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When ceramides meet immune senescence, a GIMAP5 connection

Nature Immunology volume 25, pages 196–197 (2024)Cite this article

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Apart from lifestyle, environment and chance events, genetic factors have a key role in delineating the health and longevity of an individual. Research by Park et al. has now shed light on the role of mammalian GIMAP5, a longevity-assurance (LASS) gene encoding a GTP-binding protein that regulates ceramide synthesis and cellular senescence.

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Fig. 1: Mechanism of action of GIMAP5 and opportunity to pharmacologically correct its deficiency.

References

  1. Park, A. Y. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01691-y (2024).

    Article  PubMed  Google Scholar 

  2. MacMurray, A. J. et al. Genome Res. 12, 1029–1039 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Patterson, A. R. et al. J. Allergy Clin. Immunol. 143, 245–257.e6 (2019).

    Article  CAS  PubMed  Google Scholar 

  4. Drzewiecki, K. et al. J. Exp. Med. 218, e20201745 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Limoges, M.-A., Cloutier, M., Nandi, M., Ilangumaran, S. & Ramanathan, S. Front. Immunol. 12, 679739 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Camacho-Muñoz, D. et al. Biochem. Pharmacol. 204, 115211 (2022).

    Article  PubMed  Google Scholar 

  7. Tonnetti, L., Verí, M.-C., Bonvini, E. & D’Adamio, L. J. Exp. Med. 189, 1581–1589 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Pewzner-Jung, Y., Ben-Dor, S. & Futerman, A. H. J. Biol. Chem. 281, 25001–25005 (2006).

    Article  CAS  PubMed  Google Scholar 

  9. Zhu, C. et al. Int. J. Biol. Sci. 19, 311–330 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Watters, R. J. et al. Leuk. Lymphoma 54, 1288–1296 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  11. DeLeve, L. D. Hepatology 61, 1740–1746 (2015).

    Article  CAS  PubMed  Google Scholar 

  12. Perrotta, C., De Palma, C., Falcone, S., Sciorati, C. & Clementi, E. Life Sci. 77, 1732–1739 (2005).

    Article  CAS  PubMed  Google Scholar 

  13. FDA Updates. Oncol. Times https://doi.org/10.1097/01.COT.0000514203.35081.69 (2017).

  14. Patterson, A. R. et al. Nat. Commun. 9, 430 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

C.M. is supported by a British Heart Foundation Senior Basic Science Research Fellowship (FS/SBSRF/22/31031[CM1]).

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  1. Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK

    Atrayee Gope & Claudio Mauro

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  1. Atrayee Gope
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  2. Claudio Mauro
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Correspondence to Claudio Mauro.

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The authors declare no competing interests.

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Gope, A., Mauro, C. When ceramides meet immune senescence, a GIMAP5 connection. Nat Immunol 25, 196–197 (2024). https://doi.org/10.1038/s41590-023-01736-2

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