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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy Nat. Med. (IF 82.9) Pub Date : 2024-04-17 Ryan M. Jamiolkowski, Quynh-Anh Nguyen, Jordan S. Farrell, Ryan J. McGinn, David A. Hartmann, Jeff J. Nirschl, Mateo I. Sanchez, Vivek P. Buch, Ivan Soltesz
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Nicotine e-cigarettes: considerations for healthcare providers Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Benjamin A. Toll, Tracy T. Smith, Brian A. King
Tobacco use continues to be the leading cause of preventable disease and death in the United States. There are no safe tobacco products; however, the health risks for tobacco products exist on a continuum, with combustible products such as cigarettes being the most harmful. Decades of research have documented that cigarette smoking harms nearly every organ of the body; cigarette smoke contains nearly
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A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Norah L. Crossnohere, Nicola Anderson, Judith Baumhauer, Melanie Calvert, Rebecca Esparza, Sandi Gulbransen, Lotte Haverman, Yuchen Li, Carolyn Petersen, Ameeta Retzer, Christopher Sidey-Gibbons, Angela M. Stover, Elissa Thorner, Garrett Ursin, Galina Velikova, Elliott Sparkman Walker, Michael Brundage, Claire Snyder
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Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Marie-France Hivert, Frédérique White, Catherine Allard, Kaitlyn James, Sana Majid, François Aguet, Kristin G. Ardlie, Jose C. Florez, Andrea G. Edlow, Luigi Bouchard, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe
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Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Fei Tian, Dong Liu, Na Wei, Qianqian Fu, Lin Sun, Wei Liu, Xiaolong Sui, Kathryn Tian, Genevieve Nemeth, Jingyu Feng, Jingjing Xu, Lin Xiao, Junya Han, Jingjie Fu, Yinhua Shi, Yichen Yang, Jia Liu, Chunhong Hu, Bin Feng, Yan Sun, Yunjun Wang, Guohua Yu, Dalu Kong, Meiyun Wang, Wencai Li, Kexin Chen, Xiangchun Li
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Transparent medical image AI via an image–text foundation model grounded in medical literature Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Chanwoo Kim, Soham U. Gadgil, Alex J. DeGrave, Jesutofunmi A. Omiye, Zhuo Ran Cai, Roxana Daneshjou, Su-In Lee
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Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-15 Gennaro Pagano, Kirsten I. Taylor, Judith Anzures Cabrera, Tanya Simuni, Kenneth Marek, Ronald B. Postuma, Nicola Pavese, Fabrizio Stocchi, Kathrin Brockmann, Hanno Svoboda, Dylan Trundell, Annabelle Monnet, Rachelle Doody, Paulo Fontoura, Geoffrey A. Kerchner, Patrik Brundin, Tania Nikolcheva, Azad Bonni
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How to communicate about climate change with patients BMJ (IF 105.7) Pub Date : 2024-04-17 John Kotcher, Lisa Patel, Stefan Wheat, Rebecca Philipsborn, Edward Maibach
### What you need to know Climate change is arguably the most significant global health threat of the 21st century.1 Despite the increasingly visible impacts of climate change on our lives and health, conversations about climate change seem to have been shut out of the consultation. Where time and resources are under pressure, there may be little room for wider health promotion and conversations about
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John Launer: Learning from appraisals BMJ (IF 105.7) Pub Date : 2024-04-17 John Launer
I’ve been a GP appraiser for around 20 years, more or less since appraisals were introduced. I’ve appraised colleagues across the professional spectrum, from those in serious trouble with the General Medical Council to deans of medical schools who happened to be GPs. I’ve also had many appraisals myself. Some of these have been inspiring and influential on my career, while others have been humdrum
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Health literacy matters BMJ (IF 105.7) Pub Date : 2024-04-17 Tessa Richards
New initiatives to boost health literacy in populations and organisations need broad input from patients and the public, says Tessa Richards “Sunshine, rest, exercise, diet, friends, and self-confidence” are the “six best doctors in the world,” is a popular quote. As a patient with multiple long term conditions, I’d add “peer support” to that list. I know from firsthand experience how the solidarity
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Helen Salisbury: With the NHS in crisis, why is Labour looking to private hospitals as the solution? BMJ (IF 105.7) Pub Date : 2024-04-17 Helen Salisbury
