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In situ probes into the structural changes and active state evolution of a highly selective iron-based CO2 reduction photocatalyst Chem Catal. Pub Date : 2024-04-22 Feysal M. Ali, Abdelaziz Gouda, Paul N. Duchesne, Mohamad Hmadeh, Paul G. O’Brien, Abhinav Mohan, Mireille Ghoussoub, Athanasios A. Tountas, Hussameldin Ibrahim, Doug D. Perovic, Geoffrey A. Ozin
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Gold-Zinc Co-Catalyzed Alkynoate Hydrocarboxylation with N-Protected Amino Acids for Preparation of Storable Acylating Reagents and Racemization-Free Peptide Synthesis Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-18 Ayaka Sakurada, Miyu Sato, Kosuke Higashida, Masaya Sawamura
Hydrocarboxylation of methyl 2-octynoate, a chemical commercially available at a low cost, with N-protected amino acids was developed with a gold-zinc cooperative catalyst constructed with a 5-[(2,2'-bipyridin)-5-yl]imidazo[1,5-a]pyridin-3-ylidene to prepare α-methoxycarbonyl enol esters as acylating reagents. The α-methoxycarbonyl enol esters were isolable through silica-gel column chromatography
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Progress and roadmap for electro-privileged transformations of bio-derived molecules Nat. Catal. (IF 37.8) Pub Date : 2024-04-22 Cong Tian, Roham Dorakhan, Joshua Wicks, Zhu Chen, Kyoung-Shin Choi, Nirala Singh, Joshua A. Schaidle, Adam Holewinski, Aleksandra Vojvodic, Dionisios G. Vlachos, Linda J. Broadbelt, Edward H. Sargent
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Novel mechanism of Fe4+/Ni3+ synergistic effect via exchange energy gain for boosting water oxidation Chem Catal. Pub Date : 2024-04-17 Yalei Fan, Chenjia Zhang, Lunyong Zhang, Jing Zhou, Yanzhuo Li, Yu-Cheng Huang, Jingyuan Ma, Ting-Shan Chan, Chien-Te Chen, Chao Jing, Emin Mijit, Zhiwei Hu, Jian-Qiang Wang, Linjuan Zhang
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Recent advancements in the molecular design of deep-red to near-infrared light-absorbing photocatalysts Chem Catal. Pub Date : 2024-04-17 Minling Zhong, Yujie Sun
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Solar fuels: Advancements in photothermal CO2 conversion to light olefins Chem Catal. Pub Date : 2024-04-18 Alessio Tauro, Fabio Salomone
Solar-driven catalysis has recently gained importance as a sustainable alternative to traditional energy-intensive processes. In this issue of Chem Catalysis, Song et al. thoroughly examine the mechanisms of photothermal CO2 hydrogenation to olefins. Our preview provides concise insights into their comprehensive study by highlighting perspectives and developments in CO2 utilization.
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Unraveling the deactivation mechanism of methanol-to-olefin conversion over zeolite catalysts Chem Catal. Pub Date : 2024-04-18 Runze Liu, Weili Dai
Because of the complexity of methanol-to-olefin (MTO) conversion, clarifying the deactivation mechanism is still challenging. In this issue of Chem Catalysis, Weibin Fan and co-workers clarify the formation and evolution of coke precursors, i.e., cross-linked conjugate species, over zeolite catalysts, providing new insights into the deactivation mechanism in MTO conversion.
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Taming glycosylidene carbenes through bench-stable glycosylidene diaziridines to access boro-ketosides Chem Catal. Pub Date : 2024-04-18 Charles C.J. Loh
In this issue of Chem Catalysis, He and co-workers demonstrate easy access to diverse glycosyl boro-ketosides via a rare glycosylidene carbene intermediate. They use stable glycosylidene diaziridines as precursors for carbene generation, leading to products convertible into rare sugars and pharmaceutically interesting derivatives, such as tofogliflozin.
