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Diet and the gut microbiome in patients with Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-22 Dayoon Kwon, Keren Zhang, Kimberly C. Paul, Aline D. Folle, Irish Del Rosario, Jonathan P. Jacobs, Adrienne M. Keener, Jeff M. Bronstein, Beate Ritz
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Longitudinal cognitive decline characterizes the profile of non-PD-manifest GBA1 mutation carriers npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-22 Benjamin Roeben, Inga Liepelt-Scarfone, Stefanie Lerche, Milan Zimmermann, Isabel Wurster, Ulrike Sünkel, Claudia Schulte, Christian Deuschle, Gerhard W. Eschweiler, Walter Maetzler, Thomas Gasser, Daniela Berg, Kathrin Brockmann
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Critical Alzheimer's disease legislation advances in Congress Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-21
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Dementia Prevalence, Incidence and Mortality Trends Among US Adults Ages 72 and Older, 2011-2021 J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-20 Vicki A Freedman, Jennifer C Cornman
Background U.S.-focused studies have reported decreasing dementia prevalence in recent decades, but have not yet focused on the implications of the COVID-19 pandemic for trends. Methods We use the 2011-2021 National Health and Aging Trends Study (N=48,065) to examine dementia prevalence, incidence and mortality trends among adults ages 72 and older, and the contribution to prevalence trends of changes
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Kinship And Care: Racial Disparities In Potential Dementia Caregiving In The U.S. From 2000 To 2060 J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-20 Kai Feng, Xi Song, Hal Caswell
Background Although the family plays a pivotal role in older adults’ care, there is limited research on how evolving demographic trends affect older adults’ support networks and how the trends vary by race. To fill this gap, we examine the influence of shifting family demographics on future care needs for older adults with dementia, emphasizing the unequal health and potential caregiving burdens by
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Racial/Ethnic Differences in Self-Reported Upper Limb Limitations among U.S. Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-20 Rachel N Logue Cook, Matthew A Davis, Rebecca E Hasson, Dominique Kinnett-Hopkins, Susan H Brown
Background The development of disability related to activities of daily living (ADL) is of great concern in the aging population, particularly for Hispanic and Non-Hispanic (NH) Black older adults, where disability prevalence is greater compared to NH Whites. ADL-disability is typically measured across many functional tasks without differentiating upper- versus lower-limb limitations, hindering our
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The association of the 24-hour activity cycle profiles with cognition in older adults with mild cognitive impairment: A cross-sectional study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-20 Guilherme Moraes Balbim, Ryan S Falck, Nárlon Cássio Boa Sorte Silva, Arthur F Kramer, Michelle Voss, Teresa Liu-Ambrose
Background The relationship of cognition and the 24-hour activity cycles (24-HAC), encompassing physical activity, sedentary behaviour, and sleep, in older adults with mild cognitive impairment (MCI) remains uncertain. Distinct combinations of 24-HAC behaviours can characterize unique activity profiles and influence cognition. We aimed to characterize 24-HAC activity profiles in older adults with MCI
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Sex differences in cognitive decline among middle-aged and older adults: a cohort study in Europe Age Ageing (IF 6.7) Pub Date : 2024-04-19 Katrin Wolfova, Barbora Frycova, Dominika Seblova, Sarah Tom, Vegard Fykse Skirbekk, Pavla Brennan Kearns
Objectives Previous studies on sex differences in cognitive decline provide inconsistent findings, with many European countries being underrepresented. We determined the association between sex and cognitive decline in a sample of Europeans and explored differences across birth cohorts and regions. Methods Participants 50+ years old enrolled in the Survey of Health, Ageing and Retirement in Europe
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Presynaptic density determined by SV2A PET is closely associated with postsynaptic metabotropic glutamate receptor 5 availability and independent of amyloid pathology in early cognitive impairment Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-18 Jie Wang, Qi Huang, Kun He, Junpeng Li, Tengfei Guo, Yang Yang, Zengping Lin, Songye Li, Greet Vanderlinden, Yiyun Huang, Koen Van Laere, Yihui Guan, Qihao Guo, Ruiqing Ni, Binying Li, Fang Xie
