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The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis Sci. Immunol (IF 24.8) Pub Date : 2024-03-26 Arumugam Balasubramanian, Alan Y. Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Dang Fabin, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, Hongbo Yu, Mei Chen, Steven Kolakowski, Sunia Trauger, Martin Røssel Larsen, Wenyi Wei, Hao Wu, Jonathan C. Kagan, Judy Lieberman, Hongbo R. Luo
Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD membrane translocation and pore formation are not fully understood. Here, using a proteomics approach, we identified fatty acid synthase (FASN) as a GSDMD-binding partner. S-palmitoylation of GSDMD at Cys191/192 (human/mouse), catalyzed
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Self-sustaining inflammatory cycle causes memory impairment in neuropsychiatric lupus Nat. Immunol. (IF 30.5) Pub Date : 2024-03-22
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C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire Sci. Immunol (IF 24.8) Pub Date : 2024-03-22 Ivan Kosik, Jefferson Da Silva Santos, Mathew Angel, Zhe Hu, Jaroslav Holly, James S. Gibbs, Tanner Gill, Martina Kosikova, Tiansheng Li, William Bakhache, Patrick T. Dolan, Hang Xie, Sarah F. Andrews, Rebecca A. Gillespie, Masaru Kanekiyo, Adrian B. McDermott, Theodore C. Pierson, Jonathan W. Yewdell
Antigenic drift, the gradual accumulation of amino acid substitutions in the influenza virus hemagglutinin (HA) receptor protein, enables viral immune evasion. Antibodies (Abs) specific for the drift-resistant HA stem region are a promising universal influenza vaccine target. Although anti-stem Abs are not believed to block viral attachment, here we show that complement component 1q (C1q), a 460-kilodalton
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Invasion of spontaneous germinal centers by naive B cells is rapid and persistent Sci. Immunol (IF 24.8) Pub Date : 2024-03-22 Theo van den Broek, Kristine Oleinika, Siti Rahmayanti, Carlos Castrillon, Cees E. van der Poel, Michael C. Carroll
In autoreactive germinal centers (GC) initiated by a single rogue B cell clone, wild-type B cells expand and give rise to clones that target other autoantigens, known as epitope spreading. The chronic, progressive nature of epitope spreading calls for early interventions to limit autoimmune pathologies, but the kinetics and molecular requirements for wild-type B cell invasion and participation in GC
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Intestinal tuft cell immune privilege enables norovirus persistence Sci. Immunol (IF 24.8) Pub Date : 2024-03-22 Madison S. Strine, Eric Fagerberg, Patrick W. Darcy, Gabriel M. Barrón, Renata B. Filler, Mia Madel Alfajaro, Nicole D’Angelo-Gavrish, Fang Wang, Vincent R. Graziano, Bridget L. Menasché, Martina Damo, Ya-Ting Wang, Michael R. Howitt, Sanghyun Lee, Nikhil S. Joshi, Daniel Mucida, Craig B. Wilen
The persistent murine norovirus strain MNVCR6 is a model for human norovirus and enteric viral persistence. MNVCR6 causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNVCR6 induces functional MNV-specific CD8+ T cells, these lymphocytes fail to clear infection. To examine how tuft cells promote immune escape, we interrogated tuft cell
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C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire Sci. Immunol (IF 24.8) Pub Date : 2024-03-22 Ivan Kosik, Jefferson Da Silva Santos, Mathew Angel, Zhe Hu, Jaroslav Holly, James S. Gibbs, Tanner Gill, Martina Kosikova, Tiansheng Li, William Bakhache, Patrick T. Dolan, Hang Xie, Sarah F. Andrews, Rebecca A. Gillespie, Masaru Kanekiyo, Adrian B. McDermott, Theodore C. Pierson, Jonathan W. Yewdell
Antigenic drift, the gradual accumulation of amino acid substitutions in the influenza virus hemagglutinin (HA) receptor protein, enables viral immune evasion. Antibodies (Abs) specific for the drift-resistant HA stem region are a promising universal influenza vaccine target. Although anti-stem Abs are not believed to block viral attachment, here we show that complement component 1q (C1q), a 460-kilodalton
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Invasion of spontaneous germinal centers by naive B cells is rapid and persistent Sci. Immunol (IF 24.8) Pub Date : 2024-03-22 Theo van den Broek, Kristine Oleinika, Siti Rahmayanti, Carlos Castrillon, Cees E. van der Poel, Michael C. Carroll
