Herein, we report the successful synthesis of a series of poly (N-isopropylacrylamide) (PNIPA)/layered double hydroxides (LDHs)/nano-hydroxyapatite (nano-HA) hydrogels via in-situ radical polymerization. The internal morphology, thermo sensitivity, rheological properties, swelling behavior and hemocompatibility of the PNIPA/LDHs/HA composite hydrogels were systematically investigated. Results show that the hydrogels had a reversible sol-gel transformation around 33 °C. Interactions between the positively charged LDHs and negatively charged nano-HA particles created a highly porous hydrogel network. The composite hydrogels exhibited excellent hemocompatibility, incredible mechanical toughness and reversible swelling/deswelling behavior. To our knowledge, this is the first reported study to use two types of inorganic nanoparticle with opposing charges as hydrogel crosslinking agents. Based on its properties, we expect this hydrogel has broad applications potential in tissue engineering, drug delivery and biosensor development.

在这里，我们报告通过原位自由基聚合成功合成了一系列聚（N-异丙基丙烯酰胺）（PNIPA）/层状双氢氧化物（LDHs）/纳米羟基磷灰石（nano-HA）水凝胶。系统研究了PNIPA / LDHs / HA复合水凝胶的内部形态，热敏性，流变特性，溶胀行为和血液相容性。结果表明，水凝胶在33°C左右具有可逆的溶胶-凝胶转变。带正电的LDH和带负电的纳米HA颗粒之间的相互作用产生了高度多孔的水凝胶网络。复合水凝胶显示出优异的血液相容性，令人难以置信的机械韧性和可逆的溶胀/溶胀行为。据我们所知，这是首次报道使用两种类型的带有相反电荷的无机纳米粒子作为水凝胶交联剂的研究。基于其特性，我们希望这种水凝胶在组织工程，药物输送和生物传感器开发中具有广泛的应用潜力。