-
Undernourished Household Contacts Are at Increased Risk of Tuberculosis (TB) Disease, but not TB Infection— a Multicenter Prospective Cohort Analysis Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-23 Pranay Sinha, Komala Ezhumalai, Xinyi Du, Chinnaiyan Ponnuraja, Madolyn Rose Dauphinais, Nikhil Gupte, Sonali Sarkar, Amita Gupta, Sanjay Gaikwad, Balamugesh Thangakunam, Mandar Paradkar, Devasahayam J Christopher, Vidya Mave, Vijay Viswanathan, Jerrold J Ellner, Hardy Kornfeld, C R Horsburgh, Chandrasekaran Padmapriyadarsini, Akshay Gupte
Undernutrition is the leading risk factor for tuberculosis (TB) globally and in India. This multicenter prospective cohort analysis from India suggests that undernutrition is associated with increased risk of TB disease but not TB infection among household contacts of persons with TB.
-
Investigation of genomic and pathogenicity characteristics of Streptococcus suis ST1 human strains from Guangxi Zhuang Autonomous Region (GX) between 2005 and 2020 in China Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-21 Weiming Kang, Mingliu Wang, Xueli Yi, Jianping Wang, Xiyan Zhang, Zongfu Wu, Yan Wang, Hui Sun, Marcelo Gottschalk, Han Zheng, Jianguo Xu
Streptococcus suis is a significant and emerging zoonotic pathogen. ST1 and ST7 strains are the primary agents responsible for S. suis human infections in China, including the Guangxi Zhuang Autono...
-
Invasive pneumococcal diseases in Chinese children: a multicenter hospital based active surveillance from 2019-2021 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-22 Xue Ning, Lianmei Li, Jing Liu, Fang Wang, Kun Tan, Wenhui Li, Kai Zhou, Shujun Jing, Aiwei Lin, Jing Bi, Shiyong Zhao, Huiling Deng, Chunhui Zhu, Shanshan Lv, Juan Li, Jun Liang, Qing Zhao, Yumin Wang, Biquan Chen, Liang Zhu, Guowu Shen, Jianlong Liu, Zhi Li, Jikui Deng, Xin Zhao, Mingfeng Shan, Yi Wang, Shihua Liu, Tingting Jiang, Xuexia Chen, Yufeng Zhang, Sha Cai, Lixue Wang, Xudong Lu, Jinghui
This study aimed to provide data for the clinical features of invasive pneumococcal disease (IPD) and the molecular characteristics of Streptococcus pneumoniae isolates from pediatric patients in C...
-
Changes in the Appropriateness of US Outpatient Antibiotic Prescribing After the Coronavirus Disease 2019 Outbreak: An Interrupted Time Series Analysis of 2016–2021 Data Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-22 Kao-Ping Chua, Michael A Fischer, Moshiur Rahman, Jeffrey A Linder
Background No national study has evaluated changes in the appropriateness of US outpatient antibiotic prescribing across all conditions and age groups after the coronavirus disease 2019 (COVID-19) outbreak in March 2020. Methods This was an interrupted time series analysis of Optum's de-identified Clinformatics Data Mart Database, a national commercial and Medicare Advantage claims database. Analyses
-
Transmission of blaNDM in Enterobacteriaceae among animals, food and human Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-20 Bo Fu, Jian Xu, Dandan Yin, Chengtao Sun, Dejun Liu, Weishuai Zhai, Rina Bai, Yue Cao, Qin Zhang, Shizhen Ma, Timothy R. Walsh, Fupin Hu, Yang Wang, Congming Wu, Jianzhong Shen
Despite carbapenems not being used in animals, carbapenem-resistant Enterobacterales (CRE), particularly New Delhi metallo-β-lactamase-producing CRE (NDM-CRE), are prevalent in livestock. Concurren...
-
Rodent control strategies and Lassa virus: some unexpected effects in Guinea, West Africa Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-20 Joachim Mariën, Mickaël Sage, Umaru Bangura, Alicia Lamé, Michel Koropogui, Toni Rieger, Barré Soropogui, Moussa Douno, N’Faly Magassouba, Elisabeth Fichet-Calvet
The Natal multimammate mouse (Mastomys natalensis) is the host of Lassa mammarenavirus, causing Lassa haemorrhagic fever in West Africa. As there is currently no operational vaccine and therapeutic...
-
Small regulatory RNA RSaX28 promotes virulence by reinforcing the stability of RNAIII in community-associated ST398 clonotype Staphylococcus aureus Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-20 Ying Jian, Tianchi Chen, Ziyu Yang, Guoxiu Xiang, Kai Xu, Yanan Wang, Na Zhao, Lei He, Qian Liu, Min Li
Staphylococcus aureus (S. aureus) is a notorious pathogen that cause metastatic or complicated infections. Hypervirulent ST398 clonotype strains, remarkably increased in recent years, dominated Com...
-
Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-19 Yang Liu, Yuhua Chen, Zhiyi Yang, Yaozhong Lin, Siyuan Fu, Junhong Chen, Lingyu Xu, Tengfei Liu, Beibei Niu, Qiuhong Huang, Haixia Liu, Chaofeng Zheng, Ming Liao, Weixin Jia
We characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021–2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing crucial clues for updating the H7N9 vaccine and disease prevention and control.
