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Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits Nat. Genet. (IF 30.8) Pub Date : 2024-04-19 Qianqian Peng, Xinxuan Liu, Wenran Li, Han Jing, Jiarui Li, Xingjian Gao, Qi Luo, Charles E. Breeze, Siyu Pan, Qiwen Zheng, Guochao Li, Jiaqiang Qian, Liyun Yuan, Na Yuan, Chenglong You, Siyuan Du, Yuanting Zheng, Ziyu Yuan, Jingze Tan, Peilin Jia, Jiucun Wang, Guoqing Zhang, Xianping Lu, Leming Shi, Shicheng Guo, Yun Liu, Ting Ni, Bo Wen, Changqing Zeng, Li Jin, Andrew E. Teschendorff, Fan Liu, Sijia
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Next questions in autophagy Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-19 Ana Maria Cuervo, Zvulun Elazar, Chantell Evans, Liang Ge, Malene Hansen, Marja Jäättelä, Jin Rui (Amos) Liang, Ben Loos, Noboru Mizushima, Anna Katharina Simon, Sharon Tooze, Tamotsu Yoshimori, Shuhei Nakamura
Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function in different contexts. We asked emerging and established leaders in the field to discuss the questions and areas that they are most excited about to deepen our understanding of autophagy.
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Pooled multicolour tagging for visualizing subcellular protein dynamics Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-19 Andreas Reicher, Jiří Reiniš, Maria Ciobanu, Pavel Růžička, Monika Malik, Marton Siklos, Victoria Kartysh, Tatjana Tomek, Anna Koren, André F. Rendeiro, Stefan Kubicek
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Living on Mars would probably suck — here's why Nature (IF 64.8) Pub Date : 2024-04-19
Kelly and Zach Weinersmith talk to Nature about the hurdles facing humans living in outer space.
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Detectors deep in South Pole ice pin down elusive tau neutrino Nature (IF 64.8) Pub Date : 2024-04-19
Antarctic observatory gathers the first clear evidence of mysterious subatomic particles from space.
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Dogwhistles, drilling and the roots of Western civilization: Books in brief Nature (IF 64.8) Pub Date : 2024-04-19
Andrew Robinson reviews five of the best science picks.
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Australia’s Great Barrier Reef is ‘transforming’ from repeated coral bleaching Nature (IF 64.8) Pub Date : 2024-04-19
The coral reef is currently experiencing its worst mass bleaching event on record — warming waters brought on by climate change are to blame.
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Why queasiness kills hunger: brain circuit identified Nature (IF 64.8) Pub Date : 2024-04-18
Feelings of hunger, nausea and fullness seem to be governed by separate brain circuits, finds a study in mice.
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Nearly half of China’s major cities are sinking — some ‘rapidly’ Nature (IF 64.8) Pub Date : 2024-04-18
Tens of millions of people in the country’s coastal lands might find their homes below sea level by 2120 owing to sinking and sea-level rise.
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Daily briefing: Food is medicine Nature (IF 64.8) Pub Date : 2024-04-17
Evidence is growing that targeted dietary interventions can treat, delay and even prevent some illnesses. Plus, an AI model helps track the spread of metastatic cancers and how climate lawsuits push governments and companies to act.
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Daily briefing: AI now beats humans at basic reading and maths Nature (IF 64.8) Pub Date : 2024-04-16
Artificial intelligence systems can now nearly match — and sometimes exceed — human performance in basic tasks. Plus, NASA admits that plan to bring Mars rocks to Earth won’t work and three new species of extinct giant kangaroos discovered.
