Developing therapeutic agents that target the peptidylarginine deiminase PAD4 requires better understanding of the function of the enzyme. Isozyme-selective antibodies that alter PAD4 activity have been identified recently, revealing unique modes of action.
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Unno, M. Modes of PADing. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-023-01506-z
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DOI: https://doi.org/10.1038/s41589-023-01506-z