-
Crimean-Congo Hemorrhagic Fever Virus for Clinicians—Epidemiology, Clinical Manifestations, and Prevention Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-19 Maria G. Frank, Gretchen Weaver, Vanessa Raabe
Crimean-Congo hemorrhagic fever (CCHF) is a tickborne infection that can range from asymptomatic to fatal and has been described in >30 countries. Early identification and isolation of patients with suspected or confirmed CCHF and the use of appropriate prevention and control measures are essential for preventing human-to-human transmission. Here, we provide an overview of the epidemiology, clinical
-
Long-term risk of serious infections and mortality among patients surviving drug use-associated infective endocarditis Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-20 Mary C Figgatt, David L Rosen, Vivian H Chu, Li-Tzy Wu, Asher J Schranz
Among a statewide cohort of 1,874 patients surviving hospitalization for drug use-associated endocarditis during 2017-2020, the 3-year risk of death or future hospitalization was 38% (16% for death prior to later infection, 14% for recurrent endocarditis, 14% for soft-tissue, 9% for bacteremia, 5% for bone/joint, and 4% for spinal infections).
-
Crimean-Congo Hemorrhagic Fever Virus for Clinicians—Diagnosis, Clinical Management, and Therapeutics Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-18 Maria G. Frank, Gretchen Weaver, Vanessa Raabe
Crimean-Congo hemorrhagic fever virus (CCHFV) is the most geographically widespread tickborne viral infection worldwide and has a fatality rate of up to 62%. Despite its widespread range and high fatality rate, no vaccines or treatments are currently approved by regulatory agencies in the United States or Europe. Supportive treatment remains the standard of care, but the use of antiviral medications
-
Recent development and fighting strategies for lincosamide antibiotic resistance Clin. Microbiol. Rev. (IF 36.8) Pub Date : 2024-04-18 Yingying YangShiyu XieFangjing HeYindi XuZhifang WangAwais IhsanXu Wang1National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei, China2MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei, China3MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong
Clinical Microbiology Reviews, Ahead of Print.
-
Assessment for Antibodies to Rifapentine and Isoniazid in Persons Developing Flu-like Reactions During Treatment of Latent Tuberculosis Infection J. Infect. Dis. (IF 6.4) Pub Date : 2024-04-19 Ruth N Moro, Carolina Mehaffy, Prithwiraj De, Elizabeth Phillips, Andrey S Borisov, Timothy R Sterling, Karen M Dobos
Background Flu-like reactions can occur after exposure to rifampin, rifapentine, or isoniazid. Prior studies have reported the presence of antibodies to rifampin, but associations with underlying pathogenesis are unclear. Methods We evaluated PREVENT TB study participants who received weekly isoniazid + rifapentine for 3 months (3HP) or daily isoniazid for 9 months (9H) as treatment for M. tuberculosis
-
Chlamydia trachomatis seroassays used in epidemiologic research: a narrative review and practical considerations J. Infect. Dis. (IF 6.4) Pub Date : 2024-04-19 Mary Bridget Waters, Kevin Hybiske, Ren Ikeda, Bernhard Kaltenboeck, Lisa E Manhart, Kristen M Kreisel, Christine M Khosropour
Chlamydia trachomatis (CT) is a sexually transmitted infection that can lead to adverse reproductive health outcomes. CT prevalence estimates are primarily derived from screening using nucleic acid amplification tests (NAATs). However, screening guidelines in the United States only include particular subpopulations, and NAATs only detect current infections. In contrast, seroassays identify past CT
-
Detection and phylogenetic analysis of contemporary H14N2 Avian influenza A virus in domestic ducks in Southeast Asia (Cambodia) Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-17 Jurre Y. Siegers, Michelle Wille, Sokhoun Yann, Songha Tok, Sarath Sin, Sokha Chea, Alice Porco, Sreyem Sours, Vutha Chim, Samban Chea, Kimtuo Chhel, Sothyra Tum, San Sorn, Makara Hak, Peter Thielen, Vijaykrishna Dhanasekaran, Erik A. Karlsson
Avian influenza virus (AIV) in Asia is a complex system with numerous subtypes and a highly porous wild birds-poultry interface. Certain AIV subtypes, such as H14, are underrepresented in current s...
-
Seasonal Patterns of Mpox Index Cases, Africa, 1970–2021 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-17 Camille Besombes, Festus Mbrenga, Ella Gonofio, Christian Malaka, Cedric-Stephane Bationo, Jean Gaudart, Manon Curaudeau, Alexandre Hassanin, Antoine Gessain, Romain Duda, Tamara Giles Vernick, Arnaud Fontanet, Emmanuel Nakouné, Jordi Landier
Across 133 confirmed mpox zoonotic index cases reported during 1970–2021 in Africa, cases occurred year-round near the equator, where climate is consistent. However, in tropical regions of the northern hemisphere under a dry/wet season cycle, cases occurred seasonally. Our findings further support the seasonality of mpox zoonotic transmission risk.
