Issue 57, 2023

A DNA framework-based dual signal amplification biosensor for portable detection of SARS-CoV-2 and its mutations

Abstract

We developed a rapid and accurate biosensor to detect SARS-CoV-2 and distinguish its mutations. Benefitting from a DNA framework-modified ordered interface and a dual signal amplification strategy, our biosensor could detect SARS-CoV-2 with a detection limit down to 10 fM. It performed well on pseudo virus and SARS-CoV-2 RNA standard materials, revealing the potential application in disease diagnosis and spread, in combination with a home-made smartphone.

Graphical abstract: A DNA framework-based dual signal amplification biosensor for portable detection of SARS-CoV-2 and its mutations

Supplementary files

Article information

Article type
Communication
Submitted
25 May 2023
Accepted
09 Jun 2023
First published
09 Jun 2023

Chem. Commun., 2023,59, 8838-8841

A DNA framework-based dual signal amplification biosensor for portable detection of SARS-CoV-2 and its mutations

Y. Dou, Z. Huang, T. Li, N. Maboyi, X. Ding, S. Song and J. Su, Chem. Commun., 2023, 59, 8838 DOI: 10.1039/D3CC02526H

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