INTRODUCTIONMetabotropic glutamate receptor 5 (mGluR5) is involved in regulating integrative brain function and synaptic transmission. Aberrant mGluR5 signaling and relevant synaptic failure play a key role in the pathophysiological mechanism of Alzheimer's disease (AD).METHODSTen cognitively impaired (CI) individuals and 10 healthy controls (HCs) underwent [18F]SynVesT‐1 and [18F]PSS232 positron emission
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Cognitively healthy centenarians are genetically protected against Alzheimer's disease Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-18 Niccolo’ Tesi, Sven van der Lee, Marc Hulsman, Natasja M. van Schoor, Martijn Huisman, Yolande Pijnenburg, Wiesje M. van der Flier, Marcel Reinders, Henne Holstege
BACKGROUNDAlzheimer's disease (AD) prevalence increases with age, yet a small fraction of the population reaches ages > 100 years without cognitive decline. We studied the genetic factors associated with such resilience against AD.METHODSGenome‐wide association studies identified 86 single nucleotide polymorphisms (SNPs) associated with AD risk. We estimated SNP frequency in 2281 AD cases, 3165 age‐matched
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Longitudinal cerebral perfusion in presymptomatic genetic frontotemporal dementia: GENFI results Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-16 Maurice Pasternak, Saira S. Mirza, Nicholas Luciw, Henri J. M. M. Mutsaerts, Jan Petr, David Thomas, David Cash, Martina Bocchetta, Maria Carmela Tartaglia, Sara B. Mitchell, Sandra E. Black, Morris Freedman, David Tang-Wai, Ekaterina Rogaeva, Lucy L. Russell, Arabella Bouzigues, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Robert Laforce, Pietro Tiraboschi, Barbara Borroni, Daniela Galimberti
Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers.
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Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-17 Doris Patricia Molina‐Henry, Rema Raman, Andy Liu, Oliver Langford, Keith Johnson, Leona K. Shum, Crystal M. Glover, Shobha Dhadda, Michael Irizarry, Gustavo Jimenez‐Maggiora, Joel B. Braunstein, Kevin Yarasheski, Venky Venkatesh, Tim West, Philip B. Verghese, Robert A. Rissman, Paul Aisen, Joshua D. Grill, Reisa A. Sperling
INTRODUCTIONIn trials of amyloid‐lowering drugs for Alzheimer's disease (AD), differential eligibility may contribute to under‐inclusion of racial and ethnic underrepresented groups. We examined plasma amyloid beta 42/40 and positron emission tomography (PET) amyloid eligibility for the ongoing AHEAD Study preclinical AD program (NCT04468659).METHODSUnivariate logistic regression models were used to
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White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-17 Lisa C. Silbert, Natalie E. Roese, Victoria Krajbich, Justin Hurworth, David Lahna, Daniel L. Schwartz, Hiroko H. Dodge, Randall L. Woltjer
INTRODUCTIONAge‐related magnetic resonance imaging (MRI) T2 white matter hyperintensities (WMHs) are common and associated with neurological decline. We investigated the histopathological underpinnings of MRI WMH and surrounding normal appearing white matter (NAWM), with a focus on astroglial phenotypes.METHODSBrain samples from 51 oldest old Oregon Alzheimer's Disease Research Center participants
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MINocyclinE to Reduce inflammation and blood‐brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double‐blind, placebo‐controlled experimental medicine trial Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-17 Robin B. Brown, Daniel J. Tozer, Laurence Loubière, Eric L. Harshfield, Young T. Hong, Tim D. Fryer, Guy B. Williams, Martin J. Graves, Franklin I. Aigbirhio, John T. O'Brien, Hugh S. Markus
INTRODUCTIONCerebral small vessel disease (SVD) is a common cause of stroke/vascular dementia with few effective treatments. Neuroinflammation and increased blood‐brain barrier (BBB) permeability may influence pathogenesis. In rodent models, minocycline reduced inflammation/BBB permeability. We determined whether minocycline had a similar effect in patients with SVD.METHODSMINERVA was a single‐center
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Resequencing the complete SNCA locus in Indian patients with Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-15 Asha Kishore, Marc Sturm, Kanchana Soman Pillai, Christopher Hakkaart, Divya Kalikavil Puthanveedu, Madhusoodanan Urulangodi, Syam Krishnan, Ashwin Ashok Kumar Sreelatha, Roopa Rajan, Pramod Kumar Pal, Ravi Yadav, Gangadhara Sarma, Nicolas Casadei, Thomas Gasser, Peter Bauer, Olaf Riess, Manu Sharma
