-
Paper towel shredding as a novel, affordable, noninvasive method for detecting arousals in hibernating rodents Lab Anim. (IF 6.9) Pub Date : 2024-04-18 Amalie J. Hutchinson, Brynne M. Duffy, Lauren H. Rego, James F. Staples
-
Goal commitment is supported by vmPFC through selective attention Nat. Hum. Behav. (IF 29.9) Pub Date : 2024-04-17 Eleanor Holton, Jan Grohn, Harry Ward, Sanjay G. Manohar, Jill X. O’Reilly, Nils Kolling
-
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes Nat. Hum. Behav. (IF 29.9) Pub Date : 2024-04-17 Sylvanus Toikumo, Mariela V. Jennings, Benjamin K. Pham, Hyunjoon Lee, Travis T. Mallard, Sevim B. Bianchi, John J. Meredith, Laura Vilar-Ribó, Heng Xu, Alexander S. Hatoum, Emma C. Johnson, Vanessa K. Pazdernik, Zeal Jinwala, Shreya R. Pakala, Brittany S. Leger, Maria Niarchou, Michael Ehinmowo, Greg D. Jenkins, Anthony Batzler, Richard Pendegraft, Abraham A. Palmer, Hang Zhou, Joanna M. Biernacka
-
Language in Bioethics: Beyond the Representational View Am. J. Bioethics (IF 13.4) Pub Date : 2024-04-16 Justin T. Clapp, Jacqueline M. Kruser, Margaret L. Schwarze, Rachel A. Hadler
Though assumptions about language underlie all bioethical work, the field has rarely partaken of theories of language. This article encourages a more linguistically engaged bioethics. We describe t...
-
‘How to adapt forests?’—Exploring the role of leaf trait diversity for long‐term forest biomass under new climate normals Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-17 Maik Billing, Boris Sakschewski, Werner von Bloh, Johannes Vogel, Kirsten Thonicke
Forests, critical components of global ecosystems, face unprecedented challenges due to climate change. This study investigates the influence of functional diversity—as a component of biodiversity—to enhance long‐term biomass of European forests in the context of changing climatic conditions. Using the next‐generation flexible trait‐based vegetation model, LPJmL‐FIT, we explored the impact of functional
-
Ecological baselines in the Eastern Mediterranean Sea shifted long before the availability of observational time series Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-16 Jan Steger, Cesare Bogi, Hadas Lubinevsky, Bella S. Galil, Martin Zuschin, Paolo G. Albano
-
Shedding light on the increased carbon uptake by a boreal forest under diffuse solar radiation across multiple scales Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-16 Santa Neimane‐Šroma, Maxime Durand, Anna Lintunen, Juho Aalto, T. Matthew Robson
-
NCOR1/2 and glucocorticoid receptor orchestrate hepatic function Nat. Metab. (IF 20.8) Pub Date : 2024-04-15 Chloé Van Leene, Karolien De Bosscher
-
Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis Nat. Metab. (IF 20.8) Pub Date : 2024-04-15 Amy K. Hauck, Rashid Mehmood, Bryce J. Carpenter, Maxwell T. Frankfurter, Michael C. Tackenberg, Shin-ichi Inoue, Maria K. Krieg, Fathima N. Cassim Bawa, Mohit K. Midha, Delaine M. Zundell, Kirill Batmanov, Mitchell A. Lazar
-
Correction to “Genomic architecture controls multivariate adaptation to climate change” Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-15
Terasaki Hart, D., E., & Wang, I., J. (2024). Genomic architecture controls multivariate adaptation to climate change. Global Change Biology, 30(2), e17179. doi: 10.1111/gcb.17179. Figures 4, S3, and S4 show rows of data ordered identically to other paneled figures: top-to-bottom, the rows show the results for scenarios with independent, weak, and strong linkage. However, the original row labels in
-
Environmental plastics in the context of UV radiation, climate change, and the Montreal Protocol Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-15 Marcel A. K. Jansen, Anthony L. Andrady, Paul W. Barnes, Rosa Busquets, Laura E. Revell, Janet F. Bornman, Pieter J. Aucamp, Alkiviadis F. Bais, Anastazia T. Banaszak, Germar H. Bernhard, Laura S. Bruckman, Donat‐P. Häder, Mark L. Hanson, Anu M. Heikkilä, Samuel Hylander, Robyn M. Lucas, Roy Mackenzie, Sasha Madronich, Patrick J. Neale, Rachel E. Neale, Catherine M. Olsen, Rachele Ossola, Krishna K
-
Microbial phosphorus‐cycling genes in soil under global change Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-15 Xuewei Wang, Hui Guo, Jianing Wang, Peng He, Yakov Kuzyakov, Miaojun Ma, Ning Ling