In autoreactive germinal centers (GC) initiated by a single rogue B cell clone, wild-type B cells expand and give rise to clones that target other autoantigens, known as epitope spreading. The chronic, progressive nature of epitope spreading calls for early interventions to limit autoimmune pathologies, but the kinetics and molecular requirements for wild-type B cell invasion and participation in GC
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Intestinal tuft cell immune privilege enables norovirus persistence Sci. Immunol (IF 24.8) Pub Date : 2024-03-22 Madison S. Strine, Eric Fagerberg, Patrick W. Darcy, Gabriel M. Barrón, Renata B. Filler, Mia Madel Alfajaro, Nicole D’Angelo-Gavrish, Fang Wang, Vincent R. Graziano, Bridget L. Menasché, Martina Damo, Ya-Ting Wang, Michael R. Howitt, Sanghyun Lee, Nikhil S. Joshi, Daniel Mucida, Craig B. Wilen
The persistent murine norovirus strain MNV CR6 is a model for human norovirus and enteric viral persistence. MNV CR6 causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNV CR6 induces functional MNV-specific CD8 + T cells, these lymphocytes fail to clear infection. To examine how tuft cells promote immune escape, we interrogated tuft cell
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A pre-TCRα-independent pathway of αβ T cell differentiation Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-19 Kirsty Minton
A study in Science reports 10 individuals with pre-TCRα deficiency who have late-onset or no clinical phenotype, which suggests that αβ T cells can develop through a pre-TCRα-independent, non-canonical rescue pathway.
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cGAS meets its demise in the nucleus Nat. Immunol. (IF 30.5) Pub Date : 2024-03-21 Calvin Jon A. Leonen, Hironori Funabiki
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An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors Nat. Immunol. (IF 30.5) Pub Date : 2024-03-21 Xuan Zhang, Baobao Song, Maximillian J. Carlino, Guangyuan Li, Kyle Ferchen, Mi Chen, Evrett N. Thompson, Bailee N. Kain, Dan Schnell, Kairavee Thakkar, Michal Kouril, Kang Jin, Stuart B. Hay, Sidharth Sen, David Bernardicius, Siyuan Ma, Sierra N. Bennett, Josh Croteau, Ornella Salvatori, Melvin H. Lye, Austin E. Gillen, Craig T. Jordan, Harinder Singh, Diane S. Krause, Nathan Salomonis, H. Leighton
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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy Nat. Immunol. (IF 30.5) Pub Date : 2024-03-19 Jonathan H. Chen, Linda T. Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H. Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S. Nabel, Samuel S. Freeman, Joshua D. Pirl, Chenyue Lu, Catherine B. Meador, Jaimie L. Barth, Mustafa Sakhi, Alexander L. Tang, Siranush Sarkizova, Colles Price, Nicolas F. Fernandez, George Emanuel, Jiang He, Katrina
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International nomenclature guidelines for the IL-1 family of cytokines and receptors Nat. Immunol. (IF 30.5) Pub Date : 2024-03-18 Joseph M. Gaballa, Jesper Falkesgaard Højen, Dennis M. De Graaf, Jesus Amo-Aparicio, Carlo Marchetti, Giulio Cavalli, Alberto Dinarello, Suzhao Li, Michaele Francesco Corbisiero, Isak W. Tengesdal, Jasmina S. Redzic, Tania Azam, William S. Webber, Karl A. Pankratz, Makenna J. May, Fabio Cominelli, Elan Z. Eisenmesser, Soohyun Kim, Charles A. Dinarello, Diana Boraschi
Over the past 40 years, the IL-1 family has grown to include 22 members, with 11 cytokines and 11 receptors. After the initial description of the first IL-1 family members, confusion has grown about the nomenclature of IL-1 cytokines and receptors, which was last updated in 20101. This confusion arose from different names for the proteins identified by function. Several names for the same cytokine
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Gut bacteria–derived serotonin promotes immune tolerance in early life Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Katherine Z. Sanidad, Stephanie L. Rager, Hannah C. Carrow, Aparna Ananthanarayanan, Ryann Callaghan, Lucy R. Hart, Tingting Li, Purnima Ravisankar, Julia A. Brown, Mohammed Amir, Jenny C. Jin, Alexandria Rose Savage, Ryan Luo, Florencia Mardorsky Rowdo, M. Laura Martin, Randi B. Silver, Chun-Jun Guo, Jan Krumsiek, Naohiro Inohara, Melody Y. Zeng
The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remain largely undefined. Here, we demonstrate that the neonatal gut is uniquely enriched with neurotransmitters, including serotonin, and that specific gut bacteria directly produce serotonin while down-regulating monoamine oxidase A to limit serotonin
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RORγt up-regulates RAG gene expression in DP thymocytes to expand the Tcra repertoire Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Abani Kanta Naik, Danielle J. Dauphars, Elizabeth Corbett, Lunden Simpson, David G. Schatz, Michael S. Krangel