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Anxiety in Alzheimer's disease rats is independent of memory and impacted by genotype, age, sex, and exercise Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-16 Danielle C. Lopez, Zachary J. White, Stephanie E. Hall
INTRODUCTIONAlzheimer's disease (AD) is characterized by cognitive impairments; however, heightened anxiety often accompanies and, in some cases, exacerbates cognitive its. The present study aims to understand the influence of multiple variables on anxiety‐like behavior in TgF344‐AD rats and determine whether anxiety impacts memory performance.METHODSAn elevated plus maze was used to assess anxiety‐like
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Peripheral HMGB1 is linked to O3 pathology of disease‐associated astrocytes and amyloid Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-16 Chandrama Ahmed, Hendrik J. Greve, Carla Garza‐Lombo, Jamie A. Malley, James A. Johnson, Adrian L. Oblak, Michelle L. Block
INTRODUCTIONOzone (O3) is an air pollutant associated with Alzheimer's disease (AD) risk. The lung–brain axis is implicated in O3‐associated glial and amyloid pathobiology; however, the role of disease‐associated astrocytes (DAAs) in this process remains unknown.METHODSThe O3‐induced astrocyte phenotype was characterized in 5xFAD mice by spatial transcriptomics and proteomics. Hmgb1fl/fl LysM‐Cre+
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Plasma metabolomic markers underlying skeletal muscle mitochondrial function relationships with cognition and motor function Age Ageing (IF 6.7) Pub Date : 2024-04-14 Qu Tian, Erin E Greig, Keenan A Walker, Kenneth W Fishbein, Richard G Spencer, Susan M Resnick, Luigi Ferrucci
Background Lower skeletal muscle mitochondrial function is associated with future cognitive impairment and mobility decline, but the biological underpinnings for these associations are unclear. We examined metabolomic markers underlying skeletal muscle mitochondrial function, cognition and motor function. Methods We analysed data from 560 participants from the Baltimore Longitudinal Study of Aging
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GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-13 Lara Cheslow, Matthew Byrne, Jessica S. Kopenhaver, Lorraine Iacovitti, Richard J. Smeyne, Adam E. Snook, Scott A. Waldman
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Grey matter networks in women and men with dementia with Lewy bodies npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-13 Annegret Habich, Javier Oltra, Christopher G. Schwarz, Scott A. Przybelski, Ketil Oppedal, Anna Inguanzo, Frédéric Blanc, Afina W. Lemstra, Jakub Hort, Eric Westman, Barbara Segura, Carme Junque, Val J. Lowe, Bradley F. Boeve, Dag Aarsland, Thomas Dierks, Kejal Kantarci, Daniel Ferreira
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Understanding the association between pain and delirium in older hospital inpatients: systematic review and meta-analysis Age Ageing (IF 6.7) Pub Date : 2024-04-13 Nicola White, Juan Carlos Bazo-Alvarez, Michel Koopmans, Emily West, Elizabeth L Sampson
Objective Delirium and pain are common in older adults admitted to hospital. The relationship between these is unclear, but clinically important. We aimed to systematically review the association between pain (at rest, movement, pain severity) and delirium in this population. Methods PubMed, EMBASE, CINAHL, PsycINFO, Cochrane and Web of Science were searched (January 1982–November 2022) for Medical
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Discrepancies in corrected calcium versus ionised calcium in a geriatric population: an observational study Age Ageing (IF 6.7) Pub Date : 2024-04-13 Alexandra P S P Suryapranata, Carolina J P W Keijsers, Steef Kurstjens, Astrid M Van Strien
Background Calcium can be measured as ionised (Ca-ionised) or albumin-adjusted total calcium (Ca-albumin). Current clinical guidelines predominantly utilise Ca-albumin, despite Ca-ionised being the gold standard. Discrepancies can occur between these measurement modalities and can lead to clinical dilemmas. It remains unclear how large these discrepancies are in older patients. This study investigated
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Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-12 Quyen B. Do, Humaira Noor, Ricardo Marquez-Gomez, Kaitlyn M. L. Cramb, Bryan Ng, Ajantha Abbey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne Beccano-Kelly, Jimena Baleriola, Nora Bengoa-Vergniory, Richard Wade-Martins