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Constants and variations in 69 diverse genomes of Arabidopsis thaliana Nat. Genet. (IF 30.8) Pub Date : 2024-04-18
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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder Nat. Genet. (IF 30.8) Pub Date : 2024-04-18 Caroline M. Nievergelt, Adam X. Maihofer, Elizabeth G. Atkinson, Chia-Yen Chen, Karmel W. Choi, Jonathan R. I. Coleman, Nikolaos P. Daskalakis, Laramie E. Duncan, Renato Polimanti, Cindy Aaronson, Ananda B. Amstadter, Soren B. Andersen, Ole A. Andreassen, Paul A. Arbisi, Allison E. Ashley-Koch, S. Bryn Austin, Esmina Avdibegoviç, Dragan Babić, Silviu-Alin Bacanu, Dewleen G. Baker, Anthony Batzler,
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Genetic modifiers of rare variants in monogenic developmental disorder loci Nat. Genet. (IF 30.8) Pub Date : 2024-04-18 Rebecca Kingdom, Robin N. Beaumont, Andrew R. Wood, Michael N. Weedon, Caroline F. Wright
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Londoners see what a scientist looks like up close in 50 photographs Nature (IF 64.8) Pub Date : 2024-04-18
Nature’s Where I Work images are being exhibited in the UK capital until June.
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Burnt remains of Maya royalty mark a dramatic power shift Nature (IF 64.8) Pub Date : 2024-04-18
Finds in pyramid at Guatemalan site suggest that remains were disinterred and desecrated in a public ritual.
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Violent volcanoes have wracked Jupiter’s moon Io for billions of years Nature (IF 64.8) Pub Date : 2024-04-18
Understanding the volcanic moon’s history could offer fresh insights into conditions on early Earth.
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Meet ‘goldene’: this gilded cousin of graphene is also one atom thick Nature (IF 64.8) Pub Date : 2024-04-18
Sheets of gold might find use as catalysts, or in light-sensing devices.
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AI’s keen diagnostic eye Nature (IF 64.8) Pub Date : 2024-04-18
Powered by deep-learning algorithms, artificial intelligence systems could replace agents such as chemicals currently used to augment medical scans.
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This water bottle purifies your drink with energy from your steps Nature (IF 64.8) Pub Date : 2024-04-17
Static electricity generated by the foot striking the ground can be captured to kill pathogens.
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Promiscuous G-protein activation by the calcium-sensing receptor Nature (IF 64.8) Pub Date : 2024-04-17 Hao Zuo, Jinseo Park, Aurel Frangaj, Jianxiang Ye, Guanqi Lu, Jamie J. Manning, Wesley B. Asher, Zhengyuan Lu, Guo-bin Hu, Liguo Wang, Joshua Mendez, Edward Eng, Zhening Zhang, Xin Lin, Robert Grassucci, Wayne A. Hendrickson, Oliver B. Clarke, Jonathan A. Javitch, Arthur D. Conigrave, Qing R. Fan
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Control of neuronal excitation–inhibition balance by BMP–SMAD1 signalling Nature (IF 64.8) Pub Date : 2024-04-17 Zeynep Okur, Nadia Schlauri, Vassilis Bitsikas, Myrto Panopoulou, Raul Ortiz, Michaela Schwaiger, Kajari Karmakar, Dietmar Schreiner, Peter Scheiffele
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Smoking bans are coming: what does the evidence say? Nature (IF 64.8) Pub Date : 2024-04-17
Countries are cracking down on tobacco use and vaping — the laws could save thousands of lives and billions of dollars, say scientists.
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Exploring the lung microbiome’s role in disease Nature (IF 64.8) Pub Date : 2024-04-17
Unusual microbial communities in a person’s lower airways could influence the onset and progression of lung cancer and other conditions, and might point the way to therapies.
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Dad always mows on summer Saturday mornings Nature (IF 64.8) Pub Date : 2024-04-17
A clear-cut success.
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Researchers want a ‘nutrition label’ for academic-paper facts Nature (IF 64.8) Pub Date : 2024-04-17
An ‘at a glance’ approach to publication details, such as journal acceptance rates and the number of peer reviewers, would promote transparency, scientists say.
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We must protect the global plastics treaty from corporate interference Nature (IF 64.8) Pub Date : 2024-04-17
A United Nations-backed agreement to end plastic pollution is within reach — but only if scientists, civil society and businesses unite against powerful vested interests.
