Rhodium-catalysed additive-free carbonylation of benzamides with diethyl dicarbonate as a carbonyl source

Hirotsugu Suzuki; Seigo Kiyobe; Takanori Matsuda

doi:10.1039/D4OB00059E

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Rhodium-catalysed additive-free carbonylation of benzamides with diethyl dicarbonate as a carbonyl source†

Hirotsugu Suzuki,

*^a Seigo Kiyobe^b and Takanori Matsuda

*^b

Author affiliations

* Corresponding authors

^a Tenure-Track Program for Innovative Research, University of Fukui, 3-9-1 Bunkyo, Fukui-shi, Fukui 910-8507, Japan
E-mail: h-suzuki@u-fukui.ac.jp

^b Department of Applied Chemistry, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
E-mail: mtd@rs.tus.ac.jp

Abstract

Phthalimides are prevalent in numerous pharmaceuticals, prompting various phthalimide syntheses through C–H activation. Nevertheless, the necessity for stoichiometric additives limits their practicality and versatility. Herein, we introduced diethyl dicarbonate as a carbonyl source for an additive-free carbonylation of benzamides. This transformation signifies an operationally simple and CO-free phthalimide synthesis.

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Article information

DOI: https://doi.org/10.1039/D4OB00059E
Article type: Communication
Submitted: 11 Jan 2024
Accepted: 26 Feb 2024
First published: 06 Mar 2024

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Org. Biomol. Chem., 2024,22, 2744-2748

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Rhodium-catalysed additive-free carbonylation of benzamides with diethyl dicarbonate as a carbonyl source

H. Suzuki, S. Kiyobe and T. Matsuda, Org. Biomol. Chem., 2024, 22, 2744 DOI: 10.1039/D4OB00059E

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Organic & Biomolecular Chemistry

Rhodium-catalysed additive-free carbonylation of benzamides with diethyl dicarbonate as a carbonyl source†

Abstract

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Rhodium-catalysed additive-free carbonylation of benzamides with diethyl dicarbonate as a carbonyl source

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