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Progressive reduction of nuclear receptor Nr4a1 mediates age‐dependent cognitive decline Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-12 Jiang Chen, Zhi Zhang, Ying Liu, Lili Huang, Yi Liu, Dan Yang, Xinyu Bao, Pinyi Liu, Yuhan Ge, Qingqing Li, Xin Shu, Lushan Xu, Yun Stone Shi, Xiaolei Zhu, Yun Xu
INTRODUCTIONCognitive decline progresses with age, and Nr4a1 has been shown to participate in memory functions. However, the relationship between age‐related Nr4a1 reduction and cognitive decline is undefined.METHODSNr4a1 expressions were evaluated by quantitative PCR and immunochemical approaches. The cognition of mice was examined by multiple behavioral tests. Patch‐clamp experiments were conducted
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Predictors of stress resilience in Parkinson’s disease and associations with symptom progression npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-11 Anouk van der Heide, Lisanne J. Dommershuijsen, Lara M. C. Puhlmann, Raffael Kalisch, Bastiaan R. Bloem, Anne E. M. Speckens, Rick C. Helmich
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Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-11 Zarui A. Melikyan, Claudia H. Kawas, Annlia Paganini‐Hill, Luohua Jiang, Syed Bukhari, Thomas J. Montine, Bryce A. Mander, María M. Corrada
INTRODUCTIONWe investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest‐old (age 90+) participants of The 90+ Study.METHODSParticipants self‐reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as < 7, 7 to 8 = reference, > 8 hours and dichotomized neuropathologic changes as present/absent. We estimated
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Muscle mitochondrial bioenergetic capacities are associated with multimorbidity burden in older adults: the Study of Muscle, Mobility and Aging (SOMMA) J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-11 Theresa Mau, Terri L Blackwell, Peggy M Cawthon, Anthony J A Molina, Paul M Coen, Giovanna Distefano, Philip A Kramer, Sofhia V Ramos, Daniel E Forman, Bret H Goodpaster, Frederico G S Toledo, Kate A Duchowny, Lauren M Sparks, Anne B Newman, Stephen B Kritchevsky, Steven R Cummings
Background The geroscience hypothesis posits that aging biological processes contribute to many age-related deficits, including the accumulation of multiple chronic diseases. Though only one facet of mitochondrial function, declines in muscle mitochondrial bioenergetic capacities may contribute to this increased susceptibility to multimorbidity. Methods The Study of Muscle, Mobility and Aging (SOMMA)
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Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer’s disease Geroscience (IF 5.6) Pub Date : 2024-04-10 Jordan N. Williamson, Shirley A. James, Sean P. Mullen, Bradley P. Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Yuan Yang
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Spousal bereavement and its effects on later life physical and cognitive capability: the Tromsø study Geroscience (IF 5.6) Pub Date : 2024-04-09 Bjørn Heine Strand, Asta K. Håberg, Harpa Sif Eyjólfsdóttir, Almar Kok, Vegard Skirbekk, Oliver Huxhold, Gøril Kvamme Løset, Carin Lennartsson, Henrik Schirmer, Katharina Herlofson, Marijke Veenstra
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Racial discrimination during middle age predicts higher serum phosphorylated tau and neurofilament light chain levels a decade later: A study of aging black Americans Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-10 Ronald L. Simons, Mei Ling Ong, Man‐Kit Lei, Steven R. H. Beach, Yue Zhang, Robert Philibert, Michelle M. Mielke
INTRODUCTIONRecent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans.METHODSThe present study used 17 years of data from a sample of 255 Black Americans to investigate the extent to which exposure to racial discrimination predicts subsequent changes in serum Alzheimer's Disease Research Center (ADRC) biomarkers: serum phosphorylated tau181(p‐tau181)
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Peripheral Blood Cells from Older Adults Exhibit Sex-Associated Differences in Mitochondrial Function J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-10 Gargi Mahapatra, Zhengrong Gao, James R Bateman, Samuel Neal Lockhart, Jaclyn Bergstrom, Jemima Elizabeth Piloso, Suzanne Craft, Anthony J A Molina