-
Recurrence, Microevolution, and Spatiotemporal Dynamics of Legionella pneumophila Sequence Type 1905, Portugal, 2014–2022 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-17 Vera Manageiro, Vítor Borges, Raquel Rodrigues, Célia Bettencourt, Cecília Silva, João Paulo Gomes, Paulo Gonçalves
We investigated molecular evolution and spatiotemporal dynamics of atypical Legionella pneumophila serogroup 1 sequence type 1905 and determined its long-term persistence and linkage to human disease in dispersed locations, far beyond the large 2014 outbreak epicenter in Portugal. Our finding highlights the need for public health interventions to prevent further disease spread.
-
Interventional Study of Nonpharmaceutical Measures to Prevent COVID-19 Aboard Cruise Ships Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-17 Varvara A. Mouchtouri, Leonidas Kourentis, Lemonia Anagnostopoulos, Michalis Koureas, Maria Kyritsi, Katerina Maria Kontouli, Fani Kalala, Mattheos Speletas, Christos Hadjichristodoulou
Cruise ships carrying COVID-19–vaccinated populations applied near-identical nonpharmaceutical measures during July–November 2021; passenger masking was not applied on 2 ships. Infection risk for masked passengers was 14.58 times lower than for unmasked passengers and 19.61 times lower than in the community. Unmasked passengers’ risk was slightly lower than community risk.
-
Antigenic Characterization of Novel Human Norovirus GII.4 Variants San Francisco 2017 and Hong Kong 2019 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-17 Kentaro Tohma, Michael Landivar, Lauren A. Ford-Siltz, Kelsey A. Pilewski, Joseph A. Kendra, Sandra Niendorf, Gabriel I. Parra
Norovirus is a major cause of acute gastroenteritis; GII.4 is the predominant strain in humans. Recently, 2 new GII.4 variants, Hong Kong 2019 and San Francisco 2017, were reported. Characterization using GII.4 monoclonal antibodies and serum demonstrated different antigenic profiles for the new variants compared with historical variants.
-
Tenofovir-Diphosphate and Emtricitabine-Triphosphate Adherence Benchmarks in Dried Blood Spots for Persons with HIV Receiving Tenofovir Alafenamide and Emtricitabine-based Antiretroviral Therapy (QUANTI-TAF) Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-18 Ryan P Coyle, Mary Morrow, Sarah C Mann, Vincent Mainella, Samuel L Ellis, Stefanie Schwab, Corwin Coppinger, Nicholas Barker, Lucas Ellison, Jia-Hua Zheng, Subhi Al Zuabi, Pamela E Alpert, Tony C Carnes, D Eric Buffkin, Peter R Chai, Lane R Bushman, Jennifer J Kiser, Samantha MaWhinney, Kristina M Brooks, Peter L Anderson, Jose R Castillo-Mancilla
Background QUANTI-TAF aimed to establish tenofovir-diphosphate/emtricitabine-triphosphate (TFV-DP/FTC-TP) adherence benchmarks in dried blood spots (DBS) for persons with HIV (PWH) receiving tenofovir alafenamide/emtricitabine (TAF/FTC)-based antiretroviral therapy (ART). Methods During a 16-week pharmacokinetic study, PWH received TAF/FTC-based ART co-encapsulated with an ingestible sensor to directly
-
Executive Summary: Fostering Collaborative Teamwork—A Comprehensive Approach to Vascular Graft Infection Following Arterial Reconstructive Surgery Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-18 Hussam Tabaja, Supavit Chesdachai, Aditya S Shah, Ryan W Stevens, Randall R DeMartino, Young M Erben, Walter R Wilson, Larry M Baddour, Daniel C DeSimone
Vascular graft infection (VGI) is one of the most serious complications following arterial reconstructive surgery. VGI has received increasing attention over the past decade, but many questions remain regarding its diagnosis and management. In this review, we describe our approach to VGI through multidisciplinary collaboration and discuss decision-making for challenging presentations. This document
-
Association between Causative Pathogen and Occurrence of Infection-Related Glomerulonephritis in Infective Endocarditis Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-18 Nabin K Shrestha, Emese C Kanyo, Georges N Nakhoul, Leal C Herlitz, Steven M Gordon
Among patients with pathologically-proven infective endocarditis, the association of pathogen with occurrence of infection-related glomerulonephritis (IRGN) was examined in 48 cases of IRGN and 192 propensity score-matched controls. Bartonella was very strongly associated with IRGN (OR 38.2, 95% C.I. 6.7–718.8, p-value <.001); other microorganisms were not.
