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Post-discharge Mental Healthcare and Emergency General Surgery Readmission for Patients with Serious Mental Illness. Ann. Surg. (IF 9.0) Pub Date : 2024-04-19 Danielle E Brown, Claire B Rosen, Sanford E Roberts, Adora Moneme, Chris Wirtalla, Rachel Kelz
To determine the association between post-discharge mental healthcare and odds of readmission after emergency general surgery (EGS) hospitalization for patients with serious mental illness (SMI).
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Accuracy of Conflicts in Interest in General Surgical Journals. Ann. Surg. (IF 9.0) Pub Date : 2024-04-19 Tina Bharani, Claire Yuan, Karina Mahida, Suheila Mukhtar, Hudson Bosch, Mia Linson, Eric Sheu, Divyansh Agarwal
To evaluate the accuracy of self-reported conflicts of interest (COIs) for articles published in prominent minimally invasive and general surgical journals.
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Genomic Catastrophe (Chromothripsis and Polyploidy) Correlates With Tumor Distribution in Extrauterine High-grade Serous Carcinoma. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-18 Ju-Yoon Yoon, Aarti Sharma, Azra H Ligon, Rebecca G Ramesh, T Rinda Soong, Wa Xian, David B Chapel, Christopher P Crum
Most extrauterine high-grade serous carcinomas (HGSCs) are thought to develop first in the distal fallopian tube. Most models of HGSC assume origin from relatively stable, noninvasive serous tubal intraepithelial carcinomas. However, widespread tumor involvement in the absence of a serous tubal intraepithelial carcinoma could occur after catastrophic genomic events (CGEs; such as chromothripsis or
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Management of Diverticulitis JAMA Surg. (IF 16.9) Pub Date : 2024-04-17 Olivia A. Sacks, Jason Hall
ImportanceCare of patients with diverticulitis is undergoing a paradigm shift. This narrative review summarizes the current evidence for left-sided uncomplicated and complicated diverticulitis. The latest pathophysiology, advances in diagnosis, and prevention strategies are also reviewed.ObservationsTreatment is moving to the outpatient setting, physicians are forgoing antibiotics for uncomplicated
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Placebo Control and Blinding in Randomized Trials of Procedural Interventions JAMA Surg. (IF 16.9) Pub Date : 2024-04-17 Christopher A. Rajkumar, Katharine E. Thomas, Michael Foley, Sashiananthan Ganesananthan, Holli Evans, Florentina Simader, Sharan Syam, Daniel Nour, Catherine Beattie, Caitlin Khan, Rohin K. Reddy, Fiyyaz Ahmed-Jushuf, Darrel P. Francis, Matthew Shun-Shin, Rasha K. Al-Lamee
ImportanceUnlike medications, procedural interventions are rarely trialed against placebo prior to becoming accepted in clinical practice. When placebo-controlled trials are eventually conducted, procedural interventions may be less effective than previously believed.ObjectiveTo investigate the importance of including a placebo arm in trials of surgical and interventional procedures by comparing effect
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Three-Year Outcomes of Oral Antibiotics vs Intravenous and Oral Antibiotics for Uncomplicated Acute Appendicitis JAMA Surg. (IF 16.9) Pub Date : 2024-04-17 Liisa Selänne, Jussi Haijanen, Suvi Sippola, Saija Hurme, Tero Rautio, Pia Nordström, Tuomo Rantanen, Tarja Pinta, Imre Ilves, Anne Mattila, Jukka Rintala, Harri Marttila, Sanna Meriläinen, Johanna Laukkarinen, Eeva-Liisa Sävelä, Hannu Paajanen, Juha Grönroos, Paulina Salminen
ImportanceCurrent short-term evidence has shown that uncomplicated acute appendicitis can be treated successfully with oral antibiotics alone, but longer-term results are lacking.ObjectiveTo assess the treatment effectiveness of oral antibiotic monotherapy compared with combined intravenous (IV) and oral antibiotics in computed tomography–confirmed uncomplicated acute appendicitis at a longer-term
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Comprehensive Assessment of the Intrinsic Pancreatic Microbiome. Ann. Surg. (IF 9.0) Pub Date : 2024-04-16 Austin M Eckhoff, Ashley A Fletcher, Matthew S Kelly, Anders Dohlman, Caitlin A McIntyre, Xiling Shen, Matthew K Iyer, Daniel P Nussbaum, Peter J Allen
We sought to comprehensively profile tissue and cyst fluid in patients with benign, precancerous, and cancerous conditions of the pancreas to characterize the intrinsic pancreatic microbiome.