-
Climate‐driven shifts in the diversity of plants in the Neotropical seasonally dry forest: Evaluating the effectiveness of protected areas Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-15 Avril Manrique‐Ascencio, David A. Prieto‐Torres, Fabricio Villalobos, Roger Guevara
-
Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis Redox Biol. (IF 11.4) Pub Date : 2024-04-15 Jing Zhao, Wan Ma, Sisi Wang, Kang Zhang, Qingqing Xiong, Yunqin Li, Hong Yu, Huahua Du
Iron overload can lead to oxidative stress and intestinal damage and happens frequently during blood transfusions and iron supplementation. However, how iron overload influences intestinal mucosa remains unknown. Here, the aim of current study was to investigate the effects of iron overload on the proliferation and differentiation of intestinal stem cells (ISCs). An iron overload mouse model was established
-
Bringing traits back into the equation: A roadmap to understand species redistribution Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-13 Lise Comte, Romain Bertrand, Sarah Diamond, Lesley T. Lancaster, Malin L. Pinsky, Brett R. Scheffers, J. Alex Baecher, R. M. W. J. Bandara, I‐Ching Chen, Jake A. Lawlor, Nikki A. Moore, Brunno F. Oliveira, Jerome Murienne, Jonathan Rolland, Madeleine A. Rubenstein, Jennifer Sunday, Laura M. Thompson, Fabricio Villalobos, Sarah R. Weiskopf, Jonathan Lenoir
-
Carbon fluxes of China's coastal wetlands and impacts of reclamation and restoration Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-13 Weizhi Lu, Jingfeng Xiao, Haiqiang Gao, Qingyu Jia, Zhengjie Li, Jie Liang, Qinghui Xing, Dehua Mao, Hong Li, Xiaojing Chu, Hui Chen, Haiqiang Guo, Guangxuan Han, Bin Zhao, Luzhen Chen, Derrick Y. F. Lai, Shuguang Liu, Guanghui Lin
-
Complex Polyploids: Origins, Genomic Composition, and Role of Introgressed Alleles Syst. Biol. (IF 6.5) Pub Date : 2024-04-13 J Luis Leal, Pascal Milesi, Eva Hodková, Qiujie Zhou, Jennifer James, D Magnus Eklund, Tanja Pyhäjärvi, Jarkko Salojärvi, Martin Lascoux
Introgression allows polyploid species to acquire new genomic content from diploid progenitors or from other unrelated diploid or polyploid lineages, contributing to genetic diversity and facilitating adaptive allele discovery. In some cases, high levels of introgression elicit the replacement of large numbers of alleles inherited from the polyploid’s ancestral species, profoundly reshaping the polyploid’s
-
Co-evolved genes improve the biosynthesis of secondary metabolites Nat. Metab. (IF 20.8) Pub Date : 2024-04-12
-
Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis Nat. Metab. (IF 20.8) Pub Date : 2024-04-12 Xinran Wang, Ningxin Chen, Pablo Cruz-Morales, Biming Zhong, Yangming Zhang, Jian Wang, Yifan Xiao, Xinnan Fu, Yang Lin, Suneil Acharya, Zhibo Li, Huaxiang Deng, Yuhui Sun, Linquan Bai, Xiaoyu Tang, Jay D. Keasling, Xiaozhou Luo
-
Effects of lianas on forest biogeochemistry during their lives and afterlives Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-12 Gbadamassi G. O. Dossa, Hong‐Lin Li, Bo Pan, Tial C. Ling, Douglas A. Schaefer, Mareike Roeder, Denis M. Njoroge, Juan Zuo, Liang Song, Bismark Ofosu‐Bamfo, Stefan A. Schnitzer, Rhett D. Harrison, Frans Bongers, Jiao‐Lin Zhang, Kun‐Fang Cao, Jennifer S. Powers, Ze‐Xin Fan, Ya‐Jun Chen, Richard T. Corlett, Gerhard Zotz, Jacek Oleksyn, Tomasz P. Wyka, Jean Evans Israel Codjia, Johannes H. C. Cornelissen
Climate change and other anthropogenic disturbances are increasing liana abundance and biomass in many tropical and subtropical forests. While the effects of living lianas on species diversity, ecosystem carbon, and nutrient dynamics are receiving increasing attention, the role of dead lianas in forest ecosystems has been little studied and is poorly understood. Trees and lianas coexist as the major
-
PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner Redox Biol. (IF 11.4) Pub Date : 2024-04-12 Tianyu Li, Mengqi Sun, Qinglin Sun, Xiaoke Ren, Qing Xu, Zhiwei Sun, Junchao Duan