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Engineering out-of-plane microstructure enables higher hydrogen production Chem Catal. Pub Date : 2024-04-18 Jong-Pil Jeon, Jong-Beom Baek
In this issue of Chem Catalysis, Xiong et al. describe the preparation of a strain-controlled MoS2 monolayer using bubbles toward the electrocatalytic hydrogen evolution reaction (HER). The induced microstructure and intrinsic S vacancies affected the electronic structure, exciton dynamics, and hydrogen adsorption, resulting in larger bubbles. The derived samples exhibited better acidic HER performance
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Remote enantioselective desymmetrization of cyclohexanone with carbonyl 1,2-transposition Chem Catal. Pub Date : 2024-04-18 Hong Lu, Hao Wei
In this issue of Chem Catalysis, Ye and co-workers present a bisguanidinium-catalyzed method involving an intramolecular carbonyl 1,2-transposition for the remote enantioselective desymmetrization of prochiral cyclohexanone. The comprehensive mechanistic experiments, coupled with density functional theory (DFT) calculations, lay a robust foundation for future advancements in functional-group transposition
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Highly site-selective C(sp3)–H bond functionalization enabled by framework confinements Chem Catal. Pub Date : 2024-04-18 Yuping Wang, Feihe Huang
Mimicking enzymes’ ability to orient substrates through nanoconfinement holds significant promise for the development of artificial catalysts with enhanced performance. Recently in Chem, a cyclodextrin-based metal-organic framework has been shown to undergo selective C–H bond activation in the presence of guest molecules upon photoirradiation, illustrating a crucial advance in replicating biological
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Visible Light‐Enabled Decarboxylative Alkylation of Quinoxalin‐2(1H)‐ones using Alkyl Carboxylic Acids via Energy Transfer Process Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-20 Anoop Sharma, Nihal Singh, Raman Kumar, Anuj Sharma
Here in, we describe the photochemical decarboxylative alkylation of quinoxalin‐2(1H)‐ones using commercially accessible carboxylic acids with oxygen as sole oxidant through energy transfer process. The coupling of diverse array of alkyl carboxylic acids (1o to 3o) and bioactive acids with quinoxalin‐2(1H)‐ones is successfully accomplished to achieve the desired alkylated products.
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Visible‐light mediated Ugi‐type reaction for the synthesis of 3,3‐disubstituted phthalides Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-20 Feiyu Gao, Chenxin Yin, Yi He, Shuang Zhao, Mengxiao Chen, Jia Zheng, Dan Ni, Houhua Yin, Xian Fu, Xiaoyong Zhang, Shenyou Nie
The synthesis of diverse phthalides containing quaternary carbon centers remains poorly exploited, requiring stepwise reactions with toxic reagents under high temperatures. Herein, we describe a visible‐light promoted, photo‐ and metal‐catalyst‐free protocol for the modular synthesis of 3,3‐disubstituted phthalides with water as the sole by‐product. This process featured an open‐flask operation of
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Improved Palladium Catalysis in Suzuki‐Type Coupling of Benzotriazinones for o‐Aryl/Alkenyl Benzamides Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-20 Minling Xü, Ke Xü, Gang Zou
A palladium catalyst system based on PdCl2(PPh3)2 or PdCl2(dppf) is reported for Suzuki‐type coupling of both N‐aryl and alkyl benzotriazinones with aryl/alkenyl boronic acids to afford a series of ortho‐aryl/alkenyl benzamides in yields up to 99%, showing improvements on catalytic efficiency, substrate scope and practicality. Scope and limitations of the improved protocol have been demonstrated with
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A Mild Metal‐Free Approach for the Direct Synthesis of Carbamoyl Azides from Carboxylic Acid Redox Active Esters Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-20 Yan-Hua Qiu, Yuping Zhu, Ming-Hua Rao, Chang-Qi Huang, Zi-Ying Huang, Zhengwang Chen, Jinbin Zhu, Daohong Yu
