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Assessing phage-host population dynamics by reintroducing virulent viruses to synthetic microbiomes Cell Host Microbe (IF 30.3) Pub Date : 2024-04-22 Jacob Wilde, Randy Boyes, Avery V. Robinson, Brendan A. Daisley, Alexander J. Botschner, Dylan J.L. Brettingham, Christine V. Macpherson, Elizabeth Mallory, Emma Allen-Vercoe
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The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice Cell Host Microbe (IF 30.3) Pub Date : 2024-04-22 Sang-Hoon Sin, Anthony B. Eason, Yongbaek Kim, Johann W. Schneider, Blossom Damania, Dirk P. Dittmer
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Phages get snappy Nat. Rev. Microbiol. (IF 88.1) Pub Date : 2024-04-22 Andrea Du Toit
This study shows that a single-stranded RNA phage binds to the Pseudomonas aeruginosa type IV pilus, leading to phage entry into the cell and the detachment of the pilus, which impairs bacterial motility.
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Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-22 Yan Yan, Jun Xiao, Fengtao Huang, Wei Xian, Bingbing Yu, Rui Cheng, Hui Wu, Xueling Lu, Xionglue Wang, Wenjing Huang, Jing Li, Greater Kayode Oyejobi, Carol V. Robinson, Hao Wu, Di Wu, Xiaoyun Liu, Longfei Wang, Bin Zhu
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Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-22 Yinggui Yang, Tengteng Ding, Ying Cong, Xiaomin Luo, Changlin Liu, Ting Gong, Min Zhao, Xichun Zheng, Chenglin Li, Yuanbin Zhang, Jiayi Zhou, Chuping Ni, Xueyu Zhang, Ziliang Ji, Tao Wu, Shaodong Yang, Qingchun Zhou, Dinglan Wu, Xinqi Gong, Qingyou Zheng, Xin Li
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Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis) Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-22 Julia R. Port, Jade C. Riopelle, Samuel G. Smith, Lara Myers, Franziska K. Kaiser, Matthew C. Lewis, Shane Gallogly, Atsushi Okumura, Trent Bushmaker, Jonathan E. Schulz, Rebecca Rosenke, Jessica Prado-Smith, Aaron Carmody, Sidy Bane, Brian J. Smith, Greg Saturday, Heinz Feldmann, Kyle Rosenke, Vincent J. Munster
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Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-22 Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen, Liudmila Dzhekieva, Ronald E. Painter, Yun-Ting Chen, Marina Bukhtiyarova, Andrew Leithead, Rodger Tracy, Kerim Babaoglu, Carolyn Bahnck-Teets, Alexei Buevich, Tamara D. Cabalu, Marc Labroli, Henry Lange, Ying Lei, Wei Li, Jian Liu, Paul A. Mann, Tao Meng, Helen J. Mitchell, James Mulhearn, Giovanna Scapin, Deyou Sha, Anthony W. Shaw, Qian Si
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Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-22 Catherine C. Bradley, Chen Wang, Alasdair J. E. Gordon, Alice X. Wen, Pamela N. Luna, Matthew B. Cooke, Brendan F. Kohrn, Scott R. Kennedy, Vasanthi Avadhanula, Pedro A. Piedra, Olivier Lichtarge, Chad A. Shaw, Shannon E. Ronca, Christophe Herman
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The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-22 Chih-Yen Kuo, Rebecca J. Tay, Hung-Che Lin, Sheng-Chian Juan, Guillermo Vidal-Diez de Ulzurrun, Yu-Chu Chang, Jason Hoki, Frank C. Schroeder, Yen-Ping Hsueh
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Burkholderia thailandensis uses a type VI secretion system to lyse protrusions without triggering host cell responses Cell Host Microbe (IF 30.3) Pub Date : 2024-04-18 Miro Thorsten Wilhelm Plum, Hoi Ching Cheung, Patricia Reist Iscar, Yahua Chen, Yunn-Hwen Gan, Marek Basler
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Defence systems and horizontal gene transfer in bacteria Environ. Microbiol. (IF 5.1) Pub Date : 2024-04-21 Roman Kogay, Yuri I. Wolf, Eugene V. Koonin
Horizontal gene transfer (HGT) is a fundamental process in prokaryotic evolution, contributing significantly to diversification and adaptation. HGT is typically facilitated by mobile genetic elements (MGEs), such as conjugative plasmids and phages, which often impose fitness costs on their hosts. However, a considerable number of bacterial genes are involved in defence mechanisms that limit the propagation
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Narrow-spectrum antibiotic exploits metabolic differences to inhibit Pseudomonas aeruginosa Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-19
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Recent development and fighting strategies for lincosamide antibiotic resistance Clin. Microbiol. Rev. (IF 36.8) Pub Date : 2024-04-18 Yingying YangShiyu XieFangjing HeYindi XuZhifang WangAwais IhsanXu Wang1National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei, China2MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China3MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong
Clinical Microbiology Reviews, Ahead of Print.