Exposure to PM is correlated with cardiac remodeling, of which cardiac hypertrophy is one of the main clinical manifestations. Ferroptosis plays an important role in cardiac hypertrophy. However, the potential mechanism of PM-induced cardiac hypertrophy through ferroptosis remains unclear. This study aimed to explore the molecular mechanism of cardiac hypertrophy caused by PM and the intervention role
-
Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis Redox Biol. (IF 11.4) Pub Date : 2024-04-12 Lin Wu, Yuxin Du, Litao Wang, Yingmei Zhang, Jun Ren
-
Macrophage vesicles in antidiabetic drug action Nat. Metab. (IF 20.8) Pub Date : 2024-04-11 Rinke Stienstra, Eric Kalkhoven
-
A call for accessible tools to unlock single-cell immunometabolism research Nat. Metab. (IF 20.8) Pub Date : 2024-04-11 Jason Cosgrove, Antoine Marçais, Felix J. Hartmann, Andreas Bergthaler, Ivan Zanoni, Mauro Corrado, Leïla Perié, Nina Cabezas-Wallscheid, Philippe Bousso, Theodore Alexandrov, Tammy Kielian, Nuria Martínez-Martín, Christiane A. Opitz, Costas A. Lyssiotis, Rafael J. Argüello, Jan Van den Bossche
Recent technological advances permit the profiling of metabolic changes in single cells, which sheds light on how metabolism regulates immune responses. We advocate for accessible and standardized tools to reduce the barrier of entry to immunometabolism studies and facilitate the translation of fundamental findings towards clinical applications.
-
Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization Nat. Metab. (IF 20.8) Pub Date : 2024-04-11 Theresa V. Rohm, Felipe Castellani Gomes Dos Reis, Roi Isaac, Cairo Murphy, Karina Cunha e Rocha, Gautam Bandyopadhyay, Hong Gao, Avraham M. Libster, Rizaldy C. Zapata, Yun Sok Lee, Wei Ying, Charlene Miciano, Allen Wang, Jerrold M. Olefsky
-
Streamlining mouse genome editing by integrating AAV repair template delivery and CRISPR-Cas electroporation Lab Anim. (IF 6.9) Pub Date : 2024-04-10 Natalia Moncaut
-
The emerging importance of the α-keto acid dehydrogenase complexes in serving as intracellular and intercellular signaling platforms for the regulation of metabolism Redox Biol. (IF 11.4) Pub Date : 2024-04-10 Ryan J. Mailloux
The α-keto acid dehydrogenase complex (KDHc) class of mitochondrial enzymes is composed of four members: pyruvate dehydrogenase (PDHc), α-ketoglutarate dehydrogenase (KGDHc), branched-chain keto acid dehydrogenase (BCKDHc), and 2-oxoadipate dehydrogenase (OADHc). These enzyme complexes occupy critical metabolic intersections that connect monosaccharide, amino acid, and fatty acid metabolism to Krebs
-
Museum genomics reveals the hybrid origin of an extinct crater lake endemic Syst. Biol. (IF 6.5) Pub Date : 2024-04-10 Amy R Tims, Peter J Unmack, Michael P Hammer, Culum Brown, Mark Adams, Matthew D McGee
Crater lake fishes are common evolutionary model systems, with recent studies suggesting a key role for gene flow in promoting rapid adaptation and speciation. However, the study of these young lakes can be complicated by human-mediated extinctions. Museum genomics approaches integrating genetic data from recently extinct species are therefore critical to understanding the complex evolutionary histories
-
A systematic review and multivariate meta-analysis of the physical and mental health benefits of touch interventions Nat. Hum. Behav. (IF 29.9) Pub Date : 2024-04-08 Julian Packheiser, Helena Hartmann, Kelly Fredriksen, Valeria Gazzola, Christian Keysers, Frédéric Michon
-
Water restriction still has a place Lab Anim. (IF 6.9) Pub Date : 2024-04-09 Pamela Reinagel
The citric acid (CA) method was recently proposed as an alternative to water restriction, which is commonly used to motivate rodents to perform behavioral tasks. As the person who first developed the CA method1, I read with great interest your Protocol Review article “The weights of refinement and flexibility”2. I am gratified to see that this approach is already so widely adopted and discussed, and
-
Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R Redox Biol. (IF 11.4) Pub Date : 2024-04-09 Xin Zhong, Kangwei Wang, Yonghua Wang, Luya Wang, Sudan Wang, Weijian Huang, Zhuyin Jia, Shan-Shan Dai, Zhouqing Huang
-