Recombination activating gene (RAG) expression increases as thymocytes transition from the CD4−CD8− double-negative (DN) to the CD4+CD8+ double-positive (DP) stage, but the physiological importance and mechanism of transcriptional up-regulation are unknown. Here, we show that a DP-specific component of the recombination activating genes antisilencer (DPASE) provokes elevated RAG expression in DP thymocytes
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A method for predicting drugs that can boost the efficacy of immune checkpoint blockade Nat. Immunol. (IF 30.5) Pub Date : 2024-03-18 Yun Xia, Xin Li, Nana Bie, Wen Pan, Ya-Ru Miao, Mei Yang, Yan Gao, Chuang Chen, Hanqing Liu, Lu Gan, An-Yuan Guo
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Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Lucien Turner, Tran Ngoc Van Le, Eric Cross, Clemence Queriault, Montana Knight, Krittin Trihemasava, James Davis, Patrick Schaefer, Janet Nguyen, Jimmy Xu, Brian Goldspiel, Elise Hall, Kelly Rome, Michael Scaglione, Joel Eggert, Byron Au-Yeung, Douglas C. Wallace, Clementina Mesaros, Joseph A. Baur, Will Bailis
Adaptive immunity requires the expansion of high-affinity lymphocytes from a heterogeneous pool. Whereas current models explain this through signal transduction, we hypothesized that antigen affinity tunes discrete metabolic pathways to license clonal lymphocyte dynamics. Here, we identify nicotinamide adenine dinucleotide (NAD) biosynthesis as a biochemical hub for the T cell receptor affinity–dependent
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A metabolic pacer ensures smooth running of the lymphocyte activation race Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Veera Panova, Arianne C. Richard
Upon lymphocyte stimulation, accumulation of intracellular NAD(H) reflects the strength of antigen receptor signals and controls the rate of cell cycle entry and proliferation (see related Research Article by Turner et al.).
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Bone marrow inflammation in haematological malignancies Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-15 Madelon M. E. de Jong, Lanpeng Chen, Marc H. G. P. Raaijmakers, Tom Cupedo
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Strategies for targeting cytokines in inflammatory bowel disease Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-14 Markus F. Neurath
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Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 Andrea Mencarelli, Pradeep Bist, Hae Woong Choi, Hanif Javanmard Khameneh, Alessandra Mortellaro, Soman N. Abraham
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Author Correction: The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila Nat. Immunol. (IF 30.5) Pub Date : 2024-03-15 Safia Deddouche, Nicolas Matt, Aidan Budd, Stefanie Mueller, Cordula Kemp, Delphine Galiana-Arnoux, Catherine Dostert, Christophe Antoniewski, Jules A. Hoffmann, Jean-Luc Imler
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The power of memory T cells minus antibodies Nat. Immunol. (IF 30.5) Pub Date : 2024-03-15 Thi H. O. Nguyen, Katherine Kedzierska
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Gut bacteria–derived serotonin promotes immune tolerance in early life Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Katherine Z. Sanidad, Stephanie L. Rager, Hannah C. Carrow, Aparna Ananthanarayanan, Ryann Callaghan, Lucy R. Hart, Tingting Li, Purnima Ravisankar, Julia A. Brown, Mohammed Amir, Jenny C. Jin, Alexandria Rose Savage, Ryan Luo, Florencia Mardorsky Rowdo, M. Laura Martin, Randi B. Silver, Chun-Jun Guo, Jan Krumsiek, Naohiro Inohara, Melody Y. Zeng
The gut microbiota promotes immune system development in early life, but the interactions between the gut metabolome and immune cells in the neonatal gut remain largely undefined. Here, we demonstrate that the neonatal gut is uniquely enriched with neurotransmitters, including serotonin, and that specific gut bacteria directly produce serotonin while down-regulating monoamine oxidase A to limit serotonin
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A metabolic pacer ensures smooth running of the lymphocyte activation race Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Veera Panova, Arianne C. Richard
Upon lymphocyte stimulation, accumulation of intracellular NAD(H) reflects the strength of antigen receptor signals and controls the rate of cell cycle entry and proliferation (see related Research Article by Turner et al .).