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Deadly diseases and inflatable suits: how I found my niche in virology research Nature (IF 64.8) Pub Date : 2024-04-17
Virologist Hulda Jónsdóttir studies some of the world’s most pathogenic viruses at the Spiez Laboratory in Switzerland.
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Nanoparticle fix opens up tricky technique to forensic applications Nature (IF 64.8) Pub Date : 2024-04-17 Peter J. Vikesland
A technique for measuring trace quantities of molecules in water.
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How young people benefit from Swiss apprenticeships Nature (IF 64.8) Pub Date : 2024-04-17
Computational biologist Jitao David Zhang says that the country’s vocational training programme teaches key work and life skills.
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Coupled neural activity controls working memory in humans Nature (IF 64.8) Pub Date : 2024-04-17 Ziv Williams
Temporarily holding on to information depends on coordinated brain waves.
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CERN’s impact goes way beyond tiny particles Nature (IF 64.8) Pub Date : 2024-04-17
A global effort to uncover the nature of the Universe has had resounding effects on scientists and society.
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UN plastics treaty: don’t let lobbyists drown out researchers Nature (IF 64.8) Pub Date : 2024-04-17
Tackling plastic pollution needs scientists to be in the negotiating room at upcoming talks.
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Canadian science gets biggest boost to PhD and postdoc pay in 20 years Nature (IF 64.8) Pub Date : 2024-04-17
Government budget includes more money for basic research and notable increases to postgraduate stipends.
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Humans and their livestock have sheltered in this Saudi Arabian cave for 10,000 years Nature (IF 64.8) Pub Date : 2024-04-17
Saudi herders have travelled the same routes for millennia, cave discovery suggests.
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Keys, wallet, phone: the neuroscience behind working memory Nature (IF 64.8) Pub Date : 2024-04-17
Hear the biggest stories from the world of science | 17 April 2024
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I dive for fish in the longest freshwater lake in the world Nature (IF 64.8) Pub Date : 2024-04-17
Biologist Carolin Sommer-Trembo describes her fascination for fish and why she enjoys doing science in Switzerland.
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Bacteria deploy umbrella toxins against their competitors Nature (IF 64.8) Pub Date : 2024-04-17 Sarah J. Coulthurst
Streptomyces bacteria make a previously unknown antibacterial agent.
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Surprise hybrid origins of a butterfly species Nature (IF 64.8) Pub Date : 2024-04-17 Megan E. Frayer, Jenn M. Coughlan
Longwing butterfly species found to be a rare type of hybrid.
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An exploration of how the insect-wing hinge functions Nature (IF 64.8) Pub Date : 2024-04-17 Tanvi Deora
Insights into control of the joints that connect fly wings to their body.
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AI traces mysterious metastatic cancers to their source Nature (IF 64.8) Pub Date : 2024-04-17
Algorithm examines images of metastatic cells to identify the location of the primary tumour.
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What toilets can reveal about COVID, cancer and other health threats Nature (IF 64.8) Pub Date : 2024-04-17
Wastewater testing grew tremendously during the pandemic. But is it ready to tackle the opioid crisis, air pollution and antibiotic resistance?
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The sympathetic nervous system arose in the earliest vertebrates Nature (IF 64.8) Pub Date : 2024-04-17 Uwe Ernsberger, Hermann Rohrer
Jawless vertebrate has sympathetic neurons.
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How India can become a science powerhouse Nature (IF 64.8) Pub Date : 2024-04-16
As the world’s largest election kicks off this week, India has an opportunity to reimagine science funding.
