Google Scholar 

  • Pande D, Iqbal M, Srivastava PS (2000) Effect of ZnSO4 and CuSO4 on regeneration and lepidine content in Lepidium sativum L. Biol Plant 43:253–256

    Article  Google Scholar 

  • Paramo LA, Feregrino-Pérez AA, Guevara R, Mendoza S, Esquivel K (2020) Nanoparticles in agroindustry: applications, toxicity, challenges, and trends. Nanomaterials 10(9):1654

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patil JG, Ahire ML, Nitnaware KM, Panda S, Bhatt VP, Kishor PBK, Nikam TD (2013) In vitro propagation and production of cardiotonic glycosides in shoot cultures of Digitalis purpurea L. by elicitation and precursor feeding. Appl Microbiol Biotechnol 97:2379–2393

    Article  CAS  PubMed  Google Scholar 

  • Pu X, Gao HC, Wang MJ, Zhang JH, Shan JH, Chen MH, Huang QM (2022) Integrative analysis of elicitor-induced camptothecin biosynthesis in Camptotheca acuminata plantlets through a combined omics approach. Front Plant Sci 13:851077

    Article  PubMed  PubMed Central  Google Scholar 

  • Radman R, Saez T, Bucke C, Keshavarz T (2003) Elicitation of plants and microbial cell systems. Biotechnol Appl Biochem 37(1):91–102

    Article  CAS  PubMed  Google Scholar 

  • Rafiee H, Naghdi Badi HA, Mehrafarin A, Qaderi A, Zarinpanjeh N, Sękara A, Zand E (2016) Application of plant biostimulants as new approach to improve the biological responses of medicinal plants—a critical review. J Med Plants 15(59):6–39

    Google Scholar 

  • Rai A, Sanjeev K, Kuldeep B, Nandita S, Rana PS (2017) Improvement in growth and alkaloid content of Rauwolfia serpentina on application of organic matrix entrapped biofertilizers (Azotobacter chroococcum, Azospirillum brasilense and Pseudomonas putida). J Plant Nutr 41:1–11

    Google Scholar 

  • Rajput VD, Singh RK, Verma KK, Sharma L, Quiroz-Figueroa FR, Meena M, Mandzhieva S (2021) Recent developments in enzymatic antioxidant defence mechanism in plants with special reference to abiotic stress. Biology 10(4):267

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramadan T, Sayed SA, Abd-Elaal AK, Amro A (2022) The combined efect of water defcit stress and TiO2 nanoparticles on cell membrane and antioxidant enzymes in Helianthus annuus L. Physiol Mol Biol Plants 28(2):391–409

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramirez-Estrada K, Vidal-Limon H, Hidalgo D, Moyano E, Golenioswki M, Cusidó RM, Palazon J (2016) Elicitation, an effective strategy for the biotechnological production of bioactive high-added value compounds in plant cell factories. Molecules 21(2):182

    Article  PubMed  PubMed Central  Google Scholar 

  • Rastogi R, Saxena M, Chaturvedi DK, Gupta M, Jain P, Jain R, Garg P (2022) Indian science of Yajna and Mantra to cure different diseases: an analysis amidst pandemic with a simulated approach. Bioinformatics and medical applications: big data using deep learning algorithms. Wiley, Hoboken, pp 235–267

    Chapter  Google Scholar 

  • Sachdev S, Ansari SA, Ansari MI (2023) ROS as signaling molecule under unfavorable conditions. Reactive oxygen species in plants: the right balance. Springer Nature Singapore, Singapore, pp 203–222

    Chapter  Google Scholar 

  • Salam U, Ullah S, Tang ZH, Elateeq AA, Khan Y, Khan J, Ali S (2023) Plant metabolomics: an overview of the role of primary and secondary metabolites against different environmental stress factors. Life 13(3):706

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Salehi M, Moieni A, Safaie N, Farhadi S (2020) Whole fungal elicitors boost paclitaxel biosynthesis induction in Corylus avellana cell culture. PLoS ONE 15(7):e0236191

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sardar T, Maqbool M, Ishtiaq M, Mazhar MW, El-Sheikh MA, Casini R, Elansary HO (2023) Synergistic influence of yeast extract and calcium oxide nanoparticles on the synthesis of bioactive antioxidants and metabolites in Swertia chirata in vitro callus cultures. Molecules 28(12):4607