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Portal Hemodynamics in Liver Resection and Transplantation. Ann. Surg. (IF 9.0) Pub Date : 2024-04-16 Mohamed Rela, Ashwin Rammohan, Rajesh Rajalingam, Pierre-Alain Clavien
The hepatic blood supply and its several homeostatic and pathologic processes has always been a matter of great interest. Many views commonly held today are derived from an earlier era, but major reorientations have occurred recently in almost all aspects of knowledge of the role and regulation of hepatic blood flow. Moreover, with the advent of liver transplantation (LT), especially living donor LT
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Utilization and Cost of Gender-affirming Surgery in the United States from 2012-2019. Ann. Surg. (IF 9.0) Pub Date : 2024-04-15 Jacky Chu, Meera Nagpal, Amy D Dobberfuhl
To characterize the trends in and characteristics associated with the utilization and cost of gender-affirming surgery (GAS) in the United States from 2012-2019.
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Defining the Minimal and Optimal Thresholds for Lymph Node Resection and Examination for Intraductal Papillary Mucinous Neoplasm Derived Pancreatic Cancer: A Multicenter Retrospective Analysis. Ann. Surg. (IF 9.0) Pub Date : 2024-04-12 Joseph R Habib, Ingmar F Rompen, Sarah R Kaslow, Mahip Grewal, Paul C M Andel, Shuang Zhang, D Brock Hewitt, Steven M Cohen, Hjalmar C van Santvoort, Marc G Besselink, I Quintus Molenaar, Jin He, Christopher L Wolfgang, Ammar A Javed, Lois A Daamen
To establish minimal and optimal lymphadenectomy thresholds for intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) and evaluate their prognostic value.
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Characteristics and Practice Patterns of Non-certified Surgeons Treating Medicare Patients. Ann. Surg. (IF 9.0) Pub Date : 2024-04-12 Rebecca Moreci, Rebecca S Gates, John Luckoski, Kayla Marcotte, Cody L Mullens, Chia Chye Yee, Tanvi Gupta, Daniel Kendrick, Angela Thelen, Andrew E Krumm, Brian C George
The objective of this study is to explore the patient characteristics and practice patterns of non-certified surgeons who treat Medicare patients in the United States.
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The Role of High-Resolution Manometry Prior to and Following Antireflux Surgery: The Padova Consensus. Ann. Surg. (IF 9.0) Pub Date : 2024-04-12 Renato Salvador, John E Pandolfino, Mario Costantini, C Prakash Gyawali, Jutta Keller, Sumeet Mittal, Sabine Roman, Edoardo Vincenzo Savarino, Roger Tatum, Salvatore Tolone, Frank Zerbib, Giovanni Capovilla, Anand Jain, Priya Kathpalia, Luca Provenzano, Rena Yadlapati
In the last two decades the development of high-resolution manometry (HRM) has changed and revolutionized the diagnostic assessment of patients complain foregut symptoms. The role of HRM before and after antireflux procedure remains unclear, especially in surgical practice, where a clear understanding of esophageal physiology and hiatus anatomy is essential for optimal outcome of antireflux surgery
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Patients with Classic Hodgkin Lymphoma and Follicular Lymphoma Compared to Single Malignancy Controls. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-11 Claudiu V Cotta, Shweta Bhavsar, Scott Robertson, James R Cook
Classic Hodgkin lymphoma (CHL) can arise in patients with low-grade B-cell lymphoma. The features of CHL arising in follicular lymphoma (FL) and its outcome are still unclear, mainly due to the very few cases reported. This study compares 17 patients with CHL and FL to 2 control groups: 1 of 26 patients with FL and a second of 60 patients older than 40 when diagnosed with CHL. Of the FL and CHL patients
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Operating Room Organization and Methodology of Surgical Activity Regulation JAMA Surg. (IF 16.9) Pub Date : 2024-04-10 Bertrand Mathon, Frédéric Kletz
This article discusses the implementation of surgical activity regulation methodology in the operating room to reduce organizational dysfunction, improve quality of work life of the surgical staff, and decrease staff overtime.
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Extracorporeal Shockwave for Intermittent Claudication and Quality of Life JAMA Surg. (IF 16.9) Pub Date : 2024-04-10 Paris Cai, Sean Pymer, Said Ibeggazene, Ali Raza, Louise Hitchman, Ian Chetter, George Smith
ImportanceIntermittent lower limb claudication limits function and quality of life. Supervised exercise programs are not readily available, and a noninvasive alternative is needed.ObjectiveTo assess extracorporeal corporeal shockwave therapy in improving quality of life in patients with claudication.Design, Setting, and ParticipantsIn this double-blind, placebo-controlled randomized clinical trial
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Traumatic Brain Injuries After Falls From Height vs Falls at the US-Mexico Border Wall JAMA Surg. (IF 16.9) Pub Date : 2024-04-10 Alexander Tenorio, Michael G. Brandel, Carson P. McCann, Jay J. Doucet, Todd W. Costantini, Alexander A. Khalessi, Joseph D. Ciacci
This cohort study examines the incidence, severity, and mortality of fall-related injuries among migrants at the US-Mexico border in San Diego, California.