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Shaking up that sick feeling with biofilm sugars Nat. Rev. Microbiol. (IF 88.1) Pub Date : 2024-04-18 Agustina Taglialegna
In this study, Granton et al. show that biofilm-associated exopolysaccharides produced by Pseudomonas aeruginosa control sickness during lung infection.
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Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-18 Rebekah Honce, Ana Vazquez-Pagan, Brandi Livingston, Alexandra H. Mandarano, Benjamin A. Wilander, Sean Cherry, Virginia Hargest, Bridgett Sharp, Pamela H. Brigleb, Ericka Kirkpatrick Roubidoux, Lee-Ann Van de Velde, R. Chris Skinner, Maureen A. McGargill, Paul G. Thomas, Stacey Schultz-Cherry
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Diurnal transcriptional variation is reduced in a nitrogen-fixing diatom endosymbiont ISME J. (IF 11.0) Pub Date : 2024-04-18 Heidi Abresch, Tisza Bell, Scott R Miller
Many organisms have formed symbiotic relationships with nitrogen (N)-fixing bacteria to overcome N limitation. Diatoms in the family Rhopalodiaceae host unicellular, N-fixing cyanobacterial endosymbionts called spheroid bodies (SBs). Although this relationship is relatively young, SBs share many key features with older endosymbionts, including coordinated cell division and genome reduction. Unlike
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tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-17 Jennifer L. Small-Saunders, Ameya Sinha, Talia S. Bloxham, Laura M. Hagenah, Guangxin Sun, Peter R. Preiser, Peter C. Dedon, David A. Fidock
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CryoEM structures reveal how the bacterial flagellum rotates and switches direction Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-17 Prashant K. Singh, Pankaj Sharma, Oshri Afanzar, Margo H. Goldfarb, Elena Maklashina, Michael Eisenbach, Gary Cecchini, T. M. Iverson
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Unveiling the culturable and non‐culturable actinobacterial diversity in two macroalgae species from the northern Portuguese coast Environ. Microbiol. (IF 5.1) Pub Date : 2024-04-17 Mariana Girão, Diogo A. M. Alexandrino, Weiwei Cao, Isabel Costa, Zhongjun Jia, Maria F. Carvalho
Actinomycetota, associated with macroalgae, remains one of the least explored marine niches. The secondary metabolism of Actinomycetota, the primary microbial source of compounds relevant to biotechnology, continues to drive research into the distribution, dynamics, and metabolome of these microorganisms. In this study, we employed a combination of traditional cultivation and metagenomic analysis to
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Chaperones Hsc70 and Hsp70 play distinct roles in the replication of bocaparvovirus minute virus of canines Mol. Microbiol. (IF 3.6) Pub Date : 2024-04-17 Jianhui Guo, Yan Yan, Jinhan Sun, Kai Ji, Zhiping Hei, Liang Zeng, Huanzhou Xu, Xiang Ren, Yuning Sun
Minute virus of canines (MVC) belongs to the genus Bocaparvovirus (formerly Bocavirus) within the Parvoviridae family and causes serious respiratory and gastrointestinal symptoms in neonatal canines worldwide. A productive viral infection relies on the successful recruitment of host factors for various stages of the viral life cycle. However, little is known about the MVC‐host cell interactions. In
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Anaerobic oxidation of ammonium and short-chain gaseous alkanes coupled to nitrate reduction by a bacterial consortium ISME J. (IF 11.0) Pub Date : 2024-04-16 Mengxiong Wu, Xiawei Liu, J Pamela Engelberts, Gene W Tyson, Simon J McIlroy, Jianhua Guo
The bacterial species ‘Candidatus Alkanivorans nitratireducens’ was recently demonstrated to mediate nitrate-dependent anaerobic oxidation of short-chain gaseous alkanes (SCGAs). In previous bioreactor enrichment studies1,2, the species appeared to reduce nitrate in two phases, switching from denitrification to dissimilatory nitrate reduction to ammonium (DNRA) in response to nitrite accumulation.