An orally active carbon monoxide-releasing molecule enhances beneficial gut microbial species to combat obesity in mice Redox Biol. (IF 11.4) Pub Date : 2024-04-09 Djamal Eddine Benrahla, Shruti Mohan, Matija Trickovic, Florence Anne Castelli, Ghida Alloul, Arielle Sobngwi, Rosa Abdiche, Silas Kieser, Vanessa Demontant, Elisabeth Trawinski, Céline Chollet, Christophe Rodriguez, Hiroaki Kitagishi, François Fenaille, Mirko Trajkovski, Roberto Motterlini, Roberta Foresti
-
What anaesthesia reveals about human brains and consciousness Nat. Hum. Behav. (IF 29.9) Pub Date : 2024-04-08 Andrea I. Luppi
-
Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults Nat. Hum. Behav. (IF 29.9) Pub Date : 2024-04-08 Yue-Ting Deng, Bang-Sheng Wu, Liu Yang, Xiao-Yu He, Ju-Jiao Kang, Wei-Shi Liu, Ze-Yu Li, Xin-Rui Wu, Ya-Ru Zhang, Shi-Dong Chen, Yi-Jun Ge, Yu-Yuan Huang, Jian-Feng Feng, Ying Zhu, Qiang Dong, Ying Mao, Wei Cheng, Jin-Tai Yu
-
Life goes on: Spatial heterogeneity promotes biodiversity in an urbanized coastal marine ecosystem Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-06 Shelby E. McIlroy, Isis Guibert, Anand Archana, Wing Yi Haze Chung, J. Emmett Duffy, Rinaldi Gotama, Jerome Hui, Nancy Knowlton, Matthieu Leray, Chris Meyer, Gianni Panagiotou, Gustav Paulay, Bayden Russell, Philip D. Thompson, David M. Baker
-
Humanized mouse models of drug metabolism Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Alexandra Le Bras
Accumulating evidence suggests that species differences between mice and humans can compromise drug efficacy studies. In humans, the pharmacological activity of many small molecules is altered by activity of the cytochrome P450 (CYP) system. Humans have eight genes within the CYP1A, CYP2C, CYP2D and CYP3A subfamilies, while mice have 34 genes within the CYP system. These species differences lead to
-
AAV gene therapy to treat Friedreich’s ataxia cardiomyopathy Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Jorge Ferreira
Friedreich’s ataxia (FRDA), a common inherited ataxia, affects the nervous system and the heart, causing cardiomyopathy. The disease is associated with a reduced expression of the mitochondrial protein frataxin (FXN), and adeno-associated viral vector (AAV)-mediated gene transfer can be a potential therapeutic approach to induce frataxin expression. While this approach has been effective in cardiac
-
The risk of oversight Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Lauren Danridge, Bill Greer, Michelle Aparicio, Sarah Viranda, Elysse Ann Orchard, Louis DiVincenti, Axel Wolff
A clear organizational reporting structure within the Animal Care and Use Program and a collegial working relationship between the Institutional Official, Attending Veterinarian and Institutional Animal Care and Use Committee are essential to maintain the highest standards of animal wellbeing and research quality. We invited experts from The Feinstein Institutes for Medical Research (Michelle Aparicio)
-
Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects Redox Biol. (IF 11.4) Pub Date : 2024-04-05 Viktoria Thoeni, Elitsa Y. Dimova, Thomas Kietzmann, Robert J. Usselman, Margit Egg
-
Selenite selectively kills lung fibroblasts to treat bleomycin-induced pulmonary fibrosis Redox Biol. (IF 11.4) Pub Date : 2024-04-05 Jiun-Han Lin, Chen-Chi Liu, Chao-Yu Liu, Tien-Wei Hsu, Yi-Chen Yeh, Chorng-Kuang How, Han-Shui Hsu, Shih-Chieh Hung
Interstitial lung disease (ILD) treatment is a critical unmet need. Selenium is an essential trace element for human life and an antioxidant that activates glutathione, but the gap between its necessity and its toxicity is small and requires special attention. Whether selenium can be used in the treatment of ILD remains unclear. We investigated the prophylactic and therapeutic effects of selenite,
-
Museum skins enable identification of introgression associated with cytonuclear discordance Syst. Biol. (IF 6.5) Pub Date : 2024-04-05 Sally Potter, Craig Moritz, Maxine P Piggott, Jason G Bragg, Ana C Afonso Silva, Ke Bi, Christiana McDonald-Spicer, Rustamzhon Turakulov, Mark D B Eldridge
Increased sampling of genomes and populations across closely related species has revealed that levels of genetic exchange during and after speciation are higher than previously thought. One obvious manifestation of such exchange is strong cytonuclear discordance, where the divergence in mitochondrial DNA (mtDNA) differs from that for nuclear genes more (or less) than expected from differences between