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Automated CT Analysis of Body Composition as a Frailty Biomarker in Abdominal Surgery JAMA Surg. (IF 16.9) Pub Date : 2024-04-10 Ijeamaka Anyene Fumagalli, Sidney T. Le, Peter D. Peng, Patricia Kipnis, Vincent X. Liu, Bette Caan, Vincent Chow, Mirza Faisal Beg, Karteek Popuri, Elizabeth M. Cespedes Feliciano
ImportancePrior studies demonstrated consistent associations of low skeletal muscle mass assessed on surgical planning scans with postoperative morbidity and mortality. The increasing availability of imaging artificial intelligence enables development of more comprehensive imaging biomarkers to objectively phenotype frailty in surgical patients.ObjectiveTo evaluate the associations of body composition
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TFE3-Rearranged PEComa/PEComa-like Neoplasms: Report of 25 New Cases Expanding the Clinicopathologic Spectrum and Highlighting its Association With Prior Exposure to Chemotherapy. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-10 Pedram Argani, John M Gross, Ezra Baraban, Lisa M Rooper, Suping Chen, Ming-Tseh Lin, Christopher Gocke, Abbas Agaimy, Tamara Lotan, Albert J H Suurmeijer, Cristina R Antonescu
Since their original description as a distinctive neoplastic entity, ~50 TFE3-rearranged perivascular epithelioid cell tumors (PEComas) have been reported. We herein report 25 new TFE3-rearranged PEComas and review the published literature to further investigate their clinicopathologic spectrum. Notably, 5 of the 25 cases were associated with a prior history of chemotherapy treatment for cancer. This
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"There's So Much That They're Enduring": Experiences of Older Adults Undergoing Major Elective Surgery. Ann. Surg. (IF 9.0) Pub Date : 2024-04-09 Anna Kata, Ellis C Dillon, R N Christina Keny, Veronica Yank, Kenneth E Covinsky, Patrick J Raue, Harleen K Sandhu, Victoria L Tang
This qualitative study aimed to explore the psychosocial experience of older adults undergoing major elective surgery from the perspective of both the patient and family caregiver.
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Combining Artificial Intelligence and Simplified Image Processing for the Automatic Detection of Mycobacterium tuberculosis in Acid-fast Stain: A Cross-institute Training and Validation Study. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-09 Hsiang Sheng Wang, Wen-Yih Liang
Tuberculosis (TB) poses a significant health threat in Taiwan, necessitating efficient detection methods. Traditional screening for acid-fast positive bacilli in acid-fast stain is time-consuming and prone to human error due to staining artifacts. To address this, we present an automated TB detection platform leveraging deep learning and image processing. Whole slide images from 2 hospitals were collected
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Clinicopathologic and Molecular Characterization of Xanthomatous Giant Cell Renal Cell Carcinomas: Further Support for a Close Morphologic Spectrum to Eosinophilic Solid and Cystic Renal Cell Carcinomas. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-09 Yuemei Xu, Xue Zhang, Qiuyuan Xia, Yuning Zhou, Xiaotong Wang, Ru Fang, Ya Wang, Qi Tong, Jieyu Chen, Jiong Shi, Yao Fu, Qiu Rao
A recent study described a rare subtype of tuberous sclerosis complex (TSC)-mutated renal cell carcinoma primarily characterized by Xanthomatous giant cell morphology. Only 2 cases in young individuals have been reported so far, making the correct diagnosis challenging from a pathological perspective. It remains unknown whether this tumor represents an independent subtype or belongs to other TSC-mutated
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The Impact of Next-generation Sequencing on Interobserver Agreement and Diagnostic Accuracy of Desmoplastic Melanocytic Neoplasms. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-09 Alice Chen, Natasha Sharma, Pragi Patel, Shantel Olivares, Armita Bahrami, Raymond L Barnhill, Willeke A M Blokx, Marcus Bosenberg, Klaus J Busam, Arnaud de La Fouchardière, Lyn M Duncan, David E Elder, Jennifer S Ko, Gilles Landman, Alexander J Lazar, Cecilia Lezcano, Lori Lowe, Nigel Maher, Daniela Massi, Jane Messina, Daniela Mihic-Probst, Douglas C Parker, Margaret Redpath, Richard A Scolyer, Christopher
Next-generation sequencing (NGS) is increasingly being utilized as an ancillary tool for diagnostically challenging melanocytic neoplasms. It is incumbent upon the pathology community to perform studies assessing the benefits and limitations of these tools in specific diagnostic scenarios. One of the most challenging diagnostic scenarios faced by skin pathologists involves accurate diagnosis of desmoplastic