Blood based mitochondrial bioenergetic profiling is a feasible, economical, and minimally invasive approach that can be used to examine mitochondrial function and energy metabolism in human subjects. In this study, we use two complementary respirometric techniques to evaluate mitochondrial bioenergetics in both intact and permeabilized peripheral blood mononuclear cells (PBMCs) and platelets to examine
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Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-10 Brittney S Lange-Maia, Maude Wagner, Christina A Rogers, Rupal I Mehta, David A Bennett, Christy Tangney, Michael E Schoeny, Shannon Halloway, Zoe Arvanitakis
High engagement in lifestyle health behaviors appears to be protective against cognitive decline in aging. We investigated the association between patterns of modifiable lifestyle health behaviors and common brain neuropathologies of dementia as a possible mechanism. We examined 555 decedents from the Rush Memory and Aging Project, free of dementia at their initial concurrent report of lifestyle health
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The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT Geroscience (IF 5.6) Pub Date : 2024-04-09 Jessica K. Lu, Lihuan Guan, Weilan Wang, Anna G. M. Rojer, Fedor Galkin, Jorming Goh, Andrea B. Maier
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Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans Geroscience (IF 5.6) Pub Date : 2024-04-08 Elizabeth M. L. Duxbury, Hanne Carlsson, Annabel Kimberley, Yvonne Ridge, Katie Johnson, Alexei A. Maklakov
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Elevated α-synuclein levels inhibit mitophagic flux npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-09 Inge Kinnart, Liselot Manders, Thibaut Heyninck, Dorien Imberechts, Roman Praschberger, Nils Schoovaerts, Catherine Verfaillie, Patrik Verstreken, Wim Vandenberghe
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Social isolation and the risk of Parkinson disease in the UK biobank study npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-08 Tingting Geng, Yaqi Li, Yinshun Peng, Xiao Chen, Xinming Xu, Jian Wang, Liang Sun, Xiang Gao
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20‐year depressive symptoms, dementia, and structural neuropathology in older women Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-09 Andrew J. Petkus, Xinhui Wang, Diana Younan, Lauren E. Salminen, Susan M. Resnick, Stephen R. Rapp, Mark A. Espeland, Margaret Gatz, Keith F. Widaman, Ramon Casanova, Helena Chui, Ryan T. Barnard, Sarah A. Gaussoin, Joseph S. Goveas, Kathleen M. Hayden, Victor W. Henderson, Bonnie C. Sachs, Santiago Saldana, Aladdin H. Shadyab, Sally A. Shumaker, Jiu‐Chiuan Chen
INTRODUCTIONThe course of depressive symptoms and dementia risk is unclear, as are potential structural neuropathological common causes.METHODSUtilizing joint latent class mixture models, we identified longitudinal trajectories of annually assessed depressive symptoms and dementia risk over 21 years in 957 older women (baseline age 72.7 years old) from the Women's Health Initiative Memory Study. In
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Yoga-based lifestyle intervention for healthy ageing in older adults: a two-armed, waitlist randomized controlled trial with multiple primary outcomes Geroscience (IF 5.6) Pub Date : 2024-04-07 Atmakur Snigdha, Vijaya Majumdar, N. K. Manjunath, Amrutha Jose
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Correction to “Amyloid ratios in plasma and CSF are biomarkers of pre‐symptomatic Alzheimer's disease” Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-08
Fonteh, A.N., Wu, X., Astraea, N., Elenberger, T., Buennagel, D.P., Sin, C., Spezzaferri, M., Rising, S., Nolty, A., Chui, H.C., Minazad, Y., Kloner, R.A. and Arakaki, X. (2023), Amyloid ratios in plasma and CSF are biomarkers of pre-symptomatic Alzheimer's disease. Alzheimer's Dement., 19: e079861. https://doi.org/10.1002/alz.079861 In the above article, the third author's last name was misspelled
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The association between cannabis use and neuroimaging measures in older adults: findings from the UK biobank Age Ageing (IF 6.7) Pub Date : 2024-04-08 Shiraz Vered, Sharon Sznitman, Galit Weinstein
Background Cannabis use has increased in recent years. However, the long-term implications of cannabis use on brain health remain unknown. We explored the associations of cannabis use with volumetric brain magnetic resonance imaging (MRI) measures in dementia-free older adults. Methods This cross-sectional and longitudinal study included dementia-free participants of the UK Biobank aged ≥60 years.