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sato F, Hashimoto T, Hachiya A, Tamura KI, Choi KB, Morishige T, Yamada Y (2001) Metabolic engineering of plant alkaloid biosynthesis. Proc Natl Acad Sci 98(1):367–372

    Article  CAS  PubMed  Google Scholar 

  • Savitha BC, Thimmaraju R, Bhagyalakshmi N, Ravishankar GA (2006) Different biotic and abiotic elicitors influence betalain production in hairy root cultures of Beta vulgaris in shake-flask and bioreactor. Process Biochem 41(1):50–60

    Article  CAS  Google Scholar 

  • Saxena P, Ahlawat S, Ali A, Khan S, Abdin MZ (2017) Gene expression analysis of the withanolide biosynthetic pathway in hairy root cultures of Withania somnifera elicited with methyl jasmonate and the fungus Piriformospora indica. Symbiosis 71:143–154

    Article  CAS  Google Scholar 

  • Shaikh S, Shriram V, Khare T, Kumar V (2020) Biotic elicitors enhance diosgenin production in Helicteres isora L. suspension cultures via up-regulation of CAS and HMGR genes. Physiol Mol Biol Plants 26:593–604

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shameer S, Prasad TNVKV (2018) Plant growth promoting rhizobacterium for sustainable agricultural practices with special reference to biotic and abiotic stresses. Plant Growth Regul 84(3):603–615

    Article  CAS  Google Scholar 

  • Sharma M, Bhardwaj R, Saran M, Prajapat RK, Sharma D, Mathur M (2023) Secondary metabolites and bioprospecting. Plant growth promoting microorganisms of arid region. Springer Nature Singapore, Singapore, pp 229–255

    Chapter  Google Scholar 

  • Shenavaie Zare A, Ganjeali A, Vaezi Kakhki MR, Cheniany M, Mashreghi M (2022) Plant elicitation and TiO2 nanoparticles application as an effective strategy for improving the growth, biochemical properties, and essential oil of peppermint. Physiol Mol Biol Plants 10:1–16

    Google Scholar 

  • Sheng S, Wu C, Xiang Y, Pu W, Duan S, Huang P, Liu L (2022) Polyamine: a potent ameliorator for plant growth response and adaption to abiotic stresses particularly the ammonium stress antagonized by urea. Front Plant Sci 13:104

    Article  Google Scholar 

  • Shibata S (2000) A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi 120(10):849–862

    Article  CAS  PubMed  Google Scholar 

  • Singh A, Singh N, Hussain I, Singh H, Yadav V, Singh S (2016) Green synthesis of nano zinc oxide and evaluation of its impact on germination and metabolic activity of Solanum lycopersicum. J Bio-Technol 233:84–94

    CAS  Google Scholar 

  • Singh R, Parihar P, Singh M, Bajguz A, Kumar J, Singh S, Prasad SM (2017) Uncovering potential applications of cyanobacteria and algal metabolites in biology, agriculture and medicine: current status and future prospects. Front Microbiol 8:515

    Article  PubMed  PubMed Central  Google Scholar 

  • Sivanandhan G, Kapil Dev G, Jeyaraj M, Rajesh M, Arjunan A, Muthuselvam M, Ganapathi A (2013) Increased production of withanolide A, withanone, and withaferin A in hairy root cultures of Withania somnifera (L.) Dunal elicited with methyl jasmonate and salicylic acid. Plant Cell Tiss Organ Cult 114:121–129

    Article  CAS  Google Scholar 

  • Smokvarska M (2020) Role of Rho GTP-ase nanodomains in regulation of plant’s cell signalization. Université Montpellier, Montpellier

    Google Scholar 

  • Sofowora A, Ogunbodede E, Onayade A (2013) The role and place of medicinal plants in the strategies for disease prevention. Afr J Tradit Complement Altern Med 10(5):210–229

    PubMed  PubMed Central  Google Scholar 

  • Song X, Wu H, Yin Z, Lian M, Yin C (2017) Endophytic bacteria isolated from Panax ginseng improves ginsenoside accumulation in adventitious ginseng root culture. Molecules 22(6):837