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Genomic and Pathologic Profiling of Very Well-Differentiated Gastric Adenocarcinoma of Intestinal Type: A Study With Emphasis on Diffuse-Type Transformation. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-08 Hirofumi Rokutan, Yasuhito Arai, Akiko Kunita, Satoshi Yamasaki, Hiromi Nakamura, Natsuko Hama, Atsuhito Nakayama, Fumie Hosoda, Yasushi Totoki, Mitsuhiro Fujishiro, Yasuyuki Seto, Tatsuhiro Shibata, Tetsuo Ushiku
Very well-differentiated adenocarcinoma of intestinal type is a distinct subtype of gastric cancer characterized by anastomosing glands with a hand-in-hand pattern and low-grade cytologic atypia resembling intestinal metaplasia. This is a slow-growing neoplasm with an indolent clinical course; however, a subset demonstrates transformation into adenocarcinoma with higher-grade histology, typically diffuse-type
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The Development of Serrated Epithelial Change in Ulcerative Colitis is not Significantly Associated with Increased Histologic Inflammation. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-08 Dorukhan Bahceci, Dongliang Wang, Gregory Y Lauwers, Won-Tak Choi
Serrated epithelial change (SEC) in inflammatory bowel disease is most often defined as hyperplastic polyp-like mucosal change detected on random biopsies. Although SEC has been reported to be associated with an increased risk of synchronous and/or metachronous colorectal neoplasia, it remains unknown if SEC represents a form of dysplastic lesion despite the lack of morphologic evidence of dysplasia
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An Immunohistochemical Analysis of Osteopontin and S100 Calcium-binding Protein P is Useful for Subclassifying Large- and Small-duct Type Intrahepatic Cholangiocarcinomas. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-08 Takahiro Yoshizawa, Takeshi Uehara, Mai Iwaya, Tomoyuki Nakajima, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Noriyuki Kitagawa, Hitoshi Masuo, Hiroki Sakai, Hikaru Hayashi, Hidenori Tomida, Shiori Yamazaki, Shohei Hirano, Hiroyoshi Ota, Yuji Soejima
Intrahepatic cholangiocarcinoma (iCCA) has been newly subclassified into two different subtypes: large-duct (LD) type and small-duct (SD) type. However, many cases are difficult to subclassify, and there is no consensus regarding subclassification criteria. LD type expresses the highly sensitive diagnostic marker S100 calcium-binding protein P (S100P), while SD type lacks sensitive markers. We identified
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Prognostic Immunohistochemistry for Ki-67 and OTP on Small Biopsies of Pulmonary Carcinoid Tumors: Ki-67 Index Predicts Progression-free Survival and Atypical Histology. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-08 Julia R Naso, Sarah M Jenkins, Anja C Roden, Euhee S Yi, Ying-Chun Lo, Melanie C Bois, Joseph J Maleszewski, Marie Christine Aubry, Jennifer M Boland
Prognostic stratification of pulmonary carcinoids into "typical" and "atypical" categories requires examination of large tissue volume. However, there is a need for tools that provide similar prognostic information on small biopsy samples. Ki-67 and OTP immunohistochemistry have shown promising prognostic value in studies of resected pulmonary carcinoids, but prognostic value when using biopsy/cytology
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Development of a Deep Learning System for Intra-Operative Identification of Cancer Metastases. Ann. Surg. (IF 9.0) Pub Date : 2024-04-05 Thomas Schnelldorfer, Janil Castro, Atoussa Goldar-Najafi, Liping Liu
The aim of this study was to develop and test a prototype of a deep learning surgical guidance system (CASL) that can intra-operative identify peritoneal surface metastases on routine laparoscopy images.
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Recurrence and Survival after Minimally Invasive and Open Esophagectomy for Esophageal Cancer - A Post Hoc Analysis of the Ensure Study. Ann. Surg. (IF 9.0) Pub Date : 2024-04-05 Sofie Pg Henckens, Nannet Schuring, Jessie A Elliott, Asif Johar, Sheraz R Markar, Amaia Gantxegi, Pernilla Lagergren, George B Hanna, Manuel Pera, John V Reynolds, Mark I van Berge Henegouwen, Suzanne S Gisbertz
The aim of this study was to determine the impact of operative approach (open [OE], hybrid [HMIE] and total minimally invasive esophagectomy [TMIE]) on operative and oncologic outcomes for patients treated with curative intent for esophageal and junctional cancer.
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Early Interventional Treatment of High Output Chyle Leak following Esophagectomy is Associated with Improved Survival. Ann. Surg. (IF 9.0) Pub Date : 2024-04-04 Nathaniel Deboever, Arlene M Correa, Hope Feldman, Michael Eisenberg, Mara B Antonoff, Reza J Mehran, Ravi Rajaram, David C Rice, Jack A Roth, Boris Sepesi, Stephen G Swisher, Ara A Vaporciyan, Garrett L Walsh, Wayne L Hofstetter
Our objective was to investigate overall survival (OS) and length of stay (LOS) associated with differing management for high output (>1 liter over 24 h) leaks (HOCL) following cancer related esophagectomy.