This week the shadow health secretary, Wes Streeting, promised to bring in the private sector to help reduce NHS waiting lists. He also stated that no extra resources would be available for the health service under a Labour government.1 One of the problems with this plan is that it assumes separate sets of doctors and nurses in the NHS and the private sector, with the latter group currently underemployed
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Breaking free from the stigma of diabetes BMJ (IF 105.7) Pub Date : 2024-04-17 Jazz Sethi
Stigma has tangible consequences for clinical outcomes, quality of life, and wellbeing of people with living with diabetes, says Jazz Sethi Have you ever felt the cold prickle of eyes staring at you as they silently pass judgment? Stigma is a term that carries the weight of unsaid words. And while the Oxford Dictionary might define it neatly, its repercussions are messier and more tangible in daily
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Public awareness campaign on risks of accessing weight loss surgery overseas is crucial BMJ (IF 105.7) Pub Date : 2024-04-16 Sala Abdalla
Patients need clearer warnings about the risks of having surgery abroad.1 Health tourism in weight loss and aesthetic surgery is happening with accelerating frequency. In the past few months I have had to manage several patients who had bariatric and aesthetic surgery abroad and returned with complications. I hear stories from patients about advertising that lures them to clinics …
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Concerns over physician associates are missing the wood for the trees BMJ (IF 105.7) Pub Date : 2024-04-17 Morton M Warner
Mafi, Oliver, and Salisbury identify myriad problems with the expanding workforce of physician associates (PAs).123 “Form follows function” has long been the mantra of architects. The NHS should adopt it when planning the future role of PAs. There has never been a clear policy on the clinical needs PAs should respond to or where they should be located …
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Closing the gender health gap: a £39bn boost to the economy, as well as lives BMJ (IF 105.7) Pub Date : 2024-04-17 Sarah Graham
The UK has the 12th largest gender health gap in the world. Closing it will require investment, but would also reap rewards for women and the country, reports Sarah Graham Closing the gender health gap by 2040 could add almost £39bn to the UK economy and give each British woman around 9.5 more days of good health a year. That’s according to data shared with The BMJ by the McKinsey Health Institute
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Child health: UK must regain “lost ground,” Kingdon urges next government BMJ (IF 105.7) Pub Date : 2024-04-17 Gareth Iacobucci
The outgoing RCPCH president is “ashamed” of the state of child health in the UK, she tells Gareth Iacobucci . But there are quick wins and more ambitious ideas that could turn things around with the right political will “I am a very optimistic, glass half full person. But I think we’re in a really bad position in terms of child health in this country,” says Camilla Kingdon. After a proactive three
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Not only a Western world issue: Cancer incidence in younger individuals in the United Arab Emirates CA: Cancer J. Clin. (IF 254.7) Pub Date : 2024-04-16 Humaid O. Al-Shamsi, Khaled M. Musallam
Two important reports regarding cancer incidence in the United States1 and globally2 have been recently released. In summary, almost 20 million people worldwide were diagnosed with cancer in 2022, and almost 10 million died of their disease.2 Lung cancer is the most common cancer globally, followed by female breast, colorectal, prostate, and stomach cancers. For women, breast cancer is the most common
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TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods BMJ (IF 105.7) Pub Date : 2024-04-16 Gary S Collins, Karel G M Moons, Paula Dhiman, Richard D Riley, Andrew L Beam, Ben Van Calster, Marzyeh Ghassemi, Xiaoxuan Liu, Johannes B Reitsma, Maarten van Smeden, Anne-Laure Boulesteix, Jennifer Catherine Camaradou, Leo Anthony Celi, Spiros Denaxas, Alastair K Denniston, Ben Glocker, Robert M Golub, Hugh Harvey, Georg Heinze, Michael M Hoffman, André Pascal Kengne, Emily Lam, Naomi Lee, Elizabeth
The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) statement was published in 2015 to provide the minimum reporting recommendations for studies developing or evaluating the performance of a prediction model. Methodological advances in the field of prediction have since included the widespread use of artificial intelligence (AI) powered by machine