-
Genomic Analysis and Surveillance of Respiratory Syncytial Virus (RSV) Using Wastewater-Based Epidemiology (WBE) J. Infect. Dis. (IF 6.4) Pub Date : 2024-04-18 Danielle M Allen, Marina I Reyne, Pearce Allingham, Ashley Levickas, Stephen H Bell, Jonathan Lock, Jonathon D Coey, Stephen Carson, Andrew J Lee, Cormac McSparron, Behnam Firoozi Nejad, James McKenna, Mark Shannon, Kathy Li, Tanya Curran, Lindsay J Broadbent, Damian G Downey, Ultan F Power, Helen E Groves, Jennifer M McKinley, John W McGrath, Connor G G Bamford, Deirdre F Gilpin
Respiratory syncytial virus (RSV) causes severe infections in infants, immunocompromised or elderly individuals resulting in annual epidemics of respiratory disease. Currently, limited clinical surveillance and the lack of predictable seasonal dynamics limits the public health response. Wastewater-based epidemiology (WBE) has recently been used globally as a key metric in determining prevalence of
-
Clinical severity of enteric viruses detected using a quantitative molecular assay compared to conventional assays in the Global Enteric Multicenter Study J. Infect. Dis. (IF 6.4) Pub Date : 2024-04-18 Jordan Cates, Helen Powell, James Platts-Mills, Dilruba Nasrin, Sandra Panchalingam, Samba O Sow, Awa Traore, Dipika Sur, Thandavarayan Ramamurthy, Anita K M Zaidi, Furqan Kabir, Abu S G Faruque, Dilruba Ahmed, Robert F Breiman, Richard Omore, John Benjamin Ochieng, M Jahangir Hossain, Martin Antonio, Inácio Mandomando, Delfino Vubil, James P Nataro, Myron M Levine, Umesh D Parashar, Karen L Kotloff
Background Quantitative molecular assays are increasingly used for detection of enteric viruses. Methods We compared the clinical severity using modified Vesikari score (mVS) of enteric viruses detected by conventional assays (enzyme immunoassays [EIA] for rotavirus and adenovirus 40/41 and conventional polymerase chain reaction for astrovirus, sapovirus, and norovirus) and a quantitative molecular
-
Genomic and eco-epidemiological investigations in Uruguay reveal local Chikungunya virus transmission dynamics during its expansion across the Americas in 2023 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-15 Analía Burgueño, Marta Giovanetti, Vagner Fonseca, Noelia Morel, Mauricio Lima, Emerson Castro, Natália R. Guimarães, Felipe C. M. Iani, Victoria Bormida, Maria Noel Cortinas, Viviana Ramas, Leticia Coppola, Ana I. Bento, Leticia Franco, Jairo Mendez Rico, José Lourenço, Luiz Carlos Junior Alcantara, Hector Chiparelli
Uruguay experienced its first Chikungunya virus outbreak in 2023, resulting in a significant burden to its healthcare system. We conducted analysis based on real-time genomic surveillance (30 novel...
-
Clinical outcomes of treatment-naïve HBeAg-negative patients with chronic hepatitis B virus infection with low serum HBsAg and undetectable HBV DNA Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-16 Jian Wang, Li Zhu, Shaoqiu Zhang, Zhiyi Zhang, Tao Fan, Fei Cao, Ye Xiong, Yifan Pan, Yuanyuan Li, Chao Jiang, Shengxia Yin, Xin Tong, Yali Xiong, Juan Xia, Xiaomin Yan, Yong Liu, Xingxiang Liu, Yuxin Chen, Jie Li, Chuanwu Zhu, Chao Wu, Rui Huang
Serum hepatitis B surface antigen (HBsAg) level < 100 IU/ml and undetectable hepatitis B virus (HBV) DNA have been recently proposed as an alternate endpoint of “partial cure” in chronic hepatitis ...
-
Mammalian adaptation risk in HPAI H5N8: a comprehensive model bridging experimental data with mathematical insights Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-16 Santosh Chokkakula, Sol Oh, Won-Suk Choi, Chang Il Kim, Ju Hwan Jeong, Beom Kyu Kim, Ji-Hyun Park, Seong Cheol Min, Eung-Gook Kim, Yun Hee Baek, Young Ki Choi, Min-Suk Song
Understanding the mammalian pathogenesis and interspecies transmission of HPAI H5N8 virus hinges on mapping its adaptive markers. We used deep sequencing to track these markers over five passages i...
-
Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-17 Yujie Hou, Guohua Deng, Pengfei Cui, Xianying Zeng, Bin Li, Dongxue Wang, Xinwen He, Cheng Yan, Yaping Zhang, Jiongjie Li, Jinming Ma, Yanbing Li, Xiurong Wang, Guobin Tian, Huihui Kong, Lijie Tang, Yasuo Suzuki, Jianzhong Shi, Hualan Chen
Human infections with the H7N9 influenza virus have been eliminated in China through vaccination of poultry; however, the H7N9 virus has not yet been eradicated from poultry. Carefully analysis of ...
-
SARS-CoV-2 IgG Levels as Predictors of XBB Variant Neutralization, Israel, 2022 and 2023 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-16 Yaniv Lustig, Michal Canetti, Victoria Indenbaum, Yovel Peretz, Yael Weiss-Ottolenghi, Ili Margalit, Keren Asraf, Tal Levin, Neta Zuckerman, Enosh Tomer, Michal Mandelboim, Ram Doolman, Noam Barda, Gili Regev-Yochay
Although a vaccine against SARS-CoV-2 Omicron-XBB.1.5 variant is available worldwide and recent infection is protective, the lack of recorded infection data highlights the need to assess variant-specific antibody neutralization levels. We analyzed IgG levels against receptor-binding domain–specific SARS-CoV-2 ancestral strain as a correlate for high neutralizing titers against XBB variants.