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Prevalence of trace gas-oxidizing soil bacteria increases with radial distance from Polloquere hot spring within a high-elevation Andean cold desert ISME J. (IF 11.0) Pub Date : 2024-04-16 Zachary K Garvin, Sebastian R Abades, Nicole Trefault, Fernando D Alfaro, Katie Sipes, Karen G Lloyd, Tullis C Onstott
High-elevation arid regions harbor microbial communities reliant on metabolic niches and flexibility to survive under biologically stressful conditions, including nutrient limitation that necessitates the utilization of atmospheric trace gases as electron donors. Geothermal springs present “oases” of microbial activity, diversity, and abundance by delivering water and substrates, including reduced
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Linking methanotroph phenotypes to genotypes using a simple spatially resolved model ecosystem ISME J. (IF 11.0) Pub Date : 2024-04-16 Delaney G Beals, Aaron W Puri
Connecting genes to phenotypic traits in bacteria is often challenging because of a lack of environmental context in laboratory settings. Laboratory-based model ecosystems offer a means to better account for environmental conditions compared to standard planktonic cultures, and can help link genotypes and phenotypes. Here, we present a simple, cost-effective, laboratory-based model ecosystem to study
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Iron limitation of heterotrophic bacteria in the California current system tracks relative availability of organic carbon and iron ISME J. (IF 11.0) Pub Date : 2024-04-16 Lauren E Manck, Tyler H Coale, Brandon M Stephens, Kiefer O Forsch, Lihini I Aluwihare, Christopher L Dupont, Andrew E Allen, Katherine A Barbeau
Iron is an essential nutrient for all microorganisms in the marine environment. Iron limitation of primary production has been well documented across a significant portion of the global surface ocean, but much less is known regarding the potential for iron limitation of the marine heterotrophic microbial community. In this work, we characterize the transcriptomic response of the heterotrophic bacterial
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Clonal genomic population structure of Beauveria brongniartii and Beauveria pseudobassiana: Pathogens of the common European cockchafer (Melolontha melolontha L.) Environ. Microbiol. (IF 5.1) Pub Date : 2024-04-16 Chiara Pedrazzini, Stephen A. Rehner, Hermann Strasser, Niklaus Zemp, Rolf Holderegger, Franco Widmer, Jürg Enkerli
Beauveria brongniartii is a fungal pathogen that infects the beetle Melolontha melolontha, a significant agricultural pest in Europe. While research has primarily focused on the use of B. brongniartii for controlling M. melolontha, the genomic structure of the B. brongniartii population remains unknown. This includes whether its structure is influenced by its interaction with M. melolontha, the timing
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Distinct members of the Caenorhabditis elegans CeMbio reference microbiota exert cryptic virulence that is masked by host defense Mol. Microbiol. (IF 3.6) Pub Date : 2024-04-16 Xavier Gonzalez, Javier E. Irazoqui
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Intermembrane space‐localized TbTim15 is an essential subunit of the single mitochondrial inner membrane protein translocase of trypanosomes Mol. Microbiol. (IF 3.6) Pub Date : 2024-04-16 Corinne von Känel, Silke Oeljeklaus, Christoph Wenger, Philip Stettler, Anke Harsman, Bettina Warscheid, André Schneider
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COVID-19 drug discovery and treatment options Nat. Rev. Microbiol. (IF 88.1) Pub Date : 2024-04-15 Jasper Fuk-Woo Chan, Shuofeng Yuan, Hin Chu, Siddharth Sridhar, Kwok-Yung Yuen
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DNA-targeting short Argonautes complex with effector proteins for collateral nuclease activity and bacterial population immunity Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-15 Maria Prostova, Anna Kanevskaya, Vladimir Panteleev, Lidia Lisitskaya, Kristina V. Perfilova Tugaeva, Nikolai N. Sluchanko, Daria Esyunina, Andrey Kulbachinskiy