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Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease BMJ (IF 105.7) Pub Date : 2024-04-15 Thomas Alexander Gerds, Pietro Ravani
The risk prediction model for kidney failure and death in people with chronic kidney disease (CKD) presented in the linked study is a super learner. A super learner is an algorithm that repeatedly splits the data into training and test sets and then chooses the best performing model from a list of candidate prediction models. This article describes why and how the super learner was implemented in the
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Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease: multinational, longitudinal, population based, cohort study BMJ (IF 105.7) Pub Date : 2024-04-15 Ping Liu, Simon Sawhney, Uffe Heide-Jørgensen, Robert Ross Quinn, Simon Kok Jensen, Andrew Mclean, Christian Fynbo Christiansen, Thomas Alexander Gerds, Pietro Ravani
Objective To train and test a super learner strategy for risk prediction of kidney failure and mortality in people with incident moderate to severe chronic kidney disease (stage G3b to G4). Design Multinational, longitudinal, population based, cohort study. Settings Linked population health data from Canada (training and temporal testing), and Denmark and Scotland (geographical testing). Participants
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Alternative routes into clinical research: a guide for early career doctors BMJ (IF 105.7) Pub Date : 2024-04-16 Phillip LR Nicolson, Martha Belete, Rebecca Hawes, Nicole Fowler, Cheng Hock Toh
Working in clinical research alongside clinical practice can make for a rewarding and worthwhile career.123 Building research into a clinical career starts with research training for early and mid-career doctors. Traditional research training typically involves a dedicated period within an integrated clinical academic training programme or as part of an externally funded MD or PhD degree. Informal
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Why the fuss about physician associates? BMJ (IF 105.7) Pub Date : 2024-04-16 Margaret McCartney
Features of the debate around physician associates (PAs) have crystallised a range of underlying problems in the NHS into a lightning rod. This now has serious implications for the future of general practice and the medical profession itself. Unless we look back and understand why we have medical royal colleges and regulation we risk further alienating doctors—current and future. To be clear: my argument
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Making the black box more transparent: improving the reporting of artificial intelligence studies in healthcare BMJ (IF 105.7) Pub Date : 2024-04-16 Gary S Collins
The updated TRIPOD+AI reporting guidelines can help guide the writing of research on artificial intelligence in healthcare to improve the transparency and usefulness of reporting As a scientist, when I read a paper I want to know why and how a piece of research was carried out, what the results are, what they mean, and what are the implications of the findings. But incomplete and poor reporting is
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Predicting the outcomes of chronic kidney disease in older adults BMJ (IF 105.7) Pub Date : 2024-04-15 Andre Pascal Kengne, Cindy George, Oluwatoyin Idaomeh Ameh
Clinical prediction models use mathematical functions to combine information from an individual’s characteristics and use the resulting output to estimate the chances that a condition of interest is present (diagnostic models) or will occur in the future (prognostic models).1 These estimates are in turn used to start or withhold treatments, to order new tests, or to educate individuals on their condition’s
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TRIPOD+AI: an updated reporting guideline for clinical prediction models BMJ (IF 105.7) Pub Date : 2024-04-16 Jérémie F Cohen, Patrick M M Bossuyt
New update promotes best practice in this important area of clinical research Clinical prediction models emerged in the 1990s as tools to support medical decision making through individual diagnostic and prognostic predictions based on structured clinical information. Clinical prediction rules such as the FeverPAIN score for pharyngitis1 or the PECARN rule for children with head trauma2 are based on
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Refocusing the World Health Organization’s Model List of Essential Medicines on the needs of low and middle income countries BMJ (IF 105.7) Pub Date : 2024-04-16 Veronika J Wirtz, Andrew L Gray, Sangeeta Sharma, Jing Sun, Hans V Hogerzeil