-
Detection of Recombinant African Swine Fever Virus Strains of p72 Genotypes I and II in Domestic Pigs, Vietnam, 2023 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-16 Van Phan Le, Van Tam Nguyen, Tran Bac Le, Nguyen Tuan Anh Mai, Viet Dung Nguyen, Thi Tam Than, Thi Ngoc Ha Lai, Ki Hyun Cho, Seong-Keun Hong, Yeon Hee Kim, Tran Anh Dao Bui, Thi Lan Nguyen, Daesub Song, Aruna Ambagala
African swine fever virus (ASFV) genotype II is endemic to Vietnam. We detected recombinant ASFV genotypes I and II (rASFV I/II) strains in domestic pigs from 6 northern provinces in Vietnam. The introduction of rASFV I/II strains could complicate ongoing ASFV control measures in the region.
-
Epidemiologic Survey of Crimean-Congo Hemorrhagic Fever Virus in Suids, Spain Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-16 Mario Frías, Kerstin Fischer, Sabrina Castro-Scholten, Caroline Bost, David Cano-Terriza, Maria Ángeles Risalde, Pelayo Acevedo, Saúl Jiménez-Ruiz, Balal Sadeghi, Martin H. Groschup, Javier Caballero-Gómez, Ignacio García-Bocanegra
We conducted a cross-sectional study in wild boar and extensively managed Iberian pig populations in a hotspot area of Crimean-Congo hemorrhagic fever virus (CCHFV) in Spain. We tested for antibodies against CCHFV by using 2 ELISAs in parallel. We assessed the presence of CCHFV RNA by means of reverse transcription quantitative PCR protocol, which detects all genotypes. A total of 113 (21.8%) of 518
-
Forecasting Hepatitis C Virus Status for Children in the United States: A Modeling Study Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-17 Robert B Hood, Alison H Norris, Abigail Shoben, William C Miller, Randall E Harris, Laura W Pomeroy
Background Virtually all cases of hepatitis C virus (HCV) infection in children in the United States occur through vertical transmission, but it is unknown how many children are infected. Cases of maternal HCV infection have increased in the United States, which may increase the number of children vertically infected with HCV. Infection has long-term consequences for a child's health, but treatment
-
Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis with Sulbactam-Durlobactam Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-17 Pranita D Tamma, Shanan Immel, Sara M Karaba, Caitlin L Soto, Rick Conzemius, Emily Gisriel, Tsigereda Tekle, Haley Stambaugh, Emily Johnson, Jeffrey A Tornheim, Patricia J Simner
Background The treatment of carbapenem-resistant Acinetobacter baumannii/calcoaceticus complex (CRAB) presents significant treatment challenges. Methods We report the case of a 42-year-old woman with CRAB meningitis who experienced persistently positive cerebrospinal fluid (CSF) cultures for 13 days despite treatment with high-dose ampicillin-sulbactam and cefiderocol. On day 13, she was transitioned
-
Vaccine-Preventable Disease Outbreaks among Healthcare Workers: A Scoping Review Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-17 Tasnim Hasan, Michelle Lynch, Catherine King, Charbel Wehbe, Martin Plymoth, Md Saiful Islam, Theodore Iannuzzi, Aiken Dao, Jana Lai, Alexandra Martiniuk, Shalini Desai, Meru Sheel
Background Outbreaks of vaccine preventable diseases (VPDs) in health care workers (HCWs) can result in morbidity and mortality and cause significant disruptions to health care services, patients and visitors as well as an added burden on the health system. This scoping review is aimed to describe the epidemiology of VPD outbreaks in HCW, caused by diseases which are prevented by the ten vaccines recommended
-
Retrospective monkeypox virus (MPXV) surveillance among male users of I Want The Kit in Maryland, United States Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-17 Yukari C Manabe, Justin Hardick, Katherine Uhteg, Nisha Ramdeep, Gretchen Armington, Heba H Mostafa, Matthew M Hamill
Retrospective surveillance leveraging male rectal swab sample remnants from I Want The Kit from July 2021 through October 2023, identified one symptomatic and one asymptomatic mpox case at the peak of transmission in 2022. Although sporadic cases continue to be reported in Maryland, additional asymptomatic cases were not identified in this leveraged surveillance.
-
Cost-effectiveness of 4CMenB vaccination against gonorrhea: importance of dosing schedule, vaccine sentiment, targeting strategy, and duration of protection J. Infect. Dis. (IF 6.4) Pub Date : 2024-04-17 Dariya Nikitin, Lilith K Whittles, Jeffrey W Imai-Eaton, Peter J White
Background Observational evidence suggests the 4CMenB meningococcal vaccine may partially protect against gonorrhea, with one dose being two-thirds as protective as two. We examined the cost-effectiveness of vaccinating men-who-have-sex-with-men (MSM) in England, with one- or two-dose primary vaccination. Methods Integrated transmission-dynamic health-economic modeling explored the effects of targeting
-
Chromosomal integration and plasmid fusion occurring in ST20 carbapenem-resistant Klebsiella pneumoniae isolates coharboring blaNDM-1 and blaIMP-4 induce resistance transmission and fitness variation Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-16 Qiucheng Shi, Huangdu Hu, Qian Yu, Weiyi Huang, Yinping Wang, Jingjing Quan, Junxin Zhou, Rui Weng, Ping Zhang, Yan Meng, Haiyang Liu, Yan Jiang, Yunsong Yu, Xiaoxing Du
To investigate the epidemiology of ST20 carbapenem-resistant Klebsiella pneumoniae (CRKP) in China, and further explore the genomic characteristics of blaIMP-4 and blaNDM-1 coharboring isolates and...
