Transition metal dichalcogenide (TMD) nanosheets have evoked enormous research enthusiasm and have shown increased potentials in the biomedical field. However, a great challenge lies in high-throughput, large-scale, and eco-friendly preparation of TMD nanosheet dispersions with high quality. Herein, we report a universal polyphenol-assisted strategy to facilely exfoliate various TMDs into monolayer or few-layer nanosheets. By optimizing the exfoliation condition of molybdenum disulfide (MoS₂), the yield and concentration of as-exfoliated nanosheets are up to 60.5% and 1.21 mg/mL, respectively. This is the most efficient aqueous exfoliation method at present and is versatile for the choices of polyphenols and TMD nanomaterials. The as-exfoliated MoS₂ nanosheets possess superior biomedical stability as nanocarriers to load antibiotic drugs. They show a high photothermal conversion effect and thus induce a synergetic effect of chemotherapy and photothermal therapy to harvest enhanced antibiofilm activity under near-infrared (NIR) light. All these results offer an appealing strategy toward the synthesis and application of ultrathin TMD nanosheets, with great implications for their development.

中文翻译：

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多酚辅助的过渡金属二硫属化合物剥落到纳米片中作为光热纳米载体增强抗生物膜活性。

过渡金属二卤化碳（TMD）纳米片引起了巨大的研究热情，并显示了在生物医学领域的巨大潜力。然而，巨大的挑战在于高质量的高通量，大规模和生态友好的TMD纳米片分散体的制备。在这里，我们报告了一种通用的多酚辅助策略，可以轻松地将各种TMD剥落成单层或几层纳米片。通过优化二硫化钼（MoS ₂）的剥落条件，剥落后的纳米片的产率和浓度分别高达60.5％和1.21 mg / mL。这是目前最有效的水性剥离方法，可用于多酚和TMD纳米材料的选择。脱落的MoS ₂纳米片具有优异的生物医学稳定性，可作为纳米载体来装载抗生素药物。它们显示出高的光热转化作用，从而诱导化学疗法和光热疗法的协同作用，从而在近红外（NIR）光下收获增强的抗生物膜活性。所有这些结果为超薄TMD纳米片的合成和应用提供了一种有吸引力的策略，对其发展具有重大意义。