    Article  PubMed  PubMed Central  Google Scholar 

  • Souri MK (2016) Aminochelate fertilizers: the new approach to the old problem; a review. Open Agric 1(1):118–123

    Article  Google Scholar 

  • Srivastava M, Sharma S, Misra P (2016) Elicitation based enhancement of secondary metabolites in Rauwolfia serpentina and Solanum khasianum hairy root cultures. Pharmacogn Mag 12(Suppl 3):S315

    PubMed  PubMed Central  Google Scholar 

  • Sumbul A, Ansari RA, Rizvi R, Mahmood I (2020) Azotobacter: a potential bio-fertilizer for soil and plant health management. Saudi J Biol Sci 27(12):3634–3640

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Süntar I (2020) Importance of ethnopharmacological studies in drug discovery: role of medicinal plants. Phytochem Rev 19(5):1199–1209

    Article  Google Scholar 

  • Taghizadeh M, Nasibi F, Kalantari KM, Ghanati F (2019) Evaluation of secondary metabolites and antioxidant activity in Dracocephalum polychaetum Bornm. cell suspension culture under magnetite nanoparticles and static magnetic field elicitation. Plant Cell Tiss Organ Cult 136:489–498

    Article  CAS  Google Scholar 

  • Tardast Z, Iranbakhsh A, Ebadi M, Ardebili ZO (2023) Carboxylic acid-functionalized multiwalled carbon nanotubes (COOH-MWCNTs) improved production of atropine in callus of Datura inoxia by influencing metabolism, gene regulation, and DNA cytosine methylation; an in vitro biological assessment. Plant Physiol Biochem 2021:107975

    Article  Google Scholar 

  • Taurino M, Ingrosso I, D’amico L, De Domenico S, Nicoletti I, Corradini D, Giovinazzo G (2015) Jasmonates elicit different sets of stilbenes in Vitis vinifera cv. Negramaro cell cultures. Springerplus 4(1):1–11

    Article  CAS  Google Scholar 

  • Tripathi D, Raikhy G, Kumar D (2019) Chemical elicitors of systemic acquired resistance—Salicylic acid and its functional analogs. Curr Plant Biol 17:48–59

    Article  Google Scholar 

  • Tumova L, Poustkova J, Tuma J (2001) CoCl2 and NiCl2 elicitation and flavonoid production in Ononis arvensis L. culture in vitro. Acta Pharm (zagreb) 51(2):159–162

    CAS  Google Scholar 

  • Tunsagool P, Wang X, Leelasuphakul W, Jutidamrongphan W, Phaonakrop N, Jaresitthikunchai J, Li L (2019) Metabolomic study of stress responses leading to plant resistance in mandarin fruit mediated by preventive applications of Bacillus subtilis cyclic lipopeptides. Postharvest Biol Technol 156:110946

    Article  CAS  Google Scholar 

  • Turan V, Schröder P, Bilen S, Insam H, Fernández-Delgado Juárez M (2019) Co-inoculation effect of Rhizobium and Achillea millefolium L. oil extracts on growth of common bean (Phaseolus vulgaris L.) and soil microbial-chemical properties. Sci Rep 9(1):15178

    Article  PubMed  PubMed Central  Google Scholar 

  • Ullah MA, Gul FZ, Khan T, Bajwa MN, Drouet S, Tungmunnithum D, Abbasi BH (2021) Differential induction of antioxidant and anti-inflammatory phytochemicals in agitated micro-shoot cultures of Ajuga integrifolia Buch. Ham. ex D. Don with biotic elicitors. AMB Express 11(1):1–13

    Article  Google Scholar 

  • Van Wyk BE, Wink M (2018) Medicinal plants of the world. CABI

    Google Scholar 

  • Velázquez-Gamboa MC, Rodríguez-Hernández L, Abud-Archila M, Gutiérrez-Miceli FA, González-Mendoza D, Valdez-Salas B, Luján-Hidalgo MC (2021) Agronomic biofortification of Stevia rebaudiana with zinc oxide (ZnO) phytonanoparticles and antioxidant compounds. Sugar Tech 23(2):453–460

    Article  Google Scholar 

  • Verpoorte R, Memelink J (2002) Engineering secondary metabolite production in plants. Curr Opin Biotechnol 13(2):181–187