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RORγt up-regulates RAG gene expression in DP thymocytes to expand the Tcra repertoire Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Abani Kanta Naik, Danielle J. Dauphars, Elizabeth Corbett, Lunden Simpson, David G. Schatz, Michael S. Krangel
Recombination activating gene (RAG) expression increases as thymocytes transition from the CD4 − CD8 − double-negative (DN) to the CD4 + CD8 + double-positive (DP) stage, but the physiological importance and mechanism of transcriptional up-regulation are unknown. Here, we show that a DP-specific component of the recombination activating genes antisilencer (DPASE) provokes elevated RAG expression in
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Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics Sci. Immunol (IF 24.8) Pub Date : 2024-03-15 Lucien Turner, Tran Ngoc Van Le, Eric Cross, Clemence Queriault, Montana Knight, Krittin Trihemasava, James Davis, Patrick Schaefer, Janet Nguyen, Jimmy Xu, Brian Goldspiel, Elise Hall, Kelly Rome, Michael Scaglione, Joel Eggert, Byron Au-Yeung, Douglas C. Wallace, Clementina Mesaros, Joseph A. Baur, Will Bailis
Adaptive immunity requires the expansion of high-affinity lymphocytes from a heterogeneous pool. Whereas current models explain this through signal transduction, we hypothesized that antigen affinity tunes discrete metabolic pathways to license clonal lymphocyte dynamics. Here, we identify nicotinamide adenine dinucleotide (NAD) biosynthesis as a biochemical hub for the T cell receptor affinity–dependent
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Pas de deux of NLRP3 and ASC with CD63 on mast cell granules Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 J. Magarian Blander, Yuhua Shi
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Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination Nat. Immunol. (IF 30.5) Pub Date : 2024-03-14 Valeria Fumagalli, Micol Ravà, Davide Marotta, Pietro Di Lucia, Elisa B. Bono, Leonardo Giustini, Federica De Leo, Maura Casalgrandi, Emanuele Monteleone, Violette Mouro, Chiara Malpighi, Chiara Perucchini, Marta Grillo, Sara De Palma, Lorena Donnici, Silvia Marchese, Matteo Conti, Hiromi Muramatsu, Stanley Perlman, Norbert Pardi, Mirela Kuka, Raffaele De Francesco, Marco E. Bianchi, Luca G. Guidotti
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Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants Immunity (IF 32.4) Pub Date : 2024-03-14 Timothy S. Johnston, Shuk Hang Li, Mark M. Painter, Reilly K. Atkinson, Naomi R. Douek, David B. Reeg, Daniel C. Douek, E. John Wherry, Scott E. Hensley
The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to accumulate substitutions, leading to breakthrough infections of vaccinated individuals. It remains unclear if exposures to antigenically distant SARS-CoV-2 variants can overcome memory B cell biases established by initial SARS-CoV-2 encounters. We determined the specificity and functionality of antibody
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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans Immunity (IF 32.4) Pub Date : 2024-03-14 M. Alejandra Tortorici, Amin Addetia, Albert J. Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler
Immune imprinting describes how the first exposure to a virus shapes immunological outcomes of subsequent exposures to antigenically related strains. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Omicron breakthrough infections and bivalent COVID-19 vaccination primarily recall cross-reactive memory B cells induced by prior Wuhan-Hu-1 spike mRNA vaccination rather than priming Omicron-specific
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Breaking tolerance: the autoimmune aspect of atherosclerosis Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-12 Amir Khan, Payel Roy, Klaus Ley
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Regulation of innate-like activities of neonatal CD8+ T cells Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-11 Alexandra Flemming
Recent studies have shown that neonatal CD8+ T cells can undergo ‘bystander activation’ in response to inflammatory cytokines and produce effector molecules such as IFNγ and granzyme B in the absence of cognate antigen. Some of these cells persist into adulthood. A study by Watson et al. used a multi-omics approach to investigate the epigenetic programmes and transcription factors that enable CD8+
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The eye provides an immunological gateway to the brain Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-11 Alexandra Flemming