In the wake of escalating medicine prices worldwide, Veronika Wirtz and colleagues argue for refocusing the WHO Model List of Essential Medicines on the needs of low and middle income countries, while retaining its global relevance as a model process ### Key messages First published in 1977, the World Health Organization (WHO) Model List of Essential Medicines has been one of the most effective and
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BCR signaling is required for posttransplant lymphoproliferative disease in immunodeficient mice receiving human B cells Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-10 Ting-ting Zhang, Rene Yu-Hong Cheng, Andee R. Ott, Noelle P. Dahl, Emmaline R. Suchland, Claire M. Stoffers, Gregory D. Asher, Deyin Hou, Christopher D. Thouvenel, Tyler F. Hill, David J. Rawlings, Richard G. James
Posttransplant lymphoproliferative disease (PTLD) is a major therapeutic challenge that has been difficult to study using human cells because of a lack of suitable models for mechanistic characterization. Here, we show that ex vivo–differentiated B cells isolated from a subset of healthy donors can elicit pathologies similar to PTLD when transferred into immunodeficient mice. The primary driver of
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Planetary health: challenging power and privilege is key to a fairer and healthier future BMJ (IF 105.7) Pub Date : 2024-04-15 Sophie Gepp, Melvine Anyango Otieno, Kent Buse
As the 6th Planetary Health Annual Meeting begins in Kuala Lumpur, Sophie Gepp and colleagues commend progress in the field of planetary health but call for greater accountability of organisations to ensure planetary health justice This year marks the 15th anniversary of the first publication of the framework of “planetary boundaries,” which describes the biophysical limits of Earth systems that, if
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Sudan is facing a devastating humanitarian crisis—the world must do more to protect the population’s health BMJ (IF 105.7) Pub Date : 2024-04-15 Tedros Adhanom Ghebreyesus
It’s been one year since war broke out in Sudan. The country is facing a devastating humanitarian crisis, which is not attracting sufficient attention from the international community or media headlines. Half of the population, or 25 million people, are in need of humanitarian assistance.1 Over 8.6 million people are displaced within Sudan and in neighbouring countries.2 Many of them have been forced
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How can I deal with the death of a patient? BMJ (IF 105.7) Pub Date : 2024-04-15 Abi Rimmer
It is not unusual or unprofessional to feel a sense of loss when a patient dies and there are ways to deal with it, Abi Rimmer hears Ollie Minton, Macmillan consultant in palliative medicine, University Hospitals Sussex NHS Foundation Trust, and national end of life adviser, Macmillan cancer support, says, “I don’t think it’s unreasonable to express emotion at work—within reason—and this should include
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Serious Bleeding in Patients With Atrial Fibrillation Using Diltiazem With Apixaban or Rivaroxaban JAMA (IF 120.7) Pub Date : 2024-04-15 Wayne A. Ray, Cecilia P. Chung, C. Michael Stein, Walter Smalley, Eli Zimmerman, William D. Dupont, Adriana M. Hung, James R. Daugherty, Alyson Dickson, Katherine T. Murray
ImportanceDiltiazem, a commonly prescribed ventricular rate–control medication for patients with atrial fibrillation, inhibits apixaban and rivaroxaban elimination, possibly causing overanticoagulation.ObjectiveTo compare serious bleeding risk for new users of apixaban or rivaroxaban with atrial fibrillation treated with diltiazem or metoprolol.Design, Setting, and ParticipantsThis retrospective cohort
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Protecting Privacy of Pregnant and LGBTQ+ Research Participants JAMA (IF 120.7) Pub Date : 2024-04-15 Ellen Wright Clayton, Harris T. Bland, Kathleen F. Mittendorf
This Viewpoint summarizes existing federal regulations aimed at protecting research data, describes the challenges of enforcing these regulations, and discusses how evolving privacy technologies could be used to reduce health disparities and advance health equity among pregnant and LGBTQ+ research participants.
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Leave of Absence and Medical Student Placement Into Graduate Medical Education by Race and Ethnicity JAMA (IF 120.7) Pub Date : 2024-04-15 Mytien Nguyen, Hyacinth R. C. Mason, Regina Russell, Tonya Fancher, Sarwat I. Chaudhry, Mayur M. Desai, Dowin Boatright
This study examines the association between taking a leave of absence from medical school and placement into graduate medical education (GME) by race and ethnicity.