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Isotopic evidence of long-lived volcanism on Io Science (IF 56.9) Pub Date : 2024-04-18 Katherine de Kleer, Ery C. Hughes, Francis Nimmo, John Eiler, Amy E. Hofmann, Statia Luszcz-Cook, Kathy Mandt
Jupiter’s moon Io hosts extensive volcanism, driven by tidal heating. The isotopic composition of Io’s inventory of volatile chemical elements, including sulfur and chlorine, reflects its outgassing and mass loss history, and thus records information about its evolution. We used millimeter observations of Io’s atmosphere to measure sulfur isotopes in gaseous SO 2 and SO, and chlorine isotopes in gaseous
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France needs a chief science adviser Science (IF 56.9) Pub Date : 2024-04-18 Patrick Lemaire, François Massol
France is at a crossroads, facing environmental and social challenges that are profoundly altering its society. Yet, the French government keeps prioritizing short-term political gains over long-term evidence-based planning for major transitions that France, like most countries, will undergo over the next 20 years. There is an urgent need for France to implement long-term science-informed policy-making
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Mapping twist-tuned multiband topology in bilayer WSe 2 Science (IF 56.9) Pub Date : 2024-04-18 Benjamin A. Foutty, Carlos R. Kometter, Trithep Devakul, Aidan P. Reddy, Kenji Watanabe, Takashi Taniguchi, Liang Fu, Benjamin E. Feldman
Semiconductor moiré superlattices have been shown to host a wide array of interaction-driven ground states. However, twisted homobilayers have been difficult to study in the limit of large moiré wavelengths, where interactions are most dominant. In this study, we conducted local electronic compressibility measurements of twisted bilayer WSe 2 (tWSe 2 ) at small twist angles. We demonstrated multiple
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Interferon- γ and infectious diseases: Lessons and prospects Science (IF 56.9) Pub Date : 2024-04-18 Jean-Laurent Casanova, John D. MacMicking, Carl F. Nathan
Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon- γ (IFN- γ ), a protein secreted by lymphocytes. Forty years ago, IFN-
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Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit Science (IF 56.9) Pub Date : 2024-04-18 Yangfan Peng, Antje Bjelde, Pau Vilimelis Aceituno, Franz X. Mittermaier, Henrike Planert, Sabine Grosser, Julia Onken, Katharina Faust, Thilo Kalbhenn, Matthias Simon, Helena Radbruch, Pawel Fidzinski, Dietmar Schmitz, Henrik Alle, Martin Holtkamp, Imre Vida, Benjamin F. Grewe, Jörg R. P. Geiger
The computational capabilities of neuronal networks are fundamentally constrained by their specific connectivity. Previous studies of cortical connectivity have mostly been carried out in rodents; whether the principles established therein also apply to the evolutionarily expanded human cortex is unclear. We studied network properties within the human temporal cortex using samples obtained from brain
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Phage predation, disease severity, and pathogen genetic diversity in cholera patients Science (IF 56.9) Pub Date : 2024-04-18 Naïma Madi, Emilee T. Cato, Md. Abu Sayeed, Ashton Creasy-Marrazzo, Aline Cuénod, Kamrul Islam, Md. Imam Ul Khabir, Md. Taufiqur R. Bhuiyan, Yasmin A. Begum, Emma Freeman, Anirudh Vustepalli, Lindsey Brinkley, Manasi Kamat, Laura S. Bailey, Kari B. Basso, Firdausi Qadri, Ashraful I. Khan, B. Jesse Shapiro, Eric J. Nelson
Despite an increasingly detailed picture of the molecular mechanisms of bacteriophage (phage)–bacterial interactions, we lack an understanding of how these interactions evolve and impact disease within patients. In this work, we report a year-long, nationwide study of diarrheal disease patients in Bangladesh. Among cholera patients, we quantified Vibrio cholerae (prey) and its virulent phages (predators)
