Physical activity and sleep duration are established risk factors for many diseases, but their aetiology is poorly understood, partly due to relying on self-reported evidence. Here we report a genome-wide association study (GWAS) of device-measured physical activity and sleep duration in 91,105 UK Biobank participants, finding 14 significant loci (7 novel). These loci account for 0.06% of activity and 0.39% of sleep duration variation. Genome-wide estimates of ~ 15% phenotypic variation indicate high polygenicity. Heritability is higher in women than men for overall activity (23 vs. 20%, p = 1.5 × 10^-4) and sedentary behaviours (18 vs. 15%, p = 9.7 × 10^-4). Heritability partitioning, enrichment and pathway analyses indicate the central nervous system plays a role in activity behaviours. Two-sample Mendelian randomisation suggests that increased activity might causally lower diastolic blood pressure (beta mmHg/SD: -0.91, SE = 0.18, p = 8.2 × 10^-7), and odds of hypertension (Odds ratio/SD: 0.84, SE = 0.03, p = 4.9 × 10^-8). Our results advocate the value of physical activity for reducing blood pressure.

中文翻译：

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GWAS 确定了设备测量的体力活动和睡眠持续时间的 14 个位点。

体力活动和睡眠时间是许多疾病的既定危险因素，但人们对它们的病因知之甚少，部分原因是依赖自我报告的证据。在此，我们报告了一项全基因组关联研究 (GWAS)，该研究对 91,105 名英国生物银行参与者进行了设备测量的体力活动和睡眠持续时间，发现了 14 个显着基因座（其中 7 个是新基因座）。这些位点占活动变化的 0.06% 和睡眠持续时间变化的 0.39%。全基因组估计约 15% 的表型变异表明高度多基因性。^{在整体活动（23 vs. 20%，p = 1.5 × 10 -4}）和久坐行为（18 vs. 15%，p = 9.7 × 10 ^-4）方面，女性的遗传力高于男性。遗传力划分、富集和通路分析表明中枢神经系统在活动行为中发挥作用。两个样本孟德尔随机化表明，增加活动可能会降低舒张压（β mmHg/SD：-0.91，SE = 0.18，p = 8.2 × 10 ^-7）和高血压的几率（比值比/SD：0.84，SE = 0.03，p = 4.9 × 10 ^-8）。我们的结果倡导了体力活动对于降低血压的价值。