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Age-specific nasal epithelial responses to SARS-CoV-2 infection Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-15 Maximillian N. J. Woodall, Ana-Maria Cujba, Kaylee B. Worlock, Katie-Marie Case, Tereza Masonou, Masahiro Yoshida, Krzysztof Polanski, Ni Huang, Rik G. H. Lindeboom, Lira Mamanova, Liam Bolt, Laura Richardson, Batuhan Cakir, Samuel Ellis, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy D. McHugh, Aarash Saleh, Eliz Kilich, Puja Mehta, Chris O’Callaghan, Jie Zhou, Wendy Barclay
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Lactic acid bacteria modulate the CncC pathway to enhance resistance to β-cypermethrin in the oriental fruit fly ISME J. (IF 11.0) Pub Date : 2024-04-15 Tian Zeng, Qianyan Fu, Fangyi Luo, Jian Dai, Rong Fu, Yixiang Qi, Xiaojuan Deng, Yongyue Lu, Yijuan Xu
The gut microbiota of insects has been shown to regulate host detoxification enzymes. However, the potential regulatory mechanisms involved remain unknown. Here, we report that gut bacteria increase insecticide resistance by activating the cap “n” collar isoform-C (CncC) pathway through enzymatically generated reactive oxygen species (ROS) in Bactrocera dorsalis. We demonstrated that Enterococcus casseliflavus
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MucR protein: Three decades of studies have led to the identification of a new H‐NS‐like protein Mol. Microbiol. (IF 3.6) Pub Date : 2024-04-15 Ilaria Baglivo, Gaetano Malgieri, Roy Martin Roop, Ian S. Barton, Xindan Wang, Veronica Russo, Luciano Pirone, Emilia M. Pedone, Paolo V. Pedone
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Microbial adaptability in changing environments Nat. Rev. Microbiol. (IF 88.1) Pub Date : 2024-04-12 Sharon Greenblum
This Genome Watch article highlights the recent use of large-scale monitoring of natural microbiomes to examine feedback between environmental change and microbial adaptation.
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Single-molecule epitranscriptomic analysis of full-length HIV-1 RNAs reveals functional roles of site-specific m6As Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-11 Alice Baek, Ga-Eun Lee, Sarah Golconda, Asif Rayhan, Anastasios A. Manganaris, Shuliang Chen, Nagaraja Tirumuru, Hannah Yu, Shihyoung Kim, Christopher Kimmel, Olivier Zablocki, Matthew B. Sullivan, Balasubrahmanyam Addepalli, Li Wu, Sanggu Kim
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Single-cell RNA-seq of the rare virosphere reveals the native hosts of giant viruses in the marine environment Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-11 Amir Fromm, Gur Hevroni, Flora Vincent, Daniella Schatz, Carolina A. Martinez-Gutierrez, Frank O. Aylward, Assaf Vardi
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Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease Clin. Microbiol. Rev. (IF 36.8) Pub Date : 2024-04-11 Martin HoeniglAmir ArastehfarMaiken Cavling ArendrupRoger BrüggemannAgostinho CarvalhoTom ChillerSharon ChenMatthias EggerSimon FeysJean-Pierre GangneuxJeremy A. W. GoldAndreas H. GrollJannes HeylenJeffrey D. JenksRobert KrauseKatrien LagrouFrédéric LamothJuergen PrattesSarah SedikJoost WautersNathan P. WiederholdGeorge R. Thompson1Department of Internal Medicine, Division of Infectious Diseases, ECMM
Clinical Microbiology Reviews, Ahead of Print.
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Crafty mimicry grants nuclear pore entry to HIV Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Keesiang Lim, Masaharu Hazawa, Richard W. Wong
The size of the nuclear pore should, in principle, prevent HIV-1 entry. However, HIV-1 capsid is able to gain nuclear pore entry. In a recent issue of Nature, Fu et al. and Dickson et al. demonstrate that the HIV-1 capsid mimics the nuclear transport protein karyopherins to access host nuclei.
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Fusobacterium nucleatum subsp. animalis comes to the spotlight in oral diseases Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Bibek G C, Peng Zhou, Chenggang Wu
Krieger et al.'s study in this issue of Cell Host & Microbe reveals that Fusobacterium nucleatum subsp. animalis strains, previously underestimated, are significant in disease-affected oral areas. This challenges the long-held notion of the dominance of Fusobacterium nucleatum subsp. nucleatum, reshaping our understanding of Fusobacterium distribution in the oral microbiome.