-
Molecular Epidemiology of Mayaro Virus among Febrile Patients, Roraima State, Brazil, 2018–2021 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-15 Julia Forato, Cássio A. Meira, Ingra M. Claro, Mariene R. Amorim, Gabriela F. de Souza, Stefanie P. Muraro, Daniel A. Toledo-Teixeira, Miguel F. Dias, Cátia A. R. Meneses, Rodrigo N. Angerami, Pritesh Lalwani, Scott C. Weaver, Ester C. Sabino, Nuno R. Faria, William M. de Souza, Fabiana Granja, José Luiz Proenca-Modena
We detected Mayaro virus (MAYV) in 3.4% (28/822) of febrile patients tested during 2018–2021 from Roraima State, Brazil. We also isolated MAYV strains and confirmed that these cases were caused by genotype D. Improved surveillance is needed to better determine the burden of MAYV in the Amazon Region.
-
Serogroup B Invasive Meningococcal Disease in Older Adults Identified by Genomic Surveillance, England, 2022–2023 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-15 Emily Loud, Stephen A. Clark, David S. Edwards, Elizabeth Knapper, Lynsey Emmett, Shamez Ladhani, Helen Campbell
We report a cluster of serogroup B invasive meningococcal disease identified via genomic surveillance in older adults in England and describe the public health responses. Genomic surveillance is critical for supporting public health investigations and detecting the growing threat of serogroup B Neisseria meningitidis infections in older adults.
-
Crimean Congo Hemorrhagic Fever Virus for Clinicians—Virology, Pathogenesis, and Pathology Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-15 Maria G. Frank, Gretchen Weaver, Vanessa Raabe
Crimean Congo hemorrhagic fever (CCHF), caused by CCHF virus, is a tickborne disease that can cause a range of illness outcomes, from asymptomatic infection to fatal viral hemorrhagic fever; the disease has been described in >30 countries. We conducted a literature review to provide an overview of the virology, pathogenesis, and pathology of CCHF for clinicians. The virus life cycle and molecular interactions
-
Coccidioidomycosis-Related Hospital Visits, Texas, USA, 2016–2021 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-15 Heather Mayfield, Vanora Davila, Elena Penedo
We analyzed hospital discharge records of patients with coccidioidomycosis-related codes from the International Classification of Diseases, 10th revision, Clinical Modification, to estimate the prevalence of hospital visits associated with the disease in Texas, USA. Using Texas Health Care Information Collection data for 2016–2021, we investigated the demographic characteristics and geographic distribution
-
Waning Interest in Infectious Disease Among Trainees: Is Medicine Pulling the Goalie? Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-16 George Sakoulas
Relatively low salaries in ID compared to other medical specialties in a world where cost of living is skyrocketing are an easy explanation for unmet needs of ID training programs to fill their positions. However, the interest in ID falling short of expectations may reflect that some features of the ID specialty are counter to select pervasive tendencies of modern culture, including i) slow uptake
-
Amoxicillin-clavulanate Breakpoints Against Enterobacterales: Rationale for Revision by the Clinical and Laboratory Standards Institute Clin. Infect. Dis. (IF 11.8) Pub Date : 2024-04-16 Navaneeth Narayanan, Amy J Mathers, Eric Wenzler, Nicholas M Moore, Christian G Giske, Rodrigo E Mendes, Paul H Edelstein
Amoxicillin-clavulanate (AMC) is among the most frequently prescribed antibiotics globally. It has broad antibacterial activity against gram-positive, gram-negative, and anaerobic bacteria, and has been utilized to treat infections caused by a broad range of pathogens. AMC breakpoints against Enterobacterales were initially set in the 1980s but since then increases in antibiotic resistance, advances
-
Inhibition of RhoA prevents Cryptococcus neoformans capsule glucuronoxylomannan-stimulated brain endothelial barrier disruption J. Infect. Dis. (IF 6.4) Pub Date : 2024-04-16 Melissa E Munzen, Cristian Mathew, Vanessa Enriquez, Amanjeet Minhas, Claudia L Charles-Niño, Durvinand Saytoo, Marta Reguera-Gomez, Michael R Dores, Luis R Martinez
Cryptococcus neoformans (Cn) is an opportunistic fungus that causes severe central nervous system (CNS) disease in immunocompromised individuals. Brain parenchyma invasion requires fungal traversal of the blood-brain barrier. In this study, we describe that Cn alters the brain endothelium by activating small GTPase RhoA, causing reorganization of the actin cytoskeleton and tight junction modulation