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Fusion of memristor and digital compute-in-memory processing for energy-efficient edge computing Science (IF 56.9) Pub Date : 2024-04-18 Tai-Hao Wen, Je-Min Hung, Wei-Hsing Huang, Chuan-Jia Jhang, Yun-Chen Lo, Hung-Hsi Hsu, Zhao-En Ke, Yu-Chiao Chen, Yu-Hsiang Chin, Chin-I Su, Win-San Khwa, Chung-Chuan Lo, Ren-Shuo Liu, Chih-Cheng Hsieh, Kea-Tiong Tang, Mon-Shu Ho, Chung-Cheng Chou, Yu-Der Chih, Tsung-Yung Jonathan Chang, Meng-Fan Chang
Artificial intelligence (AI) edge devices prefer employing high-capacity nonvolatile compute-in-memory (CIM) to achieve high energy efficiency and rapid wakeup-to-response with sufficient accuracy. Most previous works are based on either memristor-based CIMs, which suffer from accuracy loss and do not support training as a result of limited endurance, or digital static random-access memory (SRAM)–based
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High energy density in artificial heterostructures through relaxation time modulation Science (IF 56.9) Pub Date : 2024-04-18 Sangmoon Han, Justin S. Kim, Eugene Park, Yuan Meng, Zhihao Xu, Alexandre C. Foucher, Gwan Yeong Jung, Ilpyo Roh, Sangho Lee, Sun Ok Kim, Ji-Yun Moon, Seung-Il Kim, Sanggeun Bae, Xinyuan Zhang, Bo-In Park, Seunghwan Seo, Yimeng Li, Heechang Shin, Kate Reidy, Anh Tuan Hoang, Suresh Sundaram, Phuong Vuong, Chansoo Kim, Junyi Zhao, Jinyeon Hwang, Chuan Wang, Hyungil Choi, Dong-Hwan Kim, Jimin Kwon, Jin-Hong
Electrostatic capacitors are foundational components of advanced electronics and high-power electrical systems owing to their ultrafast charging-discharging capability. Ferroelectric materials offer high maximum polarization, but high remnant polarization has hindered their effective deployment in energy storage applications. Previous methodologies have encountered problems because of the deteriorated
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More resilient polyester membranes for high-performance reverse osmosis desalination Science (IF 56.9) Pub Date : 2024-04-18 Yujian Yao, Pingxia Zhang, Fei Sun, Wen Zhang, Meng Li, Gang Sha, Long Teng, Xianze Wang, Mingxin Huo, Ryan M. DuChanois, Tianchi Cao, Chanhee Boo, Xuan Zhang, Menachem Elimelech
Thin-film composite reverse osmosis membranes have remained the gold standard technology for desalination and water purification for nearly half a century. Polyamide films offer excellent water permeability and salt rejection but also suffer from poor chlorine resistance, high fouling propensity, and low boron rejection. We addressed these issues by molecularly designing a polyester thin-film composite
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Fast current-induced skyrmion motion in synthetic antiferromagnets Science (IF 56.9) Pub Date : 2024-04-18 Van Tuong Pham, Naveen Sisodia, Ilaria Di Manici, Joseba Urrestarazu-Larrañaga, Kaushik Bairagi, Johan Pelloux-Prayer, Rodrigo Guedas, Liliana D. Buda-Prejbeanu, Stéphane Auffret, Andrea Locatelli, Tevfik Onur Menteş, Stefania Pizzini, Pawan Kumar, Aurore Finco, Vincent Jacques, Gilles Gaudin, Olivier Boulle
Magnetic skyrmions are topological magnetic textures that hold great promise as nanoscale bits of information in memory and logic devices. Although room-temperature ferromagnetic skyrmions and their current-induced manipulation have been demonstrated, their velocity has been limited to about 100 meters per second. In addition, their dynamics are perturbed by the skyrmion Hall effect, a motion transverse
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Technological risks are not the end of the world Science (IF 56.9) Pub Date : 2024-04-18 Jack Stilgoe
