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SARS-CoV-2

Alterations of iron homeostasis as a potential druggable driver of long COVID

Nature Immunology volume 25, pages 387–389 (2024)Cite this article

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Drivers of persistent symptoms after acute COVID-19 remain largely unknown. Alterations in immune function, iron homeostasis and dysregulated erythropoiesis are described as treatable correlates of post-acute sequelae of COVID-19.

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Fig. 1: Iron dysregulation in COVID-19 infections causes an anemia of inflammation -like phenotype that may contribute to symptoms of long COVID.

References

  1. Girelli, D., Marchi, G., Busti, F. & Vianello, A. Semin Hematol 58, 182–187 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Hanson, A. L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01754-8 (2024).

    Article  Google Scholar 

  3. Galy, B., Conrad, M. & Muckenthaler, M. Nat. Rev. Mol. Cell Biol. 25, 133–155 (2024).

    Article  CAS  PubMed  Google Scholar 

  4. Marques, O., Weiss, G. & Muckenthaler, M. U. Blood 140, 2011–2023 (2022).

    Article  CAS  PubMed  Google Scholar 

  5. Bellmann-Weiler, R. et al. J. Clin. Med. 9, 2429 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Frost, J. N. et al. Med. 2, 164–179.e112 (2021).

    Article  CAS  PubMed  Google Scholar 

  7. Hippchen, T., Altamura, S., Muckenthaler, M. U. & Merle, U. Hemasphere 4, e492 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Davis, H. E., McCorkell, L., Vogel, J. M. & Topol, E. J. Nat. Rev. Microbiol. 21, 133–146 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Vinchi, F. et al. Blood 127, 473–486 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Slusarczyk, P. et al. eLife 12, e79196 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. El-Battrawy, I. et al. J. Cell Mol. Med. 26, 2520–2528 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Kalra, P. R. et al. Lancet 400, 2199–2209 (2022).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pediatric Oncology, Hematology and Immunology and Hopp Children Cancer Center (KiTZ), University Hospital Heidelberg, Heidelberg, Germany

    Oriana Marques & Martina U. Muckenthaler

  2. Molecular Medicine Partnership Unit (MMPU), EMBL and University of Heidelberg, Heidelberg, Germany

    Oriana Marques & Martina U. Muckenthaler

  3. Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany

    Martina U. Muckenthaler

  4. DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

    Martina U. Muckenthaler

Authors
  1. Oriana Marques
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  2. Martina U. Muckenthaler
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Correspondence to Martina U. Muckenthaler.

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The authors declare no competing interests.

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Marques, O., Muckenthaler, M.U. Alterations of iron homeostasis as a potential druggable driver of long COVID. Nat Immunol 25, 387–389 (2024). https://doi.org/10.1038/s41590-024-01759-3

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