-
Incidence, Clearance and Persistence of Penile High-Risk Human Papillomavirus among Rwandan Men who have Sex with Men J. Infect. Dis. (IF 6.4) Pub Date : 2024-04-16 Gad Murenzi, Hae-Young Kim, Jean Paul Mivumbi, Josephine Gasana, Athanase Munyaneza, Patrick Tuyisenge, Faustin Kanyabwisha, Thierry Zawadi, Benjamin Muhoza, Gallican Kubwimana, Adebola Adedimeji, Marcel Yotebieng, Leon Mutesa, Qiuhu Shi, Kathryn Anastos, Joel M Palefsky
Background Little is known about penile high-risk HPV among MSM in low-and-middle income countries. We aimed to determine the incidence, clearance and persistence of penile hrHPV among Rwandan MSM. Methods We enrolled 350 MSM (345 with valid HPV results), aged ≥18 years, at each visit (6-12 months apart), we collected penile PreservCyt specimens and blood for HPV and HIV testing, socio-demographic
-
Babesia duncani, A Model Organism for Investigating Intraerythrocytic Parasitism and Novel Anti-Parasitic Therapeutic Strategies J. Infect. Dis. (IF 6.4) Pub Date : 2024-04-16 Tiffany Fang, Choukri Ben Mamoun
Pathogens such as Plasmodium, Babesia, and Theileria invade and multiply within host red blood cells, leading to the pathological consequences of malaria, babesiosis and theileriosis. Establishing continuous in vitro culture systems and suitable animal models is crucial for studying these pathogens. This review spotlights the B. duncani “in culture-in mouse (ICIM)” model as a promising resource for
-
Amino acids in the polymerase complex of shorebird-isolated H1N1 influenza virus impact replication and host-virus interactions in mammalian models Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-14 Yaqin Bai, Hui Lei, Wenjun Song, Sang-Chul Shin, Jiaqi Wang, Biying Xiao, Zeynep A. Koçer, Min-Suk Song, Robert Webster, Richard J. Webby, Sook-San Wong, Mark Zanin
A diverse population of avian influenza A viruses (AIVs) are maintained in wild birds and ducks yet the zoonotic potential of AIVs in these environmental reservoirs and the host-virus interactions ...
-
The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-14 Tao Wang, Rui Luo, Jing Zhang, Jing Lan, Zhanhao Lu, Huanjie Zhai, Lian-Feng Li, Yuan Sun, Hua-Ji Qiu
African swine fever (ASF) is a highly contagious, often fatal viral disease caused by African swine fever virus (ASFV), which imposes a substantial economic burden on the global pig industry. When ...
-
Evaluation of analytical performance of the STANDARDTM M10 MPX/OPX assay for the simultaneous DNA detection and clade attribution of Monkeypox virus Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-14 Alessandro Mancon, Angelo Roberto Raccagni, Gloria Gagliardi, Davide Moschese, Alberto Rizzo, Andrea Giacomelli, Miriam Cutrera, Federica Salari, Fiorenza Bracchitta, Spinello Antinori, Andrea Gori, Giuliano Rizzardini, Antonella Castagna, Maria Rita Gismondo, Silvia Nozza, Davide Mileto
Monkeypox virus (MPXV) infection confirmation needs reliable polymerase chain reaction (PCR) assays; in addition, viral clade attribution is a key factor in containment measures, considering a more...
-
Modeling the spatial risk of malaria through probability distribution of Anopheles maculipennis s.l. and imported cases Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-15 Shirin Taheri, Mikel Alexander González, María José Ruiz-López, Sergio Magallanes, Sarah Delacour-Estrella, Javier Lucientes, Rubén Bueno-Marí, Josué Martínez-de la Puente, Daniel Bravo-Barriga, Eva Frontera, Alejandro Polina, Yasmina Martinez-Barciela, José Manuel Pereira, Josefina Garrido, Carles Aranda, Alfonso Marzal, Ignacio Ruiz-Arrondo, José Antonio Oteo, Martina Ferraguti, Rafael Gutíerrez-López
Malaria remains one of the most important infectious diseases globally due to its high incidence and mortality rates. The influx of infected cases from endemic to non-endemic malaria regions like E...
-
Efficacy of Genotype-matched Vaccine Against Re-emerging Genotype V Japanese Encephalitis Virus Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-15 Jae-Deog Kim, Ah-Ra Lee, Dah-Hyun Moon, Young-Uk Chung, Su-Yeon Hong, Hyo Je Cho, Tae Hyun Kang, Yo Han Jang, Myung Hyun Sohn, Baik-Lin Seong, Sang-Uk Seo
Japanese encephalitis (JE), caused by the Japanese encephalitis virus (JEV), is a highly threatening disease with no specific treatment. Fortunately, the development of vaccines has enabled effecti...