Carbamoyl azide is an important compound which was transformed into urea, amine and applied to nitrene insertion reaction. We developed a novel metal‐ and oxidant‐free method for the direct synthesis of carbamoyl azide from acid redox active esters. A variety of functional groups were tolerated. In addition, the late‐stage modification of natural products and drugs paves the way for the design and
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Copper‐catalyzed Alkenylation and Alkenyloxylation with‐Alkenyl(phenyl)iodonium Salts Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-20 Zhao-Xin Song, Meng-Wei Yang, Teng-Teng Wu, Yun-He Xu
An efficient and straightforward Cu‐catalyzed vinylation method for alkenyl ethers has been developed. This method demonstrates outstanding performance, delivering high yields and remarkable stereoselectivities for both cyclic and chain alkenyl ether substrates. Furthermore, we have successfully applied this method to directly vinylate the C‐2 position of protected glucals, offering a valuable tool
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Pt–Pyrrole Complex-Assisted Synthesis of Carbon-Supported Pt Intermetallics for Oxygen Reduction in Proton Exchange Membrane Fuel Cells ACS Catal. (IF 12.9) Pub Date : 2024-04-19 Yuting Jiang, Qing Zhang, Junning Qian, Yameng Wang, Yongbiao Mu, Zhiyuan Zhang, Zheng Li, Tianshou Zhao, Bilu Liu, Lin Zeng
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Boosting Hydrogen Adsorption via Manipulating the d-Band Center of Ferroferric Oxide for Anion Exchange Membrane-Based Seawater Electrolysis ACS Catal. (IF 12.9) Pub Date : 2024-04-19 Long Song, Lili Guo, Jiayu Mao, Zhipeng Li, Jiawei Zhu, Jianping Lai, Jingqi Chi, Lei Wang
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Effect of 6,6′-Substituents on Bipyridine-Ligated Ni Catalysts for Cross-Electrophile Coupling ACS Catal. (IF 12.9) Pub Date : 2024-04-19 Haotian Huang, Jose L. Alvarez-Hernandez, Nilay Hazari, Brandon Q. Mercado, Mycah R. Uehling
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Multimodal Acridine Photocatalysis Enables Direct Access to Thiols from Carboxylic Acids and Elemental Sulfur ACS Catal. (IF 12.9) Pub Date : 2024-04-19 Arka Porey, Seth O. Fremin, Sachchida Nand, Ramon Trevino, William B. Hughes, Shree Krishna Dhakal, Viet D. Nguyen, Samuel G. Greco, Hadi D. Arman, Oleg V. Larionov
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Atroposelective Synthesis of N–N Axially Chiral Indoles and Pyrroles via NHC-Catalyzed Diastereoselective (3 + 3) Annulation Strategy ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Sowmya Shree Ranganathappa, Bhabani Sankar Dehury, Gautam Kumar Singh, Sayan Shee, Akkattu T. Biju
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Christina Li, Serge Ruccolo, and Christo Sevov Selected to Receive the 2024 ACS Catalysis Lectureship for the Advancement of Catalytic Science ACS Catal. (IF 12.9) Pub Date : 2024-04-19 Cathleen Crudden
This year, we at ACS Catalysis, in partnership with the ACS Division of Catalysis Science and Technology (CATL) and the ACS Division of Organic Chemistry (ORGN), teamed up to recognize the outstanding recent contributions of one catalysis researcher in each area: heterogeneous catalysis, homogeneous catalysis, and biocatalysis/enzymology. (1) It is our pleasure to announce that the 2024 awardees are
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Exploring the High-Entropy Oxide Composition Space: Insights through Comparing Experimental with Theoretical Models for the Oxygen Evolution Reaction ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Vladislav A. Mints, Katrine L. Svane, Jan Rossmeisl, Matthias Arenz
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Substantial Impact of Spin State Evolution in OER/ORR Catalyzed by Fe–N–C ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Mingyuan Yu, Ang Li, Erjun Kan, Cheng Zhan
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Revealing Formaldehyde-Mediated Methanol-to-Aromatics Reactions over Zn-Modified Zeolites by Observing the Oxygenated and Polyunsaturated Intermediates ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Tianci Xiao, Jinsong Luo, Weixiong Huang, Lilin Lu, Chengyuan Liu, Yang Pan