There’s a scene in the movie Oppenheimer in which the protagonist is trying to explain to General Groves, his military overseer, the hazards of their endeavor. Groves asks Oppenheimer, “Are you saying there’s a chance that when we push that button, we destroy the world?“ The physicist says, “The chances are near zero.” When Groves, understandably alarmed, asks for clarification, Oppenheimer responds
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A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes Science (IF 56.9) Pub Date : 2024-04-18 Liming Zhang, Daxi Wang, Peibo Shi, Juzhen Li, Jichen Niu, Jielong Chen, Gang Wang, Linjuan Wu, Lu Chen, Zhenxing Yang, Susheng Li, Jinxin Meng, Fangchao Ruan, Yuwen He, Hailong Zhao, Zirui Ren, Yibaina Wang, Yang Liu, Xiaolu Shi, Yunfu Wang, Qiyong Liu, Junhua Li, Penghua Wang, Jinglin Wang, Yibin Zhu, Gong Cheng
The commensal microbiota of the mosquito gut plays a complex role in determining the vector competence for arboviruses. In this study, we identified a bacterium from the gut of field Aedes albopictus mosquitoes named Rosenbergiella sp. YN46 ( Rosenbergiella_ YN46) that rendered mosquitoes refractory to infection with dengue and Zika viruses. Inoculation of 1.6 × 10 3 colony forming units (CFUs) of
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Structural disorder determines capacitance in nanoporous carbons Science (IF 56.9) Pub Date : 2024-04-18 Xinyu Liu, Dongxun Lyu, Céline Merlet, Matthew J. A. Leesmith, Xiao Hua, Zhen Xu, Clare P. Grey, Alexander C. Forse
The difficulty in characterizing the complex structures of nanoporous carbon electrodes has led to a lack of clear design principles with which to improve supercapacitors. Pore size has long been considered the main lever to improve capacitance. However, our evaluation of a large series of commercial nanoporous carbons finds a lack of correlation between pore size and capacitance. Instead, nuclear
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A national-scale assessment of land subsidence in China’s major cities Science (IF 56.9) Pub Date : 2024-04-18 Zurui Ao, Xiaomei Hu, Shengli Tao, Xie Hu, Guoquan Wang, Mingjia Li, Fang Wang, Litang Hu, Xiuyu Liang, Jingfeng Xiao, Asadilla Yusup, Wenhua Qi, Qinwei Ran, Jiayi Fang, Jinfeng Chang, Zhenzhong Zeng, Yongshuo Fu, Baolin Xue, Ping Wang, Kefei Zhao, Le Li, Wenkai Li, Yumei Li, Mi Jiang, Yuanhe Yang, Haihua Shen, Xia Zhao, Yue Shi, Bo Wu, Zhengbing Yan, Mengjia Wang, Yanjun Su, Tianyu Hu, Qin Ma, Hao
China’s massive wave of urbanization may be threatened by land subsidence. Using a spaceborne synthetic aperture radar interferometry technique, we provided a systematic assessment of land subsidence in all of China’s major cities from 2015 to 2022. Of the examined urban lands, 45% are subsiding faster than 3 millimeters per year, and 16% are subsiding faster than 10 millimeters per year, affecting
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Neuroendocrine cells initiate protective upper airway reflexes Science (IF 56.9) Pub Date : 2024-04-18 Laura F. Seeholzer, David Julius
Airway neuroendocrine (NE) cells have been proposed to serve as specialized sensory epithelial cells that modulate respiratory behavior by communicating with nearby nerve endings. However, their functional properties and physiological roles in the healthy lung, trachea, and larynx remain largely unknown. In this work, we show that murine NE cells in these compartments have distinct biophysical properties
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Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need Science (IF 56.9) Pub Date : 2024-04-18 Bowen Tan, Caleb J. Browne, Tobias Nöbauer, Alipasha Vaziri, Jeffrey M. Friedman, Eric J. Nestler
Drugs of abuse are thought to promote addiction in part by “hijacking” brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping and in vivo single-neuron calcium imaging, we found that drugs of abuse augment dopaminoceptive ensemble activity in the nucleus accumbens (NAc) and disorganize overlapping ensemble responses to natural rewards in a cell type–specific