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Spatially distributed metabolites SWEETen the root for microbes Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Xiaoyan Fan, An-Hui Ge, Ertao Wang
Limited understanding exists on the spatial configuration of underground plant-microbe interactions. In this issue of Cell Host & Microbe, Loo et al. illustrate the sugar transporter-involved interdependent interaction between root metabolites and microbial spatial colonization, providing insights into metabolic-associated organization of plant-microbe interactions.
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A layered effect in bacterial defense Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Karina Ilchenko, Eugen Pfeifer
Defense systems that protect bacteria from invaders, such as viruses, are believed to be multi-layered and driven by interactions. In this issue of Cell Host & Microbe, Wu, Garushyants et al.1 delve into the dynamics between these safeguard mechanisms and unravel synergistic interactions.
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GOSpel for tiny allies Cell Host Microbe (IF 30.3) Pub Date : 2024-04-10 Wei Hu, Xiaofei Yu
Infant formulas are often supplemented to foster the development of a healthy gut microbiota. In this issue of Cell Host & Microbe, Heppner et al. present an elaborate clinical trial examining the impact of formula supplementation on the development and circadian rhythmicity of the microbiota during the first year of life.
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From sustainable feedstocks to microbial foods Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-09 Kyeong Rok Choi, Seok Yeong Jung, Sang Yup Lee
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A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-09 Connor Chain, Joseph P. Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S. Freundlich, Joshua D. Rabinowitz, Zemer Gitai
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Reversible conjugation of a CBASS nucleotide cyclase regulates bacterial immune response to phage infection Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-08 Larissa Krüger, Laura Gaskell-Mew, Shirley Graham, Sally Shirran, Robert Hertel, Malcolm F. White
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A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-08 Min Zhou, Longqiang Liu, Zihao Cong, Weinan Jiang, Ximian Xiao, Jiayang Xie, Zhengjie Luo, Sheng Chen, Yueming Wu, Xinying Xue, Ning Shao, Runhui Liu
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Making HTLV-1 and those affected visible Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-04 Carolina Rosadas
Carolina Rosadas explains why we need more research investigating human T lymphotropic virus type 1 (HTLV-1) infections, and why more public visibility is needed for those affected.
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Longitudinal dynamics of farmer and livestock nasal and faecal microbiomes and resistomes Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-03 Bejan Mahmud, Rhiannon C. Vargas, Kimberley V. Sukhum, Sanket Patel, James Liao, Lindsey R. Hall, Akhil Kesaraju, Thao Le, Terrie Kitchner, Erik Kronholm, Kyle Koshalek, Casper G. Bendixsen, Jeffrey J. VanWormer, Sanjay K. Shukla, Gautam Dantas
Globally, half a billion people are employed in animal agriculture and are directly exposed to the associated microorganisms. However, the extent to which such exposures affect resident human microbiomes is unclear. Here we conducted a longitudinal profiling of the nasal and faecal microbiomes of 66 dairy farmers and 166 dairy cows over a year-long period. We compare farmer microbiomes to those of
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Microorganisms uniquely capture and predict stony coral tissue loss disease and hurricane disturbance impacts on US Virgin Island reefs Environ. Microbiol. (IF 5.1) Pub Date : 2024-04-05 Cynthia C. Becker, Laura Weber, Joel K. Llopiz, T. Aran Mooney, Amy Apprill
Coral reef ecosystems are now commonly affected by major climate and disease disturbances. Disturbance impacts are typically recorded using reef benthic cover, but this may be less reflective of other ecosystem processes. To explore the potential for reef water‐based disturbance indicators, we conducted a 7‐year time series on US Virgin Island reefs where we examined benthic cover and reef water nutrients
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Physical models of bacterial chromosomes Mol. Microbiol. (IF 3.6) Pub Date : 2024-04-05 Janni Harju, Chase P. Broedersz
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The wound microbiota: microbial mechanisms of impaired wound healing and infection Nat. Rev. Microbiol. (IF 88.1) Pub Date : 2024-04-04 Aayushi Uberoi, Amelia McCready-Vangi, Elizabeth A. Grice
The skin barrier protects the human body from invasion by exogenous and pathogenic microorganisms. A breach in this barrier exposes the underlying tissue to microbial contamination, which can lead to infection, delayed healing, and further loss of tissue and organ integrity. Delayed wound healing and chronic wounds are associated with comorbidities, including diabetes, advanced age, immunosuppression
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Data availability is the golden rule in research Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-04
As the saying goes, sharing is caring — but when it comes to the data underlying primary research papers published at Nature Microbiology, sharing is also mandatory.
