Bacillus Calmette–Guérin (BCG) is the only available vaccine against tuberculosis. As well as being an effective vaccine against tuberculosis, BCG also provides off-target protection against various pathogens. Here, we report a mechanism for BCG-mediated cross-protection against influenza A virus (IAV), which requires a dialogue between the innate and adaptive immune memory systems.
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References
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This is a summary of: Tran, K. A. et al. BCG immunization induces CX3CR1hi effector memory T cells to provide cross-protection via IFN-γ-mediated trained immunity. Nat. Immunol. https://doi.org/10.1038/s41590-023-01739-z (2024).
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A mechanism for BCG vaccine cross-protection against pulmonary viral infections. Nat Immunol 25, 403–404 (2024). https://doi.org/10.1038/s41590-024-01775-3
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DOI: https://doi.org/10.1038/s41590-024-01775-3
