Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells lose the Y chromosome. Prevalent in haematopoietic cells, this common somatic mutation is associated with decreased longevity and an increased risk of age-related diseases, including cardiovascular disease. Haematopoietic mLOY provides further insight into the sex-specific disparities that exist in disease susceptibility.
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Sano, S., Walsh, K. Mosaic loss of chromosome Y and cardiovascular disease. Nat Rev Cardiol 21, 151–152 (2024). https://doi.org/10.1038/s41569-023-00976-x
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DOI: https://doi.org/10.1038/s41569-023-00976-x