α-Helix proteomimetics such as oligobenzamides have been shown to successfully inhibit a broad array of protein–protein interactions (PPIs) mediated by α-helices. Here we report the synthesis of a protected oligobenzamide intermediate, which can be selectively deprotected and alkylated with desired side chains to rapidly afford a library of α-helix proteomimetics.

中文翻译：

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快速合成蛋白质组折叠剂的途径†

研究表明，α-螺旋蛋白模拟物（例如寡苯甲酰胺）可以成功抑制多种由α-螺旋介导的蛋白质-蛋白质相互作用（PPI）。在这里，我们报告了一种受保护的低聚苯甲酰胺中间体的合成，该中间体可以选择性地脱保护并用所需的侧链烷基化，以快速提供α-螺旋蛋白模拟物的文库。