    Article  CAS  PubMed  Google Scholar 

  • Vivek AS, Riyas CT, Swapna TS (2023) Enhanced secondary metabolite production for drug leads. In: Sukumaran ST (ed) Conservation and sustainable utilization of bioresources: sustainable development and biodiversity. Springer, Singapore

    Google Scholar 

  • Vosoughi N, Gomarian M, Pirbalouti AG, Khaghani S, Malekpoor F (2018) Essential oil composition and total phenolic, flavonoid contents, and antioxidant activity of sage (Salvia officinalis L.) extract under chitosan application and irrigation frequencies. Ind Crops Prod 117:366–374

    Article  CAS  Google Scholar 

  • Walker TS, Bais HP, Vivanco JM (2002) Jasmonic acid-induced hypericin production in cell suspension cultures of Hypericum perforatum L. (St. John’s wort). Phytochemistry 60(3):289–293

    Article  CAS  PubMed  Google Scholar 

  • Wang C, Wu J, Mei X (2001) Enhancement of taxol production and excretion in Taxus chinensis cell culture by fungal elicitation and medium renewal. Appl Microbiol Biotechnol 55:404–410

    Article  CAS  PubMed  Google Scholar 

  • Wang SY, Bunce JA, Maas JL (2003) Elevated carbon dioxide increases contents of antioxidant compounds in field-grown strawberries. J Agric Food Chem 51(15):4315–4320

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Wang H, Shao H, Tang X (2016) Recent advances in utilizing transcription factors to improve plant abiotic stress tolerance by transgenic technology. Front Plant Sci 7:67

    PubMed  PubMed Central  Google Scholar 

  • Wang B, Kumar V, Olson A, Ware D (2019) Reviving the transcriptome studies: an insight into the emergence of single-molecule transcriptome sequencing. Front Genet 10:384

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang SH, Liang WX, Lu J, Yao L, Wang J, Gao WY (2020) Penicillium sp. YJM-2013 induces ginsenosides biosynthesis in Panax ginseng adventitious roots by inducing plant resistance responses. Chin Herbal Med 12(3):257–264

    Article  Google Scholar 

  • Williams RD, Bedard C, Chavarie C, Archambault J (1996) Production of sanguinarine by elicited plant cell culture II. Further nutritional aspects. J Biotechnol 46(2):107–120

    Article  CAS  Google Scholar 

  • Xie XG, Zhang ZZ, Chen L, Ming QL, Sheng KX, Chen X, Han T (2023) An endophytic fungus Schizophyllum commune isolated from Panax ginseng enhances hairy roots growth and ginsenoside biosynthesis. Can J Microbiol. https://doi.org/10.1139/cjm-2022-0194

    Article  PubMed  Google Scholar 

  • Xoca-Orozco LÁ, Cuellar-Torres EA, González-Morales S, Gutiérrez-Martínez P, López-García U, Herrera-Estrella L, Chacón-López A (2017) Transcriptomic analysis of avocado hass (Persea americana Mill.) in the interaction system fruit-chitosan-Colletotrichum. Front Plant Sci 8:956

    Article  PubMed  PubMed Central  Google Scholar 

  • Xu W, Jin X, Yang M, Xue S, Luo L, Cao X, Wang X (2021) Primary and secondary metabolites produced in Salvia miltiorrhiza hairy roots by an endophytic fungal elicitor from Mucor fragilis. Plant Physiol Biochem 160:404–412

    Article  CAS  PubMed  Google Scholar 

  • Yakhin OI, Lubyanov AA, Yakhin IA, Brown PH (2017) Biostimulants in plant science: a global perspective. Front Plant Sci 7:2049

    Article  PubMed  PubMed Central  Google Scholar 

  • Yamaner O, Erdag B (2013) Effects of sucrose and polyethylene glycol on hypericins content in Hypericum adenotrichum. Eurasia J Biosci. https://doi.org/10.5053/ejobios.2013.7.0.12

    Article  Google Scholar 

  • Yin H, Fretté XC, Christensen LP, Grevsen K (2012) Chitosan oligosaccharides promote the content of polyphenols in Greek oregano (Origanum vulgare ssp. hirtum). J Agric Food Chem 60(1):136–143