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Low-dose dengue virus 3 human challenge model: a phase 1 open-label study Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-01 Adam T. Waickman, Krista Newell, Joseph Q. Lu, HengSheng Fang, Mitchell Waldran, Chad Gebo, Jeffrey R. Currier, Heather Friberg, Richard G. Jarman, Michelle D. Klick, Lisa A. Ware, Timothy P. Endy, Stephen J. Thomas
Dengue human infection models present an opportunity to explore the potential of a vaccine, anti-viral or immuno-compound for clinical benefit in a controlled setting. Here we report the outcome of a phase 1 open-label assessment of a low-dose dengue virus 3 (DENV-3) challenge model (NCT04298138), in which nine participants received a subcutaneous inoculation with 0.5 ml of a 1.4 × 103 plaque-forming
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Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host Cell Host Microbe (IF 30.3) Pub Date : 2024-04-04 Marcel Sprenger, Malte Siemers, Sebastian Krautwurst, Kai Papenfort
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Preventing multi‐resistance: New insights for managing fungal adaptation Environ. Microbiol. (IF 5.1) Pub Date : 2024-04-04 Agathe Ballu, Claire Ugazio, Clémentine Duplaix, Alicia Noly, Juerg Wullschleger, Stefano F. F. Torriani, Anne Dérédec, Florence Carpentier, Anne‐Sophie Walker
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LC3B labeling of the parasitophorous vacuole membrane of Plasmodium berghei liver stage parasites depends on the V‐ATPase and ATG16L1 Mol. Microbiol. (IF 3.6) Pub Date : 2024-04-04 Annina Bindschedler, Jacqueline Schmuckli‐Maurer, Sophie Buchser, Tara D. Fischer, Rahel Wacker, Tim Davalan, Jessica Brunner, Volker T. Heussler
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Microbial food spoilage: impact, causative agents and control strategies Nat. Rev. Microbiol. (IF 88.1) Pub Date : 2024-04-03 Abigail B. Snyder, Nicole Martin, Martin Wiedmann
Microbial food spoilage is a major contributor to food waste and, hence, to the negative environmental sustainability impacts of food production and processing. Globally, it is estimated that 15–20% of food is wasted, with waste, by definition, occurring after primary production and harvesting (for example, in households and food service establishments). Although the causative agents of food spoilage
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Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life cycles Nat. Microbiol. (IF 28.3) Pub Date : 2024-04-02 Jakob T. Rostøl, Nuria Quiles-Puchalt, Pablo Iturbe-Sanz, Íñigo Lasa, José R. Penadés
Dormant prophages protect lysogenic cells by expressing diverse immune systems, which must avoid targeting their cognate prophages upon activation. Here we report that multiple Staphylococcus aureus prophages encode Tha (tail-activated, HEPN (higher eukaryotes and prokaryotes nucleotide-binding) domain-containing anti-phage system), a defence system activated by structural tail proteins of incoming
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The Lrs14 family of DNA‐binding proteins as nucleoid‐associated proteins in the Crenarchaeal order Sulfolobales Mol. Microbiol. (IF 3.6) Pub Date : 2024-04-03 Veerke De Kock, Eveline Peeters, Rani Baes
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Diurnal rhythmicity of infant fecal microbiota and metabolites: A randomized controlled interventional trial with infant formula Cell Host Microbe (IF 30.3) Pub Date : 2024-04-02 Nina Heppner, Sandra Reitmeier, Marjolein Heddes, Michael Vig Merino, Leon Schwartz, Alexander Dietrich, Markus List, Michael Gigl, Chen Meng, Daan R. van der Veen, Melanie Schirmer, Karin Kleigrewe, Hélène Omer, Silke Kiessling, Dirk Haller