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Disparities in Mentorship and Implications for US Surgical Resident Education and Wellness JAMA Surg. (IF 16.9) Pub Date : 2024-04-03 Casey M. Silver, Tarik K. Yuce, Callisia N. Clarke, Cary Jo R. Schlick, Rhami Khorfan, Daniela Amortegui, Michael Nussbaum, Patricia L. Turner, Karl Y. Bilimoria, Yue-Yung Hu
ImportanceMany surgeons cite mentorship as a critical component of training. However, little evidence exists regarding factors associated with mentorship and the influence of mentorship on trainee education or wellness.ObjectivesTo evaluate factors associated with surgical trainees’ perceptions of meaningful mentorship, assess associations of mentorship with resident education and wellness, and evaluate
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Adjuvant Transarterial Chemoembolization With Sorafenib for Portal Vein Tumor Thrombus JAMA Surg. (IF 16.9) Pub Date : 2024-04-03 Zhenwei Peng, Wenzhe Fan, Zelong Liu, Han Xiao, Jian Wu, Rong Tang, Jianfei Tu, Liangliang Qiao, Fuxi Huang, Wenxuan Xie, Wenquan Zhuang, Wenbo Guo, Shaoqiang Li, Yunpeng Hua, Shunli Shen, Qiang He, Dongming Li, Jiaping Li, Ming Kuang
ImportanceCertain patients with hepatocellular carcinoma with portal vein tumor thrombus could benefit from surgical resection, and postoperative adjuvant therapy may lower the incidence of tumor recurrence.ObjectiveTo compare the efficacy and safety of sorafenib plus transarterial chemoembolization vs sorafenib alone as postoperative adjuvant therapy for patients with hepatocellular carcinoma with
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US Liver Transplant Outcomes After Normothermic Regional Perfusion vs Standard Super Rapid Recovery JAMA Surg. (IF 16.9) Pub Date : 2024-04-03 Aleah L. Brubaker, Marty T. Sellers, Peter L. Abt, Kristopher P. Croome, Shaheed Merani, Anji Wall, Phillipe Abreu, Musab Alebrahim, Roy Baskin, Humberto Bohorquez, Robert M. Cannon, Kelly Cederquist, John Edwards, Benjamin G. Huerter, Mark J. Hobeika, Lori Kautzman, Alan N. Langnas, David D. Lee, Joao Manzi, Ahmed Nassar, Nikole Neidlinger, Trevor L. Nydam, Gabriel T. Schnickel, Farjad Siddiqui, Ashley
ImportanceNormothermic regional perfusion (NRP) is an emerging recovery modality for transplantable allografts from controlled donation after circulatory death (cDCD) donors. In the US, only 11.4% of liver recipients who are transplanted from a deceased donor receive a cDCD liver. NRP has the potential to safely expand the US donor pool with improved transplant outcomes as compared with standard super
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ABCD1 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm of the Pancreas. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-04-03 Ying-Ao Liu, Yuanhao Liu, Jiajuan Tu, Yihong Shi, Junyi Pang, Qi Huang, Xun Wang, Zhixiang Lin, Yupei Zhao, Wenze Wang, Junya Peng, Wenming Wu
The diagnosis of solid pseudopapillary neoplasm of the pancreas (SPN) can be challenging due to potential confusion with other pancreatic neoplasms, particularly pancreatic neuroendocrine tumors (NETs), using current pathological diagnostic markers. We conducted a comprehensive analysis of bulk RNA sequencing data from SPNs, NETs, and normal pancreas, followed by experimental validation. This analysis
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Long-term survival and functional outcomes of laparoscopic surgery for clinical stage I ultra-low rectal cancers located within 5 cm of the anal verge: A prospective phase II trial (Ultimate trial). Ann. Surg. (IF 9.0) Pub Date : 2024-04-01 Masaaki Ito, Yuichiro Tsukada, Jun Watanabe, Yosuke Fukunaga, Yasumitsu Hirano, Kazuhiro Sakamoto, Hiroki Hamamoto, Masanori Yoshimitsu, Hisanaga Horie, Nobuhisa Matsuhashi, Yoshiaki Kuriu, Shuntaro Nagai, Madoka Hamada, Shinichi Yoshioka, Shinobu Ohnuma, Tamuro Hayama, Koki Otsuka, Yusuke Inoue, Kazuki Ueda, Yuji Toiyama, Satoshi Maruyama, Shigeki Yamaguchi, Keitaro Tanaka, Motoko Suzuki, Takeshi
To clarify the long-term oncological outcomes and postoperative anal, urinary, and sexual functions after laparoscopic surgery for clinical stage I very low rectal carcinoma located near the anal canal.
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A Primary Report 166 Cases of Abdominal or Pelvic Neuroblastoma Surgery Utilizing the International Neuroblastoma Surgical Report Form (INSRF). Ann. Surg. (IF 9.0) Pub Date : 2024-04-01 Saishuo Chang, Shen Yang, Tong Yu, Qi Zhang, Yu Lin, Qinghua Ren, Haiyan Cheng, Xiaofeng Chang, Zhiyun Zhu, Siyu Cai, Jun Feng, Jianyu Han, Wei Yang, Hong Qin, Huanmin Wang
Surgery is pivotal in the management of neuroblastoma (NB), particularly in patients with Image-Defined Risk Factors (IDRFs). The International Neuroblastoma Surgical Report Form (INSRF) was introduced to enhance surgical reporting quality and analyze the defining role of extensive surgery in NB. This study reports our experience with INSRF and explores new criteria for evaluating the extent of surgical
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Noninvasive Artificial Intelligence System for Early Predicting Residual Cancer Burden during Neoadjuvant Chemotherapy in Breast Cancer. Ann. Surg. (IF 9.0) Pub Date : 2024-04-01 Wei Li, Yu-Hong Huang, Teng Zhu, Yi-Min Zhang, Xing-Xing Zheng, Ting-Feng Zhang, Ying-Yi Lin, Zhi-Yong Wu, Zai-Yi Liu, Ying Lin, Guo-Lin Ye, Kun Wang
To develop an artificial intelligence (AI) system for the early prediction of residual cancer burden (RCB) scores during neoadjuvant chemotherapy (NAC) in breast cancer.