A publication by Song and colleagues identifies a unique lymphatic drainage system that connects the posterior of the eye with deep cervical lymph nodes (dCLNs) and the meningeal lymphatic network. In several different mouse models, they show that vaccines delivered to the posterior of the eye can specifically induce immune responses in the central nervous system (CNS) and protect against experimental
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CARD8 kills CD4+ T cells in response to HIV entry Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-11 Alexandra Flemming
In humans, infection with HIV-1 is associated with loss of CD4+ T cells, causing severe immunodeficiency and progression to AIDS. By contrast, some non-human primates (NHPs), which are natural hosts of the closely related SIV, are tolerant of SIV infection despite showing high levels of viraemia. Interestingly, CD4+ T cell death in humans mostly effects quiescent cells that are not productively infected
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Dual checkpoint T(h1)eamwork makes the anti-cancer dream work Immunity (IF 32.4) Pub Date : 2024-03-12 Alisa Dietl, Anna Ralser, Karin Pelka
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IL-4-ever young: Type 2 cytokine signaling in macrophages slows aging Immunity (IF 32.4) Pub Date : 2024-03-12 Conor M. Finlay, Judith E. Allen
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Predicting plasma cell retention and loss over a lifetime Immunity (IF 32.4) Pub Date : 2024-03-12 Marcus J. Robinson, David M. Tarlinton
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Gasdermin and MLKL necrotic cell death effectors: Signaling and diseases Immunity (IF 32.4) Pub Date : 2024-03-12 Kate E. Lawlor, James M. Murphy, James E. Vince
Diverse inflammatory conditions, from infections to autoimmune disease, are often associated with cellular damage and death. Apoptotic cell death has evolved to minimize its inflammatory potential. By contrast, necrotic cell death via necroptosis and pyroptosis—driven by membrane-damaging MLKL and gasdermins, respectively—can both initiate and propagate inflammatory responses. In this review, we provide
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Complement-ary protection for all ages Immunity (IF 32.4) Pub Date : 2024-03-12 Geongoo Han, Shipra Vaishnava
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The price of P2X7R freedom is neuroinflammation Immunity (IF 32.4) Pub Date : 2024-03-12 Mingqian Fang, Ren Lai
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Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells Immunity (IF 32.4) Pub Date : 2024-03-12 Wei Bu, Ashish Kumar, Nathan L. Board, JungHyun Kim, Kennichi Dowdell, Shu Zhang, Yona Lei, Anna Hostal, Tammy Krogmann, Yanmei Wang, Stefania Pittaluga, Joseph Marcotrigiano, Jeffrey I. Cohen
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with B cell lymphomas. EBV glycoprotein 42 (gp42) binds HLA class II and activates membrane fusion with B cells. We isolated gp42-specific monoclonal antibodies (mAbs), A10 and 4C12, which use distinct mechanisms to neutralize virus infection. mAb A10 was more potent than the only known neutralizing gp42 mAb, F-2-1, in neutralizing
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Interleukin-2 signaling in the regulation of T cell biology in autoimmunity and cancer Immunity (IF 32.4) Pub Date : 2024-03-12 Acacia N. Shouse, Kathryn M. LaPorte, Thomas R. Malek
Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) supports the development and homeostasis of regulatory T cells and contributes to the differentiation of helper, cytotoxic, and memory T cells. A critical element for each T cell population is the expression of CD25 (Il2rα), which
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Made to order: emergency myelopoiesis and demand-adapted innate immune cell production Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-11 James W. Swann, Oakley C. Olson, Emmanuelle Passegué
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A Treg cell duo for VAT control Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-08 Maria Papatriantafyllou
Changes in populations of regulatory T (Treg) cells in visceral adipose tissue (VAT) have been linked to metabolic disorders; Valle Torres, Man et al. now characterize Treg cell heterogeneity in VAT. In addition to the previously reported population of VAT Treg cells that express PPARγ and ST2 (also known as IL-33R or IL-1RL1), the authors describe a second VAT Treg cell subset with high expression
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Lymph node resection does not impair cancer immunotherapy responses Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-03-06 Lucas Baldran-Groves, Jeroen Melief
A preprint by Zhou et al. shows that the clinical efficacy of immune checkpoint blockade in patients with cancer does not depend on the presence of tumour-draining lymph nodes, as their role is taken over by more distant lymph nodes.
