Issue 13, 2024
From the journal:

Organic & Biomolecular Chemistry

Catalyst-free visible light-promoted defunctionalization of alkyl isocyanides with a hydrosilane through C–N bond cleavage†

Yu-Qing Ma ORCID logo a  and  Shi-Kai Tian ORCID logo *a  

* Corresponding authors

a Hefei National Research Center for Physical Sciences at the Microscale, Key Laboratory of Precision and Intelligent Chemistry, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: tiansk@ustc.edu.cn

Abstract

A radical initiator-free defunctionalization reaction of alkyl isocyanides with a hydrosilane has been established through C–N bond cleavage under catalyst-free visible light irradiation. Various alkyl isocyanides participated in the defunctionalization with tris(trimethylsilyl)silane under blue light irradiation at room temperature, delivering the reduced products in good yields with high chemoselectivity.

Graphical abstract: Catalyst-free visible light-promoted defunctionalization of alkyl isocyanides with a hydrosilane through C–N bond cleavage

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Article information

DOI
https://doi.org/10.1039/D4OB00173G
Article type
Communication
Submitted
02 Feb 2024
Accepted
01 Mar 2024
First published
04 Mar 2024

Org. Biomol. Chem., 2024,22, 2562-2565

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Catalyst-free visible light-promoted defunctionalization of alkyl isocyanides with a hydrosilane through C–N bond cleavage

Y. Ma and S. Tian, Org. Biomol. Chem., 2024, 22, 2562 DOI: 10.1039/D4OB00173G

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