Continuous hydrogenation using ACMC-Pd monolith catalysts was studied for four chemistries of industrial interest. The chemistry was run in a 30.5 cm catalyst bed with repeated passes to simulate a longer commercial catalyst bed in which >97% conversion would be completed in a single pass of the reactor with no recycle. The selected liquid flow rate (0.086 cm/s) enabled >97% conversion for the four chemistries using practical ranges of temperature (60–180 °C), pressure (0.348 to 3.48 MPa), and required bed lengths (4.3 to 6.1 m). The unsaturated bonds hydrogenated included nitro, carbonyl, olefin, and aromatic bond types. The most challenging reaction was the conversion of a neat olefinic/aromatic substrate (requiring 7 moles of hydrogen per mole of product) run with a low-temperature/high-temperature reactor configuration. The same catalyst was used for all of the chemistries, and the changeover from one chemistry to another involved simple solvent/substrate rinses of the reactor. The data can be used to estimate the number of commercial reactor tubes, temperature, pressure, and bed length needed for the production of commercial quantities of specialty and pharmaceutical chemicals.

中文翻译：

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使用ACMC-Pd代替工业间歇反应器过程的连续加氢过程的运行参数

研究了使用ACMC-Pd整体催化剂进行的连续加氢反应，从而获得了四种具有工业价值的化学方法。化学反应在30.5 cm的催化剂床上进行，并进行多次通过，以模拟更长的商业催化剂床，其中单次通过反应器即可完成> 97％的转化率，而无需循环使用。选择的液体流速（0.086 cm / s），可以在温度（60–180°C），压力（0.348至3.48 MPa）和所需床长（4.3至6.1 m）的实际范围内对四种化学物质进行> 97％的转化）。氢化的不饱和键包括硝基，羰基，烯烃和芳族键类型。最具挑战性的反应是在低温/高温反应器配置下运行的纯烯烃/芳族底物的转化（每摩尔产物需要7摩尔氢）。相同的催化剂用于所有化学反应，从一种化学反应到另一种化学反应的转换涉及反应器的简单溶剂/底物冲洗。该数据可用于估计商业化反应器管的数量，温度，压力和床长度，以生产商业量的特种和医药化学品。