Abstract
Lung injury has been a serious medical problem that requires new therapeutic approaches and biomarkers. Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) that exist widely in eukaryotes. CircRNAs are single-stranded RNAs that form covalently closed loops. CircRNAs are significant gene regulators that have a role in the development, progression, and therapy of lung injury by controlling transcription, translating into protein, and sponging microRNAs (miRNAs) and proteins. Although the study of circRNAs in lung injury caused by pulmonary toxicants is just beginning, several studies have revealed their expression patterns. The function that circRNAs perform in relation to pulmonary toxicants (severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2), drug abuse, PM2.5, and cigarette smoke) is the main topic of this review. A variety of circRNAs can serve as potential biomarkers of lung injury. In this review, the biogenesis, properties, and biological functions of circRNAs were concluded, and the relationship between circRNAs and pulmonary toxicants was discussed. It is expected that the new ideas and potential treatment targets that circRNAs provide would be beneficial to research into the molecular mechanisms behind lung injury.
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This work is funded by the National Natural Science Foundation of China (No. 81973404) and Natural Science Foundation of Liaoning Province (No. 2022-MS-224).
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Conceptualization: CL, Z-WH, D-LK, and YW; writing––original draft preparation: CL and Z-WH; data analysis and literature search: RY, Y-JY, and X-RL; supervision and writing––review and editing: D-LK and YW; funding acquisition: YW. All authors read and approved the final manuscript.
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Liao, C., He, ZW., Yu, R. et al. CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants. Arch Toxicol 98, 1297–1310 (2024). https://doi.org/10.1007/s00204-024-03706-5
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DOI: https://doi.org/10.1007/s00204-024-03706-5