-
Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-15 Sijie Yang, Yuanling Yu, Fanchong Jian, Ayijiang Yisimayi, Weiliang Song, Jingyi Liu, Peng Wang, Yanli Xu, Jing Wang, Xiao Niu, Lingling Yu, Yao Wang, Fei Shao, Ronghua Jin, Youchun Wang, Yunlong Cao
Published in Emerging Microbes & Infections (Just accepted, 2024)
-
Sporotrichosis Cluster in Domestic Cats and Veterinary Technician, Kansas, USA, 2022 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-12 Ian Hennessee, Erin Barber, Erin Petro, Stephanie Lindemann, Bryan Buss, Amanda Santos, Lalitha Gade, Shawn R. Lockhart, D. Joseph Sexton, Tom Chiller, Mitsuru Toda
We describe a feline sporotrichosis cluster and zoonotic transmission between one of the affected cats and a technician at a veterinary clinic in Kansas, USA. Increased awareness of sporotrichosis and the potential for zoonotic transmission could help veterinary professionals manage feline cases and take precautions to prevent human acquisition.
-
Reemergence of Bordetella parapertussis, United States, 2019–2023 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-12 Brooklyn A. Noble, Sarah S. Jiudice, Jay D. Jones, Tristan T. Timbrook
To determine changes in Bordetella pertussis and B. parapertussis detection rates, we analyzed 1.43 million respiratory multiplex PCR test results from US facilities from 2019 through mid-2023. From mid-2022 through mid-2023, Bordetella spp. detection increased 8.5-fold; 95% of detections were B. parapertussis. While B. parapertussis rates increased, B. pertussis rates decreased.
-
Detection of Influenza D Antibodies in Dogs, Apulia Region, Italy, 2016 and 2023 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-12 Claudia Maria Trombetta, Serena Marchi, Maria Giovanna Marotta, Ana Moreno, Chiara Chiapponi, Emanuele Montomoli, Gianvito Lanave, Michele Camero, Vito Martella
Dogs are known to be susceptible to influenza A viruses, although information on influenza D virus (IDV) is limited. We investigated the seroprevalence of IDV in 426 dogs in the Apulia region of Italy during 2016 and 2023. A total of 14 samples were positive for IDV antibodies, suggesting exposure to IDV in dogs.
-
Detection of OXA-181 Carbapenemase in Shigella flexneri Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-12 Ghulam Dhabaan, Hassan Jamal, Danielle Ouellette, Sarah Alexander, Karen Arane, Aaron Campigotto, Manal Tadros, Pierre-Philippe Piché-Renaud
We report the detection of OXA-181 carbapenemase in an azithromycin-resistant Shigella spp. bacteria in an immunocompromised patient. The emergence of OXA-181 in Shigella spp. bacteria raises concerns about the global dissemination of carbapenem resistance in Enterobacterales and its implications for the treatment of infections caused by Shigella bacteria.
-
Sphingobium yanoikuyae Bacteremia, Japan Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-12 Yayoi Miyamatsu, Ryutaro Tanizaki, Satoko Yamada
We report a case of Sphingobium yanoikuyae bacteremia in an 89-year-old patient in Japan. No standard antimicrobial regimen has been established for S. yanoikuyae infections. However, ceftriaxone and ceftazidime treatments were effective in this case. Increased antimicrobial susceptibility data are needed to establish appropriate treatments for S. yanoikuyae.
-
Antimicrobial Resistance as Risk Factor for Recurrent Bacteremia after Staphylococcus aureus, Escherichia coli, or Klebsiella spp. Community-Onset Bacteremia Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-12 Salam Abbara, Didier Guillemot, David R.M. Smith, Salma El Oualydy, Maeva Kos, Cécile Poret, Stéphane Breant, Christian Brun-Buisson, Laurence Watier
We investigated links between antimicrobial resistance in community-onset bacteremia and 1-year bacteremia recurrence by using the clinical data warehouse of Europe’s largest university hospital group in France. We included adult patients hospitalized with an incident community-onset Staphylococcus aureus, Escherichia coli, or Klebsiella spp. bacteremia during 2017–2019. We assessed risk factors of
-
Rat hepatitis E virus (Rocahepevirus ratti) exposure in cats and dogs, Hong Kong Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-12 Estie Hon-Kiu Shun, Jianwen Situ, James Yiu-Hung Tsoi, Shusheng Wu, Jianpiao Cai, Kelvin Hon-Yin Lo, Nicholas Foo-Siong Chew, Zhiyu Li, Rosana Wing-Shan Poon, Jade Lee-Lee Teng, Vincent Chi-Chung Cheng, Kwok-Yung Yuen, Siddharth Sridhar
Hepatitis E virus (HEV) variants infecting humans belong to two species: Paslahepevirus balayani (bHEV) and Rocahepevirus ratti (rat hepatitis E virus; rHEV). R. ratti is a ubiquitous rodent pathog...
-
Crimean-Congo Hemorrhagic Fever Virus in Ticks Collected from Cattle, Corsica, France, 2023 Emerg. Infect. Dis. (IF 11.8) Pub Date : 2024-04-11 Paloma Kiwan, Shirley Masse, Geraldine Piorkowski, Nazli Ayhan, Morena Gasparine, Laurence Vial, Remi N. Charrel, Xavier de Lamballerie, Alessandra Falchi
We report the detection of Crimean-Congo hemorrhagic fever virus (CCHFV) in Corsica, France. We identified CCHFV African genotype I in ticks collected from cattle at 2 different sites in southeastern and central-western Corsica, indicating an established CCHFV circulation. Healthcare professionals and at-risk groups should be alerted to CCHFV circulation in Corsica.