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Transcription factor DUO1 generated by neo-functionalization is associated with evolution of sperm differentiation in plants.
Nature Communications ( IF 16.6 ) Pub Date : 2018-12-11 , DOI: 10.1038/s41467-018-07728-3
Asuka Higo 1 , Tomokazu Kawashima 2, 3 , Michael Borg 2 , Mingmin Zhao 4 , Irene López-Vidriero 5 , Hidetoshi Sakayama 6 , Sean A Montgomery 2 , Hiroyuki Sekimoto 7 , Dieter Hackenberg 4 , Masaki Shimamura 8 , Tomoaki Nishiyama 9 , Keiko Sakakibara 10 , Yuki Tomita 1 , Taisuke Togawa 11 , Kan Kunimoto 1 , Akihisa Osakabe 2 , Yutaka Suzuki 12 , Katsuyuki T Yamato 11 , Kimitsune Ishizaki 6 , Ryuichi Nishihama 1 , Takayuki Kohchi 1 , José M Franco-Zorrilla 5 , David Twell 4 , Frédéric Berger 2 , Takashi Araki 1
Affiliation  

Evolutionary mechanisms underlying innovation of cell types have remained largely unclear. In multicellular eukaryotes, the evolutionary molecular origin of sperm differentiation is unknown in most lineages. Here, we report that in algal ancestors of land plants, changes in the DNA-binding domain of the ancestor of the MYB transcription factor DUO1 enabled the recognition of a new cis-regulatory element. This event led to the differentiation of motile sperm. After neo-functionalization, DUO1 acquired sperm lineage-specific expression in the common ancestor of land plants. Subsequently the downstream network of DUO1 was rewired leading to sperm with distinct morphologies. Conjugating green algae, a sister group of land plants, accumulated mutations in the DNA-binding domain of DUO1 and lost sperm differentiation. Our findings suggest that the emergence of DUO1 was the defining event in the evolution of sperm differentiation and the varied modes of sexual reproduction in the land plant lineage.

中文翻译:

新功能化产生的转录因子DUO1与植物精子分化的进化有关。

细胞类型创新的潜在进化机制在很大程度上尚不清楚。在多细胞真核生物中,大多数谱系中尚不清楚精子分化的进化分子起源。在这里,我们报告说,在陆地植物的藻类祖先中,MYB转录因子DUO1祖先的DNA结合结构域的变化使得能够识别新的顺式调控元件。该事件导致活动精子的分化。新功能化后,DUO1在陆地植物的共同祖先中获得了精子谱系特异性表达。随后,DUO1的下游网络被重新布线,形成具有不同形态的精子。与陆地植物的姐妹群绿藻结合时,在DUO1的DNA结合域中积累了突变,并失去了精子的分化能力。
更新日期:2018-12-11
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