Asymmetric synthesis of the fully functionalized six-membered A-ring of siphonol A†
Abstract
A synthetic study toward the construction of the fully functionalized six-membered A-ring of siphonol A is described. The salient features include the introduction of a six-membered ring system through a HWE reaction, the construction of a stereocenter at C5 via a hetero-Diels–Alder reaction, and the installation of the fully functionalized six-membered A-ring of siphonol A through photolytic decarboxylation.