-
Postprandial sodium sensing by enteric neurons in Drosophila Nat. Metab. (IF 20.8) Pub Date : 2024-04-03 Byoungsoo Kim, Gayoung Hwang, Sung-Eun Yoon, Meihua Christina Kuang, Jing W. Wang, Young-Joon Kim, Greg S. B. Suh
Sodium is essential for all living organisms1. Animals including insects and mammals detect sodium primarily through peripheral taste cells2,3,4,5,6,7. It is not known, however, whether animals can detect this essential micronutrient independently of the taste system. Here, we report that Drosophila Ir76b mutants that were unable to detect sodium2 became capable of responding to sodium following a
-
Environmental enrichment improves mice motor performance Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Jorge Ferreira
Environmental enrichment (EE) is a well-established concept that shows benefits for both brain development and cognitive function. However, rodents are commonly raised in poorly enriched conditions, which can affect neuroscience data. A study in Scientific Reports shows that providing EE to mice improves conditioned responses and motor performance. EE mice showed slower acquisition of eyeblink-conditioned
-
Effect of chronic stress on metastasis Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Jorge Ferreira
Chronic stress, a common issue in daily life, is particularly pronounced in patients with cancer. Chronic stress affects the whole body and perturbs systemic homeostasis, promoting cancer growth in mice. Whether and why chronic stress increases metastasis rates is still unknown. A study in Cancer Cell shows that chronic stress promotes metastasis in a metastatic lung cancer mouse model by increasing
-
Cancer resistance in bats Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Alexandra Le Bras
Laboratory mice and rats are traditionally used as model organisms to study the molecular mechanisms of carcinogenesis. However, these cancer-prone models have limitations in understanding the mechanisms of cancer resistance. Certain long-lived mammalian species such as naked mole rats seem to have evolved unique anti-cancer mechanisms. Understanding how these animals are protected from cancer could
-
Tracking marmoset 3D movement and social behavior Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Jorge Ferreira
A broad range of research areas use behavioral analyses. Despite behavior being extensively used, it is quite uncommon for researchers to analyze long-term continuous behavior, especially in social groups, as it is challenging to accurately track individuals and their behaviors. This is even more pressing in social animals such as marmosets, which show many social close contact behaviors while moving
-
Toward phage therapy for tuberculosis Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Alexandra Le Bras
Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb), which primarily affects the lungs to cause pulmonary TB, but can also affect other tissues to cause extra-pulmonary TB. Mtb is an intracellular pathogen that can evade the immune system and proliferate within host cells, making antibiotic treatment more challenging and potentially resulting in antimicrobial
-
Rhesus macaques for human norovirus studies Lab Anim. (IF 6.9) Pub Date : 2024-04-03 Alexandra Le Bras
Norovirus is a common cause of acute gastrointestinal illness worldwide. Norovirus vaccine development is a priority for both public-health and economic reasons, but the search for a vaccine has been hampered by a lack of suitable and reliable animal models. In Nature Microbiology, Rimkute et al. show that rhesus macaques are susceptible to oral infection with human noroviruses from two different genogroups
-
Projected ocean temperatures impair key proteins used in vision of octopus hatchlings Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-04 Qiaz Q. H. Hua, Dietmar Kültz, Kathryn Wiltshire, Zoe A. Doubleday, Bronwyn M. Gillanders
-
