* Corresponding authors

^a Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA
E-mail: yguo4@vcu.edu

^b Institute for Structural Biology, Drug Discovery and Development, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23219, USA

^c Structural Biology Initiative, CUNY Advanced Science Research Center, City University of New York, New York, New York, USA

^d PhD Program in Biochemistry, The Graduate Center of the City University of New York, New York, New York, USA

^e Department of Chemical Engineering, Virginia Tech, Blacksburg, VA2 4060, USA

^f Department of Chemistry & Biochemistry, City College of New York, New York, New York, USA