Issue 13, 2024
From the journal:

Organic & Biomolecular Chemistry

A visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction†

Ming Qia  and  An-Wu Xu ORCID logo *a  

* Corresponding authors

a Division of Nanomaterials and Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, People's Republic of China
E-mail: anwuxu@ustc.edu.cn

Abstract

This study presents a green and practical visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction using aldehydes as alkyl radical precursors. The photocatalytic system exhibits a broad substrate scope and synthetically useful yields. Mechanistic experiments revealed that alkyl radicals could be generated through auto-oxidation of aldehydes under irradiation, which is a mild and effective method for achieving late-stage functionalization of N-heteroarenes. Some biologically active N-heteroarenes could be alkylated using this photocatalytic system smoothly.

Graphical abstract: A visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction

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Article information

DOI
https://doi.org/10.1039/D4OB00021H
Article type
Paper
Submitted
05 Jan 2024
Accepted
04 Mar 2024
First published
05 Mar 2024

Org. Biomol. Chem., 2024,22, 2654-2661

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A visible-light-induced photosensitizer-free decarbonylative Minisci-type reaction

M. Qi and A. Xu, Org. Biomol. Chem., 2024, 22, 2654 DOI: 10.1039/D4OB00021H

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