    Article  CAS  PubMed  Google Scholar 

  • Yuan G, Wang X, Guo R, Wang Q (2010) Effect of salt stress on phenolic compounds, glucosinolates, myrosinase and antioxidant activity in radish sprouts. Food Chem 121(4):1014–1019

    Article  CAS  Google Scholar 

  • Zahir A, Nadeem M, Ahmad W, Giglioli-Guivarch N, Hano C, Abbasi BH (2019) Chemogenic silver nanoparticles enhance lignans and neolignans in cell suspension cultures of Linum usitatissimum L. Plant Cell Tiss Organ Cult 136:589–596

    Article  CAS  Google Scholar 

  • Zehra A, Raytekar NA, Meena M, Swapnil P (2021) Efficiency of microbial bio-agents as elicitors in plant defense mechanism under biotic stress: a review. Curr Res Microbial Sci 2:100054

    Article  CAS  Google Scholar 

  • Zhan X, Chen Z, Chen R, Shen C (2022) Environmental and genetic factors involved in plant protection-associated secondary metabolite biosynthesis pathways. Front Plant Sci 13:877304

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang C, Yan Q, Cheuk WK, Wu J (2004) Enhancement of tanshinone production in Salvia miltiorrhiza hairy root culture by Ag+ elicitation and nutrient feeding. Planta Med 70(02):147–151

    Article  CAS  PubMed  Google Scholar 

  • Zhang Z, Zhao P, Zhang P, Su L, Jia H, Wei X, Jia H (2020) Integrative transcriptomics and metabolomics data exploring the effect of chitosan on postharvest grape resistance to Botrytis cinerea. Postharvest Biol Technol 167:111248

    Article  CAS  Google Scholar 

  • Zhao J, Davis LC, Verpoorte R (2005) Elicitor signal transduction leading to production of plant secondary metabolites. Biotechnol Adv 23(4):283–333

    Article  CAS  PubMed  Google Scholar 

  • Zhong JJ (2001) Biochemical engineering of the production of plant-specific secondary metabolites by cell suspension cultures. Plant Cells. https://doi.org/10.1007/3-540-45302-4_1

    Article  Google Scholar 

  • Zhou LS, Tang K, Guo SX (2018) The plant growth-promoting fungus (PGPF) Alternaria sp. A13 markedly enhances Salvia miltiorrhiza root growth and active ingredient accumulation under greenhouse and field conditions. Int J Mol Sci 19(1):270

    Article  PubMed  PubMed Central  Google Scholar 

  • Złotek U (2017) Effect of jasmonic acid and yeast extract elicitation on low-molecular antioxidants and antioxidant activity of marjoram (Origanum majorana L.). Acta Sci Pol Technol Aliment 16(4):371–377

    PubMed  Google Scholar 

  • Zobayed SMA, Afreen F, Kozai T (2005) Temperature stress can alter the photosynthetic efficiency and secondary metabolite concentrations in St. John’s Wort. Plant Physiol Biochem 43(10–11):977–984

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

No funds, grants, or other support was received.

Author information

Authors and Affiliations

  1. School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab, 144411, India

    Nidhi Selwal, Umesh Goutam, Nahid Akhtar & Monika Sood

  2. School of Agriculture, Lovely Professional University, Phagwara, Punjab, 144411, India

    Sarvjeet Kukreja

Authors
  1. Nidhi Selwal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Umesh Goutam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nahid Akhtar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Monika Sood
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sarvjeet Kukreja
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conceptualization: NS; equally contributed to writing the original draft: NS, SK; writing—review, editing, valuable feedback: NS, SK, UG, NA and MS; manuscript corrections and draft formatting: SK, UG, MS, NA; supervision, visualization: NS. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Sarvjeet Kukreja.

Ethics declarations

Competing interests

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Additional information

Handling Editor: Ariel D. Arencibia.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Selwal, N., Goutam, U., Akhtar, N. et al. Elicitation: “A Trump Card” for Enhancing Secondary Metabolites in Plants. J Plant Growth Regul (2024). https://doi.org/10.1007/s00344-024-11294-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00344-024-11294-y

Keywords

Search

Navigation