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Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multi-Center, Real-World Risk-Matched Analysis. Ann. Surg. (IF 9.0) Pub Date : 2024-04-01 Chase J Wehrle, Mingyi Zhang, Mazhar Khalil, Alejandro Pita, Jamak Modaresi Esfeh, Teresa Diago-Uso, Jaekeun Kim, Federico Aucejo, David Ch Kwon, Khaled Ali, Beatrice Cazzaniga, Yuki Miyazaki, Qiang Liu, Sami Fares, Hanna Hong, Munkhbold Tuul, Chunbao Jiao, Keyue Sun, Robert L Fairchild, Cristiano Quintini, Masato Fujiki, Antonio D Pinna, Charles Miller, Koji Hashimoto, Andrea Schlegel
Assess cost and complication outcomes after liver transplantation (LT) using normothermic machine perfusion (NMP).
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The Importance of Circulation in Airway Management: Preventing Post-Intubation Hypotension in The Trauma Bay. Ann. Surg. (IF 9.0) Pub Date : 2024-04-01 Tanya Anand, Hamidreza Hosseinpour, Michael Ditillo, Sai Krishna Bhogadi, Malak N Akl, William J Collins, Louis J Magnotti, Bellal Joseph
To identify the modifiable and non-modifiable risk factors associated with post-intubation hypotension (PIH) among trauma patients who required endotracheal intubation (ETI) in the trauma bay.
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Evaluation of Short- and Long-Term Outcomes After Resection in Patients with Locally Advanced versus (Borderline) Resectable Pancreatic Cancer. Ann. Surg. (IF 9.0) Pub Date : 2024-04-01 Lilly J H Brada, Thijs J Schouten, Lois A Daamen, Leonard W F Seelen, Marieke S Walma, Ronald van Dam, Ignace H de Hingh, Mike S L Liem, Vincent E de Meijer, Gijs A Patijn, Sebastiaan Festen, Martijn W J Stommel, Koop Bosscha, Marc G Besselink, Hjalmar C van Santvoort, Izaak Quintus Molenaar
This study aims to evaluate short- and long-term outcomes following pancreatectomy in patients with LAPC compared to (B)RPC patients.
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Anti-intercellular adhesion molecule 1 monomaintenance therapy induced long-term liver allograft survival without chronic rejection Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-30 Dong Kyu Han, Suk Kyun Hong, Il Hee Yun, Ji-Jing Yan, Jisu Park, Sang Wha Kim, Seung Hyeok Seok, Haeryoung Kim, Gilyong Ji, YoungRok Choi, Kwang-Woong Lee, Kyung-Suk Suh, Jaeseok Yang, Nam-Joon Yi
Calcineurin inhibitors (CNIs) are essential in liver transplantation (LT); however, their long-term use leads to various adverse effects. The anti–intercellular adhesion molecule (ICAM)-1 monoclonal antibody MD3 is a potential alternative to CNI. Despite its promising results with short-term therapy, overcoming the challenge of chronic rejection remains important. Thus, we aimed to investigate the
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Microbiome composition recovery after liver transplantation correlates with initial liver disease severity and antibiotics treatment Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Sara Vega-Abellaneda, Cristina Dopazo, Francisca Yañez, Zaida Soler, Zixuan Xie, Aleix Canalda-Baltrons, Marc Pons-Tarín, Itxarone Bilbao, Chaysavanh Manichanh
Liver transplantation (LT) is crucial for end-stage liver disease, but it is linked to infection risks. Pathobionts, microorganisms potentially harmful under specific conditions, can cause complications posttransplant. Monitoring such pathogens in fecal samples can be challenging and therefore remains underexplored post-LT. This study aimed to analyze the gut microbiome before and after LT, tracking
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Maternal-fetal microchimerism as a durable but finite and replaceable alloantigen reservoir Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Eva M. Gillis-Buck, James M. Gardner
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Xenotransplantation moves toward clinical trials Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Lara C. Pullen PhD
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Total robotic liver transplant: the final frontier of minimally invasive surgery Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Adeel S. Khan, Meranda Scherer, Roheena Panni, Darren Cullinan, Greg Martens, Ivan Kangarga, Christopher R. King, Richard Benzinger, Jason R. Wellen MD, William C. Chapman, Majella B. Doyle
The use of robotic surgery in transplantation is increasing; however, robotic liver transplantation (RLT) remains a challenging undertaking. To our knowledge, this is a report of the first RLT in North America and the first RLT using a whole graft from a deceased donor in the world. This paper describes the preparation leading to the RLT and the surgical technique of the operation. The operation was
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Do you transplant hearts from donation after circulatory determination of death donors? Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Lara C. Pullen PhD
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Intraoperative Completion Studies and their Associations with Carotid Endarterectomy Outcomes. Ann. Surg. (IF 9.0) Pub Date : 2024-03-28 Christoph Knappich, Bianca Bohmann, Felix Kirchhoff, Vanessa Lohe, Shamsun Naher, Michael Kallmayer, Hans-Henning Eckstein, Andreas Kuehnl
This study aimed at assessing outcomes after carotid endarterectomy (CEA) in dependence of center policy with respect to imaging intraoperative completion study (ICSi) usage.