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Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-06 Velma T. E. Aho, Matthias Klee, Zied Landoulsi, Anna Heintz-Buschart, Lukas Pavelka, Anja K. Leist, Rejko Krüger, Patrick May, Paul Wilmes
Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition
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Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-04 Kristiana Xhima, Julie Ottoy, Erin Gibson, Katherine Zukotynski, Christopher Scott, Ginelle J. Feliciano, Sabrina Adamo, Phillip H. Kuo, Michael J. Borrie, Howard Chertkow, Richard Frayne, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Maged Goubran, Sandra E. Black, Joel Ramirez
Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood.
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Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-04 Ariane Bollack, Lyduine E. Collij, David Vállez García, Mahnaz Shekari, Daniele Altomare, Pierre Payoux, Bruno Dubois, Oriol Grau-Rivera, Mercè Boada, Marta Marquié, Agneta Nordberg, Zuzana Walker, Philip Scheltens, Michael Schöll, Robin Wolz, Jonathan M. Schott, Rossella Gismondi, Andrew Stephens, Christopher Buckley, Giovanni B. Frisoni, Bernard Hanseeuw, Pieter Jelle Visser, Rik Vandenberghe, Alexander
To support clinical trial designs focused on early interventions, our study determined reliable early amyloid-β (Aβ) accumulation based on Centiloids (CL) in pre-dementia populations.
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On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-02 Sanghun Lee, Julian Hecker, Georg Hahn, Kristina Mullin, , Sharon M. Lutz, Rudolph E. Tanzi, Christoph Lange, Dmitry Prokopenko
Genome-wide association studies have identified numerous disease susceptibility loci (DSLs) for Alzheimer's disease (AD). However, only a limited number of studies have investigated the dependence of the genetic effect size of established DSLs on genetic ancestry.
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Abstracts BMAS Summer School 2023—2nd Bone Marrow Adiposity Society Summer School Meeting 2023 J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-06 Biagio Palmisano, Michaela Tencerova
Fat is the main component of an adult bone marrow and constitutes the so-called bone marrow adipose tissue (BMAT). Marrow adipocytes, which are the fat cells in the bone marrow, become more abundant with age, and may influence the whole-body metabolism. In osteoporotic patients, the amount of BMAT has an inverse correlation with the amount of bone mass. In people with anorexia nervosa that lose weight
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Modulation of subthalamic beta oscillations by movement, dopamine, and deep brain stimulation in Parkinson’s disease npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-05 Varvara Mathiopoulou, Roxanne Lofredi, Lucia K. Feldmann, Jeroen Habets, Natasha Darcy, Wolf-Julian Neumann, Katharina Faust, Gerd-Helge Schneider, Andrea A. Kühn
Subthalamic beta band activity (13–35 Hz) is known as a real-time correlate of motor symptom severity in Parkinson’s disease (PD) and is currently explored as a feedback signal for closed-loop deep brain stimulation (DBS). Here, we investigate the interaction of movement, dopaminergic medication, and deep brain stimulation on subthalamic beta activity in PD patients implanted with sensing-enabled,
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Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-03 Elijah Mak, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Christopher G. Schwarz, Matthew L. Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R. Jack, Hoon Ki Min, Manoj K. Jain, Toji Miyagawa, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff-Radford, David T. Jones, Hugo Botha, Erik K. St. Louis, David S. Knopman, Vijay K. Ramanan, Dennis W. Dickson, Neill R.
