In this paper, a catalyst‐free procedure is described for the synthesis of novel carboxamide derivatives through a one pot five‐component reaction of cycloalkylidene‐substituted Meldrum's acid, alkyl isocyanide, and 4,4′‐methylene‐ or 4,4′‐oxydianiline. Any by‐product was not prepared through this reaction, and products were separated by a simple work‐up procedure. The other noticeable benefits of this procedure are good yields, mild reaction conditions and use of available materials.

中文翻译：

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基于异氰化物的多组分反应：一锅无催化剂的羧酰胺合成

在本文中，描述了一种无催化剂的方法，该方法通过环亚烷基取代的麦德鲁姆酸，烷基异氰化物和4,4'-亚甲基或4,4'-的一锅五组分反应合成新型羧酰胺衍生物。羟二苯胺。没有通过该反应制备任何副产物，并且通过简单的后处理程序分离了产物。该方法的其他显着优势是产率高，反应条件温和以及使用可用材料。