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Same-Day Ileostomy Closure Discharge Reduces Costs without Compromising Outcomes: An Economic Analysis. Ann. Surg. (IF 9.0) Pub Date : 2024-03-28 Davide Ferrari, Tommaso Violante, James P Moriarty, Bijan J Borah, Amit Merchea, Luca Stocchi, David W Larson
This study aims to assess the costs of a Same-Day Discharge Enhanced Recovery Pathway (SDD) for diverting loop ileostomy closure compared to a standard institutional enhanced recovery protocol (ERP).
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ZIP Code to Genomic Code: Neighborhood Disadvantage, Aggressive Breast Cancer Biology, and Breast Cancer Outcomes. Ann. Surg. (IF 9.0) Pub Date : 2024-03-28 Neha Goel, Alexandra E Hernandez, Michael H Antoni, Susan Kesmodel, Paulo S Pinheiro, Erin Kobetz, Nipun Merchant, Steve Cole
To determine the association between objective (geospatial) and subjective (perceived) measures of neighborhood disadvantage (ND) and aggressive breast cancer (BCa) tumor biology, defined using validated social adversity-associated transcription factor (TF) activity and clinical outcomes.
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Defining the Role of Social Vulnerability in Treatment and Survival in Localized Colon Cancer: A Retrospective Cohort Study. Ann. Surg. (IF 9.0) Pub Date : 2024-03-28 Jennie Meier, Gilbert Murimwa, Mithin Nehrubabu, Adam Yopp, Lisa DiMartino, Amit G Singal, Herbert J Zeh, Patricio Polanco
To determine whether variations in Social Vulnerability Index (SVI) are associated with disparities in colon cancer surgery and mortality.
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Estrogen Receptor Expression in DICER1-related Lesions is Associated with the Presence of Cystic Components. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-03-28 Paul Scott Thorner, Anne-Laure Chong, Maria Apellaniz-Ruiz, Naciba Benlimame, Paula Marrano, Fadi Brimo, Somruetai Shuangshoti, Shanop Shuangshoti, William D Foulkes
DICER1 tumor predisposition syndrome results from pathogenic variants in DICER1 and is associated with a variety of benign and malignant lesions, typically involving kidney, lung, and female reproductive system. Over 70% of sarcomas in DICER1 tumor predisposition syndrome occur in females. Notably, pediatric cystic nephroma (pCN), a classic DICER1 tumor predisposition syndrome lesion, shows estrogen
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Quality of Life After Axillary Lymph Node Dissection Among Racial and Ethnic Minority Women JAMA Surg. (IF 16.9) Pub Date : 2024-03-27 Danielle R. Heller, Bayley Axelrod, Varadan Sevilimedu, Monica Morrow, Babak J. Mehrara, Andrea V. Barrio
ImportanceHigher lymphedema rates after axillary lymph node dissection (ALND) have been found in Black and Hispanic women; however, there is poor correlation between subjective symptoms, quality of life (QOL), and measured lymphedema. Additionally, racial and ethnic differences in QOL have been understudied.ObjectiveTo evaluate the association of race and ethnicity with long-term QOL in patients with
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Year-Over-Year Ventral Hernia Recurrence Rates and Risk Factors JAMA Surg. (IF 16.9) Pub Date : 2024-03-27 Priya Bhardwaj, Maria T. Huayllani, Molly A. Olson, Jeffrey E. Janis
ImportanceRecurrence is one of the most challenging adverse events after ventral hernia repair as it impacts quality of life, utilization of resources, and subsequent need for re-repair. Rates of recurrence range from 30% to 80% after ventral hernia repair.ObjectiveTo determine the contemporary ventral hernia recurrence rate over time in patients with previous hernia repair and to determine risk factors
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Type 2 cytokines safeguard against cellular senescence and aging Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Xian C. Li
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Molecular diagnosis of antibody-mediated rejection: Evaluating biopsy-based transcript diagnostics in the presence of donor-specific antibodies but without microvascular inflammation, a single-center descriptive analysis Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Dusan Harmacek, Lukas Weidmann, Kai Castrezana Lopez, Nicolas Schmid, Raphael Korach, Nicola Bortel, Seraina von Moos, Elena Rho, Birgit Helmchen, Ariana Gaspert, Thomas Schachtner
Biopsy-based transcript diagnostics may identify molecular antibody-mediated rejection (AMR) when microvascular inflammation (MVI) is absent. In this single-center cohort, biopsy-based transcript diagnostics were validated in 326 kidney allograft biopsies. A total of 71 histological AMR and 35 T cell–mediated rejection (TCMR) cases were identified as molecular AMR and TCMR in 55% and 63%, respectively