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Does This Infant Have a Dislocated Hip? JAMA (IF 120.7) Pub Date : 2024-04-15 Abhinav Singh, Ryckie George Wade, David Metcalfe, Daniel C. Perry
ImportanceDelayed diagnosis of a dislocated hip in infants can lead to complex childhood surgery, interruption to family life, and premature osteoarthritis.ObjectiveTo evaluate the diagnostic accuracy of clinical examination in identifying dislocated hips in infants.Data SourcesSystematic search of CINAHL, Embase, MEDLINE, and the Cochrane Library from the inception of each database until October 31
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Twenty-Five Years after Columbine — Firearms and Public Health in the United States N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-13 David Hemenway From the Harvard T.H. Chan School of Public Health, Boston.
Since the Columbine shooting, the gun problem in the United States has worsened, and the Supreme Court’s new interpretations of the Second Amendment don’t help. But there are some reasons for hope.
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Advocating for a Healthy Response to Climate Change — COP28 and the Health Community N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-13 Jeni Miller, Courtney Howard, and Lujain Alqodmani From the Global Climate and Health Alliance, Berkeley, CA (J.M., C.H.), the Department of Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, and Stanton Territorial Hospital, Yellowknife, NT — both in Canada (C.H.), the World Medical Association, Ferney-Voltaire, France, and EAT, Vienna (L.A.).
At the recent COP28 climate negotiations in Dubai, participants from the health care and public health communities advocated for a focus on both health and phasing out of fossil fuels.
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Silver Resident N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-13 Farrin A. Manian From the Department of Medicine, Mercy Hospital, St. Louis.
Increasingly, lifelong learning is not an option but a necessity, even for senior clinician educators. What should the roles — and goals — of such “silver residents” be?
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Expanding Applications of Clinical Genetic Testing — Ethical Challenges N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-13 Stephanie M. Fullerton, and Kyle B. Brothers From the Department of Bioethics and Humanities, University of Washington School of Medicine, Seattle (S.M.F.), and the Norton Children’s Research Institute, University of Louisville School of Medicine, Louisville, KY (K.B.B.).
The widening scope and scale of genetic tests are posing new challenges, and the need to address these challenges is becoming immediately relevant for all clinicians, not just genetics experts.
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Hemotympanum with a Basilar Skull Fracture N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-13 Carlos Carazo Casas, and Marimar Medina Gonzalez Hospital Universitario Ramón y Cajal, Madrid, Spain
A 15-year-old boy presented with a 1-hour history of hearing loss and pain in the left ear after he had tripped and fallen on the street. An otoscopic examination of the left ear showed blood behin...
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When I use a word . . . Medical eggcorns BMJ (IF 105.7) Pub Date : 2024-04-12 Jeffrey K Aronson
There are many different types of verbal errors that people make from time to time. They include folk etymology, mondegreens, and malapropisms. Eggcorns are verbal errors in which a word is replaced by another that sounds like it and typically shares with it some semantic connotation. Old-timer’s disease for Alzheimer’s is a good example. In this week’s column I list and discuss some medical examples
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Designer antibiotics by generative AI Nat. Med. (IF 82.9) Pub Date : 2024-04-12
Researchers developed an AI model that designs novel, synthesizable antibiotic compounds — several of which showed potent in vitro activity against priority pathogens.