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Unraveling Two Pathways for Electrocatalytic Acetonitrile Reduction ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Qi Zhang, Zunjian Ke, Dong He, Chaoning Huang, Huan Dai, Chongyang Tang, Boling Liu, Xiangheng Xiao
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Ce4+/Ce3+ Redox-Promoted Electron Transfer for Efficient Neutral H2O2 Electrosynthesis from Two-Electron Oxygen Reduction ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Sohee Kim, Young Jin Sa
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Catalytic N-Acylation for Access to N–N Atropisomeric N-Aminoindoles: Choice of Acylation Reagents and Mechanistic Insights ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Chaoyang Song, Chen Pang, Youlin Deng, Hui Cai, Xiuhai Gan, Yonggui Robin Chi
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Functional Enhancement of Flavin-Containing Monooxygenase through Machine Learning Methodology ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Takuma Matsushita, Shinji Kishimoto, Kodai Hara, Hiroshi Hashimoto, Hideki Yamaguchi, Yutaka Saito, Kenji Watanabe
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Improving the Catalytic Efficiency of a GH5 Processive Endoglucanase by a Combinatorial Strategy Using Consensus Mutagenesis and Loop Engineering ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Kemin Lv, Xiaozhou Li, Kequan Chen, Bin Wu, Bingfang He, Gerhard Schenk
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Interplay between Catalyst Corrosion and Homogeneous Reactive Oxygen Species in Electrochemical Ozone Production ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Rayan Alaufey, Lingyan Zhao, Andrew Lindsay, Tana Siboonruang, Qin Wu, John A. Keith, Ezra Wood, Maureen Tang
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Rational Design of Heteroatom-Doped Fe–N–C Single-Atom Catalysts for Oxygen Reduction Reaction via Simple Descriptor ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Jin Liu, Jiqin Zhu, Haoxiang Xu, Daojian Cheng
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Synthesis of 2‐Amino‐3‐arylindoles and their Fused Analogues via Intramolecular C‐Arylation. Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-19 K. Žáková, P. Králová, M. Soural
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Access to Benzyl Oxindoles via Electron Donor–Acceptor Complex Photoactivation Using Thianthrenium Salts and Potassium Carbonate Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-19 Pau Sarró, Albert Gallego Gamo, Roser Pleixats, Adelina Vallribera, Carolina Gimbert Suriñach, Albert Granados Toda
A photochemical synthesis of biologically relevant benzyl oxindoles is presented via electron‐donor acceptor (EDA) complex strategy. This exogenous photocatalyst‐free method describes the formation of a new electron donor‐acceptor complex based on potassium carbonate and thianthrenium salts for C(sp2)–C(sp3) bond formation. This transition‐metal free reaction allows a rapid increase in oxindoles molecular
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Gold‐Catalyzed Synthesis of Ortho‐Quinone Methide Analogues as Reactive Synthetic Precursors. Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-19 T. Yamada, A. Fujii, C. Furugen, K. Kobayashi, T. Hyodo, T. Ikawa, H. Sajiki
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Mapping of the Reaction Trajectory Catalyzed by Class I Ketol-Acid Reductoisomerase ACS Catal. (IF 12.9) Pub Date : 2024-04-18 Xin Lin, Thierry Lonhienne, You Lv, Julia L. Kurz, Ross P. McGeary, Gerhard Schenk, Luke W. Guddat
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Palladium‐Catalyzed Two‐fold Annulation Reaction of 2,6‐Dihalogenobiphenyls with o‐Chloroaromatic Carboxylic Acids to Access (Aza)dibenzo[fg,op]tetracenes Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-18 Ji-Fa Zhu, Song Li, Xin-Yuan Long, Yingbo Shi, Bi-Qin Wang, Chun Feng, Hai-Liang Ni, Shi-Kai Xiang
A palladium‐catalyzed two‐fold annulation reaction of 2,6‐dihalogenobiphenyls with o‐chloroaromatic carboxylic acids has been developed. This method enables the synthesis of various dibenzo[fg,op]tetracenes and azadibenzo[fg,op]tetracenes. Preliminary investigations indicate that the resulting product, dimethyl 5,6,12,13‐tetrakis(hexyloxy)dibenzo[fg,op]tetracene‐2,9‐dicarboxylate, demonstrates favorable