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Differential induction of donor-reactive forkhead box P3+ regulatory T cell via blockade of CD154 vs CD40 Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Danya Liu, Hongmin Yao, Mandy L. Ford
Recently published studies in both murine models and a meta-analysis of non-human primate renal transplant studies showed that anti-CD154 reagents conferred a significant survival advantage over CD40 blockers in both animal models and across multiple organs. Here we sought to compare the induction of donor-reactive forkhead box P3+-induced regulatory T cells (Foxp3 iTreg) in mice treated with anti-CD154
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Nonconventional Dysplasia is Frequently Associated With Goblet Cell Deficient and Serrated Variants of Colonic Adenocarcinoma in Inflammatory Bowel Disease. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-03-27 Andrew Xiao, Masato Yozu, Bence P Kővári, Lindsay Yassan, Xiaoyan Liao, Marcela Salomao, Maria Westerhoff, Anita Sejben, Gregory Y Lauwers, Won-Tak Choi
Various subtypes of nonconventional dysplasia have been recently described in inflammatory bowel disease (IBD). We hypothesized that goblet cell deficient dysplasia and serrated dysplasia may be the primary precursor lesions for goblet cell deficient (GCDAC) and serrated (SAC) variants of colonic adenocarcinoma, respectively. Clinicopathologic features of 23 GCDAC and 10 SAC colectomy cases were analyzed
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Lymphomatoid Papulosis With T-cell Receptor-Gamma Delta Expression: A Clinicopathologic Case-series of 26 Patients of an Underrecognized Immunophenotypic Variant of Lymphomatoid Papulosis. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-03-27 Erica Mark, Werner Kempf, Joan Guitart, Melissa Pulitzer, Christina Mitteldorf, Alexandra Hristov, Carlos Torres-Cabala, Enrica Marchi, Thomas Cropley, Socorro Maria Rodriguez Pinilla, Teresa Griffin, Rony Fernandez, Stefano Pileri, Alessandro Pileri, Valentina Tabanelli, Lisa Borretta, Antonio Subtil, Jose Antonio Plaza, Jose A Miguel Angel Piris, Andrew L Feldman, Lorenzo Cerroni, Alejandro A Gru
Lymphomatoid papulosis (LyP) has several histopathologic presentations. LyP featuring gamma-delta (γδ) T-cell receptor expression may masquerade as and may be misdiagnosed as aggressive cutaneous T-cell lymphoma, particularly primary cutaneous γδ T-cell lymphoma (PCGDTL) or γδ mycosis fungoides. We performed a clinicopathologic analysis of the largest series of LyP featuring γδ T-cell expression. We
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Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-26 Philip F. Halloran, Katelynn Madill-Thomsen, Arezu Z. Aliabadi-Zuckermann, Martin Cadeiras, Marisa G. Crespo-Leiro, Eugene C. Depasquale, Mario Deng, Johannes Gökler, Shelley Hall, Aayla Jamil, Daniel H. Kim, Jon Kobashigawa, Peter Macdonald, Vojtech Melenovsky, Jignesh Patel, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann
The first-generation Molecular Microscope (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose not only T cell–mediated rejection (TCMR) and antibody-mediated rejection (ABMR) but also acute injury. However, the ideal system should detect rejection without being influenced by injury, to permit analysis of the relationship
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Bridging the critically ill patient with acute to chronic liver failure to liver transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-26 Javier Fernández, Annabel Blasi, Ernest Hidalgo, Constantine J. Karvellas
Liver transplantation (LT) has emerged as an effective therapy for severe forms of acute-on-chronic liver failure (ACLF), an entity characterized by the development of multiorgan failure and high short-term mortality. The aim of critical care management of ACLF patients is to rapidly treat precipitating events and aggressively support failing organs to ensure that patients may successfully undergo
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Primary NTRK-rearranged Spindle Cell Neoplasm of the Gastrointestinal Tract: A Clinicopathological and Molecular Analysis of 8 Cases. Am. J. Surg. Pathol. (IF 5.6) Pub Date : 2024-03-25 Xiaojiao Gao, Song Xu, Peipei Zhu, I Weng Lao, Lin Yu, Jian Wang
NTRK-rearranged spindle cell neoplasm occurs predominantly in the superficial or deep soft tissues of extremities or trunk. Occurrence in the visceral organs is extremely rare. Herein, we describe 8 cases of NTRK-rearranged spindle cell neoplasm that arose primarily in the gastrointestinal tract. Patients included 5 males and 3 females with age at presentation ranging from 6 to 63 years (median: 29