Dementia with Lewy bodies (DLB) is a neurodegenerative condition often co-occurring with Alzheimer’s disease (AD) pathology. Characterizing white matter tissue microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) may help elucidate the biological underpinnings of white matter injury in individuals with DLB. In this study, diffusion tensor imaging (DTI) and NODDI metrics were
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RedOx regulation of LRRK2 kinase activity by active site cysteines npj Parkinsons Dis. (IF 9.304) Pub Date : 2024-04-03 Chiara R. Trilling, Jui-Hung Weng, Pallavi Kaila Sharma, Viktoria Nolte, Jian Wu, Wen Ma, Daniela Boassa, Susan S. Taylor, Friedrich W. Herberg
Mutations of the human leucine-rich repeat kinase 2 (LRRK2) have been associated with both, idiopathic and familial Parkinson’s disease (PD). Most of these pathogenic mutations are located in the kinase domain (KD) or GTPase domain of LRRK2. In this study we describe a mechanism in which protein kinase activity can be modulated by reversible oxidation or reduction, involving a unique pair of adjacent
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The behavioural effect of short-term cognitive and physical intervention therapies in old dogs Geroscience (IF 5.6) Pub Date : 2024-04-03
Abstract Efforts to counteract age-related decline have resulted in the emergence of various interventions. However, everyday benefits are rarely reported in elderly people. Dogs provide an excellent model for studying aging and interventions due to their similarities to humans. Our aim was to investigate whether a combined physical and cognitive intervention (most effective in humans) could enhance
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Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging Geroscience (IF 5.6) Pub Date : 2024-04-03
Abstract Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective
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Plasma oxysterols are associated with serum lipids and dementia risk in older women Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-04 Michelle M. Dunk, Stephen R. Rapp, Kathleen M. Hayden, Mark A. Espeland, Ramon Casanova, JoAnn E. Manson, Aladdin H. Shadyab, Robert Wild, Ira Driscoll
INTRODUCTIONApolipoprotein E4 (APOE4) carriers’ tendency toward hypercholesterolemia may contribute to Alzheimer's disease (AD) risk through oxysterols, which traverse the blood‐brain barrier.METHODSRelationships between baseline plasma oxysterols, APOE status, serum lipids, and cognitive impairment risk were examined in 328 postmenopausal women from the Women's Health Initiative Memory Study. Women
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Sex‐specific associations between AD genotype and the microbiome of human amyloid beta knock‐in (hAβ‐KI) mice Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-04 Sage J. B. Dunham, Julio Avelar‐Barragan, Jason A. Rothman, Eric D. Adams, Gina Faraci, Stefania Forner, Shimako Kawauchi, Andrea J. Tenner, Kim N. Green, Frank M. LaFerla, Grant R. MacGregor, Mark Mapstone, Katrine L. Whiteson
INTRODUCTIONEmerging evidence links changes in the gut microbiome to late‐onset Alzheimer's disease (LOAD), necessitating examination of AD mouse models with consideration of the microbiome.METHODSWe used shotgun metagenomics and untargeted metabolomics to study the human amyloid beta knock‐in (hAβ‐KI) murine model for LOAD compared to both wild‐type (WT) mice and a model for early‐onset AD (3xTg‐AD)
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Data‐driven classification of cognitively normal and mild cognitive impairment subtypes predicts progression in the NACC dataset Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-04 Emily C. Edmonds, Kelsey R. Thomas, Steven Z. Rapcsak, Shannon L. Lindemer, Lisa Delano‐Wood, David P. Salmon, Mark W. Bondi
INTRODUCTIONData‐driven neuropsychological methods can identify mild cognitive impairment (MCI) subtypes with stronger associations to dementia risk factors than conventional diagnostic methods.METHODSCluster analysis used neuropsychological data from participants without dementia (mean age = 71.6 years) in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (n = 26,255) and the “normal
