Bacterial infection is the most common risk factor that causes the failure of implantation surgery. Therefore, the development of biocompatible implants with excellent antibacterial properties is of utmost importance. In this study, NIR light-driven AgBiS₂@ZIF-8 hybrid photocatalysts for rapid bacteria-killing were prepared. AgBiS₂@ZIF-8 exhibited excellent photocatalytic activity due to the rapid transfer of photoelectrons from AgBiS₂ to ZIF-8, resulting in abundant reactive oxygen species (ROS) to kill bacteria. Meanwhile, AgBiS₂@ZIF-8 exhibited a noteworthy photothermal effect, which could effectively convert NIR light into heat. Subsequently, the NIR light-driven antibacterial activity of AgBiS₂@ZIF-8/Ti against S. aureus and E. coli was studied. The experimental results showed that AgBiS₂@ZIF-8 displayed enhanced photodynamic therapy (PDT) and photothermal therapy (PTT) performance. Under irradiation with 808 nm NIR light for 10 min, AgBiS₂@ZIF-8/Ti could effectively eliminate 98.55% of S. aureus in vitro, 99.34% of E. coli in vitro and 95% S. aureus in vivo. At the same time, AgBiS₂@ZIF-8/Ti had good biocompatibility. Therefore, AgBiS₂@ZIF-8/Ti showed potential as an antibacterial material, which provided a strategy to fight polymicrobial infections.