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Acid‐Mediated Condensation of 2‐Aminoaryl Cyclopropyl Ketones with Aldehydes for the Synthesis of 2,3‐Dihydrofuro[3,2‐c]quinolines Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-18 Wenbo Cai, Cong Zhang, Xin Wang, Chuanjun Song
A method for the synthesis of 2,3‐dihydrofuro[3,2‐c]quinolines via TfOH or TMSOTf mediated condensation of 2‐aminoaryl cyclopropyl ketones with aldehydes has been developed. The reaction proceeds under transition metal or halogen free conditions, giving access to the target molecules in 27‐90% isolated yields. Mechanistic study indicates that the reaction sequence involves imine formation, intramolecular
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Iridium‐Catalysed C(sp3)−H Activation and Hydrogen Isotope Exchange via Nitrogen‐Based Carbonyl Directing Groups Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-18 Nathan Knight, James Thompson, John Andrew Parkinson, David Lindsay, Tell Tuttle, William Kerr
. Growing interest in improved structural diversity within the pharmaceutical industry has led to a focus on more sp3‐rich drug frameworks. Meanwhile, spiralling pharmaceutical research and development costs continue to require expedited adsorption, distribution, metabolism, excretion, and toxicity studies, which are heavily reliant on the use of molecules incorporating deuterium and tritium. Herein
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Water-Mediated Photocatalytic Coproduction of Diesel Fuel Additives and Hydrogen from Dimethyl Ether ACS Catal. (IF 12.9) Pub Date : 2024-04-17 Shiyang Liu, Yike Huang, Nengchao Luo, Jian Zhang, Botao Qiao, Feng Wang
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Differentiating Plasmon-Enhanced Chemical Reactions on AgPd Hollow Nanoplates through Surface-Enhanced Raman Spectroscopy ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Sulin Jiao, Kun Dai, Lucas V. Besteiro, Hongen Gao, Xuan Chen, Weichao Wang, Yuan Zhang, Chuntai Liu, Ignacio Pérez-Juste, Jorge Pérez-Juste, Isabel Pastoriza-Santos, Guangchao Zheng
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Arginine Kinase Activates Arginine for Phosphorylation by Pyramidalization and Polarization ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Fabio Falcioni, Robert W. Molt, Jr., Yi Jin, Jonathan P. Waltho, Sam Hay, Nigel G. J. Richards, G. Michael Blackburn
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Coupling Cu+ Species and Zr Single Atoms for Synergetic Catalytic Transfer Hydrodeoxygenation of 5-Hydroxymethylfurfural ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Lincai Peng, Yixuan Yu, Shenghan Gao, Miaomiao Wang, Junhua Zhang, Rui Zhang, Wenlong Jia, Yong Sun, Huai Liu
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Asymmetric Photoenolization/Diels–Alder Reaction of 2-Methylbenzaldehydes and 2-Alkylbenzophenones with Chromones ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Yuhao Mo, Lichao Ning, Zhe Luo, Liangkun Yang, Shi Tang, Shunxi Dong, Qi-Lin Zhou, Xiaoming Feng
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Halide Perovskites for Photoelectrochemical Water Splitting and CO2 Reduction: Challenges and Opportunities ACS Catal. (IF 12.9) Pub Date : 2024-04-15 Krzysztof Bienkowski, Renata Solarska, Linh Trinh, Justyna Widera-Kalinowska, Basheer Al-Anesi, Maning Liu, G. Krishnamurthy Grandhi, Paola Vivo, Burcu Oral, Beyza Yılmaz, Ramazan Yıldırım
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Key Role of CO Coverage for Chain Growth in Co-Based Fischer–Tropsch Synthesis ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Konstantijn T. Rommens, G.T. Kasun Kalhara Gunasooriya, Mark Saeys
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Plasma Catalysis for Hydrogen Production: A Bright Future for Decarbonization ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Ni Wang, Hope O. Otor, Gerardo Rivera-Castro, Jason C. Hicks
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Photoenzymatic Redox-Neutral Radical Hydrosulfonylation Initiated by FMN ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Linye Jiang, Dannan Zheng, Xiaoyang Chen, Dong Cui, Xinyu Duan, Zhiguo Wang, Jingyan Ge, Jian Xu
