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Three cytokine pairs modulate sepsis effects at the organism level

Nature Immunology volume 25, pages 202–203 (2024)Cite this article

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Sepsis is a global health issue in great need of effective therapies. Analysis of gene expression profiles in different tissues and at the whole-body level in mice enabled the characterization of the organism-wide host response to sepsis, which will help to build a unified mechanistic framework for the disease.

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Fig. 1: Three cytokine pairs recapitulate the transcriptional responses of organs to sepsis.

References

  1. Singer, M. et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315, 801–810 (2016). This review provides updated definitions and clinical criteria for sepsis and septic shock.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Cavaillon, J.-M., Singer, M. & Skirecki, T. Sepsis therapies: learning from 30 years of failure of translational research to propose new leads. EMBO Mol. Med. 12, e10128 (2020). This review discusses the challenges in sepsis translational research.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Lewis, A. J., Seymour, C. W. & Rosengart, M. R. Current murine models of sepsis. Surg. Infect. (Larchmt) 17, 385–393 (2016). This review provides an overview of current mouse models of sepsis.

    Article  PubMed  Google Scholar 

  4. Poll, T., van der, Shankar-Hari, M. & Wiersinga, W. J. The immunology of sepsis. Immunity 54, 2450–2464 (2021). This review presents current knowledge of immune dysregulations in sepsis.

    Article  PubMed  Google Scholar 

  5. Fajgenbaum, D. C. & June, C. H. Cytokine storm. N. Engl. J. Med. 383, 2255–2273 (2020). This review provides an overview of the pathophysiological features of cytokine storm syndromes.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Takahama, M. et al. A pairwise cytokine code explains the organism-wide response to sepsis. Nat. Immunol. https://doi.org/10.1038/s41590-023-01722-8 (2024).

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Three cytokine pairs modulate sepsis effects at the organism level. Nat Immunol 25, 202–203 (2024). https://doi.org/10.1038/s41590-024-01742-y

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