* Corresponding authors

^a Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
E-mail: aaronfrc@kmu.edu.tw

^b Institute of Pharmaceutical Chemistry and HUN-REN-Stereochemistry Research Group, University of Szeged, Szeged 6720, Hungary
E-mail: szatmari.istvan@szte.hu

^c Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

^d Institute of Pharmacognosy, University of Szeged, Szeged 6720, Hungary

^e Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung County 907101, Taiwan

^f Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

^g Department of General Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan

^h Department of Biomedical Science and Environmental Biology, PhD Program in Life Sciences, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

ⁱ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

^j Department of Otorhinolaryngology-Head and Neck Surgery, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City 242062, Taiwan

^k School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan

^l Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan

^m Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan

ⁿ Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

^o Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807378, Taiwan

^p Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan