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Flexible heteroionic calcium-magnesium alginate beads for controlled drug release
Carbohydrate Polymers ( IF 11.2 ) Pub Date : 2018-11-30 , DOI: 10.1016/j.carbpol.2018.11.096
Noelia M. Sanchez-Ballester , Ian Soulairol , Bernard Bataille , Tahmer Sharkawi

In the present work heteroionic calcium-magnesium alginate beads have been prepared by ionotropic gelation using different Ca:Mg ratios. This simple and straightforward approach allowed the obtention of CaMg-alginate beads presenting different mechanical performance depending on the Mg:Ca ratio. The dynamic swelling behavior of the beads was investigated. Increase in the quantity of Mg2+ incorporated in the beads increased the rate of swelling at pH 1.2 and pH 7.2. Finally, the release of ibuprofen was investigated. It was found that increasing the Mg2+ present in the beads raised the drug release rate.



中文翻译:

柔性杂离子海藻酸钙镁微珠,可控药物释放

在本工作中,已经使用不同的Ca:Mg比通过离子凝胶法制备了异离子钙镁海藻酸盐微珠。这种简单明了的方法使得获得的CaMg-藻酸盐珠粒呈现出不同的机械性能,这取决于Mg:Ca的比例。研究了珠粒的动态溶胀行为。珠粒中Mg 2+掺入量的增加增加了在pH 1.2和pH 7.2下的溶胀速率。最后,研究了布洛芬的释放。发现增加存在于珠粒中的Mg 2+可以提高药物释放速率。

更新日期:2018-12-01
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