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The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis Nat. Immunol. (IF 30.5) Pub Date : 2024-03-07 Xin He, Xiantao Zhang, Bolin Wu, Jieyi Deng, Yongli Zhang, Airu Zhu, Yaochang Yuan, Yingtong Lin, Achun Chen, Jinzhu Feng, Xiumei Wang, Shijian Wu, Yingying Liu, Jie Liu, Yalin Wang, Rong Li, Chaofeng Liang, Quyu Yuan, Yu Liang, Qiannan Fang, Zhihui Xi, Wenjie Li, Liting Liang, Zhenglai Zhang, Hui Tang, Yi Peng, Changwen Ke, Xiancai Ma, Weibin Cai, Ting Pan, Bingfeng Liu, Kai Deng, Jun Chen, Jincun
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Beyond T cell exhaustion: TIM-3 regulation of myeloid cells Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Karen O. Dixon, Gonzalo Fernandez Lahore, Vijay K. Kuchroo
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4+ and CD8+ T cells. Since then, our understanding of its role in immune responses has significantly expanded. Here, we review emerging evidence demonstrating unexpected roles for TIM-3 as a key regulator of myeloid cell function, in addition
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Transmembrane domain–driven PD-1 dimers mediate T cell inhibition Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Elliot A. Philips, Jia Liu, Audun Kvalvaag, Alexander M. Mørch, Anna S. Tocheva, Charles Ng, Hong Liang, Ian M. Ahearn, Ruimin Pan, Christina C. Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R. Littman, Michael L. Dustin, Jun Wang, Xiang-Peng Kong
Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolerance. Antagonism of PD-1 signaling has proven effective in cancer immunotherapy, and conversely, agonists of the receptor may have a role in treating autoimmune disease. Some immune receptors function as dimers
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Subcapsular sinus macrophages maximize germinal center development in non-draining lymph nodes during blood-borne viral infection Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Cynthia C. Aguilar, Anurag Kalia, Morgan E. Brisse, Kimberly A. Dowd, Olivia Wise-Dent, Katherine E. Burgomaster, Joanna Droppo, Theodore C. Pierson, Heather D. Hickman
Lymph node (LN) germinal centers (GCs) are critical sites for B cell activation and differentiation. GCs develop after specialized CD169+ macrophages residing in LN sinuses filter antigens (Ags) from the lymph and relay these Ags into proximal B cell follicles. Many viruses, however, first reach LNs through the blood during viremia (virus in the blood), rather than through lymph drainage from infected
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Beyond T cell exhaustion: TIM-3 regulation of myeloid cells Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Karen O. Dixon, Gonzalo Fernandez Lahore, Vijay K. Kuchroo
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4 + and CD8 + T cells. Since then, our understanding of its role in immune responses has significantly expanded. Here, we review emerging evidence demonstrating unexpected roles for TIM-3 as a key regulator of myeloid cell function, in
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Subcapsular sinus macrophages maximize germinal center development in non-draining lymph nodes during blood-borne viral infection Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Cynthia C. Aguilar, Anurag Kalia, Morgan E. Brisse, Kimberly A. Dowd, Olivia Wise-Dent, Katherine E. Burgomaster, Joanna Droppo, Theodore C. Pierson, Heather D. Hickman
Lymph node (LN) germinal centers (GCs) are critical sites for B cell activation and differentiation. GCs develop after specialized CD169 + macrophages residing in LN sinuses filter antigens (Ags) from the lymph and relay these Ags into proximal B cell follicles. Many viruses, however, first reach LNs through the blood during viremia (virus in the blood), rather than through lymph drainage from infected
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Transmembrane domain–driven PD-1 dimers mediate T cell inhibition Sci. Immunol (IF 24.8) Pub Date : 2024-03-08 Elliot A. Philips, Jia Liu, Audun Kvalvaag, Alexander M. Mørch, Anna S. Tocheva, Charles Ng, Hong Liang, Ian M. Ahearn, Ruimin Pan, Christina C. Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R. Littman, Michael L. Dustin, Jun Wang, Xiang-Peng Kong
Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolerance. Antagonism of PD-1 signaling has proven effective in cancer immunotherapy, and conversely, agonists of the receptor may have a role in treating autoimmune disease. Some immune receptors function as dimers
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Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression Nat. Immunol. (IF 30.5) Pub Date : 2024-03-06 Kaitlin R. Carroll, Mark Mizrachi, Sean Simmons, Bahtiyar Toz, Czeslawa Kowal, Jeffrey Wingard, Nazila Tehrani, Aida Zarfeshani, Nina Kello, Lara El Khoury, Rachel Weissman-Tsukamoto, Joshua Z. Levin, Bruce T. Volpe, Betty Diamond
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Differentiation route determines the functional outputs of adult megakaryopoiesis Immunity (IF 32.4) Pub Date : 2024-03-05 Jing-Jing Li, Jingkun Liu, Yunqian Evelyn Li, Lin Veronica Chen, Hui Cheng, Yueying Li, Tao Cheng, Qian-Fei Wang, Bo O. Zhou
Emerging evidence has revealed a direct differentiation route from hematopoietic stem cells to megakaryocytes (direct route), in addition to the classical differentiation route through a series of restricted hematopoietic progenitors (stepwise route). This raises the question of the importance of two alternative routes for megakaryopoiesis. Here, we developed fate-mapping systems to distinguish the
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Tuning of plasma cell lifespan by competition explains the longevity and heterogeneity of antibody persistence Immunity (IF 32.4) Pub Date : 2024-03-05 Benjamin D. Simons, Omer Karin
Plasma cells that emerge after infection or vaccination exhibit heterogeneous lifespans; most survive for days to months, whereas others persist for decades, providing antigen-specific long-term protection. We developed a mathematical framework to explore the dynamics of plasma cell removal and its regulation by survival factors. Analyses of antibody persistence following hepatitis A and B and HPV
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CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy Immunity (IF 32.4) Pub Date : 2024-03-04 Amelie Franken, Michel Bila, Aurelie Mechels, Sam Kint, Jeroen Van Dessel, Valentina Pomella, Sebastiaan Vanuytven, Gino Philips, Orian Bricard, Jieyi Xiong, Bram Boeckx, Sigrid Hatse, Thomas Van Brussel, Rogier Schepers, Cedric Van Aerde, Sarah Geurs, Vincent Vandecaveye, Esther Hauben, Vincent Vander Poorten, Sara Verbandt, Katy Vandereyken, Junbin Qian, Sabine Tejpar, Thierry Voet, Paul M. Clement
Cancer patients often receive a combination of antibodies targeting programmed death-ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of-opportunity study in head and neck squamous cell carcinoma (HNSCC) to examine the contribution of anti-CTLA4 to anti-PD-L1 therapy. Single-cell profiling of on- versus pre-treatment biopsies identified T cell expansion as an early
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Learning from cancer mutations Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Nicholas J. Bernard
T cell lymphomas acquire mutations that endow them with advantages to endure the immunosuppressive tumor microenvironment. Researchers have now found a way to turn the tables on cancer by using these mutations to develop more effective chimeric antigen receptor (CAR) T cell therapies. In a study published in Nature, the authors created a barcoded library of mutant genes from T cell malignancies and
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Complement profile Nat. Immunol. (IF 30.5) Pub Date : 2024-03-01 Ioana Staicu
Severe COVID-19 has been associated with complement activation, hypercoagulation and vascular injury. In Science, Cervia-Hasler et al. report persistent complement-mediated immunopathology and thromboinflammation in long COVID as well. High-throughput proteomics on serum from 113 SARS-CoV-2-infected individuals (40 of which reported persisting symptoms at 6 months) at acute and 6 months after severe