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How on earth did I miss that? BMJ (IF 105.7) Pub Date : 2024-04-11 Giles Maskell
Radiological errors will always happen, writes Giles Maskell. Acknowledging that is not the same as complacency I have been speaking to radiologists about error for several years. Recently I have had the opportunity to discuss the issues with other groups including lawyers, journalists, and regulators. Two questions tend to recur in these conversations. The first concerns the existence of an “acceptable”
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Choosing Wisely in a time of resource constraints BMJ (IF 105.7) Pub Date : 2024-04-12 Karen B. Born, Wendy Levinson, C S Pramesh, Eve A. Kerr
Healthcare systems globally are facing multiple intersecting and overlapping crises including unprecedented resource constraints and a burnt out, demoralised workforce.1 Clinicians are being asked to do more with less in the face of backlogs in access to services alongside rising health inequalities and increases in patient complexity. Evidence based ways to curb wasteful spending and encourage sustainability
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Haytox: what is the evidence for a Botox spray for hay fever? BMJ (IF 105.7) Pub Date : 2024-04-12 Sangeetha Nadarajah
A popular Botox nasal spray for hay fever is the subject of bold claims despite a lack of clinical evidence, reports Sangeetha Nadarajah A spray treatment has gained popularity among people with hay fever in Australia and the UK over the past two years.1 It is administered in clinic to the nasal passage as an aerosol through a disposable intranasal atomiser device typically used to administer emergency
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Sustainability is critical for future proofing the NHS BMJ (IF 105.7) Pub Date : 2024-04-11 Rita Issa, Callum Forbes, Catherine Baker, Matt Morgan, Kate Womersley, Bob Klaber, Elaine Mulcahy, Rachel Stancliffe
Interventions that consider climate change, sustainability, and nature should be integral to health system functioning. Placing sustainability at the core of the NHS’s future offers opportunities to deliver better services, support healthier populations, and save costs. The combined threats of climate change and biodiversity loss are a global public health emergency requiring urgent attention.12 The
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NHS and the whole of society must act on social determinants of health for a healthier future BMJ (IF 105.7) Pub Date : 2024-04-11 Lucinda Hiam, Bob Klaber, Annabel Sowemimo, Michael Marmot
Health is going in the wrong direction in the UK, and reversing the trend requires political and societal commitment to deal with the underlying causes The UK is facing a prolonged and serious health crisis. At a time when the future of the NHS is in jeopardy after over a decade of austerity, and with public satisfaction at an all time low,1 it must pick up the pieces of failures across government
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Produce Prescriptions Sound Good, but Data to Support Them Is Lacking—That Could Soon Change JAMA (IF 120.7) Pub Date : 2024-04-12 Maryn McKenna
This Medical News article discusses research initiatives to support produce prescriptions and other “food is medicine” nutrition programs in health care settings.
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Non–High-Density Lipoprotein Cholesterol Levels From Childhood to Adulthood and Cardiovascular Disease Events JAMA (IF 120.7) Pub Date : 2024-04-12 Feitong Wu, David R. Jacobs, Stephen R. Daniels, Mika Kähönen, Jessica G. Woo, Alan R. Sinaiko, Jorma S. A. Viikari, Lydia A. Bazzano, Julia Steinberger, Elaine M. Urbina, Alison J. Venn, Olli T. Raitakari, Terence Dwyer, Markus Juonala, Costan G. Magnussen
ImportanceElevated non–high-density lipoprotein cholesterol (non–HDL-C; a recommended measure of lipid-related cardiovascular risk) is common in children and increases risk of adult cardiovascular disease (CVD). Whether resolution of elevated childhood non–HDL-C levels by adulthood is associated with reduced risk of clinical CVD events is unknown.ObjectiveTo examine the associations of non–HDL-C status
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Why diversity is needed at every level of clinical trials, from participants to leaders Nat. Med. (IF 82.9) Pub Date : 2024-04-11 Khadijah Breathett
Diversity in clinical trials must be accompanied by justice and equity, including benefits for underrepresented participants, in order to boost population health.