Interplay of management and environmental drivers shifts size structure of reef fish communities Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-04 Steven W. J. Canty, A. Justin Nowakowski, Courtney E. Cox, Abel Valdivia, Daniel M. Holstein, Benjamin Limer, Jonathan S. Lefcheck, Nicole Craig, Ian Drysdale, Ana Giro, Mélina Soto, Melanie McField
-
Increasing spread rates of tropical non‐native macrophytes in the Mediterranean Sea Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-04 Marlene Wesselmann, Iris E. Hendriks, Mark Johnson, Gabriel Jordà, Frederic Mineur, Núria Marbà
-
S-nitrosocysteamine-functionalised porous graphene oxide nanosheets as nitric oxide delivery vehicles for cardiovascular applications Redox Biol. (IF 11.4) Pub Date : 2024-04-04 Tanveer A. Tabish, Mian Zahid Hussain, Sevasti Zervou, William K. Myers, Weiming Tu, Jiabao Xu, Irina Beer, Wei E. Huang, Rona Chandrawati, Mark J. Crabtree, Paul G. Winyard, Craig A. Lygate
Nitric oxide (NO) is a key signalling molecule released by vascular endothelial cells that is essential for vascular health. Low NO bioactivity is associated with cardiovascular diseases, such as hypertension, atherosclerosis, and heart failure and NO donors are a mainstay of drug treatment. However, many NO donors are associated with the development of tolerance and adverse effects, so new formulations
-
Gut bacteria exacerbates TNBS-induced colitis and kidney injury through oxidative stress Redox Biol. (IF 11.4) Pub Date : 2024-04-04 Yang Sui, Rui Jiang, Manabu Niimi, Xin Wang, Yijun Xu, Yingyu Zhang, Zhuheng Shi, Mika Suda, Zhimin Mao, Jianglin Fan, Jian Yao
-
The extracellular matrix differentially directs myoblast motility and differentiation in distinct forms of muscular dystrophy: Dystrophic matrices alter myoblast motility Matrix Biol. (IF 6.9) Pub Date : 2024-04-04 Ashlee M. Long, Jason M. Kwon, GaHyun Lee, Nina L. Reiser, Lauren A. Vaught, Joseph G. O'Brien, Patrick G.T. Page, Michele Hadhazy, Joseph C. Reynolds, Rachelle H. Crosbie, Alexis R. Demonbreun, Elizabeth M. McNally
-
Salmonella Typhimurium employs spermidine to exert protection against ROS-mediated cytotoxicity and rewires host polyamine metabolism to ameliorate its survival in macrophages Redox Biol. (IF 11.4) Pub Date : 2024-04-03 Abhilash Vijay Nair, Anmol Singh, R.S. Rajmani, Dipshikha Chakravortty
-
S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease Redox Biol. (IF 11.4) Pub Date : 2024-04-03 Leire Goicoechea, Sandra Torres, Laura Fàbrega, Mónica Barrios, Susana Núñez, Josefina Casas, Gemma Fabrias, Carmen García-Ruiz, José C. Fernández-Checa
-
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2 Redox Biol. (IF 11.4) Pub Date : 2024-04-03 Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne
-
Specificity and dynamics of H2O2 detoxification by the cytosolic redox regulatory network as revealed by in vitro reconstitution Redox Biol. (IF 11.4) Pub Date : 2024-04-03 Lara Vogelsang, Jürgen Eirich, Iris Finkemeier, Karl-Josef Dietz
The thiol redox state is a decisive functional characteristic of proteins in cell biology. Plasmatic cell compartments maintain a thiol-based redox regulatory network linked to the glutathione/glutathione disulfide couple (GSH/GSSG) and the NAD(P)H system. The basic network constituents are known and cell imaging with gene-encoded probes have revealed insight into the dynamics of the [GSH]/[GSSG] redox
-
A spatiotemporal proteomic map of human adipogenesis Nat. Metab. (IF 20.8) Pub Date : 2024-04-02 Felix Klingelhuber, Scott Frendo-Cumbo, Muhmmad Omar-Hmeadi, Lucas Massier, Pamela Kakimoto, Austin J. Taylor, Morgane Couchet, Sara Ribicic, Martin Wabitsch, Ana C. Messias, Arcangela Iuso, Timo D. Müller, Mikael Rydén, Niklas Mejhert, Natalie Krahmer
White adipocytes function as major energy reservoirs in humans by storing substantial amounts of triglycerides, and their dysfunction is associated with metabolic disorders; however, the mechanisms underlying cellular specialization during adipogenesis remain unknown. Here, we generate a spatiotemporal proteomic atlas of human adipogenesis, which elucidates cellular remodelling as well as the spatial
-
Microbial evolution—An under‐appreciated driver of soil carbon cycling Glob. Change Biol. (IF 11.6) Pub Date : 2024-04-02 Elsa Abs, Alexander B. Chase, Stefano Manzoni, Philippe Ciais, Steven D. Allison