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Catalytic Consequences of Protons in Methanol Oxidative Dehydrogenation on Molybdenum-Based Polyoxometalate Clusters ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Guangming Cai, Ya-Huei Cathy Chin
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Coupling Waste Plastic Upgrading and CO2 Photoreduction to High-Value Chemicals by a Binuclear Re–Ru Heterogeneous Catalyst ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Mei Li, Shengbo Zhang
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Photocatalytic Regeneration of Reactive Cofactors with InP Quantum Dots for the Continuous Chemical Synthesis ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Indra Narayan Chakraborty, Vanshika Jain, Pradyut Roy, Pawan Kumar, Chathakudath P. Vinod, Pramod P. Pillai
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Synergistic Organoboron/Palladium Cocatalyzed Dehydrative Couplings of Azoles with Allylic Alcohols: A Combined Experimental and Computational Mechanistic Investigation ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Matthew T. Zambri, Teh Ren Hou, Sofia Jdanova, Mark S. Taylor
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Construction of Diazo Compounds via Catalytic [3 + 2] Annulation of Vinyldiazoacetates and Their Synthetic Applications ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Ming Bao, Diana Victoria Navarrete Carriola, Daniel Wherritt, Michael P. Doyle
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Steric Effects on the Oxygen Reduction Reaction with Cobalt Porphyrin Atropisomers ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Tao Liu, Haonan Qin, Yuhan Xu, Xinyang Peng, Wei Zhang, Rui Cao
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Enantioselective Synthesis of Axially Chiral Diaryl Ethers through Chiral Phosphoric Acid-Catalyzed Desymmetric Acylation with Azlactones ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Jiawei Xu, Wei Lin, Hanliang Zheng, Xin Li
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CsPbBr3 Perovskite Polyhedral Nanocrystal Photocatalysts for Decarboxylative Alkylation via Csp3–H Bond Activation of Unactivated Ethers ACS Catal. (IF 12.9) Pub Date : 2024-04-16 Soumya Mondal, Souvik Banerjee, Suman Bera, Subal Mondal, Siba P. Midya, Rajkumar Jana, Rakesh Kumar Behera, Ayan Datta, Narayan Pradhan, Pradyut Ghosh
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Sensitized and Self-Sensitized Photocatalytic CO2 Reduction to HCO2– and CO under Visible Light with Ni(II) CNC-Pincer Catalysts ACS Catal. (IF 12.9) Pub Date : 2024-04-15 Sonya Y. Manafe, Nghia Le, Ethan C. Lambert, Christine Curiac, Dinesh Nugegoda, Sanjit Das, Leigh Anna Hunt, Fengrui Qu, Logan M. Whitt, Igor Fedin, Nathan I. Hammer, Charles Edwin Webster, Jared H. Delcamp, Elizabeth T. Papish
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Stereoselective access to β‐gem‐difluorinated alcohols through enzymatic reduction Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-17 Lucas Bacheley, Julien Boutet, Gérard Guillamot, Pierre Gilles, Juliette Martin, Phannarath Phansavath, Virginie Ratovelomanana-Vidal
We report here a mild and efficient process to access diversely functionalized enantioenriched b‐gemdifluorinated (S)‐alcohols by using biocatalytic reduction in > 99% yield and enantiomeric excesses ranging from 96% to >99%. This novel approach involves enzymatic reduction of α‐gem‐difluorinated heterocyclic and carbocyclic ketone derivatives as well as an acyclic gem‐difluorinated β‐ketosulfone and
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Manganese‐Mediated Electrooxidative Ring‐Opening Azidation of Cyclobutanol Derivatives with TMSN3 Adv. Synth. Catal. (IF 5.4) Pub Date : 2024-04-17 Wenchao Gao, Jie Yang, Yong Teng, Wendian Li, Wenguang Li, Ting Li
A Mn‐electrocatalytic ring‐opening azidation of tert‐cyclobutanols has been developed. The regioselective method is applicable for the azidation of a diverse array of cyclobutanols to provide γ‐azido ketones in 23‐91% yields under chemical oxidants‐free reaction conditions. Detailed mechanistic studies suggest the process of Mn‐mediated alkoxy radical generation followed by β‐scission to form carbon‐centered