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Functional precision medicine for pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-04-11 M. Emmy M. Dolman, Paul G. Ekert
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Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-04-11 Arlet M. Acanda De La Rocha, Noah E. Berlow, Maggie Fader, Ebony R. Coats, Cima Saghira, Paula S. Espinal, Jeanette Galano, Ziad Khatib, Haneen Abdella, Ossama M. Maher, Yana Vorontsova, Cristina M. Andrade-Feraud, Aimee Daccache, Alexa Jacome, Victoria Reis, Baylee Holcomb, Yasmin Ghurani, Lilliam Rimblas, Tomás R. Guilarte, Nan Hu, Daria Salyakina, Diana J. Azzam
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Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-10 Zilong Bai, Nicholas Bartelo, Maryam Aslam, Elisabeth A. Murphy, Caryn R. Hale, Nathalie E. Blachere, Salina Parveen, Edoardo Spolaore, Edward DiCarlo, Ellen M. Gravallese, Melanie H. Smith, Accelerating Medicines Partnership RA/SLE Network, Mayu O. Frank, Caroline S. Jiang, Haotan Zhang, Christina Pyrgaki, Myles J. Lewis, Shafaq Sikandar, Costantino Pitzalis, Joseph B. Lesnak, Khadijah Mazhar, Theodore
It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in the synovium; however, recent studies reveal that pain scores in patients do not correlate with synovial inflammation. We developed a machine-learning approach (graph-based gene expression module identification or GbGMI) to identify an 815-gene expression module associated with pain in synovial biopsy samples
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Integrating Public Health and Health Care — Protecting Health as a Team Sport N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-10 Charlene A. Wong, Debra Houry, and Mandy K. Cohen From the Centers for Disease Control and Prevention, Atlanta.
Protecting health is a team sport — yet the public health and clinical care systems meant to advance this goal have been siloed for too long.
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Corporate Medicine 2.0 — Special Purpose Acquisition Companies in the United States N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-10 Nishant Uppal, and Zirui Song From the Department of Medicine, Brigham and Women’s Hospital (N.U.), the Department of Health Care Policy and the Center for Primary Care, Harvard Medical School (Z.S.), and the Department of Medicine, Massachusetts General Hospital (Z.S.) — all in Boston.
So-called special purpose acquisition companies represent a new phase in the corporatization of medicine, and their activities could have implications for providers, patients, and policymakers.
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Walking the Dog N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-11
This podcast episode considers what happens when the rigors of training and the pursuit of excellence in medicine collide with the mental health needs of trainees.
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Case 11-2024: An 82-Year-Old Woman with Falls and Cognitive Decline N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-11 Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, and Tara Corpuz, Sharon A. Chung, Ambrose J. Huang, Mandakolathur R. Murali, Bart K. Chwalisz, Zachary S. Wallace, and Liana N. Kozanno From the Department of Medicine, University of California, San Francisco, San Francisco (S.A.C.), and the Departments
An 82-year-old woman was admitted because of difficulty walking, falls, and cognitive decline. Light touch of the right hand, right knee, and both feet caused pain. A diagnosis was made.
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Central Cyanosis in Acquired Methemoglobinemia N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-11 Pankaj Das, and Gautam Singh Base Hospital Delhi Cantt, Delhi, India
A 35-year-old man being treated for leprosy presented with a 4-day history of anxiety, insomnia, and resting tremor of the hands and feet. Bluish discoloration of the lips and tongue was seen on ex...
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Money as Medicine — Clinicism, Cash Transfers, and the Political–Economic Determinants of Health N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-11 Debra Malina, Eric Reinhart From the Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago.
Cash transfers to individuals that the U.S. government made during the Covid pandemic demonstrated how such a policy tool could help address the political–economic determinants of health.
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Adjuvant Alectinib in ALK-Rearranged NSCLC — Here and Now N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-11 Antonio Passaro, and Solange Peters From the Division of Thoracic Oncology, European Institute of Oncology IRCCS, Milan (A.P.), and Lausanne University Hospital, Lausanne, Switzerland (S.P.).
In 2009, the groundbreaking Iressa Pan-Asia Study (IPASS)1 showed the activity of gefitinib, a first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), and marked a...
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CAR T-Cell Therapy for Glioblastoma N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-11 Elizabeth G. Phimister, Misty R. Jenkins, and Katharine J. Drummond From the Immunology Division, Walter and Eliza Hall Institute, and the Department of Medical Biology, University of Melbourne, Parkville, VIC (M.R.J.), and the Department of Surgery, University of Melbourne, Melbourne, VIC (K.J.D.) — all in Australia.
Glioblastoma is the most formidable of primary brain tumors, owing to its aggressive nature and the limited efficacy of the best available treatment, which comprises maximal safe surgical resection...