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Early molecular events of autosomal‐dominant Alzheimer's disease in marmosets with PSEN1 mutations Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-04 Gregg E. Homanics, Jung Eun Park, Lauren Bailey, David J. Schaeffer, Lauren Schaeffer, Jie He, Shuoran Li, Tingting Zhang, Annat Haber, Catrina Spruce, Anna Greenwood, Takeshi Murai, Laura Schultz, Lauren Mongeau, Seung‐Kwon Ha, Julia Oluoch, Brianne Stein, Sang Ho Choi, Hasi Huhe, Amantha Thathiah, Peter L. Strick, Gregory W. Carter, Afonso C. Silva, Stacey J. Sukoff Rizzo
INTRODUCTIONFundamental questions remain about the key mechanisms that initiate Alzheimer's disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically engineered marmosets that carry knock‐in (KI) point mutations in the presenilin 1 (PSEN1) gene that can be studied from birth throughout lifespan.METHODSCRISPR/Cas9 was used to generate
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Automatic classification of AD pathology in FTD phenotypes using natural speech Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-04 Sunghye Cho, Christopher A. Olm, Sharon Ash, Sanjana Shellikeri, Galit Agmon, Katheryn A. Q. Cousins, David J. Irwin, Murray Grossman, Mark Liberman, Naomi Nevler
INTRODUCTIONScreening for Alzheimer's disease neuropathologic change (ADNC) in individuals with atypical presentations is challenging but essential for clinical management. We trained automatic speech‐based classifiers to distinguish frontotemporal dementia (FTD) patients with ADNC from those with frontotemporal lobar degeneration (FTLD).METHODSWe trained automatic classifiers with 99 speech features
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Results from the long‐term extension of PRIME: A randomized Phase 1b trial of aducanumab Alzheimers Dement. (IF 14.0) Pub Date : 2024-04-03 Tianle Chen, John O'Gorman, Carmen Castrillo‐Viguera, Rajasimhan Rajagovindan, Gioacchino G. Curiale, Ying Tian, Dakshaben Patel, Philipp von Rosenstiel, Christian von Hehn, Stephen Salloway, Christoph Hock, Roger M. Nitsch, Samantha Budd Haeberlein, Alfred Sandrock, Priya Singhal
INTRODUCTIONAducanumab selectively targets aggregated forms of amyloid beta (Aβ), a neuropathological hallmark of Alzheimer's disease (AD).METHODSPRIME was a Phase 1b, double‐blind, randomized clinical trial of aducanumab. During the 12‐month placebo‐controlled period, participants with prodromal AD or mild AD dementia were randomized to receive aducanumab or placebo. At week 56, participants could
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The Drug Burden Index is associated with Measures of Cognitive Function Among Older Adults in the Health, Aging, and Body Composition Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-03 Janie C DiNatale, Ian M McDonough, Amy C Ellis, Joy W Douglas, Kristine Yaffe, Kristi M Crowe-White
BACKGROUND Anticholinergic and sedative medications impact cognition among older adults. The Drug Burden Index (DBI) is a validated measure of exposure to these medications, with higher DBI scores indicating higher drug burden. This ancillary analysis investigated the association between DBI and cognition assessed by the Modified Mini-Mental State Examination (3MS) and the Digit Symbol Substitution
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An Increase in Vascular Stiffness is Positively Associated with Mitochondrial Bioenergetics Impairment of Peripheral Blood Mononuclear Cells in the Elderly Population J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-03 Tanawat Attachaipanich, Sirawit Sriwichaiin, Nattayaporn Apaijai, Sasiwan Kerdphoo, Nisakron Thongmung, Prin Vathesatogkit, Piyamitr Sritara, Nipon Chattipakorn, Chagriya Kitiyakara, Siriporn C Chattipakorn
The cardio-ankle vascular index (CAVI) is a non-invasive parameter reflecting vascular stiffness. CAVI correlates with the burden of atherosclerosis and future cardiovascular events. Mitochondria of peripheral blood mononuclear cells (PBMCs) have been identified as a non-invasive source for assessing systemic mitochondrial bioenergetics. This study aimed to investigate the relationship between CAVI
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Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-03 David A Ganz, Denise Esserman, Nancy K Latham, Michael Kane, Lillian C Min, Thomas M Gill, David B Reuben, Peter Peduzzi, Erich J Greene
Background Diagnosis-code-based algorithms to identify fall injuries in Medicare data are useful for ascertaining outcomes in interventional and observational studies. However, these algorithms have not been validated against a fully external reference standard, in ICD-10-CM, or in Medicare Advantage (MA) data. Methods We linked self-reported fall injuries leading to medical attention (FIMA) from the