The purpose of this study was to investigate the viscoelastic behaviors of cancer cells and normal cells using the micropipette aspiration technique combined with the standard linear viscoelastic solid model. The viscoelastic behaviors of pairs of cell lines (human skin cells and human skin cancer cells, human fetal lung fibroblasts and human lung cancer cells, human mammary fibroblasts and human breast cancer cells, and human hepatocyte cells and human hepatocellular carcinoma cells) were tested by the micropipette aspiration technique. The cellular viscoelastic parameters (the instantaneous modulus E₀, the equilibrium modulus associated with long term equilibrium E_∞, and the apparent viscosity μ) were calculated using a Kelvin standard linear viscoelastic solid model. The present results indicate that the cancer cells were easier to deform, and the viscoelastic parameters (E₀, E_∞, μ) of the cancer cells were significantly lower than their corresponding normal cells (P < 0.0001). The viscoelastic parameters (E₀, E_∞, μ) among some normal cells showed significant differences (P < 0.05), while the different cancer cells showed no significant differences (P > 0.05). These findings may be relevant for the identification and diagnosis of cancer cells as well as providing an explanation of this occurrence mechanism in cancer cells and cancer treatment.

这项研究的目的是使用微量移液器抽吸技术结合标准线性粘弹性固体模型研究癌细胞和正常细胞的粘弹性行为。通过以下方法测试了成对的细胞系（人类皮肤细胞和人类皮肤癌细胞，人类胎儿肺成纤维细胞和人类肺癌细胞，人类乳房成纤维细胞和人类乳腺癌细胞以及人类肝细胞和人类肝癌细胞）的粘弹性行为。微量移液器抽吸技术。蜂窝粘弹性参数（瞬时模量ë ₀，具有长期平衡相关联的平衡模量ë _∞，和表观粘度μ）是使用开尔文标准线性粘弹性固体模型计算的。本结果表明，癌细胞对变形比较容易，并且粘弹性参数（ê ₀，ê _∞，μ）的癌细胞比其相应的正常细胞（分别显著降低P <0.0001）。粘弹性参数（ê ₀，ê _∞，μ一些正常细胞中）显示显著差异（P <0.05），而不同的癌细胞没有显示出差异显著（P> 0.05）。这些发现可能与癌细胞的鉴定和诊断有关，并为癌细胞和癌症治疗中这种发生机制的解释提供了依据。